ZA200603062B - Method of delivering drugs to the brain - Google Patents
Method of delivering drugs to the brain Download PDFInfo
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- ZA200603062B ZA200603062B ZA200603062A ZA200603062A ZA200603062B ZA 200603062 B ZA200603062 B ZA 200603062B ZA 200603062 A ZA200603062 A ZA 200603062A ZA 200603062 A ZA200603062 A ZA 200603062A ZA 200603062 B ZA200603062 B ZA 200603062B
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- HCPOCMMGKBZWSJ-UHFFFAOYSA-N ethyl 3-hydrazinyl-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)NN HCPOCMMGKBZWSJ-UHFFFAOYSA-N 0.000 description 1
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- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
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- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
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- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US48209603P | 2003-06-24 | 2003-06-24 |
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| ZA200603062B true ZA200603062B (en) | 2007-04-25 |
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| ZA200603062A ZA200603062B (en) | 2003-06-24 | 2006-04-18 | Method of delivering drugs to the brain |
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| NO (1) | NO20061537L (de) |
| WO (1) | WO2004112747A2 (de) |
| ZA (1) | ZA200603062B (de) |
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| BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
| US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
| AU2004249172A1 (en) | 2003-06-24 | 2004-12-29 | Baxter International Inc. | Specific delivery of drugs to the brain |
| US20050202094A1 (en) * | 2004-01-29 | 2005-09-15 | Werling Jane O. | Nanosuspensions of anti-retroviral agents for increased central nervous system delivery |
| KR20070034524A (ko) * | 2004-05-28 | 2007-03-28 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린 수용체 조정자 |
| RU2006144851A (ru) * | 2004-06-15 | 2008-06-20 | Бакстер Интернэшнл Инк. (Us) | Применение терапевтических средств ex-vivo в виде твердых микрочастиц |
| US20060228420A1 (en) * | 2005-03-15 | 2006-10-12 | Queen Mary & Westfield College | Pharmaceutical compositions comprising microparticles for delivery into neurons |
| US9943481B2 (en) | 2005-05-26 | 2018-04-17 | Biorest Ltd. | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
| WO2007016501A2 (en) * | 2005-08-01 | 2007-02-08 | The University Of Chicago | Compositions and method for brain specific targeted delivery of therapeutic agents |
| KR100762954B1 (ko) * | 2006-01-26 | 2007-10-04 | 나재운 | 항암제가 봉입된, 소수성 담즙산이 결합된 친수성 키토산올리고당 나노입자 및 그 제조방법 |
| KR100785656B1 (ko) * | 2007-05-14 | 2007-12-17 | 재단법인서울대학교산학협력재단 | 소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체 |
| CA2691531C (en) | 2007-06-22 | 2016-11-01 | Board Of Regents,The University Of Texas System | Formation of stable submicron peptide or protein particles by thin film freezing |
| RU2496482C2 (ru) * | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Композиции и способы для доставки лекарственных средств |
| EP2376522A4 (de) * | 2008-11-16 | 2013-12-25 | Univ Texas | Niederviskose hochkonzentrierte suspensionen |
| WO2010068899A1 (en) | 2008-12-12 | 2010-06-17 | Creighton University | Nanoparticles comprising combinations of antiretroviral agents and use thereof |
| US10952965B2 (en) * | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
| DK2921486T3 (da) | 2009-08-07 | 2017-11-13 | American Life Science Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til behandling af beta-amyloid-relaterede sygdomme |
