PT96807A - Processo melhorado para a sintese de analogos de lh-rh (hormona de libertacao da hormona de luteinizacao) com proteccao minima temporaria - Google Patents

Processo melhorado para a sintese de analogos de lh-rh (hormona de libertacao da hormona de luteinizacao) com proteccao minima temporaria

Info

Publication number: PT96807A
Authority: PT; Portugal
Prior art keywords: hormone; luteinization; analogue; synthetic; improved process
Prior art date: 1990-02-20

Application number

PT96807A

Other languages

English (en)

Other versions

PT96807B (pt

Inventor

John J Nestor Jr

Natalie L Mc Clure

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-20

Filing date

1991-02-19

Publication date

1991-10-31

1991-02-19 Application filed by Syntex Inc filed Critical Syntex Inc

1991-10-31 Publication of PT96807A publication Critical patent/PT96807A/pt

1998-07-31 Publication of PT96807B publication Critical patent/PT96807B/pt

Links

XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 2
239000005556 hormone Substances 0.000 title 2
229940088597 hormone Drugs 0.000 title 2
101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 title 1
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title 1
230000029849 luteinization Effects 0.000 title 1
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000012351 deprotecting agent Substances 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Bipolar Integrated Circuits (AREA)
Amplifiers (AREA)
Liquid Developers In Electrophotography (AREA)
Escalators And Moving Walkways (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Electrophonic Musical Instruments (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Golf Clubs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Variable-Direction Aerials And Aerial Arrays (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Semiconductor Integrated Circuits (AREA)
Fuses (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

PT96807A 1990-02-20 1991-02-19 Processo melhorado para a sintese de analogos de lh-rh (hormona de libertacao da hormona de luteinizacao) com proteccao minima temporaria PT96807B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48242890A	1990-02-20	1990-02-20

Publications (2)

Publication Number	Publication Date
PT96807A true PT96807A (pt)	1991-10-31
PT96807B PT96807B (pt)	1998-07-31

Family

ID=23916033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96807A PT96807B (pt)	1990-02-20	1991-02-19	Processo melhorado para a sintese de analogos de lh-rh (hormona de libertacao da hormona de luteinizacao) com proteccao minima temporaria

Country Status (18)

Country	Link
EP (1)	EP0443532B1 (pt)
JP (1)	JP2927978B2 (pt)
KR (1)	KR0152276B1 (pt)
AT (1)	ATE107931T1 (pt)
AU (1)	AU639751B2 (pt)
CA (1)	CA2036657C (pt)
DE (1)	DE69102659T2 (pt)
DK (1)	DK0443532T3 (pt)
ES (1)	ES2057624T3 (pt)
FI (1)	FI102538B1 (pt)
HK (1)	HK43097A (pt)
HU (1)	HU208158B (pt)
IE (1)	IE71945B1 (pt)
NO (1)	NO309428B1 (pt)
NZ (1)	NZ237159A (pt)
PH (1)	PH31062A (pt)
PT (1)	PT96807B (pt)
ZA (1)	ZA911233B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104231055A (zh) *	2013-06-18	2014-12-24	深圳翰宇药业股份有限公司	加尼瑞克前体以及由其制备醋酸加尼瑞克的方法
KR101971418B1 (ko) *	2017-06-30	2019-04-24	애니젠 주식회사	고세렐린의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4301066A (en) *	1980-05-08	1981-11-17	American Home Products Corp.	Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
US4632979A (en) *	1984-06-18	1986-12-30	Tulane Educational Fund	Therapeutic LHRH analogs
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists

1991
- 1991-02-19 PT PT96807A patent/PT96807B/pt not_active IP Right Cessation
- 1991-02-19 NZ NZ237159A patent/NZ237159A/en unknown
- 1991-02-19 IE IE55691A patent/IE71945B1/en not_active IP Right Cessation
- 1991-02-19 ES ES91102370T patent/ES2057624T3/es not_active Expired - Lifetime
- 1991-02-19 FI FI910788A patent/FI102538B1/fi active
- 1991-02-19 AT AT91102370T patent/ATE107931T1/de not_active IP Right Cessation
- 1991-02-19 PH PH42022A patent/PH31062A/en unknown
- 1991-02-19 EP EP91102370A patent/EP0443532B1/en not_active Expired - Lifetime
- 1991-02-19 NO NO910664A patent/NO309428B1/no not_active IP Right Cessation
- 1991-02-19 KR KR1019910002623A patent/KR0152276B1/ko not_active Expired - Lifetime
- 1991-02-19 HU HU91543A patent/HU208158B/hu unknown
- 1991-02-19 CA CA002036657A patent/CA2036657C/en not_active Expired - Lifetime
- 1991-02-19 AU AU71176/91A patent/AU639751B2/en not_active Expired
- 1991-02-19 ZA ZA911233A patent/ZA911233B/xx unknown
- 1991-02-19 DK DK91102370.3T patent/DK0443532T3/da active
- 1991-02-19 DE DE69102659T patent/DE69102659T2/de not_active Expired - Lifetime
- 1991-02-20 JP JP3026462A patent/JP2927978B2/ja not_active Expired - Lifetime
1997
- 1997-04-03 HK HK43097A patent/HK43097A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI910788A0 (fi)	1991-02-19
PT96807B (pt)	1998-07-31
PH31062A (en)	1998-02-05
IE910556A1 (en)	1991-08-28
HK43097A (en)	1997-04-11
DE69102659T2 (de)	1995-02-23
AU639751B2 (en)	1993-08-05
DK0443532T3 (da)	1994-07-25
KR0152276B1 (ko)	1998-10-01
ES2057624T3 (es)	1994-10-16
ZA911233B (en)	1992-10-28
CA2036657C (en)	2003-02-11
JPH04211096A (ja)	1992-08-03
IE71945B1 (en)	1997-03-12
JP2927978B2 (ja)	1999-07-28
NO309428B1 (no)	2001-01-29
NO910664L (no)	1991-08-21
KR910021411A (ko)	1991-12-20
FI910788L (fi)	1991-08-21
HU208158B (en)	1993-08-30
EP0443532B1 (en)	1994-06-29
NO910664D0 (no)	1991-02-19
NZ237159A (en)	1992-11-25
HU910543D0 (en)	1991-09-30
FI102538B (fi)	1998-12-31
ATE107931T1 (de)	1994-07-15
CA2036657A1 (en)	1991-08-21
AU7117691A (en)	1991-08-22
FI102538B1 (fi)	1998-12-31
EP0443532A3 (en)	1992-02-26
EP0443532A2 (en)	1991-08-28
HUT57234A (en)	1991-11-28
DE69102659D1 (de)	1994-08-04

Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910708

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980413

2013-04-23

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20130415

Publication	Publication Date	Title
KR950700728A (ko)	1995-02-20	약제형 및 그밖의 다른 복용형(Pharmaceutical and other dosage forms)
DK0792287T3 (da)	2004-08-30	Peptidanaloger af humant basisk myelinprotein
NO901399L (no)	1990-10-01	Aminosyrederivater.
PT81991B (pt)	1988-03-03	Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas
BR7604460A (pt)	1977-07-26	Processo para a preparacao de n-(3-trifluor-metil-4-halogeno-fenil)-n'-benzoil-ureias,e composicoes inseticidas a base destas
ATE121755T1 (de)	1995-05-15	Deletionsanaloga von magaininpeptiden.
FR2609998B1 (fr)	1994-04-15	Nouvelles substances antioxydantes derivees d'acides amines
NO921256D0 (no)	1992-03-31	Aminosyre-beta-lyaseenzyminhibitor som deodoranter
IT8319160A0 (it)	1983-01-18	Procedimento di sintesi di peptidi e agenti di bloccaggio di amminoacidi.
IT1125557B (it)	1986-05-14	Peptide antibatterico a base di amminoacidi
ATE171708T1 (de)	1998-10-15	Flüssigphasensynthese von peptiden und peptidderivaten
PT90504A (pt)	1989-11-30	Processo para a preparacao de alcoois peptidicos com actividade anticoagulante
ATE165369T1 (de)	1998-05-15	Antikoagulierende peptide
NO901533D0 (no)	1990-04-04	Aminosyrederivater.
AU639751B2 (en)	1993-08-05	Temporary minimal protection synthesis of lh-rh analogs
NO883520D0 (no)	1988-08-08	Fremgangsmaate for fremstilling av et injeksjonspreparat.
ES2112921T3 (es)	1998-04-16	Peptidos y anticuerpos para el tratamiento de la artritis reumatoide.
FR2710243B3 (fr)	1995-10-13	Composition énergétique à base d'acides aminés à chaîne ramifiée.
NO901519L (no)	1990-10-05	Aminosyrederivater.
EP0671935A4 (en)	1997-12-17	AMINIC ACID CONJUGATES OF AMINE CYCLOHEXAPEPTIDES.
ES1021120Y (es)	1993-03-16	Calzado tipo bota perfeccionado.
IT1228077B (it)	1991-05-28	Linea di trasporto per sottoporre calzature all'esecuzione sequenziale di lavorazioni da parte di rispettive macchine operatrici.