ZA868933B - New cyclic amine derivatives,pharmaceutical compositions containing these compounds and processes for preparing them - Google Patents

New cyclic amine derivatives,pharmaceutical compositions containing these compounds and processes for preparing them

Info

Publication number: ZA868933B
Authority: ZA; South Africa
Prior art keywords: group; carbon atoms; general formula; hereinbefore; alkyl
Prior art date: 1985-11-27

Application number

ZA868933A

Other languages

English (en)

Inventor

Manfred Psiorz

Joachim Heider

Andreas Bomhard

Manfred Reiffen

Norbert Hauel

Klaus Noll

Berthold Narr

Christian Lillie

Juergen Dr Daemmgen

Walter Prof Dr Kobinger

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-11-27

Filing date

1986-11-26

Publication date

1988-07-27

1986-11-26 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1988-07-27 Publication of ZA868933B publication Critical patent/ZA868933B/xx

Links

-1 cyclic amine Chemical class 0.000 title abstract 30
150000001875 compounds Chemical class 0.000 title abstract 22
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 26
125000000217 alkyl group Chemical group 0.000 abstract 24
125000003545 alkoxy group Chemical group 0.000 abstract 10
125000005843 halogen group Chemical group 0.000 abstract 10
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 9
125000003282 alkyl amino group Chemical group 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000006239 protecting group Chemical group 0.000 abstract 8
239000002904 solvent Substances 0.000 abstract 8
125000002947 alkylene group Chemical group 0.000 abstract 6
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 6
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 5
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
239000002253 acid Substances 0.000 abstract 4
125000005530 alkylenedioxy group Chemical group 0.000 abstract 4
125000004663 dialkyl amino group Chemical group 0.000 abstract 4
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 4
125000002071 phenylalkoxy group Chemical group 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 3
125000005236 alkanoylamino group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000007789 gas Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
230000000269 nucleophilic effect Effects 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA868933A 1985-11-27 1986-11-26 New cyclic amine derivatives,pharmaceutical compositions containing these compounds and processes for preparing them ZA868933B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19853541811 DE3541811A1 (de)	1985-11-27	1985-11-27	Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ZA868933B true ZA868933B (en)	1988-07-27

Family

ID=6286902

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA868933A ZA868933B (en)	1985-11-27	1986-11-26	New cyclic amine derivatives,pharmaceutical compositions containing these compounds and processes for preparing them

Country Status (25)

Country	Link
EP (1)	EP0224794B1 (fr)
JP (1)	JPH0625128B2 (fr)
KR (1)	KR950007589B1 (fr)
AT (1)	ATE56447T1 (fr)
AU (1)	AU589712B2 (fr)
CA (1)	CA1321194C (fr)
CZ (1)	CZ410391A3 (fr)
DD (1)	DD256132A5 (fr)
DE (2)	DE3541811A1 (fr)
DK (1)	DK174564B1 (fr)
ES (1)	ES2018152B3 (fr)
FI (1)	FI88299C (fr)
GR (1)	GR3001107T3 (fr)
HK (1)	HK123993A (fr)
HU (1)	HU196787B (fr)
IE (1)	IE59487B1 (fr)
IL (1)	IL80758A (fr)
MX (1)	MX9202813A (fr)
NO (1)	NO168034C (fr)
NZ (1)	NZ218412A (fr)
PH (1)	PH22944A (fr)
PT (1)	PT83815B (fr)
SU (1)	SU1442073A3 (fr)
UA (1)	UA8034A1 (fr)
ZA (1)	ZA868933B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1298427C (fr) *	1987-03-13	1992-03-31	Johannes Adrianus Maria Van Broekhoven	Methode pour separer les residus d'un catalyseur au palladium de copolymeres de monoxyde de carbone et de composes renfermant une ou plusieurs fonctions olefiniques
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2634207B1 (fr) *	1988-07-12	1990-09-07	Synthelabo	Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
DE10018401A1 (de) *	2000-04-13	2001-10-25	Boehringer Ingelheim Pharma	Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
US20040138306A1 (en)	2002-07-25	2004-07-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
DE60200160T2 (de) *	2002-07-25	2004-11-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Cilobradine oder pharmazeutisch akzeptablen Salze zur Behandlung oder Prävention von Herzversagen
EP1762179A1 (fr)	2005-09-07	2007-03-14	Boehringer Ingelheim Vetmedica Gmbh	Méthode pour l'amélioration de la qualité de diagnostic dans l'échocardiographie
KR20140057604A (ko)	2011-08-12	2014-05-13	베링거잉겔하임베트메디카게엠베하	고양잇과 동물의 심부전을 치료 및 예방하는 방법에 사용하기 위한 퍼니 전류 억제제
WO2014122248A1 (fr)	2013-02-11	2014-08-14	Boehringer Ingelheim Vetmedica Gmbh	Kit d'éléments

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2639718C2 (de) *	1976-09-03	1987-03-05	Dr. Karl Thomae Gmbh, 7950 Biberach	1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
CH645632A5 (en) *	1977-01-01	1984-10-15	Thomae Gmbh Dr K	Arylalkylamines
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418271A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

