ATE107931T1 - Synthese von lh-rh-analogen unter anwendung eines zeitlich begrenzten minimalen schutzes. - Google Patents

Synthese von lh-rh-analogen unter anwendung eines zeitlich begrenzten minimalen schutzes.

Info

Publication number: ATE107931T1
Authority: AT; Austria
Prior art keywords: synthesis; analogues; minimal protection; temporary; temporary minimal
Prior art date: 1990-02-20

Application number

AT91102370T

Other languages

English (en)

Inventor

John J Nestor Jr

Natalie L Mcclure

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-20

Filing date

1991-02-19

Publication date

1994-07-15

1991-02-19 Application filed by Syntex Inc filed Critical Syntex Inc

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107931T1 publication Critical patent/ATE107931T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000012351 deprotecting agent Substances 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Bipolar Integrated Circuits (AREA)
Amplifiers (AREA)
Liquid Developers In Electrophotography (AREA)
Escalators And Moving Walkways (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Electrophonic Musical Instruments (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Fuses (AREA)
Investigating Or Analysing Biological Materials (AREA)
Semiconductor Integrated Circuits (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Golf Clubs (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Variable-Direction Aerials And Aerial Arrays (AREA)

AT91102370T 1990-02-20 1991-02-19 Synthese von lh-rh-analogen unter anwendung eines zeitlich begrenzten minimalen schutzes. ATE107931T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48242890A	1990-02-20	1990-02-20

Publications (1)

Publication Number	Publication Date
ATE107931T1 true ATE107931T1 (de)	1994-07-15

Family

ID=23916033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91102370T ATE107931T1 (de)	1990-02-20	1991-02-19	Synthese von lh-rh-analogen unter anwendung eines zeitlich begrenzten minimalen schutzes.

Country Status (18)

Country	Link
EP (1)	EP0443532B1 (de)
JP (1)	JP2927978B2 (de)
KR (1)	KR0152276B1 (de)
AT (1)	ATE107931T1 (de)
AU (1)	AU639751B2 (de)
CA (1)	CA2036657C (de)
DE (1)	DE69102659T2 (de)
DK (1)	DK0443532T3 (de)
ES (1)	ES2057624T3 (de)
FI (1)	FI102538B (de)
HK (1)	HK43097A (de)
HU (1)	HU208158B (de)
IE (1)	IE71945B1 (de)
NO (1)	NO309428B1 (de)
NZ (1)	NZ237159A (de)
PH (1)	PH31062A (de)
PT (1)	PT96807B (de)
ZA (1)	ZA911233B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104231055A (zh)	2013-06-18	2014-12-24	深圳翰宇药业股份有限公司	加尼瑞克前体以及由其制备醋酸加尼瑞克的方法
KR101971418B1 (ko) *	2017-06-30	2019-04-24	애니젠 주식회사	고세렐린의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4301066A (en) *	1980-05-08	1981-11-17	American Home Products Corp.	Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
US4632979A (en) *	1984-06-18	1986-12-30	Tulane Educational Fund	Therapeutic LHRH analogs
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists

1991
- 1991-02-19 DK DK91102370.3T patent/DK0443532T3/da active
- 1991-02-19 EP EP91102370A patent/EP0443532B1/de not_active Expired - Lifetime
- 1991-02-19 NZ NZ237159A patent/NZ237159A/en unknown
- 1991-02-19 HU HU91543A patent/HU208158B/hu unknown
- 1991-02-19 FI FI910788A patent/FI102538B/fi active
- 1991-02-19 KR KR1019910002623A patent/KR0152276B1/ko not_active Expired - Lifetime
- 1991-02-19 DE DE69102659T patent/DE69102659T2/de not_active Expired - Lifetime
- 1991-02-19 NO NO910664A patent/NO309428B1/no not_active IP Right Cessation
- 1991-02-19 CA CA002036657A patent/CA2036657C/en not_active Expired - Lifetime
- 1991-02-19 PT PT96807A patent/PT96807B/pt not_active IP Right Cessation
- 1991-02-19 ZA ZA911233A patent/ZA911233B/xx unknown
- 1991-02-19 ES ES91102370T patent/ES2057624T3/es not_active Expired - Lifetime
- 1991-02-19 IE IE55691A patent/IE71945B1/en not_active IP Right Cessation
- 1991-02-19 AT AT91102370T patent/ATE107931T1/de not_active IP Right Cessation
- 1991-02-19 AU AU71176/91A patent/AU639751B2/en not_active Expired
- 1991-02-19 PH PH42022A patent/PH31062A/en unknown
- 1991-02-20 JP JP3026462A patent/JP2927978B2/ja not_active Expired - Lifetime
1997
- 1997-04-03 HK HK43097A patent/HK43097A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0443532A2 (de)	1991-08-28
FI910788L (fi)	1991-08-21
AU639751B2 (en)	1993-08-05
NO910664D0 (no)	1991-02-19
NO309428B1 (no)	2001-01-29
DE69102659D1 (de)	1994-08-04
EP0443532B1 (de)	1994-06-29
HU208158B (en)	1993-08-30
CA2036657C (en)	2003-02-11
JPH04211096A (ja)	1992-08-03
FI102538B1 (fi)	1998-12-31
KR910021411A (ko)	1991-12-20
JP2927978B2 (ja)	1999-07-28
PT96807B (pt)	1998-07-31
KR0152276B1 (ko)	1998-10-01
DK0443532T3 (da)	1994-07-25
DE69102659T2 (de)	1995-02-23
IE71945B1 (en)	1997-03-12
IE910556A1 (en)	1991-08-28
HUT57234A (en)	1991-11-28
ES2057624T3 (es)	1994-10-16
HU910543D0 (en)	1991-09-30
NZ237159A (en)	1992-11-25
PT96807A (pt)	1991-10-31
ZA911233B (en)	1992-10-28
AU7117691A (en)	1991-08-22
FI910788A0 (fi)	1991-02-19
CA2036657A1 (en)	1991-08-21
PH31062A (en)	1998-02-05
EP0443532A3 (en)	1992-02-26
FI102538B (fi)	1998-12-31
HK43097A (en)	1997-04-11
NO910664L (no)	1991-08-21

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2011-05-15	EELA	Cancelled due to lapse of time