ZA954374B - New lipid esters of nucleoside monophosphates use as immunosuppresive drugs - Google Patents

New lipid esters of nucleoside monophosphates use as immunosuppresive drugs

Info

Publication number: ZA954374B
Authority: ZA; South Africa
Prior art keywords: desoxy; chain; branched; saturated; straight
Prior art date: 1994-05-28

Application number

ZA954374A

Other languages

English (en)

Inventor

Dieter Herrmann

Hans-Georg Optiz

Harald Zilch

Alfred Mertens

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-28

Filing date

1995-05-29

Publication date

1996-11-29

1995-05-29 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1996-11-29 Publication of ZA954374B publication Critical patent/ZA954374B/xx

Links

-1 lipid esters Chemical class 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
229940079593 drug Drugs 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title abstract 2
230000001506 immunosuppresive effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
AYWFLOPQIYDGTP-RJDJZVBFSA-N (2R,3S,4R,5R)-4-amino-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 4-amino-1-[(2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol (2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-azido-2-(hydroxymethyl)oxolan-3-ol 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Chemical compound FC=1N=C(C=2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2N1)N.FC=1C(NC(N([C@H]2C[C@H](O)[C@@H](CO)O2)C1)=O)=O.N(=[N+]=[N-])[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C(=O)N=C(N)C=C1.N(=[N+]=[N-])[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C=NC=2C(N)=NC=NC12.N[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C=NC=2C(N)=NC=NC12 AYWFLOPQIYDGTP-RJDJZVBFSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

ZA954374A 1994-05-28 1995-05-29 New lipid esters of nucleoside monophosphates use as immunosuppresive drugs ZA954374B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4418690A DE4418690A1 (de)	1994-05-28	1994-05-28	Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel

Publications (1)

Publication Number	Publication Date
ZA954374B true ZA954374B (en)	1996-11-29

Family

ID=6519215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA954374A ZA954374B (en)	1994-05-28	1995-05-29	New lipid esters of nucleoside monophosphates use as immunosuppresive drugs

Country Status (27)

