ZA200711119B - Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibotors - Google Patents

Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibotors

Info

Publication number
ZA200711119B
ZA200711119B ZA200711119A ZA200711119A ZA200711119B ZA 200711119 B ZA200711119 B ZA 200711119B ZA 200711119 A ZA200711119 A ZA 200711119A ZA 200711119 A ZA200711119 A ZA 200711119A ZA 200711119 B ZA200711119 B ZA 200711119B
Authority
ZA
South Africa
Prior art keywords
inhibotors
carboxylase
acc
acetyl coenzyme
spirochromanone
Prior art date
Application number
ZA200711119A
Other languages
English (en)
Inventor
Takeru Yamakawa
Kenji Niiyama
Tomoharu Lino
Hideaki Imamura
Lihu Yang
Hideki Jona
Koji Yamada
Mitsuru Ohkubo
Jun Kusunoki
Original Assignee
Merck & Co Inc
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Banyu Pharma Co Ltd filed Critical Merck & Co Inc
Publication of ZA200711119B publication Critical patent/ZA200711119B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200711119A 2005-07-19 2007-12-20 Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibotors ZA200711119B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70038205P 2005-07-19 2005-07-19

Publications (1)

Publication Number Publication Date
ZA200711119B true ZA200711119B (en) 2009-12-30

Family

ID=37317248

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200711119A ZA200711119B (en) 2005-07-19 2007-12-20 Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibotors

Country Status (20)

Country Link
US (2) US7410976B2 (de)
EP (1) EP1910375B1 (de)
JP (1) JP5076159B2 (de)
KR (1) KR20080036041A (de)
CN (1) CN101238132A (de)
AR (1) AR054842A1 (de)
AT (1) ATE509023T1 (de)
AU (1) AU2006270145B2 (de)
BR (1) BRPI0613427A2 (de)
CA (1) CA2614963C (de)
DO (1) DOP2006000170A (de)
IL (1) IL188417A0 (de)
MX (1) MX2008000966A (de)
NO (1) NO20080865L (de)
NZ (1) NZ564591A (de)
PE (1) PE20070527A1 (de)
RU (1) RU2422446C2 (de)
TW (1) TW200728307A (de)
WO (2) WO2007011811A1 (de)
ZA (1) ZA200711119B (de)

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WO2008065508A1 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Spiroketone acetyl-coa carboxylase inhibitors
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
WO2008088692A2 (en) * 2007-01-12 2008-07-24 Merck & Co., Inc. Spirochromanon derivatives
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EP2297164A1 (de) * 2008-05-28 2011-03-23 Pfizer Inc. Pyrazolospiroketone als inhibitoren von acetyl-coa-carboxylase
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CN103189377B (zh) 2010-10-29 2015-02-25 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
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EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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Also Published As

Publication number Publication date
WO2007011809A1 (en) 2007-01-25
CA2614963A1 (en) 2007-01-25
EP1910375B1 (de) 2011-05-11
US7410976B2 (en) 2008-08-12
RU2008106243A (ru) 2009-08-27
AU2006270145B2 (en) 2011-04-14
AR054842A1 (es) 2007-07-18
KR20080036041A (ko) 2008-04-24
MX2008000966A (es) 2008-03-26
NO20080865L (no) 2008-04-18
PE20070527A1 (es) 2007-06-14
US7935712B2 (en) 2011-05-03
IL188417A0 (en) 2008-11-03
DOP2006000170A (es) 2007-03-31
US20090131464A1 (en) 2009-05-21
BRPI0613427A2 (pt) 2012-10-30
RU2422446C2 (ru) 2011-06-27
NZ564591A (en) 2010-01-29
JP2009502785A (ja) 2009-01-29
TW200728307A (en) 2007-08-01
CN101238132A (zh) 2008-08-06
CA2614963C (en) 2014-10-07
WO2007011811A1 (en) 2007-01-25
US20070021453A1 (en) 2007-01-25
ATE509023T1 (de) 2011-05-15
JP5076159B2 (ja) 2012-11-21
AU2006270145A1 (en) 2007-01-25
EP1910375A1 (de) 2008-04-16

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