AR035069A1 - Compuestos inhibidores de espiropirimidin-2,4,6-triona metaloproteinasas, composicion farmaceutica, procedimiento de tratamiento - Google Patents

Compuestos inhibidores de espiropirimidin-2,4,6-triona metaloproteinasas, composicion farmaceutica, procedimiento de tratamiento

Info

Publication number: AR035069A1
Authority: AR; Argentina
Prior art keywords: alkyl; ring; heteroaryl; independently selected; cycloalkyl
Prior art date: 2000-10-26

Application number

ARP010104977A

Other languages

English (en)

Spanish (es)

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-26

Filing date

2001-10-24

Publication date

2004-04-14

2001-10-24 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-04-14 Publication of AR035069A1 publication Critical patent/AR035069A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
125000001072 heteroaryl group Chemical group 0.000 abstract 10
125000000623 heterocyclic group Chemical group 0.000 abstract 10
125000001424 substituent group Chemical group 0.000 abstract 9
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 8
125000000041 C6-C10 aryl group Chemical group 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052757 nitrogen Inorganic materials 0.000 abstract 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
229920001774 Perfluoroether Polymers 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 4
125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 3
102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 3
108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
102000005741 Metalloproteases Human genes 0.000 abstract 2
108010006035 Metalloproteases Proteins 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102000003843 Metalloendopeptidases Human genes 0.000 abstract 1
108090000131 Metalloendopeptidases Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
210000002808 connective tissue Anatomy 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000002458 infectious effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000017169 kidney disease Diseases 0.000 abstract 1
210000004185 liver Anatomy 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000009933 reproductive health Effects 0.000 abstract 1
230000000241 respiratory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

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ARP010104977A 2000-10-26 2001-10-24 Compuestos inhibidores de espiropirimidin-2,4,6-triona metaloproteinasas, composicion farmaceutica, procedimiento de tratamiento AR035069A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24338900P	2000-10-26	2000-10-26

Publications (1)

Publication Number	Publication Date
AR035069A1 true AR035069A1 (es)	2004-04-14

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ID=22918584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP010104977A AR035069A1 (es)	2000-10-26	2001-10-24	Compuestos inhibidores de espiropirimidin-2,4,6-triona metaloproteinasas, composicion farmaceutica, procedimiento de tratamiento

Country Status (32)

Country	Link
EP (1)	EP1332146A2 (fr)
JP (1)	JP2004518635A (fr)
KR (1)	KR20040004412A (fr)
CN (1)	CN1501937A (fr)
AP (1)	AP2001002318A0 (fr)
AR (1)	AR035069A1 (fr)
AU (1)	AU2002210813A1 (fr)
BG (1)	BG107653A (fr)
BR (1)	BR0114913A (fr)
CA (1)	CA2425283A1 (fr)
CZ (1)	CZ20031083A3 (fr)
EA (1)	EA005762B1 (fr)
EC (1)	ECSP034567A (fr)
EE (1)	EE200300196A (fr)
GT (1)	GT200100213A (fr)
HN (1)	HN2001000244A (fr)
HR (1)	HRP20030332A2 (fr)
HU (1)	HUP0301577A3 (fr)
IL (1)	IL154948A0 (fr)
IS (1)	IS6762A (fr)
MA (1)	MA26957A1 (fr)
MX (1)	MXPA03003735A (fr)
NO (1)	NO20031853L (fr)
OA (1)	OA12529A (fr)
PA (1)	PA8531401A1 (fr)
PE (1)	PE20020589A1 (fr)
PL (1)	PL366201A1 (fr)
SK (1)	SK4972003A3 (fr)
SV (1)	SV2003000705A (fr)
TN (1)	TNSN01149A1 (fr)
WO (1)	WO2002034753A2 (fr)
ZA (1)	ZA200302190B (fr)