1985
- 1985-11-27 DE DE19853541811 patent/DE3541811A1/de not_active Withdrawn
1986
- 1986-11-11 SU SU864028479A patent/SU1442073A3/ru active
- 1986-11-11 UA UA4028479A patent/UA8034A1/uk unknown
- 1986-11-18 ES ES86116002T patent/ES2018152B3/es not_active Expired - Lifetime
- 1986-11-18 DE DE8686116002T patent/DE3674159D1/de not_active Expired - Lifetime
- 1986-11-18 EP EP86116002A patent/EP0224794B1/fr not_active Expired - Lifetime
- 1986-11-18 AT AT86116002T patent/ATE56447T1/de not_active IP Right Cessation
- 1986-11-25 FI FI864785A patent/FI88299C/fi not_active IP Right Cessation
- 1986-11-25 DD DD86296626A patent/DD256132A5/de not_active IP Right Cessation
- 1986-11-25 CA CA000523713A patent/CA1321194C/fr not_active Expired - Lifetime
- 1986-11-25 IL IL80758A patent/IL80758A/xx not_active IP Right Cessation
- 1986-11-26 IE IE311086A patent/IE59487B1/en not_active IP Right Cessation
- 1986-11-26 NZ NZ218412A patent/NZ218412A/xx unknown
- 1986-11-26 KR KR1019860009986A patent/KR950007589B1/ko not_active Expired - Lifetime
- 1986-11-26 JP JP61281636A patent/JPH0625128B2/ja not_active Expired - Lifetime
- 1986-11-26 PT PT83815A patent/PT83815B/pt unknown
- 1986-11-26 ZA ZA868933A patent/ZA868933B/xx unknown
- 1986-11-26 NO NO864744A patent/NO168034C/no not_active IP Right Cessation
- 1986-11-26 DK DK198605683A patent/DK174564B1/da not_active IP Right Cessation
- 1986-11-26 HU HU864901A patent/HU196787B/hu unknown
- 1986-11-27 PH PH34532A patent/PH22944A/en unknown
- 1986-11-27 AU AU65764/86A patent/AU589712B2/en not_active Expired
1990
- 1990-11-26 GR GR90400965T patent/GR3001107T3/el unknown
1991
- 1991-12-27 CZ CS914103A patent/CZ410391A3/cs unknown
1992
- 1992-06-12 MX MX9202813A patent/MX9202813A/es unknown
1993
- 1993-11-11 HK HK1239/93A patent/HK123993A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6576486A (en)	1987-06-04
NO168034B (no)	1991-09-30
ATE56447T1 (de)	1990-09-15
FI864785A7 (fi)	1987-05-28
EP0224794A3 (en)	1988-10-19
HK123993A (en)	1993-11-19
ES2018152B3 (es)	1991-04-01
SU1442073A3 (ru)	1988-11-30
MX9202813A (es)	1992-06-30
HU196787B (en)	1989-01-30
CZ410391A3 (en)	1993-03-17
DE3674159D1 (de)	1990-10-18
PT83815B (pt)	1989-06-30
FI864785A0 (fi)	1986-11-25
NO864744D0 (no)	1986-11-26
KR950007589B1 (ko)	1995-07-12
FI88299C (fi)	1993-04-26
JPH0625128B2 (ja)	1994-04-06
PT83815A (de)	1986-12-01
GR3001107T3 (en)	1992-05-12
KR870004973A (ko)	1987-06-02
FI88299B (fi)	1993-01-15
DE3541811A1 (de)	1987-06-04
IL80758A (en)	1991-01-31
DK174564B1 (da)	2003-06-10
CA1321194C (fr)	1993-08-10
NO168034C (no)	1992-01-08
DK568386D0 (da)	1986-11-26
AU589712B2 (en)	1989-10-19
DD256132A5 (de)	1988-04-27
IE59487B1 (en)	1994-03-09
IL80758A0 (en)	1987-02-27
HUT43056A (en)	1987-09-28
EP0224794B1 (fr)	1990-09-12
IE863110L (en)	1987-05-27
UA8034A1 (uk)	1995-12-26
PH22944A (en)	1989-02-03
JPS62138491A (ja)	1987-06-22
DK568386A (da)	1987-05-28
NZ218412A (en)	1989-05-29
EP0224794A2 (fr)	1987-06-10

Publication	Publication Date	Title
AU589712B2 (en)	1989-10-19	Cyclic amine derivatives
KR870007180A (ko)	1987-08-17	티에노-1,4-디아제핀의 제조방법
ES8301481A1 (es)	1982-12-01	Procedimiento para la preparacion de nuevos compuestos heterociclos derivados de azepina.
ATE79376T1 (de)	1992-08-15	Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IE811830L (en)	1982-02-12	Indoles.
GB1421970A (en)	1976-01-21	8-azapurin-6-one derivatives
IE890464L (en)	1989-08-15	New 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives and process for their preparation
ATE231136T1 (de)	2003-02-15	Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven eigenschaften, verfahren zu deren herstellung und pharmazeutischen zusammenstellungen, die sie enthalten
DE3764910D1 (de)	1990-10-18	Diselenobisbenzoesaeureamide primaerer heterocyclischer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE62663T1 (de)	1991-05-15	Indan-derivate, verfahren zu ihrer herstellung und die erhaltenen zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
HU902624D0 (en)	1990-09-28	Process for the preparation of acryloyl-piperazine derivatives and pharmaceutical compositions containing them
GB9612600D0 (en)	1996-08-21	Chemical compounds
ATE52509T1 (de)	1990-05-15	Thiazolidinderivate und verfahren zu ihrer herstellung.
AU566564B2 (en)	1987-10-22	Propylamine derivatives
DK93580A (da)	1980-09-07	Fremgangsmaade til fremstilling af guanidinothiazolforbindelser eller syreadditionssalte deraf
EP0215622A3 (en)	1988-07-06	Naphthalene anti-psoriatic agents and process for making them