ZA987975B - Methods and compositions for NMR structure determinations. - Google Patents

Methods and compositions for NMR structure determinations.

Info

Publication number
ZA987975B
ZA987975B ZA9807975A ZA987975A ZA987975B ZA 987975 B ZA987975 B ZA 987975B ZA 9807975 A ZA9807975 A ZA 9807975A ZA 987975 A ZA987975 A ZA 987975A ZA 987975 B ZA987975 B ZA 987975B
Authority
ZA
South Africa
Prior art keywords
methods
compositions
labeled
proteins
nmr structure
Prior art date
Application number
ZA9807975A
Other languages
English (en)
Inventor
Frank Elbert Anderson Iii
Philip Edward Coughlin
Charles Tobias Weller
Jonathan Miles Brown
Steven William Homans
Carrie Ann Zimmerman-Wilson
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Publication of ZA987975B publication Critical patent/ZA987975B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA9807975A 1997-09-02 1998-09-01 Methods and compositions for NMR structure determinations. ZA987975B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/921,554 US6111066A (en) 1997-09-02 1997-09-02 Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains

Publications (1)

Publication Number Publication Date
ZA987975B true ZA987975B (en) 2000-01-21

Family

ID=25445613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9807975A ZA987975B (en) 1997-09-02 1998-09-01 Methods and compositions for NMR structure determinations.

Country Status (12)

Country Link
US (4) US6111066A (fr)
EP (2) EP1009725B1 (fr)
JP (1) JP2001514239A (fr)
AT (1) ATE420061T1 (fr)
AU (1) AU754232B2 (fr)
CA (1) CA2301046C (fr)
DE (1) DE69840448D1 (fr)
HU (1) HUP0003383A3 (fr)
NO (1) NO20001052L (fr)
TW (1) TW581772B (fr)
WO (1) WO1999011589A1 (fr)
ZA (1) ZA987975B (fr)

