ZA987975B - Methods and compositions for NMR structure determinations. - Google Patents

Methods and compositions for NMR structure determinations.

Info

Publication number
ZA987975B
ZA987975B ZA9807975A ZA987975A ZA987975B ZA 987975 B ZA987975 B ZA 987975B ZA 9807975 A ZA9807975 A ZA 9807975A ZA 987975 A ZA987975 A ZA 987975A ZA 987975 B ZA987975 B ZA 987975B
Authority
ZA
South Africa
Prior art keywords
methods
compositions
labeled
proteins
nmr structure
Prior art date
Application number
ZA9807975A
Other languages
English (en)
Inventor
Frank Elbert Anderson Iii
Philip Edward Coughlin
Charles Tobias Weller
Jonathan Miles Brown
Steven William Homans
Carrie Ann Zimmerman-Wilson
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Publication of ZA987975B publication Critical patent/ZA987975B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ZA9807975A 1997-09-02 1998-09-01 Methods and compositions for NMR structure determinations. ZA987975B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/921,554 US6111066A (en) 1997-09-02 1997-09-02 Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains

Publications (1)

Publication Number Publication Date
ZA987975B true ZA987975B (en) 2000-01-21

Family

ID=25445613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9807975A ZA987975B (en) 1997-09-02 1998-09-01 Methods and compositions for NMR structure determinations.

Country Status (12)

Country Link
US (4) US6111066A (de)
EP (2) EP1009725B1 (de)
JP (1) JP2001514239A (de)
AT (1) ATE420061T1 (de)
AU (1) AU754232B2 (de)
CA (1) CA2301046C (de)
DE (1) DE69840448D1 (de)
HU (1) HUP0003383A3 (de)
NO (1) NO20001052L (de)
TW (1) TW581772B (de)
WO (1) WO1999011589A1 (de)
ZA (1) ZA987975B (de)

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US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
AU2002224440A1 (en) * 2000-10-20 2002-05-06 Martek Biosciences Corporation Rapid determination of protein global folds
US6882939B2 (en) * 2000-10-20 2005-04-19 Prospect Pharma Rapid determination of protein global folds
WO2003002724A2 (en) * 2001-03-12 2003-01-09 Affinium Pharmaceuticals, Inc. Proteins, druggable regions of proteins and target analysis for chemistry of therapeutics
WO2003006488A1 (en) * 2001-07-13 2003-01-23 The Regents Of The University Of California In-cell nmr spectroscopy
JP2003096098A (ja) * 2001-09-25 2003-04-03 Nippon Sanso Corp 安定同位体標識抗体及びその製造方法ならびにこれを用いた検出方法
US20030077572A1 (en) * 2001-10-11 2003-04-24 Abramson Fred P. Quantitative differential display using isotope ratio monitoring
US20040030239A1 (en) * 2001-12-13 2004-02-12 The Johns Hopkins University School Of Medicine Method for MR/NMR imaging
EP1457482B9 (de) * 2001-12-19 2012-10-24 Japan Science and Technology Agency Mit stabilen Isotopen markierte Aminosäure, Verfahren zu deren Einschleusung in ein Zielprotein, Verfahren zur NMR-Strukturanalyse von Protein
EP1551291A4 (de) * 2002-06-10 2007-11-28 Prospect Pharma Verfahren zur gewinnung von dynamischen und strukturellen daten in bezug auf proteine und protein/liganden-komplexe
EP1572950B1 (de) 2002-06-17 2012-10-10 Thrasos, Inc. Einzeldomäne-tdf-verwandte verbindungen und analoge davon
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7553455B1 (en) * 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US7672791B2 (en) * 2003-06-13 2010-03-02 International Business Machines Corporation Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules
AU2004256368B2 (en) 2003-07-11 2010-08-05 Tatiana A. Egorova-Zachernyuk Compositions and methods for stable isotope labelling of biological compounds
EP1678198A4 (de) * 2003-10-07 2007-12-05 Prospect Pharma Seitenkettendeuterierte aminosäuren und anwendungsverfahren
EP1679302B1 (de) 2003-10-31 2014-04-30 Japan Science and Technology Agency Mit einem stabilen isotop markierte aromatische aminosäure, verfahren zu deren einbau in ein target-protein und verfahren zur analyse der proteinstruktur durch nmr
JP4475237B2 (ja) * 2004-02-02 2010-06-09 三菱化学株式会社 Ｎｍｒシグナル帰属方法
EP2789342A1 (de) 2004-06-17 2014-10-15 Thrasos Innovation, Inc. Verbindungen im Zusammenhang mit TDF und Analoga davon
US7372895B2 (en) * 2004-12-08 2008-05-13 Telefonaktiebolaget Lm Ericsson (Publ) Method of and system for delay estimation with minimized finger allocation
US7480356B2 (en) * 2004-12-08 2009-01-20 Telefonaktiebolaget L M Ericsson (Publ) Method of and system for path selection in rich multipath conditions
ES2909600T3 (es) 2005-06-07 2022-05-09 Dsm Nutritional Products Ag Microorganismos eucarióticos para producir lípidos y antioxidantes
US8299212B2 (en) 2005-09-20 2012-10-30 Thrasos Therapeutics, Inc. TDF-related compounds and analogs thereof, analogs and bioactive fragments
US20070196280A1 (en) * 2006-02-21 2007-08-23 The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services In vivo magnetic resonance spectroscopy of aspartate transaminase activity
GB0604647D0 (en) * 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Ｎｍｒシグナルの帰属方法
US9023616B2 (en) * 2006-08-01 2015-05-05 Dsm Nutritional Products Ag Oil producing microbes and method of modification thereof
US8637486B2 (en) * 2008-03-14 2014-01-28 Retrotope, Inc. Therapeutic substances that modulate genome methylation
DK2268604T3 (en) * 2008-03-14 2017-03-27 Retrotope Inc CANCER THERAPIES BY USING ISOTO-SUBSTITUTED LYSIN
DK2493296T3 (en) 2009-10-30 2019-04-15 Retrotope Inc REMOVAL OF OXIDATIVE STRESS STATES WITH PUFA DERIVATIVES
CN101914030B (zh) * 2010-07-23 2013-04-24 上海化工研究院 一种13c，15n双标记甘氨酸的合成方法
KR102020579B1 (ko) 2011-04-26 2019-09-10 레트로토프 인코포레이티드 에너지 프로세싱 손상 장애 및 미토콘드리아 결함
US10154983B2 (en) 2011-04-26 2018-12-18 Retrotope, Inc. Neurodegenerative disorders and muscle diseases implicating PUFAs
WO2012148929A2 (en) 2011-04-26 2012-11-01 Retrotope, Inc. Disorders implicating pufa oxidation
US10058522B2 (en) 2011-04-26 2018-08-28 Retrotope, Inc. Oxidative retinal diseases
AU2014229307B2 (en) 2013-03-13 2017-08-31 Dsm Nutritional Products Ag Engineering microorganisms
WO2017091279A1 (en) 2015-11-23 2017-06-01 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
FR3055337A1 (fr) * 2016-08-24 2018-03-02 Commissariat A L'energie Atomique Et Aux Energies Alternatives Methode de preparation de milieux de culture riches pour le marquage d'acides amines incorpores dans des proteines
EP4107163A4 (de) 2020-02-21 2024-06-19 Retrotope, Inc. Verfahren zur isotopenmodifizierung von mehrfach ungesättigten fettsäuren und deren derivaten
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS
US11491130B2 (en) 2021-02-05 2022-11-08 Retrotope, Inc. Methods of treating amyotrophic lateral sclerosis

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JPH0768446B2 (ja) * 1988-11-09 1995-07-26 三菱化学株式会社 芳香族ポリカーボネート樹脂組成物を用いた医療用部品
JP2518917B2 (ja) 1989-02-07 1996-07-31 日本電子株式会社 蛋白質の構造解析方法
ES2102984T3 (es) 1989-06-14 1997-08-16 Martek Corp Medios para el crecimiento de celulas y procedimiento para preparar los mismos.
JP2517688B2 (ja) * 1989-12-25 1996-07-24 日本電子株式会社 ３次元核磁気共鳴スペクトルの対称化処理方法
JPH0446143A (ja) * 1990-06-11 1992-02-17 Hitachi Ltd 同位体多重標識アミノ酸の合成法
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5891643A (en) 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US6043024A (en) 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains

Also Published As

Publication number Publication date
HUP0003383A3 (en) 2003-07-28
NO20001052D0 (no) 2000-03-01
US6111066A (en) 2000-08-29
CA2301046A1 (en) 1999-03-11
EP1009725B1 (de) 2009-01-07
CA2301046C (en) 2009-03-10
DE69840448D1 (de) 2009-02-26
AU9298898A (en) 1999-03-22
US6340578B1 (en) 2002-01-22
WO1999011589A1 (en) 1999-03-11
ATE420061T1 (de) 2009-01-15
HUP0003383A2 (hu) 2001-02-28
JP2001514239A (ja) 2001-09-11
US6335196B1 (en) 2002-01-01
US6376253B1 (en) 2002-04-23
TW581772B (en) 2004-04-01
AU754232B2 (en) 2002-11-07
EP1889823A1 (de) 2008-02-20
EP1009725A1 (de) 2000-06-21
NO20001052L (no) 2000-04-28

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