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MXPA05001783A (es)	2002-08-13	2005-04-25	Warner Lambert Co	Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz.
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US7208490B2 (en)	2002-10-07	2007-04-24	Pharmacia & Upjohn Company Llc	Tricyclic tetrahydroquinoline antibacterial agents
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WO2004084903A1 (fr) *	2003-03-27	2004-10-07	F. Hoffmann-La Roche Ag	Utilisation d'une trioxopyrimidine pour le traitement et la prevention de l'angiogenese pathologique oculaire
WO2004084902A1 (fr) *	2003-03-28	2004-10-07	F. Hoffmann-La Roche Ag	Utilisation d'une trioxopyrimidine dans le traitement de lesions chroniques
FR2858232B1 (fr) *	2003-07-29	2006-03-03	Pierre Potier	Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb
AU2005230379B2 (en) *	2004-04-01	2010-07-22	Universite De Liege	Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
DOP2006000268A (es)	2005-12-22	2007-07-31	Pfizer Prod Inc	Agentes antibacterianos
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CN102285934B (zh) *	2009-01-08	2013-08-14	四川大学	螺环二烯酮衍生物及其制备方法和用途
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KR101594506B1 (ko) *	2014-03-20	2016-02-17	한국화학연구원	골 관련 질환 치료용 조성물
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CN110092790B (zh) *	2019-06-11	2020-07-24	东北农业大学	一种生物碱类化合物及其制备方法和应用
WO2025226892A1 (fr) *	2024-04-24	2025-10-30	Septerna, Inc.	Agonistes de diaminométhylène pyrimidine-2,4,6-trione contenant un spirocycle de récepteurs 1 de l'hormone parathyroïdienne et de l'incrétine
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2001
- 2001-10-23 CN CNA018179231A patent/CN1501937A/zh active Pending
- 2001-10-23 AU AU2002210813A patent/AU2002210813A1/en not_active Abandoned
- 2001-10-23 HR HR20030332A patent/HRP20030332A2/hr not_active Application Discontinuation
- 2001-10-23 CZ CZ20031083A patent/CZ20031083A3/cs unknown
- 2001-10-23 EE EEP200300196A patent/EE200300196A/xx unknown
- 2001-10-23 SK SK497-2003A patent/SK4972003A3/sk unknown
- 2001-10-23 OA OA1200300123A patent/OA12529A/en unknown
- 2001-10-23 AP APAP/P/2001/002318A patent/AP2001002318A0/en unknown
- 2001-10-23 MX MXPA03003735A patent/MXPA03003735A/es unknown
- 2001-10-23 IL IL15494801A patent/IL154948A0/xx unknown
- 2001-10-23 WO PCT/IB2001/001986 patent/WO2002034753A2/fr not_active Ceased
- 2001-10-23 EP EP01978721A patent/EP1332146A2/fr not_active Withdrawn
- 2001-10-23 KR KR10-2003-7005753A patent/KR20040004412A/ko not_active Ceased
- 2001-10-23 PL PL01366201A patent/PL366201A1/xx not_active Application Discontinuation
- 2001-10-23 JP JP2002537743A patent/JP2004518635A/ja not_active Withdrawn
- 2001-10-23 BR BR0114913-0A patent/BR0114913A/pt not_active IP Right Cessation
- 2001-10-23 HU HU0301577A patent/HUP0301577A3/hu unknown
- 2001-10-23 EA EA200300306A patent/EA005762B1/ru not_active IP Right Cessation
- 2001-10-23 CA CA002425283A patent/CA2425283A1/fr not_active Abandoned
- 2001-10-24 HN HN2001000244A patent/HN2001000244A/es unknown
- 2001-10-24 AR ARP010104977A patent/AR035069A1/es unknown
- 2001-10-25 TN TNTNSN01149A patent/TNSN01149A1/fr unknown
- 2001-10-25 SV SV2001000705A patent/SV2003000705A/es unknown
- 2001-10-25 PE PE2001001060A patent/PE20020589A1/es not_active Application Discontinuation
- 2001-10-25 GT GT200100213A patent/GT200100213A/es unknown
- 2001-10-26 PA PA20018531401A patent/PA8531401A1/es unknown
2003
- 2003-03-19 ZA ZA200302190A patent/ZA200302190B/en unknown
- 2003-03-20 BG BG107653A patent/BG107653A/bg unknown
- 2003-03-27 IS IS6762A patent/IS6762A/is unknown
- 2003-04-22 MA MA27117A patent/MA26957A1/fr unknown
- 2003-04-24 NO NO20031853A patent/NO20031853L/no not_active Application Discontinuation
- 2003-04-25 EC EC2003004567A patent/ECSP034567A/es unknown