| EP2550018B1 (de) * | 2010-03-22 | 2019-02-27 | F.Hoffmann-La Roche Ag | Zusammensetzungen und verfahren zur stabilizierung von proteinen enthaltenden formulierungen |
| MX2013004981A (es) * | 2010-11-02 | 2013-11-04 | Univ Nebraska | Composiciones y metodos para la administracion de agentes terapeuticos. |
| WO2012138003A1 (ko) * | 2011-04-08 | 2012-10-11 | 경북대학교 산학협력단 | 탈황산화된 헤파린-담즙산 유도체의 염증성 질환의 예방 및 치료 용도 |
| DE102012009570A1 (de) | 2012-05-09 | 2013-11-14 | Naum Goldstein | Komposition für nasale Anwendung |
| DE102012015248A1 (de) * | 2012-08-05 | 2014-02-06 | Naum Goldstein | Verfahren zur Einbringung biologisch aktiver Substanzen ins Gehirn |
| WO2015108945A2 (en) | 2014-01-14 | 2015-07-23 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| WO2016057866A1 (en) | 2014-10-09 | 2016-04-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| US10123969B2 (en) | 2015-10-15 | 2018-11-13 | Wisconsin Alumni Research Foundation | Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid |
| CA3126348A1 (en) | 2018-01-12 | 2020-07-18 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| US11458136B2 (en) | 2018-04-09 | 2022-10-04 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| EP4076527A4 (de) | 2020-01-10 | 2024-05-15 | Consynance Therapeutics, Inc. | Therapeutische wirkstoffkombinationen und verfahren zu ihrer verwendung |
| WO2021148990A1 (en) * | 2020-01-23 | 2021-07-29 | Axcess Limited | Cellular uptake |
| WO2023004113A2 (en) | 2021-07-22 | 2023-01-26 | The Regents Of The University Of California | Compositions and methods for using purified human rna editing enzymes |
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| GB0329310D0 (en) | 2003-12-18 | 2004-01-21 | Univ Keele | Method |
| US20050202094A1 (en) | 2004-01-29 | 2005-09-15 | Werling Jane O. | Nanosuspensions of anti-retroviral agents for increased central nervous system delivery |
| DK2992901T3 (da) | 2004-02-02 | 2020-01-27 | Engeneic Molecular Delivery Pty Ltd | Sammensætninger og fremgangsmåder til målrettet in vitro- og in vivo-medicinlevering til pattedyrceller via bakterielt afledte intakte miniceller |
| RU2006144851A (ru) | 2004-06-15 | 2008-06-20 | Бакстер Интернэшнл Инк. (Us) | Применение терапевтических средств ex-vivo в виде твердых микрочастиц |
| JPWO2006080243A1 (ja) | 2005-01-28 | 2008-06-19 | コニカミノルタエムジー株式会社 | 被覆磁性粒子含有製剤およびその製造方法、並びに診断治療システム |
| EP1896007B1 (de) | 2005-05-04 | 2014-03-19 | Medigene AG | Verfahren zur verabreichung einer katonischen zubereitung aus liposomen, welche paclitaxel enthält |
| CN1772303A (zh) | 2005-10-25 | 2006-05-17 | 朱宏 | 恶性肿瘤磁热疗用纳米磁粉－抗体靶向药物 |
-
2004
- 2004-06-15 AU AU2004249172A patent/AU2004249172A1/en not_active Abandoned
- 2004-06-15 WO PCT/US2004/018850 patent/WO2004112747A2/en not_active Ceased
- 2004-06-15 EP EP04776540A patent/EP1663158A2/de not_active Withdrawn
- 2004-06-15 US US10/868,680 patent/US9044381B2/en active Active
- 2004-06-15 BR BRPI0414970-0A patent/BRPI0414970A2/pt not_active Application Discontinuation
- 2004-06-15 CA CA002540695A patent/CA2540695A1/en not_active Abandoned
-
2006
- 2006-04-04 NO NO20061537A patent/NO20061537L/no not_active Application Discontinuation
- 2006-04-18 ZA ZA200603062A patent/ZA200603062B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9044381B2 (en) | 2015-06-02 |
| EP1663158A2 (de) | 2006-06-07 |
| NO20061537L (no) | 2006-04-04 |
| WO2004112747A3 (en) | 2005-03-03 |
| AU2004249172A1 (en) | 2004-12-29 |
| BRPI0414970A2 (pt) | 2012-12-11 |
| CA2540695A1 (en) | 2004-12-29 |
| WO2004112747A2 (en) | 2004-12-29 |
| US20050048002A1 (en) | 2005-03-03 |
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