ZA883653B - Prostaglandin-lipid formulations - Google Patents

Prostaglandin-lipid formulations

Info

Publication number: ZA883653B
Authority: ZA; South Africa
Prior art keywords: prostaglandin; transmembrane; liposomes; lipid formulations; gradient
Prior art date: 1987-05-22

Application number

ZA883653A

Other languages

English (en)

Inventor

Robert P Lenk

P Lenk Robert

Michelle M Tomsho

M Tomsho Michelle

Robert L Suddith

L Suddith Robert

Robert J Klimchak

J Klimchak Robert

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-23

Publication date

1989-03-29

1988-05-23 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1989-03-29 Publication of ZA883653B publication Critical patent/ZA883653B/xx

Links

239000000203 mixture Substances 0.000 title abstract 3
238000009472 formulation Methods 0.000 title 1
239000002502 liposome Substances 0.000 abstract 4
150000003180 prostaglandins Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 1
229960000711 alprostadil Drugs 0.000 abstract 1
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

ZA883653A 1987-05-22 1988-05-23 Prostaglandin-lipid formulations ZA883653B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5330587A	1987-05-22	1987-05-22

Publications (1)

Publication Number	Publication Date
ZA883653B true ZA883653B (en)	1989-03-29

Family

ID=21983292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA883653A ZA883653B (en)	1987-05-22	1988-05-23	Prostaglandin-lipid formulations

Country Status (13)

Country	Link
US (1)	US5082664A (pt)
EP (1)	EP0292403B1 (pt)
KR (1)	KR970005171B1 (pt)
AT (1)	ATE109982T1 (pt)
AU (1)	AU617678B2 (pt)
CA (1)	CA1323838C (pt)
DE (1)	DE3851090T2 (pt)
ES (1)	ES2058317T3 (pt)
FI (1)	FI95199C (pt)
HK (1)	HK1007496A1 (pt)
PT (1)	PT87545B (pt)
WO (1)	WO1988009170A1 (pt)
ZA (1)	ZA883653B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9203808A (es) *	1987-03-05	1992-07-01	Liposome Co Inc	Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5262168A (en) *	1987-05-22	1993-11-16	The Liposome Company, Inc.	Prostaglandin-lipid formulations
US5811118A (en) *	1987-05-22	1998-09-22	The Liposome Company, Inc.	Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations
US5925375A (en) *	1987-05-22	1999-07-20	The Liposome Company, Inc.	Therapeutic use of multilamellar liposomal prostaglandin formulations
ATE135207T1 (de) *	1989-04-04	1996-03-15	Beiersdorf Ag	Mittel zur atopieprophylaxe
US5591446A (en) *	1989-04-04	1997-01-07	Beiersdorf, A.G.	Methods and agents for the prophylaxis of atopy
DE3910761A1 (de) *	1989-04-04	1990-10-11	Bodo Dr Med Melnik	Mittel zur atopie-prophylaxe
JPH0395118A (ja) *	1989-09-07	1991-04-19	Green Cross Corp:The	プロスタグランジン含有脂肪小体製剤
US5882678A (en) *	1990-01-12	1999-03-16	The Liposome Co, Inc.	Interdigitation-fusion liposomes containing arachidonic acid metabolites
ATE176401T1 (de) *	1991-05-07	1999-02-15	Liposome Co Inc	Liposomale prostaglandinformulierungen
DE4125255A1 (de) *	1991-07-31	1993-02-04	Knoll Ag	Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung
US6005100A (en) *	1992-12-02	1999-12-21	Kabushiki Kaisha Hayashibara Seitbutsu Kagaku Kenkyujo	Trehalose composition for prolonging product shelf life
JP3168550B2 (ja) *	1992-12-02	2001-05-21	株式会社林原生物化学研究所	脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
WO1994022430A1 (en) *	1993-04-02	1994-10-13	The Liposome Company, Inc.	Method of producing liposomes
DE69426884T2 (de)	1993-07-08	2001-06-21	The Liposome Co.,Inc.	Verfahren zum kontrollieren der liposomengrösse
US5853755A (en) *	1993-07-28	1998-12-29	Pharmaderm Laboratories Ltd.	Biphasic multilamellar lipid vesicles
ATE187071T1 (de) *	1993-10-27	1999-12-15	Upjohn Co	Stabilisiertes prostaglandin e1
EP0726763B1 (en) *	1993-11-04	2000-03-29	The Liposome Company, Inc.	Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations
EP0729352B1 (en) *	1993-11-16	1999-02-03	The Liposome Company, Inc.	Interdigitation-fusion liposomes containing arachidonic acid metabolites
US5840328A (en) *	1994-01-11	1998-11-24	The Liposome Company, Inc.	Treatment using arachidonic acid metabolite and particulate formulations
US5716526A (en) *	1994-01-14	1998-02-10	The Liposome Company, Inc.	Method of separating materials from liposomes or lipid complexes
JPH10508578A (ja) *	1994-09-23	1998-08-25	ザリポソームカンパニー、インコーポレーテッド	凍結乾燥リポソーム生成物の製造方法
US5718917A (en) *	1995-12-15	1998-02-17	Harvard Scientific Corporation	PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction
US6447800B2 (en) *	1996-01-18	2002-09-10	The University Of British Columbia	Method of loading preformed liposomes using ethanol
US5980551A (en) *	1997-02-07	1999-11-09	Endovasc Ltd., Inc.	Composition and method for making a biodegradable drug delivery stent
US6001333A (en) *	1997-09-12	1999-12-14	See; Jackie R.	Methods of preparing micro encapsulated agents for use in the detection of tumors by CT imaging
US6019999A (en) *	1997-12-03	2000-02-01	Miller; David F.	Process for making liposomal ion-exchange whey protein and products thereof
JP2003342196A (ja) *	2002-05-31	2003-12-03	Mukku:Kk	静脈注射用組成物、その製造法およびその製剤
US20060280789A1 (en) *	2004-12-27	2006-12-14	Eisai Research Institute	Sustained release formulations
WO2008029763A1 (en) *	2006-09-05	2008-03-13	Q.P. Corporation	Prostaglandin fat emulsion, method for producing the same, method for stabilizing the same, and emulsifying agent
US20090035725A1 (en) *	2007-08-02	2009-02-05	Ondine International, Ltd.	Photodisinfection of oral cavity
EP2331070A1 (en) *	2008-09-26	2011-06-15	Phares Pharmaceutical Research N.V.	Method of solubilising biologically active compounds
US9835618B1 (en) *	2009-02-06	2017-12-05	Los Alamos National Security, Llc	Discovery, detection and use of biomarkers
IT1397867B1 (it) *	2010-02-03	2013-02-04	Brotzu	Liposomi contenenti prostaglandina e1 (pge1), formulazioni che li contengono e loro uso
WO2012021107A2 (en) *	2010-08-12	2012-02-16	Nanyang Technological University	A liposomal formulation for ocular drug delivery
US9956195B2 (en)	2014-01-07	2018-05-01	Nanyang Technological University	Stable liposomal formulations for ocular drug delivery
US9962393B1 (en) *	2015-06-21	2018-05-08	Angiosoma Research, Inc.	Method for treating vascular disease by administering a liposomal prostaglandin composition
EP3790554B1 (en) *	2018-05-07	2025-10-15	Pharmosa Biopharm Inc.	Pharmaceutical composition for controlled release of treprostinil
EP4312536A1 (en)	2021-04-01	2024-02-07	Vestaron Corporation	Liposome formulations for pesticide delivery and methods for producing and using the same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2274122A1 (fr) *	1974-06-07	1976-01-02	Cgr Mev	Procede de centrage d'un faisceau de balayage a rayonnement ionisant et dispositif permettant la mise en oeuvre de ce procede
US3993754A (en) *	1974-10-09	1976-11-23	The United States Of America As Represented By The United States Energy Research And Development Administration	Liposome-encapsulated actinomycin for cancer chemotherapy
US4086257A (en) *	1976-10-12	1978-04-25	Sears Barry D	Phosphatidyl quaternary ammonium compounds
GB1575343A (en) *	1977-05-10	1980-09-17	Ici Ltd	Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (pt) *	1977-08-05	1981-02-13	Battelle Memorial Institute
US4235871A (en) *	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
JPS55153713A (en) *	1979-05-02	1980-11-29	Kureha Chem Ind Co Ltd	Pharmaceutical preparation of ribosome containing active substance
US4522803A (en) *	1983-02-04	1985-06-11	The Liposome Company, Inc.	Stable plurilamellar vesicles, their preparation and use
JPS58222014A (ja) *	1982-06-18	1983-12-23	Taisho Pharmaceut Co Ltd	プロスタグランジンｅ↓１脂肪乳剤
US4588578A (en) *	1983-08-08	1986-05-13	The Liposome Company, Inc.	Lipid vesicles prepared in a monophase
EP0153955A1 (en) *	1983-09-06	1985-09-11	Health Research, Inc.	Liposome delivery method for decreasing the toxicity of an antitumor drug
JPH0818989B2 (ja) *	1984-01-12	1996-02-28	株式会社ミドリ十字	脂肪乳剤中のプロスタグランジンの安定化方法
US4721612A (en) *	1984-04-12	1988-01-26	The Liposome Company, Inc.	Steroidal liposomes
CA1264668A (en) *	1984-06-20	1990-01-23	Pieter R. Cullis	Extrusion techniques for producing liposomes
CA1270198A (en) *	1984-08-08	1990-06-12	Marcel B. Bally	Encapsulation of antineoplastic agents in liposomes
US4880635B1 (en) *	1984-08-08	1996-07-02	Liposome Company	Dehydrated liposomes
JPS61100518A (ja) *	1984-10-22	1986-05-19	Ono Pharmaceut Co Ltd	ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤
DE3689769T2 (de) *	1985-07-05	1994-07-21	Liposome Co Inc	Multilamellare liposome mit verbesserter einschliessungswirkung.

1988
- 1988-05-18 WO PCT/US1988/001714 patent/WO1988009170A1/en not_active Ceased
- 1988-05-18 AU AU19545/88A patent/AU617678B2/en not_active Ceased
- 1988-05-18 KR KR1019890700041A patent/KR970005171B1/ko not_active Expired - Fee Related
- 1988-05-18 US US07/195,228 patent/US5082664A/en not_active Expired - Lifetime
- 1988-05-20 AT AT88401235T patent/ATE109982T1/de not_active IP Right Cessation
- 1988-05-20 ES ES88401235T patent/ES2058317T3/es not_active Expired - Lifetime
- 1988-05-20 PT PT87545A patent/PT87545B/pt active IP Right Grant
- 1988-05-20 EP EP88401235A patent/EP0292403B1/en not_active Expired - Lifetime
- 1988-05-20 CA CA000567474A patent/CA1323838C/en not_active Expired - Fee Related
- 1988-05-20 DE DE3851090T patent/DE3851090T2/de not_active Expired - Fee Related
- 1988-05-23 ZA ZA883653A patent/ZA883653B/xx unknown
1989
- 1989-11-21 FI FI895554A patent/FI95199C/fi not_active IP Right Cessation
1998
- 1998-06-25 HK HK98106741A patent/HK1007496A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0292403B1 (en)	1994-08-17
AU617678B2 (en)	1991-12-05
FI95199B (fi)	1995-09-29
DE3851090D1 (de)	1994-09-22
HK1007496A1 (en)	1999-04-16
WO1988009170A1 (en)	1988-12-01
FI895554A0 (fi)	1989-11-21
ATE109982T1 (de)	1994-09-15
EP0292403A2 (en)	1988-11-23
PT87545A (pt)	1989-05-31
KR970005171B1 (ko)	1997-04-14
AU1954588A (en)	1988-12-21
EP0292403A3 (en)	1988-12-21
PT87545B (pt)	1992-12-31
ES2058317T3 (es)	1994-11-01
US5082664A (en)	1992-01-21
KR890701093A (ko)	1989-12-19
CA1323838C (en)	1993-11-02
DE3851090T2 (de)	1995-01-12
FI95199C (fi)	1996-01-10

Publication	Publication Date	Title
EP0292403A3 (en)	1988-12-21	Prostaglandin-lipid formulations
DK98189A (da)	1989-03-01	Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold
DE3378353D1 (en)	1988-12-08	Lung surfactant
NO172729C (no)	1993-09-01	Fremgangsmaate for fremstilling av en suspensjon av fosfolipidvesikler.
FI883597A7 (fi)	1989-02-05	Menetelmä sytotoksisten aineiden kasvainsoluihin toimittamiseen käyttökelpoisen vasta-aine-entsyymikonjugaatin valmistamiseksi
SE8603582D0 (sv)	1986-08-26	Komposition innehallande l-dopa
AR241117A2 (es)	1991-11-15	Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos
ES8307240A1 (es)	1983-06-16	Un procedimiento para la preparacion de un dihidroxi-compuesto.
HU896737D0 (en)	1990-02-28	Process for the preparation of compounds useful as intermediates in the preparation of tetrazole derivatives reducing the pathologically high cholesterin level in blood
ZA794188B (en)	1980-09-24	2-cycloalkyl-pyrimidin-5-yl-(thiono)(thiol)-phosphoric-(phosphonic)acid esters and esteramides,process for their preparation and their use as insecticides,acaricides and nematicides
PT81429A (en)	1985-12-01	Process for preparing solid drug formulations and stable suspensions containing 4-hydroxy- or 4-aciloxi-4-androstene-3,17-diones
Armato et al.	1983	Prostaglandins of the F series are extremely powerful growth factors for primary neonatal rat hepatocytes
EP0150710A3 (en)	1985-11-13	7-oxabicycloheptane prostaglandin analogs
ES473087A1 (es)	1979-04-16	Procedimiento para la preparacion de eritrocitos intactos modificados.
McClenaghan et al.	1997	Induction of a glucose-dependent insulin secretory response by the nonmetabolizable amino acid α-aminoisobutyric acid
PT87091A (pt)	1988-04-01	Process for preparing 3(5)-cyano-1h-pyrazole-4-carboxylic acid esters
BG44029A3 (en)	1988-09-15	Method for preparing of n- dimethyl morphinanic derivatives
DK183788A (da)	1988-10-07	Fremgangsmaade til foroegelse af levedygtigheden af frysetoerrede, maelkesyreproducerende bakteriekulturkoncentrater
GB2001995A (en)	1979-02-14	An immunostimulant, a process for preparing it, and compositions containing it
FR2617185B1 (fr)	1990-03-09	Procede de stabilisation de membranes cellulaires et son app lication a la conservation des cellules sous une forme protegeant l'essentiel de leurs antigenes de surface
IL83606A (en)	1992-03-29	Esters of 3-(3-substituted-3,3-difluoro-1-propenyl)2,2-dimethyl-cyclopropanecarboxylic acid,their preparation and their use as insecticides and acaricides
BG37445A1 (en)	1985-06-14	Alkyl esters of 5- chlor- 2- keto- bicyclo (2, 2, 1) heptane- 7- carbonic acid and method for its preparing
JPS5696693A (en)	1981-08-04	Production of human standard enzyme sample from human placenta
FR2598621B1 (fr)	1988-09-16	Nouvelle fraction antigenique obtenue par liberation dans un milieu de culture de vibrions choleriques, procede de preparation d'une telle fraction et son application a la preparation d'un vaccin cholerique oral
BG44281A1 (en)	1988-11-15	Bis (omega- chidroxyethoxyethylic) ester of 2- methyl- metoxy carbonyl- ethane phosphonic acid and method for its preparation