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US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
US6882939B2 (en) * 2000-10-20 2005-04-19 Prospect Pharma Rapid determination of protein global folds
EP1328815A1 (fr) * 2000-10-20 2003-07-23 Martek Biosciences Corporation Determination rapide de pliages de proteines globaux
US20030068650A1 (en) * 2001-03-12 2003-04-10 Jack Greenblatt Target analysis for chemistry of specific and broad spectrum anti-infectives and other therapeutics
WO2003006488A1 (fr) * 2001-07-13 2003-01-23 The Regents Of The University Of California Spectroscopie rmn intracellulaire
JP2003096098A (ja) * 2001-09-25 2003-04-03 Nippon Sanso Corp 安定同位体標識抗体及びその製造方法ならびにこれを用いた検出方法
US20030077572A1 (en) * 2001-10-11 2003-04-24 Abramson Fred P. Quantitative differential display using isotope ratio monitoring
AU2002364728A1 (en) * 2001-12-13 2003-06-23 The Johns Hopkins University School Of Medicine Method for mr/nmr imaging
WO2003053910A1 (fr) * 2001-12-19 2003-07-03 Japan Science And Technology Agency Amino acide marque par isotope stable, technique d'integration de cet amino acide dans une proteine cible, technique d'analyse structurelle par irm de proteine et technique de production d'acide fumarique et d'acide tartrique marques par isotope stable a selection de site
US20060154323A1 (en) * 2002-06-10 2006-07-13 Prospect Pharma Method for obtaining dynamic and structural data pertaining to proteins and protein/ligand complexes
WO2003106656A2 (fr) 2002-06-17 2003-12-24 Thrasos, Inc. Composés à domaine unique associés à tdf et analogues de ceux-ci
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7553455B1 (en) * 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US7672791B2 (en) * 2003-06-13 2010-03-02 International Business Machines Corporation Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules
WO2005005616A2 (fr) 2003-07-11 2005-01-20 Egorova-Zachernyuk Tatiana A Compositions et procedes de marquage de composes biologiques avec des isotopes stables
US20070275442A1 (en) * 2003-10-07 2007-11-29 Prospect Pharma Side Chain Deuterated Amino Acids Methods Of Use
JP5019280B2 (ja) 2003-10-31 2012-09-05 独立行政法人科学技術振興機構 安定同位体標識芳香族アミノ酸、その標的蛋白質への組み込み方法並びに蛋白質のｎｍｒ構造解析方法
US20080293150A1 (en) * 2004-02-02 2008-11-27 Toshiyuki Kohno Nmr Signal Assignment Method
US8410246B2 (en) 2004-06-17 2013-04-02 Thrasos, Inc. TDF-related compounds and analogs thereof
US7480356B2 (en) * 2004-12-08 2009-01-20 Telefonaktiebolaget L M Ericsson (Publ) Method of and system for path selection in rich multipath conditions
US7372895B2 (en) * 2004-12-08 2008-05-13 Telefonaktiebolaget Lm Ericsson (Publ) Method of and system for delay estimation with minimized finger allocation
ES2626018T3 (es) 2005-06-07 2017-07-21 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
DK2497780T3 (en) 2005-09-20 2015-06-01 Thrasos Innovation Inc TDF-related compounds and analogs thereof
US20070196280A1 (en) * 2006-02-21 2007-08-23 The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services In vivo magnetic resonance spectroscopy of aspartate transaminase activity
GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Ｎｍｒシグナルの帰属方法
CN101981201A (zh) * 2006-08-01 2011-02-23 加拿大海洋营养食品有限公司 产油微生物及改良这些微生物的方法
US8637486B2 (en) * 2008-03-14 2014-01-28 Retrotope, Inc. Therapeutic substances that modulate genome methylation
JP2011514361A (ja) * 2008-03-14 2011-05-06 レトロトップ、 インコーポレイテッド 同位体で置換されたリジンを用いたがん治療
US10052299B2 (en) 2009-10-30 2018-08-21 Retrotope, Inc. Alleviating oxidative stress disorders with PUFA derivatives
CN101914030B (zh) * 2010-07-23 2013-04-24 上海化工研究院 一种13c，15n双标记甘氨酸的合成方法
WO2012148930A2 (fr) 2011-04-26 2012-11-01 Retrotope, Inc. Rétinopathies oxydatives
JP6145087B2 (ja) 2011-04-26 2017-06-07 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． Ｐｕｆａ酸化関与障害
KR102112087B1 (ko) 2011-04-26 2020-05-18 레트로토프 인코포레이티드 에너지 프로세싱 손상 장애 및 미토콘드리아 결함
JP6106157B2 (ja) 2011-04-26 2017-03-29 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． 神経変性障害および筋疾患に関与するｐｕｆａ
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
EP3950649A1 (fr) 2015-11-23 2022-02-09 Retrotope, Inc. Marquage isotopique spécifique de site de systèmes 1,4-diènes
FR3055337A1 (fr) * 2016-08-24 2018-03-02 Commissariat A L'energie Atomique Et Aux Energies Alternatives Methode de preparation de milieux de culture riches pour le marquage d'acides amines incorpores dans des proteines
IL295783B2 (en) 2020-02-21 2026-03-01 Retrotope Inc Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS

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JPH0768446B2 (ja) * 1988-11-09 1995-07-26 三菱化学株式会社 芳香族ポリカーボネート樹脂組成物を用いた医療用部品
JP2518917B2 (ja) 1989-02-07 1996-07-31 日本電子株式会社 蛋白質の構造解析方法
EP0474790B1 (fr) 1989-06-14 1997-05-21 Martek Corporation Milieux destines a la croissance des cellules et procede servant a les produire
JP2517688B2 (ja) * 1989-12-25 1996-07-24 日本電子株式会社 ３次元核磁気共鳴スペクトルの対称化処理方法
JPH0446143A (ja) * 1990-06-11 1992-02-17 Hitachi Ltd 同位体多重標識アミノ酸の合成法
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5891643A (en) 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US6043024A (en) 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains

Also Published As

Publication number Publication date
TW581772B (en) 2004-04-01
NO20001052L (no) 2000-04-28
CA2301046C (fr) 2009-03-10
US6340578B1 (en) 2002-01-22
US6335196B1 (en) 2002-01-01
HUP0003383A2 (hu) 2001-02-28
US6376253B1 (en) 2002-04-23
DE69840448D1 (de) 2009-02-26
US6111066A (en) 2000-08-29
EP1009725A1 (fr) 2000-06-21
EP1009725B1 (fr) 2009-01-07
EP1889823A1 (fr) 2008-02-20
HUP0003383A3 (en) 2003-07-28
AU9298898A (en) 1999-03-22
WO1999011589A1 (fr) 1999-03-11
CA2301046A1 (fr) 1999-03-11
AU754232B2 (en) 2002-11-07
ATE420061T1 (de) 2009-01-15
NO20001052D0 (no) 2000-03-01
JP2001514239A (ja) 2001-09-11

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