ZA891493B - 4-substituted imidazole derivatives useful in perioperative care - Google Patents

4-substituted imidazole derivatives useful in perioperative care

Info

Publication number: ZA891493B
Authority: ZA; South Africa
Prior art keywords: imidazole derivatives; derivatives useful; substituted imidazole; perioperative care; perioperative
Prior art date: 1988-02-29

Application number

ZA891493A

Other languages

English (en)

Inventor

Mervyn Maze

Maze Mervyn

Mika Scheinin

Scheinin Mika

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-29

Filing date

1989-02-27

Publication date

1989-11-29

1989-02-27 Application filed by Farmos Oy filed Critical Farmos Oy

1989-11-29 Publication of ZA891493B publication Critical patent/ZA891493B/xx

Links

-1 4-substituted imidazole Chemical class 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
CUHVIMMYOGQXCV-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CNC=N1 CUHVIMMYOGQXCV-UHFFFAOYSA-N 0.000 abstract 2
230000003444 anaesthetic effect Effects 0.000 abstract 1
229960002140 medetomidine Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Anesthesiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA891493A 1988-02-29 1989-02-27 4-substituted imidazole derivatives useful in perioperative care ZA891493B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8804683A GB2215206B (en)	1988-02-29	1988-02-29	4-substituted imidazole derivatives useful in perioperative care

Publications (1)

Publication Number	Publication Date
ZA891493B true ZA891493B (en)	1989-11-29

Family

ID=10632543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA891493A ZA891493B (en)	1988-02-29	1989-02-27	4-substituted imidazole derivatives useful in perioperative care

Country Status (13)

