ZA200802667B - Argatroban formulation - Google Patents

Argatroban formulation

Info

Publication number: ZA200802667B
Authority: ZA; South Africa
Prior art keywords: argatroban; formulation; argatroban formulation; solubilize; aqueous
Prior art date: 2005-09-01

Application number

ZA200802667A

Other languages

English (en)

Inventor

Owoo George

Richard A Burgos

Original Assignee

Baxter Int

Baxter Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-01

Filing date

2008-03-26

Publication date

2009-01-28

2008-03-26 Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int

2009-01-28 Publication of ZA200802667B publication Critical patent/ZA200802667B/xx

Links

KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 title abstract 3
229960003856 argatroban Drugs 0.000 title abstract 3
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229960000935 dehydrated alcohol Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200802667A 2005-09-01 2008-03-26 Argatroban formulation ZA200802667B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71340305P	2005-09-01	2005-09-01

Publications (1)

Publication Number	Publication Date
ZA200802667B true ZA200802667B (en)	2009-01-28

Family

ID=37809398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200802667A ZA200802667B (en)	2005-09-01	2008-03-26	Argatroban formulation

Country Status (22)

Country	Link
US (3)	US7642271B2 (fr)
EP (1)	EP1948133B1 (fr)
JP (1)	JP5189980B2 (fr)
KR (3)	KR101753949B1 (fr)
CN (2)	CN101257890B (fr)
AT (1)	ATE514416T1 (fr)
AU (1)	AU2006285097B2 (fr)
BR (1)	BRPI0616127B8 (fr)
CA (1)	CA2617920C (fr)
CY (1)	CY1112109T1 (fr)
DK (1)	DK1948133T3 (fr)
ES (1)	ES2368758T3 (fr)
IL (2)	IL189290A (fr)
IN (1)	IN2015DN03947A (fr)
MX (1)	MX2008002177A (fr)
NZ (1)	NZ565821A (fr)
PL (1)	PL1948133T3 (fr)
PT (1)	PT1948133E (fr)
RU (1)	RU2416393C2 (fr)
SI (1)	SI1948133T1 (fr)
WO (1)	WO2007027565A2 (fr)
ZA (1)	ZA200802667B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101257890B (zh) *	2005-09-01	2012-10-31	巴克斯特国际公司	含有酸作为增溶剂的阿加曲班制剂
US7687516B2 (en) *	2006-09-27	2010-03-30	Eagle Pharmaceuticals, Inc.	Alcohol free formulation of argatroban
US7589106B2 (en)	2006-09-27	2009-09-15	Eagle Pharmaceuticals, Inc.	Alcohol free formulation of argatroban
US20100076019A1 (en) *	2006-10-11	2010-03-25	Eagle Pharmaceuticals, Inc.	Alcohol free formulation of argatroban
US7915290B2 (en)	2008-02-29	2011-03-29	Baxter International Inc.	Argatroban formulations and methods for making and using same
US20090221637A1 (en) *	2008-02-29	2009-09-03	Baxter International Inc.	Solid-state salt argatroban formulations and methods for producing and using the same
CN101598725B (zh) *	2009-06-23	2012-07-18	南通大学附属医院	阿加曲班在血细胞和生化常规分析中的应用
LT2616064T (lt)	2010-10-21	2019-11-25	Rtu Pharmaceuticals Llc	Parengtos naudoti ketorolako kompozicijos
CN102120026A (zh) *	2011-03-03	2011-07-13	天津市炜杰科技有限公司	以醇作为增溶剂的21(s)阿加曲班静脉注射液
CN102119922A (zh) *	2011-03-03	2011-07-13	天津市炜杰科技有限公司	以酸作为增溶剂的21(s)阿加曲班静脉注射液
CN102228677A (zh) *	2011-06-17	2011-11-02	天津市炜杰科技有限公司	以酸作为增溶剂的21(r)阿加曲班静脉注射液
TWI679977B (zh) *	2011-10-19	2019-12-21	大塚製藥股份有限公司	口服溶液
WO2017096298A1 (fr) *	2015-12-04	2017-06-08	Regents Of The University Of California	Inhibiteurs d'histone désacétylase
CN107773533A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种新型凝血酶抑制剂及其制备方法
CN115381927A (zh) *	2022-09-20	2022-11-25	晓恩医药包装材料(安庆)有限公司	一种用于治疗缺血性脑梗塞的药物预灌装注射剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE420919B (sv) *	1973-08-13	1981-11-09	Mitsubishi Chem Ind	Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav
US5214052A (en) *	1987-07-28	1993-05-25	Mitsubishi Kasei Corporation	Method for dissolving arginineamides and pharmaceutical compositions containing them
CA2091715A1 (fr) *	1992-03-18	1993-09-19	Mitsubishi Kasei Corporation	Preparations d'argatroban pour usage ophtalmique
US5506241A (en) *	1992-03-18	1996-04-09	Mitsubishi Chemical Corporation	Argatroban preparations for ophthalmic use
JPH06219949A (ja) *	1993-01-25	1994-08-09	Mitsubishi Kasei Corp	抗トロンビン剤及びその製造方法
JPH06219948A (ja)	1993-01-25	1994-08-09	Mitsubishi Kasei Corp	抗トロンビン剤及びその製造方法
ATE177635T1 (de)	1993-04-22	1999-04-15	Senju Pharma Co	Wässrige arzneizubereitungen enthaltend argatroban und cyclodextrin oder coffein
JPH07228532A (ja) *	1993-04-22	1995-08-29	Senju Pharmaceut Co Ltd	水性液剤、その有効成分の溶解性向上方法および安定化方法
US5998019A (en) *	1993-11-16	1999-12-07	Baxter International Inc.	Multi-layered polymer structure for medical products
US5849843A (en) *	1993-11-16	1998-12-15	Baxter International Inc.	Polymeric compositions for medical packaging and devices
FR2715566B1 (fr) *	1994-02-03	1996-03-08	Synthelabo	Solutions aqueuses concentrées d'argatroban.
US5840733A (en) *	1996-07-01	1998-11-24	Redcell, Canada, Inc.	Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
JPH10316569A (ja) *	1997-05-19	1998-12-02	Mitsubishi Chem Corp	アルガトロバンの可溶化方法及びそれによるアルガトロバン含有外用水性薬剤
KR101010547B1 (ko) *	2003-03-20	2011-01-24	미쓰비시 타나베 파마 코퍼레이션	알기닌아미드류를 함유하는 의약 제제
EP1648232A4 (fr)	2003-07-17	2009-12-30	Smithkline Beecham Corp	Methode de traitement a l'argatroban pour des patients souffrant de thrombocytopenie induite par l'heparine
CN101257890B (zh) *	2005-09-01	2012-10-31	巴克斯特国际公司	含有酸作为增溶剂的阿加曲班制剂

