ZA938019B - Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses - Google Patents

Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Info

Publication number: ZA938019B
Authority: ZA; South Africa
Prior art keywords: ones; pyran; dihydropyran; retroviruses; useful
Prior art date: 1992-11-13

Application number

ZA938019A

Other languages

English (en)

Inventor

Suvit Thaisrivongs

Chih-Ping Yang

Joseph Walter Strohbach

Steven Ronald Turner

Donna Lee Romero

Louis L Skaletzki

Paul Adrian Aristoff

Ronald B Gammill

Paul D Johnson

Harvey Irving Skulnick

Richard C Piper

Ruben A Tommasi

Qingwei Zhang

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-13

Filing date

1993-10-27

Publication date

1995-04-28

1993-10-27 Application filed by Upjohn Co filed Critical Upjohn Co

1995-04-28 Publication of ZA938019B publication Critical patent/ZA938019B/xx

Links

QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 title 1
ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title 1
241001430294 unidentified retrovirus Species 0.000 title 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 2
150000000464 2H-pyran-2-ones Chemical class 0.000 abstract 1
208000002874 Acne Vulgaris Diseases 0.000 abstract 1
201000004384 Alopecia Diseases 0.000 abstract 1
206010020112 Hirsutism Diseases 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
206010039792 Seborrhoea Diseases 0.000 abstract 1
206010000496 acne Diseases 0.000 abstract 1
231100000360 alopecia Toxicity 0.000 abstract 1
208000008742 seborrheic dermatitis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Cosmetics (AREA)

ZA938019A 1992-11-13 1993-10-27 Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses ZA938019B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US97534392A	1992-11-13	1992-11-13
US9087693A	1993-07-13	1993-07-13
US13064193A	1993-10-01	1993-10-01

Publications (1)

Publication Number	Publication Date
ZA938019B true ZA938019B (en)	1995-04-28

Family

ID=27376682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA938019A ZA938019B (en)	1992-11-13	1993-10-27	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Country Status (26)

Country	Link
EP (2)	EP1203770B1 (de)
JP (1)	JP3583127B2 (de)
KR (1)	KR100314975B1 (de)
CN (1)	CN1040321C (de)
AT (2)	ATE290531T1 (de)
AU (1)	AU687368B2 (de)
BR (1)	BR9307451A (de)
CA (1)	CA2145661C (de)
CZ (1)	CZ291853B6 (de)
DE (2)	DE69332292T2 (de)
DK (2)	DK0668860T3 (de)
ES (2)	ES2237624T3 (de)
FI (1)	FI120399B (de)
GE (1)	GEP20094660B (de)
HU (1)	HU228126B1 (de)
IL (1)	IL107556A (de)
LV (1)	LV13088B (de)
MY (1)	MY119031A (de)
NO (1)	NO319914B1 (de)
NZ (1)	NZ258013A (de)
PL (1)	PL178653B1 (de)
PT (2)	PT668860E (de)
RU (1)	RU2134691C1 (de)
SK (1)	SK285001B6 (de)
WO (1)	WO1994011361A1 (de)
ZA (1)	ZA938019B (de)

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DE69433705T2 (de) *	1993-11-19	2005-03-10	Parke, Davis & Company	5,6-Dihydropyronderivate als Proteaseinhibitoren und Antiviralmittel
CA2176044A1 (en) *	1993-11-19	1995-05-26	Elizabeth Lunney	Pyrone derivatives as protease inhibitors and antiviral agents
SK283240B6 (sk) *	1993-11-19	2003-04-01	Parke, Davis & Company	5,6-Dihydropyrónové deriváty ako inhibítory proteázy a protivírusové činidlá a farmaceutická kompozícia obsahujúca tieto deriváty
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RU2236852C1 (ru) *	2003-06-23	2004-09-27	Закрытое акционерное общество "ДЕСКО"	Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций
CN101693664A (zh)	2003-10-24	2010-04-14	隆萨股份公司	6,6,6-三卤-3,5-二氧代己酸酯的制备方法
HRP20110845T1 (hr) *	2006-06-16	2011-12-31	Pharma Mar	Antitumorski dihidropiran-2-onski spojevi
PT2231633E (pt)	2007-12-20	2014-01-20	Pharma Mar Sa	Compostos antitumorais
DE102008055916A1 (de)	2008-11-05	2010-05-06	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung
DE102008055914A1 (de)	2008-11-05	2010-05-06	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung
WO2010051883A1 (de)	2008-11-05	2010-05-14	Clariant International Ltd	Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
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DE102008056342A1 (de)	2008-11-07	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
EP2367835B1 (de)	2008-11-11	2013-12-11	Clariant Finance (BVI) Limited	Verfahren zur herstellung von mono-allylfunktionalisierten dialkylphosphinsäuren, deren salze und ester mit allylischen verbindungen und ihre verwendung
DE102008060036A1 (de) *	2008-12-02	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060035A1 (de)	2008-12-02	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) *	2008-12-04	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
KR101697948B1 (ko)	2008-12-18	2017-01-19	클라리언트 파이넌스 (비브이아이)리미티드	아세틸렌을 사용하는 에틸렌디알킬포스핀산, 에틸렌디알킬포스핀산 에스테르 및 에틸렌디알킬포스핀산 염의 제조방법 및 이의 용도
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DE102008064003A1 (de)	2008-12-19	2010-06-24	Clariant International Limited	Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
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CN102690275A (zh) *	2011-03-25	2012-09-26	中国人民解放军第二军医大学	四氢呋喃并[3,4-c]吡喃酮类化合物及其制备方法和用途
CN103044375B (zh) *	2012-12-02	2015-08-12	大理学院	一种二氢吡喃酮化合物及其制备方法和药物用途
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FR1276654A (fr) *	1958-10-01	1961-11-24		Nouveaux dérivés de l'hydroxy-4-alpha-2-pyrone
FR1276645A (fr) *	1959-12-28	1961-11-17	Wild Heerbrugg Ag	Objectif de microscope
ZA883034B (en) *	1987-04-29	1989-03-29	Smithkline Beckman Corp	Steroid 5-alpha-reductase inhibitors
WO1989007939A2 (en) *	1988-03-01	1989-09-08	The Upjohn Company	Coumarins to inhibit reverse transcriptase in humans
WO1991004663A1 (en) *	1989-09-26	1991-04-18	The Regents Of The University Of California	6-amino-1,2-benzopyrones useful for treatment of viral diseases
WO1991006561A1 (en) *	1989-10-27	1991-05-16	The Upjohn Company	Method for treating hiv and other retroviruses and compounds useful therefor
DE4103904C2 (de) *	1991-02-08	1995-06-14	Analyticon Ges Fuer Chemische	Neue Arzneimittel aus Gamma-Pyronen, Gamma-Pyridonen sowie Gamma-Thiopyronen

