ZA200507933B - Acetylene derivatives as inhibitors of histone deacetylase - Google Patents

Acetylene derivatives as inhibitors of histone deacetylase Download PDF

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Publication number
ZA200507933B
ZA200507933B ZA200507933A ZA200507933A ZA200507933B ZA 200507933 B ZA200507933 B ZA 200507933B ZA 200507933 A ZA200507933 A ZA 200507933A ZA 200507933 A ZA200507933 A ZA 200507933A ZA 200507933 B ZA200507933 B ZA 200507933B
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South Africa
Prior art keywords
hydroxy
benzamide
ynyl
prop
optionally substituted
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ZA200507933A
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English (en)
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Sendzik Martin
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Axys Pharm Inc
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ZA200507933A 2003-08-20 2004-08-19 Acetylene derivatives as inhibitors of histone deacetylase ZA200507933B (en)

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US (2) US7368572B2 (fr)
EP (1) EP1656348B1 (fr)
JP (1) JP2007502838A (fr)
KR (1) KR20060079798A (fr)
CN (1) CN1795175A (fr)
AT (1) ATE353319T1 (fr)
AU (1) AU2004267085B2 (fr)
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7381825B2 (en) 2003-03-17 2008-06-03 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
GB0403038D0 (en) 2004-02-11 2004-03-17 Novartis Ag Organic compounds
US20080248506A1 (en) * 2004-10-07 2008-10-09 Pharmacyclics, Inc. Method of Monitoring Anti-Tumor Activity of an Hdac Inhibitor
EP1824831A2 (fr) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
EP1896436A2 (fr) 2005-05-11 2008-03-12 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
EA200800321A1 (ru) 2005-07-14 2008-06-30 Такеда Сан Диего, Инк. Ингибиторы гистондеацетилазы
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2008053131A1 (fr) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates en tant qu'inhibiteurs de l'histone désacétylase
US8796330B2 (en) * 2006-12-19 2014-08-05 Methylgene Inc. Inhibitors of histone deacetylase and prodrugs thereof
US8012955B2 (en) * 2006-12-28 2011-09-06 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
JP2008266322A (ja) 2007-03-28 2008-11-06 Santen Pharmaceut Co Ltd ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤
US20100285516A1 (en) * 2007-04-13 2010-11-11 Pharmacyclics, Inc. Calcium flux as a pharmacoefficacy biomarker for inhibitors of histone deacetylase
JP2011517313A (ja) 2007-12-11 2011-06-02 ビアメト ファーマシューティカルズ,インク. 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
US20090270497A1 (en) * 2008-04-24 2009-10-29 Pharmacyclics, Inc. Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors
RU2010153656A (ru) 2008-06-04 2012-07-20 Амбрилиа Байофарма Инк. (Ca) Ингибиторы интегразы вич из пиридоксина
US8623853B2 (en) 2008-07-23 2014-01-07 The Brigham And Women's Hospital, Inc. Treatment of cancers characterized by chromosomal rearrangement of the NUT gene
GB0903480D0 (en) 2009-02-27 2009-04-08 Chroma Therapeutics Ltd Enzyme Inhibitors
US8217079B2 (en) 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
CN102775368B (zh) * 2011-05-10 2016-08-17 上海驺虞医药科技有限公司 一类噻唑类化合物及其制备方法和用途
CN102875479B (zh) * 2012-10-24 2015-06-10 南京化工职业技术学院 喹唑啉二酮衍生物及其制备方法、其药物组合物及用途
CN103896911B (zh) * 2014-03-06 2015-12-30 南方医科大学 2-(3,4-二甲氧基)苯甲酰基-5-(4-取代苯乙炔基)噻吩及其制备方法及应用
ITUB20155193A1 (it) 2015-11-03 2017-05-03 Italfarmaco Spa Sospensioni orali di Givinostat fisicamente e chimicamente stabili
WO2018054960A1 (fr) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction et de traitement de la résistance à la chimiothérapie dans le lagc à npm-alk(+)
SG11202006246PA (en) * 2018-01-17 2020-07-29 Aurigene Discovery Tech Ltd Substituted alkynylene compounds as anticancer agents
CN113288888B (zh) * 2021-05-28 2023-02-03 烟台邦杰生物科技有限公司 具有血管舒张活性的化合物
CN119264047A (zh) * 2023-06-29 2025-01-07 山东大学 一种喹啉类衍生物组蛋白去乙酰化酶抑制剂及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109007D0 (en) 1991-04-26 1991-06-12 Merck Sharp & Dohme Therapeutic method
NZ257955A (en) 1992-12-02 1996-05-28 Pfizer Catechol diethers pharmaceutical compositions
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
US5958957A (en) * 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
CA2322311C (fr) * 1998-03-04 2009-10-13 Bristol-Myers Squibb Company Inhibiteurs de la proteine tyrosine kinase, a base d'imidazopyrazine a substitution heterocyclo
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
AU6936500A (en) 1999-08-24 2001-03-19 Regents Of The University Of California, The Non-quinoline inhibitors of malaria parasites
EP1748046A3 (fr) * 1999-11-23 2007-08-22 Methylgene, Inc. Inhibiteurs d'histone déacetylase
DE60102137T2 (de) 2000-03-17 2004-10-21 Bristol Myers Squibb Pharma Co Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren
ATE372314T1 (de) 2000-07-13 2007-09-15 Merck Patent Gmbh Chirale verbindungen ii
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
EP1335898B1 (fr) 2000-09-29 2005-11-23 TopoTarget UK Limited Composes d'acide carbamique comprenant un enchainement amide comme inhibiteurs hdac
JP4975941B2 (ja) 2000-09-29 2012-07-11 トポターゲット ユーケー リミテッド (e)−n−ヒドロキシ−3−(3−スルファモイル−フェニル)アクリルアミド化合物及びその治療用途
AU9598601A (en) * 2000-10-20 2002-04-29 Eisai Co Ltd Nitrogenous aromatic ring compounds
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2003000194A2 (fr) 2001-06-21 2003-01-03 Pfizer Inc. Derives bicycliques de pyridine et de pyrimidine utiles en tant qu'agents anticancereux
WO2003053941A2 (fr) * 2001-12-20 2003-07-03 Bristol-Myers Squibb Company Derives de l'acide barbiturique utilises comme inhibiteurs de l'enzyme de conversion du tnf-alpha (tace) et/ou de metalloproteases matricielles
JPWO2003070691A1 (ja) 2002-02-21 2005-06-09 財団法人大阪産業振興機構 N−ヒドロキシカルボキサミド誘導体

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