ZA911233B - Temporary minimal protection synthesis of lh-rh analogs - Google Patents

Temporary minimal protection synthesis of lh-rh analogs

Info

Publication number: ZA911233B
Authority: ZA; South Africa
Prior art keywords: analogs; synthesis; minimal protection; protection synthesis; temporary
Prior art date: 1990-02-20

Application number

ZA911233A

Other languages

English (en)

Inventor

John Joseph Nestor Jr

Joseph Nestor John Jr

Natlaie Lewis Mcclure

Lewis Mcclure Natlaie

Humberto Arzeno

Arzeno Humberto

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-20

Filing date

1991-02-19

Publication date

1992-10-28

1991-02-19 Application filed by Syntex Inc filed Critical Syntex Inc

1992-10-28 Publication of ZA911233B publication Critical patent/ZA911233B/xx

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000012351 deprotecting agent Substances 0.000 abstract 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Bipolar Integrated Circuits (AREA)
Liquid Developers In Electrophotography (AREA)
Amplifiers (AREA)
Escalators And Moving Walkways (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Electrophonic Musical Instruments (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Investigating Or Analysing Biological Materials (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Fuses (AREA)
Semiconductor Integrated Circuits (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Variable-Direction Aerials And Aerial Arrays (AREA)
Golf Clubs (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA911233A 1990-02-20 1991-02-19 Temporary minimal protection synthesis of lh-rh analogs ZA911233B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48242890A	1990-02-20	1990-02-20

Publications (1)

Publication Number	Publication Date
ZA911233B true ZA911233B (en)	1992-10-28

Family

ID=23916033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA911233A ZA911233B (en)	1990-02-20	1991-02-19	Temporary minimal protection synthesis of lh-rh analogs

Country Status (18)

Country	Link
EP (1)	EP0443532B1 (fr)
JP (1)	JP2927978B2 (fr)
KR (1)	KR0152276B1 (fr)
AT (1)	ATE107931T1 (fr)
AU (1)	AU639751B2 (fr)
CA (1)	CA2036657C (fr)
DE (1)	DE69102659T2 (fr)
DK (1)	DK0443532T3 (fr)
ES (1)	ES2057624T3 (fr)
FI (1)	FI102538B1 (fr)
HK (1)	HK43097A (fr)
HU (1)	HU208158B (fr)
IE (1)	IE71945B1 (fr)
NO (1)	NO309428B1 (fr)
NZ (1)	NZ237159A (fr)
PH (1)	PH31062A (fr)
PT (1)	PT96807B (fr)
ZA (1)	ZA911233B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104231055A (zh)	2013-06-18	2014-12-24	深圳翰宇药业股份有限公司	加尼瑞克前体以及由其制备醋酸加尼瑞克的方法
KR101971418B1 (ko) *	2017-06-30	2019-04-24	애니젠 주식회사	고세렐린의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4301066A (en) *	1980-05-08	1981-11-17	American Home Products Corp.	Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
US4632979A (en) *	1984-06-18	1986-12-30	Tulane Educational Fund	Therapeutic LHRH analogs
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists

1991
- 1991-02-19 DE DE69102659T patent/DE69102659T2/de not_active Expired - Lifetime
- 1991-02-19 KR KR1019910002623A patent/KR0152276B1/ko not_active Expired - Lifetime
- 1991-02-19 CA CA002036657A patent/CA2036657C/fr not_active Expired - Lifetime
- 1991-02-19 NZ NZ237159A patent/NZ237159A/en unknown
- 1991-02-19 PT PT96807A patent/PT96807B/pt not_active IP Right Cessation
- 1991-02-19 PH PH42022A patent/PH31062A/en unknown
- 1991-02-19 DK DK91102370.3T patent/DK0443532T3/da active
- 1991-02-19 IE IE55691A patent/IE71945B1/en not_active IP Right Cessation
- 1991-02-19 HU HU91543A patent/HU208158B/hu unknown
- 1991-02-19 NO NO910664A patent/NO309428B1/no not_active IP Right Cessation
- 1991-02-19 ZA ZA911233A patent/ZA911233B/xx unknown
- 1991-02-19 EP EP91102370A patent/EP0443532B1/fr not_active Expired - Lifetime
- 1991-02-19 FI FI910788A patent/FI102538B1/fi active
- 1991-02-19 AU AU71176/91A patent/AU639751B2/en not_active Expired
- 1991-02-19 AT AT91102370T patent/ATE107931T1/de not_active IP Right Cessation
- 1991-02-19 ES ES91102370T patent/ES2057624T3/es not_active Expired - Lifetime
- 1991-02-20 JP JP3026462A patent/JP2927978B2/ja not_active Expired - Lifetime
1997
- 1997-04-03 HK HK43097A patent/HK43097A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2036657A1 (fr)	1991-08-21
FI102538B (fi)	1998-12-31
NO309428B1 (no)	2001-01-29
EP0443532B1 (fr)	1994-06-29
PH31062A (en)	1998-02-05
JP2927978B2 (ja)	1999-07-28
DK0443532T3 (da)	1994-07-25
EP0443532A2 (fr)	1991-08-28
AU7117691A (en)	1991-08-22
HU208158B (en)	1993-08-30
IE71945B1 (en)	1997-03-12
HK43097A (en)	1997-04-11
NO910664D0 (no)	1991-02-19
ES2057624T3 (es)	1994-10-16
PT96807A (pt)	1991-10-31
NO910664L (no)	1991-08-21
FI910788A0 (fi)	1991-02-19
FI910788L (fi)	1991-08-21
CA2036657C (fr)	2003-02-11
PT96807B (pt)	1998-07-31
JPH04211096A (ja)	1992-08-03
HU910543D0 (en)	1991-09-30
KR0152276B1 (ko)	1998-10-01
NZ237159A (en)	1992-11-25
HUT57234A (en)	1991-11-28
AU639751B2 (en)	1993-08-05
IE910556A1 (en)	1991-08-28
DE69102659T2 (de)	1995-02-23
KR910021411A (ko)	1991-12-20
ATE107931T1 (de)	1994-07-15
FI102538B1 (fi)	1998-12-31
DE69102659D1 (de)	1994-08-04
EP0443532A3 (en)	1992-02-26

Publication	Publication Date	Title
DK0580635T3 (da)	1998-01-19	Modificerede plantevirus som vektorer
FI942005L (fi)	1994-10-30	Peptidianalogeja irreversiibeleinä interleukiini-1beta-proteaasi-inhibiittoreina
FI923280A0 (fi)	1992-07-17	Aminosubstituerade piperazinderivat.
FI934225A7 (fi)	1993-10-15	Bis-naftaali-imideja, jotka sisältävät aminohapoista johdettuja kytken täaineita syövänvastaisina aineina
FR2626874B1 (fr)	1992-05-07	Fertilisant azote ameliore
NO921256D0 (no)	1992-03-31	Aminosyre-beta-lyaseenzyminhibitor som deodoranter
KR0180256B1 (en)	1999-04-01	Bpc peptides, their preparation and use
EP0176106A3 (en)	1987-08-19	N,n',n-tris((2,2,6,6-tetramethyl-4-piperidyl)triazinyl)-undecane triamines as stabilizers for synthetic polymers
EP0328090A3 (fr)	1990-08-16	Analogues du LHRH
ZA893346B (en)	1990-01-31	Anticoagulant peptide alcohols
EP0443532A3 (en)	1992-02-26	Temporary minimal protection synthesis of lh-rh analogs
FR2710243B3 (fr)	1995-10-13	Composition énergétique à base d'acides aminés à chaîne ramifiée.
BR9101964A (pt)	1991-12-24	Composto amino
FI941394L (fi)	1994-03-25	Peptidejä,jotka kykenevät säätelemään akrosomireaktiota
ITTO920891A1 (it)	1994-05-03	Macchina spandiconcime di tipo centrifugo.
EP0671935A4 (fr)	1997-12-17	Conjugues d'acides amines d'amines cyclohexapeptidyles.
FI991120A0 (fi)	1999-05-17	Vesiliukoisten peptidien pitkäaikaisesti vapautuvat koostumukset
ITMI921477A0 (it)	1992-06-17	Derivato dell'alfa tocoferolo solubile
ITMI922675A0 (it)	1992-11-23	Peptidi immunogenici
IT1224850B (it)	1990-10-24	2-[n-(3,4-dimetossifenil-1,3-ditiano-1,1,3,3,-tetraossido-3-propil)ammino]-6,7-dimetossi tetraline
ITRE920037A1 (it)	1993-11-07	Giostra tipo tagada'
IT1237400B (it)	1993-06-01	Composizioni erbicide a base di acetanilidi a selettivita' migliorata.
IT228889Y1 (it)	1998-05-28	Zappatrice agricola di tipo perfezionato