1993
- 1993-10-27 ZA ZA938019A patent/ZA938019B/xx unknown
- 1993-11-09 DK DK94900546T patent/DK0668860T3/da active
- 1993-11-09 AT AT02002073T patent/ATE290531T1/de active
- 1993-11-09 AT AT94900546T patent/ATE223910T1/de active
- 1993-11-09 HU HU9501411A patent/HU228126B1/hu unknown
- 1993-11-09 JP JP51221794A patent/JP3583127B2/ja not_active Expired - Lifetime
- 1993-11-09 AU AU55493/94A patent/AU687368B2/en not_active Expired
- 1993-11-09 DE DE69332292T patent/DE69332292T2/de not_active Expired - Lifetime
- 1993-11-09 ES ES02002073T patent/ES2237624T3/es not_active Expired - Lifetime
- 1993-11-09 CA CA002145661A patent/CA2145661C/en not_active Expired - Lifetime
- 1993-11-09 DK DK02002073T patent/DK1203770T3/da active
- 1993-11-09 CZ CZ19951078A patent/CZ291853B6/cs not_active IP Right Cessation
- 1993-11-09 PT PT94900546T patent/PT668860E/pt unknown
- 1993-11-09 KR KR1019950701926A patent/KR100314975B1/ko not_active Expired - Lifetime
- 1993-11-09 PT PT02002073T patent/PT1203770E/pt unknown
- 1993-11-09 EP EP02002073A patent/EP1203770B1/de not_active Expired - Lifetime
- 1993-11-09 NZ NZ258013A patent/NZ258013A/en not_active IP Right Cessation
- 1993-11-09 WO PCT/US1993/010645 patent/WO1994011361A1/en not_active Ceased
- 1993-11-09 MY MYPI93002343A patent/MY119031A/en unknown
- 1993-11-09 SK SK616-95A patent/SK285001B6/sk not_active IP Right Cessation
- 1993-11-09 PL PL93308998A patent/PL178653B1/pl unknown
- 1993-11-09 EP EP94900546A patent/EP0668860B1/de not_active Expired - Lifetime
- 1993-11-09 BR BR9307451-4A patent/BR9307451A/pt not_active IP Right Cessation
- 1993-11-09 RU RU95112465A patent/RU2134691C1/ru active
- 1993-11-09 ES ES94900546T patent/ES2182837T3/es not_active Expired - Lifetime
- 1993-11-09 DE DE69333771T patent/DE69333771T2/de not_active Expired - Lifetime
- 1993-11-10 IL IL10755693A patent/IL107556A/en not_active IP Right Cessation
- 1993-11-12 CN CN93114470A patent/CN1040321C/zh not_active Expired - Lifetime
1995
- 1995-05-11 FI FI952302A patent/FI120399B/fi not_active IP Right Cessation
- 1995-05-12 NO NO19951899A patent/NO319914B1/no not_active IP Right Cessation
2003
- 2003-09-11 LV LVP-03-101A patent/LV13088B/en unknown
2008
- 2008-05-06 GE GEAP200810686A patent/GEP20094660B/en unknown

