ZA200501082B - Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof - Google Patents

Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof

Info

Publication number: ZA200501082B
Authority: ZA; South Africa
Prior art keywords: derivatives; diphenylprop; substituted; preparation; concerns
Prior art date: 2002-07-08

Application number

ZA200501082A

Other languages

English (en)

Inventor

Najib Jamila

Caumont-Bertrand Karine

Original Assignee

Genfit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-08

Filing date

2005-02-07

Publication date

2007-01-31

2005-02-07 Application filed by Genfit filed Critical Genfit

2007-01-31 Publication of ZA200501082B publication Critical patent/ZA200501082B/xx

Links

DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 title abstract 2
201000006474 Brain Ischemia Diseases 0.000 abstract 1
206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

ZA200501082A 2002-07-08 2005-02-07 Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof ZA200501082B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0208571A FR2841900B1 (fr)	2002-07-08	2002-07-08	Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations

Publications (1)

Publication Number	Publication Date
ZA200501082B true ZA200501082B (en)	2007-01-31

Family

ID=29725283

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501082A ZA200501082B (en)	2002-07-08	2005-02-07	Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof

Country Status (24)

Country	Link
US (3)	US7943661B2 (de)
EP (1)	EP1525177B1 (de)
JP (1)	JP4575771B2 (de)
KR (1)	KR100974577B1 (de)
CN (1)	CN100548960C (de)
AT (1)	ATE365703T1 (de)
AU (1)	AU2003264698B2 (de)
BR (1)	BRPI0312398B8 (de)
CA (1)	CA2490986C (de)
CY (1)	CY1108085T1 (de)
DE (1)	DE60314633T2 (de)
DK (1)	DK1525177T3 (de)
EA (1)	EA011090B1 (de)
ES (1)	ES2287528T3 (de)
FR (1)	FR2841900B1 (de)
IL (2)	IL165696A0 (de)
MX (1)	MXPA05000427A (de)
NO (1)	NO329700B1 (de)
NZ (1)	NZ538051A (de)
PL (1)	PL207362B1 (de)
PT (1)	PT1525177E (de)
SI (1)	SI1525177T1 (de)
WO (1)	WO2004005233A1 (de)
ZA (1)	ZA200501082B (de)

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FR2841900B1 (fr)	2002-07-08	2007-03-02	Genfit S A	Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr)	2002-07-08	2007-03-02		Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
US7547729B2 (en) *	2004-01-08	2009-06-16	Genfit	1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same
FR2902789A1 (fr)	2006-06-21	2007-12-28	Genfit Sa	Derives de 1,3-diphenylpropane substitues, preparations et utilisations
US20100285126A1 (en) *	2007-08-02	2010-11-11	Rahul Dabre	Pharmaceutical compositions of fenofibrate
EA020849B1 (ru)	2009-11-26	2015-02-27	Женфит	Применение 1,3-дифенилпроп-2-ен-1-оновых производных для лечения заболеваний печени
US10722575B2 (en)	2009-11-26	2020-07-28	Genfit	Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US9221751B2 (en)	2009-11-26	2015-12-29	Genfit	Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en)	2009-12-29	2011-07-07	Genfit	Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
SI2571843T1 (en) *	2010-05-17	2018-04-30	Genfit	Improved preparation of calcium derivatives
TWI415600B (zh) *	2011-08-10	2013-11-21	高雄醫學大學	用於治療動脈粥狀硬化的組合物及其製備方法
SG11201403107TA (en)	2011-12-28	2014-09-26	Genfit	1,3-diphenylpropane derivatives, preparations and uses thereof
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WO2014111584A1 (en) *	2013-01-18	2014-07-24	Genfit	Methods of treatment of fibrosis and cancers
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FR3056908B1 (fr)	2016-09-30	2019-04-19	Nashpharm	Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
CA3047098A1 (en) *	2016-12-16	2018-06-21	Jia Zhou	Inhibitors of bromodomain-containing protein 4 (brd4)
WO2018133705A1 (zh) *	2017-01-22	2018-07-26	苏州科睿思制药有限公司	Gft-505的晶型及其制备方法和用途
KR20190117632A (ko)	2017-02-21	2019-10-16	장피트	Ppar 효현제와 fxr 효현제의 병용
CA3051977A1 (en)	2017-02-24	2018-08-30	Genfit	Pharmaceutical compositions for combination therapy
CN110536682B (zh)	2017-04-18	2023-01-06	基恩菲特公司	依拉非诺或其衍生物与抗nash、抗纤维化或抗胆汁淤积药剂的组合
CN108658908B (zh)	2017-07-31	2019-05-10	广州必贝特医药技术有限公司	1，3-二取代烯酮类化合物及其应用
BR112020002261A2 (pt)	2017-08-04	2020-07-28	Advitech Advisory And Technologies Sa	processo para a preparação de elafibranor, composto e uso de pelo menos um composto
US20200276178A1 (en)	2017-09-13	2020-09-03	Novartis Ag	Combinations comprising fxr agonists
EP3710425A1 (de)	2017-11-16	2020-09-23	Teva Pharmaceuticals International GmbH	Festkörperformen von elafibranor
US11332457B2 (en)	2017-11-30	2022-05-17	Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.	Aromatic compound, pharmaceutical composition and use thereof
EP3514541A1 (de) *	2018-01-17	2019-07-24	Siemens Healthcare Diagnostics Products GmbH	Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
WO2019186410A1 (en) *	2018-03-27	2019-10-03	Lupin Limited	Solid forms of elafibranor and processes thereof
EP3830070A1 (de) *	2018-08-03	2021-06-09	Genfit	Elafibranorsalze
WO2020039297A1 (en) *	2018-08-24	2020-02-27	Mankind Pharma Ltd.	Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof
WO2020115628A1 (en) *	2018-12-03	2020-06-11	Mankind Pharma Ltd.	Solid forms of elafibranor and process of preparation thereof
CN110156648A (zh) *	2019-05-30	2019-08-23	河北科技大学	一种Elafibranor中间体的制备方法
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CA3153784A1 (en)	2019-10-28	2021-05-06	Nicolas STANKOVIC-VALENTIN	Combination therapy of elafibranor and nitazoxanide having antioxident properties
CN112824380B (zh) *	2019-11-21	2024-11-29	杭州百诚医药科技股份有限公司	α-氟代查耳酮类衍生物及其应用
CN111138264B (zh) *	2019-11-29	2023-08-04	温州医科大学	一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113121394B (zh) *	2019-12-30	2022-11-08	中国药科大学	一种苯氧乙酸类衍生物的制备方法
EP4103546A1 (de)	2020-02-10	2022-12-21	Genfit	Polymorphe von elafibranor
CN114901641B (zh) *	2020-02-28	2025-06-17	四川科伦博泰生物医药股份有限公司	芳香族化合物及其药物组合物和用途
AU2021275381A1 (en)	2020-05-18	2022-11-24	Genfit	Elafibranor for the treatment of primary sclerosing cholangitis
WO2022043367A1 (en)	2020-08-26	2022-03-03	Genfit	Compositions and methods for the treatment of primary biliary cholangitis
CN113230240B (zh) *	2021-03-22	2022-12-27	广州医科大学	1,3-二苯基丙-2-烯-1-酮衍生物及其应用
CN114853686B (zh)	2021-08-23	2023-06-20	中国药科大学	三氮唑酮类化合物及其医药用途
CN115894379B (zh)	2022-01-20	2025-06-27	哈尔滨三联药业股份有限公司	海因类化合物及其医药用途
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WO2025224044A1 (en)	2024-04-22	2025-10-30	Ipsen Pharma	Methods of treatment of primary biliary cholangitis
CN118363355B (zh) *	2024-06-19	2024-08-30	武汉名实生物医药科技有限责任公司	一种产品生产实时监控系统

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FR2841900B1 (fr)	2002-07-08	2007-03-02	Genfit S A	Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2857361B1 (fr)	2003-07-08	2005-09-09	Genfit S A	PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
US7547729B2 (en) *	2004-01-08	2009-06-16	Genfit	1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same