2006
- 2006-08-28 CN CN2006800322085A patent/CN101257890B/zh not_active Expired - Fee Related
- 2006-08-28 CN CN201210353437.4A patent/CN102895179B/zh not_active Expired - Fee Related
- 2006-08-28 CA CA2617920A patent/CA2617920C/fr not_active Expired - Fee Related
- 2006-08-28 EP EP06802424A patent/EP1948133B1/fr not_active Not-in-force
- 2006-08-28 SI SI200631063T patent/SI1948133T1/sl unknown
- 2006-08-28 RU RU2008112311/15A patent/RU2416393C2/ru active
- 2006-08-28 JP JP2008529147A patent/JP5189980B2/ja not_active Expired - Fee Related
- 2006-08-28 PL PL06802424T patent/PL1948133T3/pl unknown
- 2006-08-28 PT PT06802424T patent/PT1948133E/pt unknown
- 2006-08-28 KR KR1020147000036A patent/KR101753949B1/ko not_active Expired - Fee Related
- 2006-08-28 NZ NZ565821A patent/NZ565821A/en not_active IP Right Cessation
- 2006-08-28 IN IN3947DEN2015 patent/IN2015DN03947A/en unknown
- 2006-08-28 KR KR1020157025457A patent/KR20150108430A/ko not_active Ceased
- 2006-08-28 DK DK06802424.9T patent/DK1948133T3/da active
- 2006-08-28 ES ES06802424T patent/ES2368758T3/es active Active
- 2006-08-28 MX MX2008002177A patent/MX2008002177A/es active IP Right Grant
- 2006-08-28 US US11/510,981 patent/US7642271B2/en active Active
- 2006-08-28 AU AU2006285097A patent/AU2006285097B2/en not_active Ceased
- 2006-08-28 WO PCT/US2006/033432 patent/WO2007027565A2/fr not_active Ceased
- 2006-08-28 AT AT06802424T patent/ATE514416T1/de active
- 2006-08-28 KR KR1020087007748A patent/KR20080042155A/ko not_active Ceased
- 2006-08-28 BR BRPI0616127A patent/BRPI0616127B8/pt not_active IP Right Cessation
2008
- 2008-02-05 IL IL189290A patent/IL189290A/en active IP Right Grant
- 2008-03-26 ZA ZA200802667A patent/ZA200802667B/xx unknown
2009
- 2009-12-28 US US12/647,854 patent/US8034830B2/en active Active
- 2009-12-28 US US12/647,841 patent/US7985757B2/en active Active
2010
- 2010-09-16 IL IL208183A patent/IL208183A0/en unknown
2011
- 2011-08-30 CY CY20111100825T patent/CY1112109T1/el unknown