Also Published As

Publication number	Publication date
CA2145661C (en)	2008-04-01
PL178653B1 (pl)	2000-05-31
BR9307451A (pt)	1999-08-31
CN1040321C (zh)	1998-10-21
DK1203770T3 (da)	2005-05-23
PL308998A1 (en)	1995-09-18
RU95112465A (ru)	1997-03-20
FI952302A0 (fi)	1995-05-11
DE69332292T2 (de)	2003-05-28
KR100314975B1 (ko)	2002-02-28
SK285001B6 (sk)	2006-04-06
HU228126B1 (en)	2012-12-28
EP0668860B1 (de)	2002-09-11
RU2134691C1 (ru)	1999-08-20
EP1203770B1 (de)	2005-03-09
CZ107895A3 (en)	1995-12-13
IL107556A0 (en)	1994-02-27
PT668860E (pt)	2003-01-31
CA2145661A1 (en)	1994-05-26
JPH08503216A (ja)	1996-04-09
MY119031A (en)	2005-03-31
JP3583127B2 (ja)	2004-10-27
NO951899D0 (no)	1995-05-12
HUT71558A (en)	1995-12-28
CN1090279A (zh)	1994-08-03
DK0668860T3 (da)	2003-01-20
EP1203770A1 (de)	2002-05-08
IL107556A (en)	2001-08-08
NZ258013A (en)	1997-02-24
CZ291853B6 (cs)	2003-06-18
GEP20094660B (en)	2009-03-25
LV13088B (en)	2004-01-20
DE69333771T2 (de)	2006-04-06
WO1994011361A1 (en)	1994-05-26
ATE223910T1 (de)	2002-09-15
ES2182837T3 (es)	2003-03-16
FI952302L (fi)	1995-05-11
DE69333771D1 (de)	2005-04-14
SK61695A3 (en)	1995-10-11
DE69332292D1 (de)	2002-10-17
HU9501411D0 (en)	1995-06-28
AU5549394A (en)	1994-06-08
NO319914B1 (no)	2005-10-03
ES2237624T3 (es)	2005-08-01
PT1203770E (pt)	2005-05-31
AU687368B2 (en)	1998-02-26
NO951899L (no)	1995-07-12
FI120399B (fi)	2009-10-15
ATE290531T1 (de)	2005-03-15
EP0668860A1 (de)	1995-08-30
KR950704290A (ko)	1995-11-17

Publication	Publication Date	Title
IL107556A0 (en)	1994-02-27	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses
GB2344532A (en)	2000-06-14	Electromagnetic radiation therapy
AU6393896A (en)	1997-01-30	Method for treating benign prostatic hyperplasia with thermal therapy
IL111357A0 (en)	1994-12-29	16-substituted-4-aza-androstanes, their preparation and pharmaceutical compositions containing them
AU7010694A (en)	1995-11-29	A surgical instrument, particularly for operative treatment of the prostate gland
FI931765A7 (fi)	1993-10-21	Steroidijohdannaisia eturauhasen liikakasvun käsittelyyn, niiden valmistus ja käytöt
ATE143942T1 (de)	1996-10-15	Carbonsäurederivate als 5-alpha-reduktase- inhibitor
EP0641208A4 (de)	1995-08-30	4-azasteroide als 5-alpha-reduktase.
ATE178795T1 (de)	1999-04-15	7-substituierte-4-aza-steroid-derivate als 5- alpha-reductase-hemmer
IL109863A0 (en)	1994-10-07	Aromatic acetylcholinesterase inhibitors
HU9501286D0 (en)	1995-06-28	Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis
DE69519728D1 (de)	2001-02-01	17 beta-aryl-4-aza-steroidderivate
EP0633781A4 (de)	1995-04-19	Zusammensetzungen und verfahren zur behandlung der benignen prostatahypertropie.
AU5457694A (en)	1994-05-24	Methods and compositions of (-) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis
IL135516A0 (en)	2001-05-20	Process for n-desmethylating erythromycins and derivatives thereof
HK1012275A (en)	1999-07-30	Compositions and methods for treating benign prostatic hypertrophy
ZA922810B (en)	1992-11-25	New combination treatment for benign prostatic hyperplasia
Bobisud et al.	1993	BACTERIAL WILT-TOLERANT SOMACLONES OF TOMATO (LYCOPERSICON ESCULENTUM Mill.).
AU6374798A (en)	1998-06-18	Methods and compositions of (+) doxazosin for the treatment of hypertension and benign prostatic hyperplasia
ZA922010B (en)	1992-11-25	Improved method of treatment for benign prostatic hyperplasia
AUPO410796A0 (en)	1997-01-09	Method of treating benign prostatic hyperplasia
AU2002300339A8 (en)	2003-01-16	Process For Producing Arsenic Trioxide Formulations And Methods For Treating Cancer Using Arsenic Trioxide Or Melarsoprol
AU2002300339A1 (en)	2002-12-19	Process For Producing Arsenic Trioxide Formulations And Methods For Treating Cancer Using Arsenic Trioxide Or Melarsoprol
MX9710075A (es)	1998-03-29	Antagonistas melatonina para el tratamiento en la hiperplasia prostatica benigna.
HK1029939A (en)	2001-04-20	Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol