ZA97948B - Method for the production of rDSPA Ó1. - Google Patents

Method for the production of rDSPA Ó1.

Info

Publication number
ZA97948B
ZA97948B ZA9700948A ZA97948A ZA97948B ZA 97948 B ZA97948 B ZA 97948B ZA 9700948 A ZA9700948 A ZA 9700948A ZA 97948 A ZA97948 A ZA 97948A ZA 97948 B ZA97948 B ZA 97948B
Authority
ZA
South Africa
Prior art keywords
rdspa
chromatography
production
ending
alpha
Prior art date
Application number
ZA9700948A
Other languages
English (en)
Inventor
Michael Mccaman
Carol Sounders
Erno Pungor
Mei P Tan
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA97948B publication Critical patent/ZA97948B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paper (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
ZA9700948A 1996-02-05 1997-02-05 Method for the production of rDSPA Ó1. ZA97948B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1

Publications (1)

Publication Number Publication Date
ZA97948B true ZA97948B (en) 1997-08-19

Family

ID=24389906

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9700948A ZA97948B (en) 1996-02-05 1997-02-05 Method for the production of rDSPA Ó1.

Country Status (22)

Country Link
US (1) US5731186A (pt)
EP (1) EP1015568B1 (pt)
JP (1) JP3805378B2 (pt)
KR (1) KR100508043B1 (pt)
CN (1) CN1242059C (pt)
AT (1) ATE233316T1 (pt)
AU (1) AU706286B2 (pt)
CZ (1) CZ294827B6 (pt)
DE (1) DE69719382T2 (pt)
DK (1) DK1015568T3 (pt)
ES (1) ES2193349T3 (pt)
HU (1) HU223902B1 (pt)
IL (1) IL124952A (pt)
NO (1) NO322527B1 (pt)
PL (1) PL186410B1 (pt)
PT (1) PT1015568E (pt)
RU (1) RU2223315C2 (pt)
SK (1) SK284179B6 (pt)
TW (1) TW385313B (pt)
UA (1) UA62925C2 (pt)
WO (1) WO1997029188A1 (pt)
ZA (1) ZA97948B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100436655B1 (ko) * 2001-07-25 2004-06-22 (주)엘피스바이오텍 광범위한 단백질에 적용할 수 있는 단백질의 농축 및정제 방법
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
WO2007134617A1 (en) * 2006-05-19 2007-11-29 Paion Deutschland Gmbh Use of desmodus salivary plasminogen activator (dspa) for treating venous thromboembolism
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2011107299A2 (en) * 2010-04-16 2011-09-09 Paion Deutschland Gmbh Method for the manufacture of recombinant dspa alpha1
US20120258519A1 (en) * 2011-04-10 2012-10-11 Therapeutic Proteins Inc. Protein Harvesting
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
CA2046632C (en) * 1989-02-13 1999-05-11 Schering Aktiengesellschaft Thrombolytic from vampire bat saliva
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr

Also Published As

Publication number Publication date
CZ294827B6 (cs) 2005-03-16
PL328146A1 (en) 1999-01-18
RU2223315C2 (ru) 2004-02-10
CN1242059C (zh) 2006-02-15
JP2000504565A (ja) 2000-04-18
AU1546297A (en) 1997-08-28
KR19990082306A (ko) 1999-11-25
HK1018795A1 (en) 2000-01-07
NO983579L (no) 1998-10-05
HUP9901029A3 (en) 2001-10-29
IL124952A (en) 2002-08-14
CN1210559A (zh) 1999-03-10
AU706286B2 (en) 1999-06-10
NO322527B1 (no) 2006-10-16
KR100508043B1 (ko) 2005-12-21
DE69719382D1 (de) 2003-04-03
UA62925C2 (en) 2004-01-15
HU223902B1 (hu) 2005-03-29
PL186410B1 (pl) 2004-01-30
PT1015568E (pt) 2003-07-31
TW385313B (en) 2000-03-21
SK103298A3 (en) 1999-03-12
WO1997029188A1 (en) 1997-08-14
ES2193349T3 (es) 2003-11-01
NO983579D0 (no) 1998-08-04
SK284179B6 (sk) 2004-10-05
US5731186A (en) 1998-03-24
ATE233316T1 (de) 2003-03-15
HUP9901029A2 (hu) 1999-07-28
JP3805378B2 (ja) 2006-08-02
EP1015568B1 (en) 2003-02-26
IL124952A0 (en) 1999-01-26
DK1015568T3 (da) 2003-06-10
CZ245598A3 (cs) 1999-01-13
DE69719382T2 (de) 2003-11-27
EP1015568A1 (en) 2000-07-05

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