2002
- 2002-07-08 FR FR0208571A patent/FR2841900B1/fr not_active Expired - Fee Related
2003
- 2003-07-08 EP EP03762749A patent/EP1525177B1/de not_active Expired - Lifetime
- 2003-07-08 DK DK03762749T patent/DK1525177T3/da active
- 2003-07-08 CN CNB038163667A patent/CN100548960C/zh not_active Expired - Lifetime
- 2003-07-08 JP JP2004518890A patent/JP4575771B2/ja not_active Expired - Lifetime
- 2003-07-08 SI SI200330864T patent/SI1525177T1/sl unknown
- 2003-07-08 US US10/520,079 patent/US7943661B2/en active Active
- 2003-07-08 CA CA2490986A patent/CA2490986C/fr not_active Expired - Fee Related
- 2003-07-08 NZ NZ538051A patent/NZ538051A/en not_active IP Right Cessation
- 2003-07-08 BR BRPI0312398A patent/BRPI0312398B8/pt not_active IP Right Cessation
- 2003-07-08 WO PCT/FR2003/002127 patent/WO2004005233A1/fr not_active Ceased
- 2003-07-08 IL IL16569603A patent/IL165696A0/xx unknown
- 2003-07-08 EA EA200500169A patent/EA011090B1/ru not_active IP Right Cessation
- 2003-07-08 AT AT03762749T patent/ATE365703T1/de active
- 2003-07-08 DE DE60314633T patent/DE60314633T2/de not_active Expired - Lifetime
- 2003-07-08 ES ES03762749T patent/ES2287528T3/es not_active Expired - Lifetime
- 2003-07-08 KR KR1020057000349A patent/KR100974577B1/ko not_active Expired - Fee Related
- 2003-07-08 PT PT03762749T patent/PT1525177E/pt unknown
- 2003-07-08 MX MXPA05000427A patent/MXPA05000427A/es active IP Right Grant
- 2003-07-08 AU AU2003264698A patent/AU2003264698B2/en not_active Ceased
- 2003-07-08 PL PL372809A patent/PL207362B1/pl unknown
2004
- 2004-12-03 NO NO20045301A patent/NO329700B1/no not_active IP Right Cessation
- 2004-12-09 IL IL165696A patent/IL165696A/en active IP Right Grant
2005
- 2005-02-07 ZA ZA200501082A patent/ZA200501082B/xx unknown
2006
- 2006-07-26 US US11/493,040 patent/US7566737B2/en not_active Expired - Lifetime
2007
- 2007-08-03 CY CY20071101040T patent/CY1108085T1/el unknown
2011
- 2011-04-11 US US13/083,659 patent/US8058308B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT1525177E (pt)	2007-09-06
IL165696A (en)	2012-09-24
CN1668565A (zh)	2005-09-14
EA200500169A1 (ru)	2005-06-30
EA011090B1 (ru)	2008-12-30
SI1525177T1 (sl)	2007-10-31
DE60314633D1 (de)	2007-08-09
WO2004005233A1 (fr)	2004-01-15
JP4575771B2 (ja)	2010-11-04
US8058308B2 (en)	2011-11-15
FR2841900A1 (fr)	2004-01-09
US20070032543A1 (en)	2007-02-08
AU2003264698B2 (en)	2009-09-17
ES2287528T3 (es)	2007-12-16
KR20050025327A (ko)	2005-03-14
ATE365703T1 (de)	2007-07-15
BRPI0312398B1 (pt)	2016-11-08
MXPA05000427A (es)	2005-09-30
NO20045301L (no)	2005-02-04
BR0312398A (pt)	2005-04-12
CA2490986C (fr)	2012-09-18
CY1108085T1 (el)	2014-02-12
NO329700B1 (no)	2010-12-06
BRPI0312398B8 (pt)	2021-05-25
EP1525177B1 (de)	2007-06-27
AU2003264698A1 (en)	2004-01-23
NZ538051A (en)	2007-11-30
IL165696A0 (en)	2006-01-15
CA2490986A1 (fr)	2004-01-15
PL372809A1 (en)	2005-08-08
US20050176808A1 (en)	2005-08-11
US20110190515A1 (en)	2011-08-04
KR100974577B1 (ko)	2010-08-06
EP1525177A1 (de)	2005-04-27
PL207362B1 (pl)	2010-12-31
JP2005532385A (ja)	2005-10-27
DK1525177T3 (da)	2007-10-22
US7566737B2 (en)	2009-07-28
FR2841900B1 (fr)	2007-03-02
US7943661B2 (en)	2011-05-17
CN100548960C (zh)	2009-10-14
DE60314633T2 (de)	2008-02-28

Publication	Publication Date	Title
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