Country	Link
EP (1)	EP0331374B1 (de)
JP (1)	JP2856410B2 (de)
KR (1)	KR0136790B1 (de)
AT (1)	ATE101514T1 (de)
AU (1)	AU611262B2 (de)
CA (1)	CA1338556C (de)
DE (1)	DE68913054T2 (de)
DK (1)	DK175282B1 (de)
GB (1)	GB2215206B (de)
HU (1)	HU202751B (de)
IE (1)	IE60538B1 (de)
NZ (1)	NZ228125A (de)
ZA (1)	ZA891493B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI894911A0 (fi) *	1989-10-17	1989-10-17	Farmos Oy	En terapeutiskt vaerdefull foerening.
GB9111732D0 (en) *	1991-05-31	1991-07-24	Orion Yhtymae Oy	The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2281206A (en) *	1993-08-25	1995-03-01	Orion Yhtymae Oy	Use of dexmedetomidine
AU5127996A (en) *	1995-12-28	1997-07-28	Procter & Gamble Company, The	Substituted 6-r-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
RU2157210C2 (ru) *	1995-12-28	2000-10-10	Проктер энд Гэмбл Компани	Замещенные 6h-1,3,4-тиадиазин-2-амины, их применение в качестве анестезирующих, сердечно-сосудистых и гипометаболических средств и содержащие их фармацевтические композиции
ATE213415T1 (de)	1995-12-28	2002-03-15	N T Predpr Sligands Obschestvo	Substituierte 6-h-1,3,4,-thiadiazin-2-amine, deren verwendung als anaesthetisierende, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
ES2165930T3 (es) *	1995-12-28	2002-04-01	N T Predpr Ligand Obschestvo S	6-h-1,3,4-tiadiazin-2-amina sustituidos, su empleo como agentes anestesicos, cardiovasculares e hipometabolicos, y composicion farmaceutica que los contiene.
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
WO2007085556A2 (en)	2006-01-27	2007-08-02	F. Hoffmann-La Roche Ag	Use of 4-imidazole derivatives for cns disorders
AU2007312390B2 (en)	2006-10-19	2013-03-28	F. Hoffmann-La Roche Ag	Aminomethyl-4-imidazoles
CA2668454A1 (en)	2006-11-02	2008-05-08	F. Hoffmann-La Roche Ag	Substituted 2-imidazoles
WO2008058867A2 (en)	2006-11-16	2008-05-22	F. Hoffmann-La Roche Ag	Substituted 4-imidazoles
ES2364701T3 (es)	2006-12-13	2011-09-12	F. Hoffmann-La Roche Ag	Nuevos 2-imidazoles como ligandos para receptores asociados a aminas trazas.
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
EP2114906B1 (de)	2007-02-02	2014-08-06	F. Hoffmann-La Roche AG	2-aminooxazolinverbindungen als taar1-liganden für erkrankungen des zentralen nervensystems
CA2676944C (en)	2007-02-15	2016-01-19	F. Hoffmann-La Roche Ag	2-aminooxazolines as taar1 ligands
WO2009003868A2 (en)	2007-07-02	2009-01-08	F. Hoffmann-La Roche Ag	2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
AU2008270444A1 (en)	2007-07-03	2009-01-08	F. Hoffmann-La Roche Ag	4-imidazolines and their use as antidepressants
CA2694362A1 (en)	2007-07-27	2009-02-05	F. Hoffmann-La Roche Ag	2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
AU2008285795A1 (en)	2007-08-03	2009-02-12	F. Hoffmann-La Roche Ag	Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
EP3241553B1 (de) *	2009-02-13	2019-04-10	Allergan, Inc.	Pharmazeutische zusammensetzungen mit (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
EP2782569A1 (de)	2011-11-21	2014-10-01	Allergan, Inc.	Pharmazeutische zusammensetzungen mit 4-[1-(2,3-dimethylphenyl-)ethyl-]3h-imidazolderivaten zur behandlung von netzhauterkrankungen
BR112016006848A2 (pt)	2013-10-07	2017-08-01	Teikoku Pharma Usa Inc	métodos e composições para distribuição transdérmica de uma quantidade não sedativa de dexmedetomidina
KR101827980B1 (ko)	2013-10-07	2018-02-13	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
CA2924233C (en)	2013-10-07	2018-10-23	Teikoku Pharma Usa, Inc.	Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
WO2017157873A1 (en)	2016-03-17	2017-09-21	F. Hoffmann-La Roche Ag	5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
TWI764951B (zh) *	2016-10-31	2022-05-21	美商帝國製藥美國股份有限公司	用於處理疼痛之右美托咪啶經皮遞送裝置
US12472158B2 (en)	2019-02-27	2025-11-18	Vanderbilt University	Methods of treating trigeminal nerve pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3202660A (en)	1961-10-09	1965-08-24	Boehringer Sohn Ingelheim	Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
FI844786A0 (fi) *	1984-12-04	1984-12-04	Farmos Oy	Terapeutiskt utnyttjbar foerening.
FI864570A0 (fi) *	1986-11-11	1986-11-11	Farmos Oy	Terapeutiskt anvaendbar foerening.
GB2206880B (en) *	1987-07-16	1991-04-24	Farmos Oy	Optical isomers of an imidazole derivative

1988
- 1988-02-29 GB GB8804683A patent/GB2215206B/en not_active Expired - Fee Related
1989
- 1989-02-02 DK DK198900464A patent/DK175282B1/da not_active IP Right Cessation
- 1989-02-23 AU AU30272/89A patent/AU611262B2/en not_active Expired
- 1989-02-24 DE DE68913054T patent/DE68913054T2/de not_active Expired - Fee Related
- 1989-02-24 AT AT89301866T patent/ATE101514T1/de not_active IP Right Cessation
- 1989-02-24 NZ NZ228125A patent/NZ228125A/en unknown
- 1989-02-24 EP EP89301866A patent/EP0331374B1/de not_active Expired - Lifetime
- 1989-02-27 ZA ZA891493A patent/ZA891493B/xx unknown
- 1989-02-27 KR KR1019890002361A patent/KR0136790B1/ko not_active Expired - Lifetime
- 1989-02-27 JP JP1048391A patent/JP2856410B2/ja not_active Expired - Lifetime
- 1989-02-27 HU HU89917A patent/HU202751B/hu not_active IP Right Cessation
- 1989-02-28 IE IE63989A patent/IE60538B1/en not_active IP Right Cessation
- 1989-02-28 CA CA000592371A patent/CA1338556C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB8804683D0 (en)	1988-03-30
IE890639L (en)	1989-08-29
EP0331374A2 (de)	1989-09-06
JPH01294623A (ja)	1989-11-28
KR0136790B1 (ko)	1998-04-25
DK175282B1 (da)	2004-08-09
DK46489A (da)	1989-08-30
KR890012647A (ko)	1989-09-18
ATE101514T1 (de)	1994-03-15
EP0331374B1 (de)	1994-02-16
DK46489D0 (da)	1989-02-02
HU202751B (en)	1991-04-29
AU3027289A (en)	1989-08-31
GB2215206B (en)	1991-07-03
NZ228125A (en)	1996-12-20
AU611262B2 (en)	1991-06-06
DE68913054T2 (de)	1994-07-07
EP0331374A3 (en)	1990-10-10
GB2215206A (en)	1989-09-20
HUT51139A (en)	1990-04-28
CA1338556C (en)	1996-08-27
IE60538B1 (en)	1994-07-27
DE68913054D1 (de)	1994-03-24
JP2856410B2 (ja)	1999-02-10