Also Published As

Publication number	Publication date
CN1501937A (zh)	2004-06-02
WO2002034753A2 (fr)	2002-05-02
NO20031853D0 (no)	2003-04-24
KR20040004412A (ko)	2004-01-13
EA005762B1 (ru)	2005-06-30
ECSP034567A (es)	2003-06-25
MA26957A1 (fr)	2004-12-20
EE200300196A (et)	2003-10-15
BR0114913A (pt)	2003-07-01
PE20020589A1 (es)	2002-07-06
WO2002034753A3 (fr)	2002-08-15
ZA200302190B (en)	2004-04-28
IL154948A0 (en)	2003-10-31
MXPA03003735A (es)	2003-07-28
NO20031853L (no)	2003-06-23
PL366201A1 (en)	2005-01-24
EA200300306A1 (ru)	2003-08-28
HUP0301577A3 (en)	2006-02-28
PA8531401A1 (es)	2003-06-30
GT200100213A (es)	2002-07-03
AU2002210813A1 (en)	2002-05-06
TNSN01149A1 (fr)	2005-11-10
HUP0301577A2 (hu)	2003-11-28
CA2425283A1 (fr)	2002-05-02
IS6762A (is)	2003-03-27
SK4972003A3 (en)	2004-05-04
SV2003000705A (es)	2003-01-13
OA12529A (en)	2006-06-02
EP1332146A2 (fr)	2003-08-06
AP2001002318A0 (en)	2001-12-31
BG107653A (bg)	2003-12-31
HRP20030332A2 (en)	2003-06-30
CZ20031083A3 (cs)	2004-03-17
HN2001000244A (es)	2003-11-07
JP2004518635A (ja)	2004-06-24

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2007-06-06	FB	Suspension of granting procedure

Publication	Publication Date	Title
AR035069A1 (es)	2004-04-14	Compuestos inhibidores de espiropirimidin-2,4,6-triona metaloproteinasas, composicion farmaceutica, procedimiento de tratamiento
RU2441869C2 (ru)	2012-02-10	Противовирусные соединения
CY1110969T1 (el)	2015-06-11	5-υποκατεστημενα-2-φαινυλαμινο-βενζαμιδια ως αναστολεiς μεκ
EP1566379A4 (fr)	2005-11-09	DERIVES DE QUINOLINE ET DE QUINAZOLINE INHIBANT L'AUTOPHOSPHORYLATION DE Flt3 ET COMPOSITIONS MEDICALES LES CONTENANT
CO5261625A1 (es)	2003-03-31	Novedoso derivados fenilheteroalquilamina, procesos para su prepraracion, coposiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia
ES2295609T3 (es)	2008-04-16	Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor.
SE9702799D0 (sv)	1997-07-25	New compounds
BRPI0410979A (pt)	2006-07-04	composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia
ATE194987T1 (de)	2000-08-15	Substituierte dibenzoxazepinverbindungen, pharmazeutische zusammensetzungen und anwendungsmethoden
ECSP045469A (es)	2005-01-28	El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas
AR040928A1 (es)	2005-04-27	Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas
RU2004122427A (ru)	2006-01-20	Пирролидин-2-оны в качестве ингибиторов фактора ха
DE602004015277D1 (de)	2008-09-04	Substituierte-1-phthalazinamine als vr-1-antagonisten
NO923199L (no)	1993-02-16	Terapeutiske forbindelser
UY28688A1 (es)	2005-07-29	Derivados de amida
PT871626E (pt)	2002-04-29	Triazolonas utilizadas como inibidores de sintese da apoliproteina b
DK1412332T3 (da)	2005-05-30	Quinolinderivater og anvendelse deraf som antitumormidler
AR038094A1 (es)	2004-12-29	Derivados de benzotiazol-4,7-dionas y benzooxazol-4,7-dionas, su uso para preparar un medicamento y composicion farmaceutica
FI923662A0 (fi)	1992-08-14	Terapeutiska medel.
DE60103034D1 (de)	2004-06-03	Neue phenylheteroalkylamin-derivate
DE50109320D1 (de)	2006-05-11	Verwendung von 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
AU2002222225A1 (en)	2002-06-24	Substituted-4-quinolones
ATE265428T1 (de)	2004-05-15	Neue verwendung von phenylheteroalkylamin- derivaten
DE60005525D1 (de)	2003-10-30	2-aminotetraline zur behandlung von glaukom
AR035219A1 (es)	2004-05-05	Compuesto de 1, 2, 3, 4, 4a, 5, 6, 7, 8, 8 a-decahidroisoquinolina, su uso para preparar una composicion farmaceutica, dicha composicion farmaceutica y procedimiento para preparar dicho compuesto