Also Published As

Publication number	Publication date
US20070049617A1 (en)	2007-03-01
KR20080042155A (ko)	2008-05-14
MX2008002177A (es)	2008-04-22
US20100099705A1 (en)	2010-04-22
JP5189980B2 (ja)	2013-04-24
PT1948133E (pt)	2011-08-01
JP2009507018A (ja)	2009-02-19
IL189290A0 (en)	2008-06-05
AU2006285097A1 (en)	2007-03-08
KR20150108430A (ko)	2015-09-25
CA2617920C (fr)	2014-05-27
US8034830B2 (en)	2011-10-11
HK1123193A1 (en)	2009-06-12
SI1948133T1 (sl)	2011-08-31
US20100099706A1 (en)	2010-04-22
HK1178053A1 (en)	2013-09-06
WO2007027565A3 (fr)	2007-10-04
IL189290A (en)	2011-10-31
US7985757B2 (en)	2011-07-26
BRPI0616127B8 (pt)	2021-05-25
RU2008112311A (ru)	2009-10-10
CY1112109T1 (el)	2015-11-04
ES2368758T3 (es)	2011-11-22
CN101257890B (zh)	2012-10-31
ATE514416T1 (de)	2011-07-15
NZ565821A (en)	2010-05-28
CN101257890A (zh)	2008-09-03
EP1948133A2 (fr)	2008-07-30
IN2015DN03947A (fr)	2015-10-02
WO2007027565A2 (fr)	2007-03-08
CN102895179B (zh)	2014-10-22
BRPI0616127A2 (pt)	2011-06-07
CN102895179A (zh)	2013-01-30
EP1948133B1 (fr)	2011-06-29
AU2006285097B2 (en)	2011-08-18
RU2416393C2 (ru)	2011-04-20
PL1948133T3 (pl)	2012-03-30
KR101753949B1 (ko)	2017-07-04
KR20140009599A (ko)	2014-01-22
DK1948133T3 (da)	2011-10-03
BRPI0616127B1 (pt)	2020-05-12
CA2617920A1 (fr)	2007-03-08
US7642271B2 (en)	2010-01-05
IL208183A0 (en)	2010-12-30

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IL189290A0 (en)	2008-06-05	Argatroban formulation
UA95199C2 (en)	2011-07-11	Aqueous formulation of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
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EA201071167A1 (ru)	2011-06-30	Стабилизированные олеосомные композиции и способы их получения
EA201171399A1 (ru)	2012-05-30	Способ и композиция для улучшения всасывания лекарственных средств
HK1219222A1 (zh)	2017-03-31	包含降血脂药的制剂
TNSN07435A1 (en)	2009-03-17	Novel piperidine carboxylic acid amide derivatives
NO20085213L (no)	2009-01-13	Nye pyridinanaloger
WO2007110834A3 (fr)	2007-12-06	Malates et formes polymorphes de l'acide (3s,5s)-7-[3-amino-5-méthyl-pipéridinyl]-1-cyclopropyl-1,4-dihydro-8-méthoxy-4-oxo-3-quinoléine-carboxylique
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NO20080650L (no)	2008-05-13	Forbindelser omfattende DMXAA for behandling av kreft
ATE485261T1 (de)	2010-11-15	Salicylsäurederivate
CY1107277T1 (el)	2012-11-21	Βενζισοξαζολες
WO2007025764A3 (fr)	2007-08-16	Formulation pharmaceutique pour sels d'acides monobasiques avec du clopidogrel
EA200701741A1 (ru)	2007-12-28	Композиция, содержащая окаперидон
WO2009148288A3 (fr)	2010-03-11	COMPOSITION POUR PRÉVENIR ET TRAITER DES MALADIES IMMUNITAIRES, CONTENANT UN NOUVEAU COMPOSÉ D'α-ISO-CUBÈBÈNE EXTRAIT DE SCHISANDRA CHINENSIS EN TANT QU'INGRÉDIENT ACTIF
WO2007039821A3 (fr)	2007-06-21	Nouveaux inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine et dans des cosmetiques
NZ597861A (en)	2013-08-30	2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same