Publication	Publication Date	Title
GB2215206B (en)	1991-07-03	4-substituted imidazole derivatives useful in perioperative care
ATE86109T1 (de)	1993-03-15	Verwendung von substituierten imidazolen zur herstellung eines analgetikums.
NO174508C (de)	1994-05-18
DK0671161T3 (da)	2004-02-09	Ectoin og ectoinderivater som fugtighedsgiver i kosmetikprodukter
SE8503680D0 (sv)	1985-08-01	Indolderivat
YU47204B (sh)	1995-01-31	Derivati didehidro-vitamina d3
AU2169195A (en)	1995-12-21	Methods of administering CRF antagonists
CS782686A2 (en)	1990-05-14	Method of benzimidazole derivatives production
DK508985A (da)	1986-06-05	Anvendelse af 4-((alfa-metyl)-2,3-dimetylbenzyl)-imidazol til fremstilling af veterinaere praeparater
EP0627241A3 (de)	1995-02-08	Spannungsregler für Herzschrittmacher.
DE69516186D1 (de)	2000-05-11	Verwendung von Beta-Aminopropionsäure-Derivaten als Fungizide
ATE102191T1 (de)	1994-03-15	Substituierte 4-(1h-imidazol-1-yl>benzamide als antiarrhythmische mittel.
ATE173476T1 (de)	1998-12-15	1-(4-(imidazol-1-yl)benzoyl>piperidin-derivate als antiarrhythmica
ATE121401T1 (de)	1995-05-15	2-substituierte 4,5-diphenylimidazole.
AU1643592A (en)	1992-11-17	Novel compound and use of the same as medicine
MX9205186A (es)	1993-03-01	Derivados de 4-[4-[4-(4-hidroxifenil)-1-piperazinil]-fenil]-5-metil-3h-1,2,4-triazo l-3-ona
AU7668087A (en)	1988-02-11	Immunologically active phenyl and substituted carbonyl amino heterocyclic derivatives
IL87561A0 (en)	1989-01-31	Benzimidazole derivatives and pharmaceutical compositions containing the same
IL84096A (en)	1991-07-18	Therapeutic compositions for the treatment of peptic ulcer disease comprising a 1-(oxoalkyl)-3,7-dialkylxanthine
ATE66921T1 (de)	1991-09-15	Verwendung von triazolylderivate zur bekaempfung von pilzen.
LV11461A (lv)	1996-08-20	Dihloraizvietotie imidazola atvasinajumi ka pretsenisu lidzekli
PL298827A1 (en)	1993-11-15	Novel enantiomers derivatives of (s)-2-amino(3,4-dichlorobenzyl) propanol-1
ATE54912T1 (de)	1990-08-15	Mevalonolactonaehnliche imidazole und derivate.
ATE120086T1 (de)	1995-04-15	Therapeutische verwendung des 1,3-dimethylol-5,5- dimethylhydantoins.