CA2425283A1 - Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione - Google Patents

Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione Download PDF

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Publication number
CA2425283A1
CA2425283A1 CA002425283A CA2425283A CA2425283A1 CA 2425283 A1 CA2425283 A1 CA 2425283A1 CA 002425283 A CA002425283 A CA 002425283A CA 2425283 A CA2425283 A CA 2425283A CA 2425283 A1 CA2425283 A1 CA 2425283A1
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CA
Canada
Prior art keywords
alkyl
group
pyridin
spiro
triaza
Prior art date
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Abandoned
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CA002425283A
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English (en)
Inventor
Brian Scott Bronk
Mark Carl Noe
Martin James Wythes
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Pfizer Products Inc
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Individual
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Publication of CA2425283A1 publication Critical patent/CA2425283A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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Abstract

La présente invention concerne des inhibiteurs de métalloprotéinase 5-spiro-pyrimidine-2,4,6-trione selon la formule (I), où "A" est un noyau hétérocyclique à 5-7 éléments, tel qu'il est défini dans la spécification, ainsi que des compositions et des procédés pharmaceutiques pour traiter des inflammations, le cancer et d'autres maladies.
CA002425283A 2000-10-26 2001-10-23 Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione Abandoned CA2425283A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24338900P 2000-10-26 2000-10-26
US60/243,389 2000-10-26
PCT/IB2001/001986 WO2002034753A2 (fr) 2000-10-26 2001-10-23 Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione

Publications (1)

Publication Number Publication Date
CA2425283A1 true CA2425283A1 (fr) 2002-05-02

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CA002425283A Abandoned CA2425283A1 (fr) 2000-10-26 2001-10-23 Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione

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EP (1) EP1332146A2 (fr)
JP (1) JP2004518635A (fr)
KR (1) KR20040004412A (fr)
CN (1) CN1501937A (fr)
AP (1) AP2001002318A0 (fr)
AR (1) AR035069A1 (fr)
AU (1) AU2002210813A1 (fr)
BG (1) BG107653A (fr)
BR (1) BR0114913A (fr)
CA (1) CA2425283A1 (fr)
CZ (1) CZ20031083A3 (fr)
EA (1) EA005762B1 (fr)
EC (1) ECSP034567A (fr)
EE (1) EE200300196A (fr)
GT (1) GT200100213A (fr)
HN (1) HN2001000244A (fr)
HR (1) HRP20030332A2 (fr)
HU (1) HUP0301577A3 (fr)
IL (1) IL154948A0 (fr)
IS (1) IS6762A (fr)
MA (1) MA26957A1 (fr)
MX (1) MXPA03003735A (fr)
NO (1) NO20031853L (fr)
OA (1) OA12529A (fr)
PA (1) PA8531401A1 (fr)
PE (1) PE20020589A1 (fr)
PL (1) PL366201A1 (fr)
SK (1) SK4972003A3 (fr)
SV (1) SV2003000705A (fr)
TN (1) TNSN01149A1 (fr)
WO (1) WO2002034753A2 (fr)
ZA (1) ZA200302190B (fr)

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BR0114913A (pt) 2003-07-01
MXPA03003735A (es) 2003-07-28
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TNSN01149A1 (fr) 2005-11-10
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BG107653A (bg) 2003-12-31
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