Country	Link
US (1)	US6025343A (de)
EP (2)	EP0763049B1 (de)
JP (1)	JP3802057B2 (de)
KR (1)	KR100279087B1 (de)
CN (1)	CN1168735C (de)
AT (2)	ATE236189T1 (de)
AU (1)	AU688516B2 (de)
BR (1)	BR9507785A (de)
CA (1)	CA2190983C (de)
CZ (1)	CZ291846B6 (de)
DE (3)	DE4418690A1 (de)
DK (2)	DK1229040T3 (de)
ES (2)	ES2206429T3 (de)
FI (1)	FI117673B (de)
HU (1)	HU220336B (de)
IL (1)	IL113865A (de)
MX (1)	MX9605809A (de)
NO (1)	NO308998B1 (de)
NZ (1)	NZ287434A (de)
PL (1)	PL185290B1 (de)
PT (2)	PT763049E (de)
RU (1)	RU2165429C2 (de)
SK (1)	SK284207B6 (de)
TW (1)	TW420686B (de)
UA (1)	UA45339C2 (de)
WO (1)	WO1995032984A1 (de)
ZA (1)	ZA954374B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
JP3839857B2 (ja) *	1994-09-20	2006-11-01	塩野義製薬株式会社	エーテル型チオリン脂質化合物の製造方法
ES2206522T3 (es) *	1994-12-13	2004-05-16	Taiho Pharmaceutical Co., Ltd.	Derivados de nucleosido sustituidos en 3'.
WO1999051613A1 (en) *	1998-04-03	1999-10-14	Medivir Ab	Prodrugs of phosphorous-containing pharmaceuticals
CA2348470C (en)	1998-11-05	2007-06-05	Centre National De La Recherche Scientifique	Nucleosides with anti-hepatitis b virus activity
US6407077B1 (en)	1998-11-05	2002-06-18	Emory University	β-L nucleosides for the treatment of HIV infection
DE19855963A1 (de) *	1998-12-04	2000-06-08	Herbert Schott	Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
US7026469B2 (en)	2000-10-19	2006-04-11	Wake Forest University School Of Medicine	Compositions and methods of double-targeting virus infections and cancer cells
US6620796B1 (en)	1999-11-08	2003-09-16	Micrologix Biotech Inc.	Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US6787526B1 (en)	2000-05-26	2004-09-07	Idenix Pharmaceuticals, Inc.	Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en)	2000-06-15	2005-04-05	Idenix Pharmaceuticals, Inc.	3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002057498A1 (en) *	2001-01-22	2002-07-25	Emergen, Inc.	Isotopically enriched nucleic acids and associated methods for the production and purification thereof
WO2002092006A2 (en)	2001-05-16	2002-11-21	Micrologix Biotech, Inc.	Nucleic acid-based compounds and methods of use thereof
EP1448579A1 (de) *	2001-11-21	2004-08-25	Heidelberg Pharma Holding GmbH	Phospholipid-derivate von nucleosiden als antitumorale arzneimittel
US9512125B2 (en)	2004-11-19	2016-12-06	The Regents Of The University Of California	Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
RU2322450C2 (ru) *	2004-11-25	2008-04-20	Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ"	Модифицированные 5'-фосфонаты азт в качестве активных компонентов для потенциальных противовирусных препаратов
US8101745B2 (en)	2004-12-16	2012-01-24	The Regents Of The University Of California	Lung-targeted drugs
EP1835916B1 (de)	2004-12-30	2009-04-01	Medivir Ab	Verbindungen zur behandlung von hiv
GB0505781D0 (en) *	2005-03-21	2005-04-27	Univ Cardiff	Chemical compounds
KR20080034947A (ko) *	2005-07-22	2008-04-22	지울리아니 인터내셔널 리미티드	개선된 6-티오구아노신 트리포스페이트의 유사 화합물,의학 분야에 있어서의 이들의 용도 및 이들의 제조 방법
ITRM20050391A1 (it) *	2005-07-22	2007-01-23	Giuliani Spa	Composti analoghi della 6-tioguanosina trifosfato, loro uso in campo medico e procedimento per la loro preparazione.
KR20150038395A (ko)	2006-04-04	2015-04-08	더 리젠트스 오브 더 유니이버시티 오브 캘리포니아	키나제 길항물질
GB0608876D0 (en)	2006-05-05	2006-06-14	Medivir Ab	Combination therapy
US7378401B2 (en) *	2006-07-14	2008-05-27	Heidelberg Pharma Gmbh	Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
US9296776B2 (en)	2007-07-09	2016-03-29	Eastern Virginia Medical School	Substituted nucleoside derivatives with antiviral and antimicrobial properties
US20110160232A1 (en)	2007-10-04	2011-06-30	Pingda Ren	Certain chemical entities and therapeutic uses thereof
BRPI0906473A8 (pt)	2008-01-04	2016-02-10	Intellikine Inc	Certas entidades químicas, composições e métodos
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
WO2009114870A2 (en)	2008-03-14	2009-09-17	Intellikine, Inc.	Kinase inhibitors and methods of use
US8993580B2 (en)	2008-03-14	2015-03-31	Intellikine Llc	Benzothiazole kinase inhibitors and methods of use
MX2011000216A (es)	2008-07-08	2011-03-29	Intellikine Inc	Inhibidores de cinasa y metodos para su uso.
US20110224223A1 (en)	2008-07-08	2011-09-15	The Regents Of The University Of California, A California Corporation	MTOR Modulators and Uses Thereof
WO2010036380A1 (en)	2008-09-26	2010-04-01	Intellikine, Inc.	Heterocyclic kinase inhibitors
AU2009305669A1 (en)	2008-10-16	2010-04-22	The Regents Of The University Of California	Fused ring heteroaryl kinase inhibitors
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja)	2009-05-07	2015-10-07	インテリカイン，エルエルシー	複素環式化合物およびその使用
US8980899B2 (en)	2009-10-16	2015-03-17	The Regents Of The University Of California	Methods of inhibiting Ire1
JP5951600B2 (ja)	2010-05-21	2016-07-13	インフィニティーファーマシューティカルズ，インコーポレイテッド	キナーゼ調節のための、化合物、組成物および方法
WO2012064973A2 (en)	2010-11-10	2012-05-18	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP3238722B1 (de)	2011-01-10	2019-03-13	Infinity Pharmaceuticals, Inc.	Festen formen von isochinolinonen
TWI592411B (zh)	2011-02-23	2017-07-21	英特爾立秦有限責任公司	激酶抑制劑之組合及其用途
EP2734520B1 (de)	2011-07-19	2016-09-14	Infinity Pharmaceuticals, Inc.	Heterocyclische verbindungen und ihre verwendung
US9056877B2 (en)	2011-07-19	2015-06-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
PE20141371A1 (es)	2011-08-29	2014-10-13	Infinity Pharmaceuticals Inc	Compuestos heterociclicos y usos de los mismos
WO2013077921A2 (en)	2011-09-02	2013-05-30	The Regents Of The University Of California	Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CA2886240A1 (en)	2012-09-26	2014-04-03	The Regents Of The University Of California	Modulation of ire1
RU2702908C2 (ru)	2012-11-01	2019-10-14	Инфинити Фармасьютикалз, Инк.	Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
KR20150130355A (ko)	2013-03-15	2015-11-23	더 리전트 오브 더 유니버시티 오브 캘리포니아	비환식 뉴클레오사이드 포스포네이트 디에스테르
US9481667B2 (en)	2013-03-15	2016-11-01	Infinity Pharmaceuticals, Inc.	Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3964507A1 (de)	2013-10-04	2022-03-09	Infinity Pharmaceuticals, Inc.	Heterocyclische verbindungen und verwendungen davon
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN106456628A (zh)	2014-03-19	2017-02-22	无限药品股份有限公司	用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2015160975A2 (en)	2014-04-16	2015-10-22	Infinity Pharmaceuticals, Inc.	Combination therapies
DE102014112055A1 (de) *	2014-08-22	2016-02-25	Universität Hamburg	Di- und Triphosphat-Propharmaka
MX377983B (es)	2014-09-15	2025-03-04	Univ California	Análogos de nucleótidos.
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN114230571B (zh)	2015-09-14	2025-07-08	无限药品股份有限公司	异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
EP3875462A1 (de)	2015-09-15	2021-09-08	The Regents of The University of California	Nukleotidanaloga
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP3474856B1 (de)	2016-06-24	2022-09-14	Infinity Pharmaceuticals, Inc.	Kombinationstherapie
KR20250052378A (ko)	2022-07-21	2025-04-18	안티바 바이오사이언시즈, 인크.	Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
CN122249209A (zh) *	2023-09-26	2026-06-19	内布拉斯加大学评议会	膦酸酯前药及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2930904A1 (de) *	1979-07-30	1981-02-19	Kailash Kumar Dr Gauri	Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3476770D1 (en) *	1983-04-11	1989-03-23	Meito Sangyo Kk	Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
IT1188654B (it) *	1985-04-15	1988-01-20	Toyo Jozo Kk	Coniugato nucleo side-fosfolipide
DE3778626D1 (de) *	1986-09-27	1992-06-04	Toyo Jozo Kk	Nukleosid-phospholipid-konjugat.
JP2796089B2 (ja) *	1986-10-06	1998-09-10	旭化成工業株式会社	リン脂質誘導体の製造法
DE3730542A1 (de) *	1987-09-11	1989-04-06	Hoechst Ag	Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
US5463092A (en) *	1989-11-22	1995-10-31	Vestar, Inc.	Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5563257A (en) *	1990-08-20	1996-10-08	Boehringer Mannheim Gmbh	Phospholipid derivatives of nucleosides
DE4026265A1 (de) *	1990-08-20	1992-02-27	Boehringer Mannheim Gmbh	Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
DE4111730A1 (de) *	1991-04-10	1992-10-15	Knoll Ag	Neue cytarabin-derivate, ihre herstellung und verwendung
CA2112803A1 (en) *	1991-07-12	1993-01-21	Karl Y. Hostetler	Antiviral liponucleosides: treatment of hepatitis b
DE4204032A1 (de) *	1992-02-12	1993-08-19	Boehringer Mannheim Gmbh	Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
US5512671A (en) *	1993-02-16	1996-04-30	Wake Forest University	Ether lipid-nucleoside covalent conjugates

1994
- 1994-05-28 DE DE4418690A patent/DE4418690A1/de not_active Withdrawn
1995
- 1995-05-23 NZ NZ287434A patent/NZ287434A/en not_active IP Right Cessation
- 1995-05-23 DK DK02008360T patent/DK1229040T3/da active
- 1995-05-23 CN CNB951943715A patent/CN1168735C/zh not_active Expired - Fee Related
- 1995-05-23 SK SK1518-96A patent/SK284207B6/sk not_active IP Right Cessation
- 1995-05-23 CZ CZ19963477A patent/CZ291846B6/cs not_active IP Right Cessation
- 1995-05-23 EP EP95920864A patent/EP0763049B1/de not_active Expired - Lifetime
- 1995-05-23 AT AT95920864T patent/ATE236189T1/de not_active IP Right Cessation
- 1995-05-23 ES ES02008360T patent/ES2206429T3/es not_active Expired - Lifetime
- 1995-05-23 PT PT95920864T patent/PT763049E/pt unknown
- 1995-05-23 RU RU96124383/04A patent/RU2165429C2/ru active
- 1995-05-23 AT AT02008360T patent/ATE249472T1/de not_active IP Right Cessation
- 1995-05-23 EP EP02008360A patent/EP1229040B8/de not_active Expired - Lifetime
- 1995-05-23 DE DE69531749T patent/DE69531749T2/de not_active Expired - Fee Related
- 1995-05-23 AU AU26154/95A patent/AU688516B2/en not_active Ceased
- 1995-05-23 JP JP50026296A patent/JP3802057B2/ja not_active Expired - Fee Related
- 1995-05-23 CA CA002190983A patent/CA2190983C/en not_active Expired - Fee Related
- 1995-05-23 PT PT02008360T patent/PT1229040E/pt unknown
- 1995-05-23 HU HU9603269A patent/HU220336B/hu not_active IP Right Cessation
- 1995-05-23 WO PCT/EP1995/001951 patent/WO1995032984A1/en not_active Ceased
- 1995-05-23 KR KR1019960706690A patent/KR100279087B1/ko not_active Expired - Fee Related
- 1995-05-23 BR BR9507785A patent/BR9507785A/pt not_active Application Discontinuation
- 1995-05-23 MX MX9605809A patent/MX9605809A/es not_active IP Right Cessation
- 1995-05-23 DE DE69530197T patent/DE69530197T2/de not_active Expired - Fee Related
- 1995-05-23 DK DK95920864T patent/DK0763049T3/da active
- 1995-05-23 UA UA96114469A patent/UA45339C2/uk unknown
- 1995-05-23 ES ES95920864T patent/ES2199250T3/es not_active Expired - Lifetime
- 1995-05-24 TW TW084105233A patent/TW420686B/zh active
- 1995-05-25 IL IL113865A patent/IL113865A/en not_active IP Right Cessation
- 1995-05-29 ZA ZA954374A patent/ZA954374B/xx unknown
1996
- 1996-11-21 PL PL95317380A patent/PL185290B1/pl not_active IP Right Cessation
- 1996-11-27 NO NO965054A patent/NO308998B1/no not_active IP Right Cessation
- 1996-11-27 US US08/753,633 patent/US6025343A/en not_active Expired - Fee Related
- 1996-11-27 FI FI964727A patent/FI117673B/fi active IP Right Grant

Also Published As

Publication number	Publication date
NO308998B1 (no)	2000-11-27
ES2206429T3 (es)	2004-05-16
EP1229040A2 (de)	2002-08-07
SK284207B6 (en)	2004-11-03
DE69530197D1 (de)	2003-05-08
IL113865A (en)	2008-12-29
BR9507785A (pt)	1997-09-23
DE4418690A1 (de)	1996-01-11
PL317380A1 (en)	1997-04-01
NZ287434A (en)	1998-01-26
CZ291846B6 (cs)	2003-06-18
JPH10500964A (ja)	1998-01-27
DK1229040T3 (da)	2003-12-22
ATE249472T1 (de)	2003-09-15
CN1168735C (zh)	2004-09-29
SK151896A3 (en)	1997-06-04
PL185290B1 (pl)	2003-04-30
CA2190983C (en)	2006-08-15
NO965054L (no)	1997-01-28
WO1995032984A1 (en)	1995-12-07
CA2190983A1 (en)	1995-12-07
TW420686B (en)	2001-02-01
PT763049E (pt)	2003-08-29
JP3802057B2 (ja)	2006-07-26
CZ347796A3 (en)	1997-04-16
EP1229040B8 (de)	2003-11-05
FI964727A0 (fi)	1996-11-27
ATE236189T1 (de)	2003-04-15
DE69531749D1 (de)	2003-10-16
DE69531749T2 (de)	2004-07-29
ES2199250T3 (es)	2004-02-16
HUT75340A (en)	1997-05-28
AU2615495A (en)	1995-12-21
FI117673B (fi)	2007-01-15
HU220336B (hu)	2001-12-28
DE69530197T2 (de)	2004-01-29
DK0763049T3 (da)	2003-07-28
US6025343A (en)	2000-02-15
EP0763049A1 (de)	1997-03-19
MX9605809A (es)	1997-12-31
NO965054D0 (no)	1996-11-27
EP1229040B1 (de)	2003-09-10
FI964727L (fi)	1996-11-27
WO1995032984A8 (en)	2003-01-16
EP0763049B1 (de)	2003-04-02
KR100279087B1 (ko)	2001-01-15
HU9603269D0 (en)	1997-01-28
EP1229040A3 (de)	2002-08-21
CN1154111A (zh)	1997-07-09
AU688516B2 (en)	1998-03-12
KR970703354A (ko)	1997-07-03
RU2165429C2 (ru)	2001-04-20
PT1229040E (pt)	2003-12-31
UA45339C2 (uk)	2002-04-15
IL113865A0 (en)	1995-08-31

Publication	Publication Date	Title
HUT75340A (en)	1997-05-28	New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
HUT50841A (en)	1990-03-28	Process for producing (cycloalkylamino)-methylene-bis(phosphoric acid) derivatives and pharmaceutical compositions comprising such compounds as active ingredient
KR960000230A (ko)	1996-01-25	간담즙성 질병 치료제
ES514240A0 (es)	1984-04-16	Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
TW343975B (en)	1998-11-01	New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
SE8700914L (sv)	1987-03-04	Anvendning av adenosinderivat
PT82547A (en)	1986-06-01	Hexenoic acids
ATE198746T1 (de)	2001-02-15	Pyrimidinderivate und pharmazeutische zusammensetzungen
HUT48259A (en)	1989-05-29	Herbicide compositions containing new macrolide active components, and process for producing new macrolide compounds and pharmaceutical compositions containing them as active components
ATE309212T1 (de)	2005-11-15	Optisch aktive 1-phenylpyrrolidonderivate
IT1248558B (it)	1995-01-19	Derivati della fisovenina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.