DK0443532T3 - Syntese af LH-RH analoger ved temporær minimalbeskyttelse - Google Patents

Syntese af LH-RH analoger ved temporær minimalbeskyttelse

Info

Publication number: DK0443532T3
Authority: DK; Denmark
Prior art keywords: synthesis; analogs; minimal protection; temporary; temporary minimal
Prior art date: 1990-02-20

Application number

DK91102370.3T

Other languages

Danish (da)

English (en)

Inventor

John J Nestor Jr

Natalie L Mcclure

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-20

Filing date

1991-02-19

Publication date

1994-07-25

1991-02-19 Application filed by Syntex Inc filed Critical Syntex Inc

1994-07-25 Application granted granted Critical

1994-07-25 Publication of DK0443532T3 publication Critical patent/DK0443532T3/da

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000012351 deprotecting agent Substances 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Bipolar Integrated Circuits (AREA)
Amplifiers (AREA)
Liquid Developers In Electrophotography (AREA)
Escalators And Moving Walkways (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Electrophonic Musical Instruments (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Golf Clubs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Variable-Direction Aerials And Aerial Arrays (AREA)
Fuses (AREA)
Investigating Or Analysing Biological Materials (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Semiconductor Integrated Circuits (AREA)

DK91102370.3T 1990-02-20 1991-02-19 Syntese af LH-RH analoger ved temporær minimalbeskyttelse DK0443532T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48242890A	1990-02-20	1990-02-20

Publications (1)

Publication Number	Publication Date
DK0443532T3 true DK0443532T3 (da)	1994-07-25

Family

ID=23916033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91102370.3T DK0443532T3 (da)	1990-02-20	1991-02-19	Syntese af LH-RH analoger ved temporær minimalbeskyttelse

Country Status (18)

Country	Link
EP (1)	EP0443532B1 (de)
JP (1)	JP2927978B2 (de)
KR (1)	KR0152276B1 (de)
AT (1)	ATE107931T1 (de)
AU (1)	AU639751B2 (de)
CA (1)	CA2036657C (de)
DE (1)	DE69102659T2 (de)
DK (1)	DK0443532T3 (de)
ES (1)	ES2057624T3 (de)
FI (1)	FI102538B1 (de)
HK (1)	HK43097A (de)
HU (1)	HU208158B (de)
IE (1)	IE71945B1 (de)
NO (1)	NO309428B1 (de)
NZ (1)	NZ237159A (de)
PH (1)	PH31062A (de)
PT (1)	PT96807B (de)
ZA (1)	ZA911233B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104231055A (zh)	2013-06-18	2014-12-24	深圳翰宇药业股份有限公司	加尼瑞克前体以及由其制备醋酸加尼瑞克的方法
KR101971418B1 (ko) *	2017-06-30	2019-04-24	애니젠 주식회사	고세렐린의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4301066A (en) *	1980-05-08	1981-11-17	American Home Products Corp.	Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
US4632979A (en) *	1984-06-18	1986-12-30	Tulane Educational Fund	Therapeutic LHRH analogs
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists

1991
- 1991-02-19 IE IE55691A patent/IE71945B1/en not_active IP Right Cessation
- 1991-02-19 HU HU91543A patent/HU208158B/hu unknown
- 1991-02-19 CA CA002036657A patent/CA2036657C/en not_active Expired - Lifetime
- 1991-02-19 PT PT96807A patent/PT96807B/pt not_active IP Right Cessation
- 1991-02-19 DE DE69102659T patent/DE69102659T2/de not_active Expired - Lifetime
- 1991-02-19 ZA ZA911233A patent/ZA911233B/xx unknown
- 1991-02-19 NZ NZ237159A patent/NZ237159A/en unknown
- 1991-02-19 KR KR1019910002623A patent/KR0152276B1/ko not_active Expired - Lifetime
- 1991-02-19 PH PH42022A patent/PH31062A/en unknown
- 1991-02-19 DK DK91102370.3T patent/DK0443532T3/da active
- 1991-02-19 FI FI910788A patent/FI102538B1/fi active
- 1991-02-19 AU AU71176/91A patent/AU639751B2/en not_active Expired
- 1991-02-19 NO NO910664A patent/NO309428B1/no not_active IP Right Cessation
- 1991-02-19 AT AT91102370T patent/ATE107931T1/de not_active IP Right Cessation
- 1991-02-19 EP EP91102370A patent/EP0443532B1/de not_active Expired - Lifetime
- 1991-02-19 ES ES91102370T patent/ES2057624T3/es not_active Expired - Lifetime
- 1991-02-20 JP JP3026462A patent/JP2927978B2/ja not_active Expired - Lifetime
1997
- 1997-04-03 HK HK43097A patent/HK43097A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO309428B1 (no)	2001-01-29
EP0443532B1 (de)	1994-06-29
ATE107931T1 (de)	1994-07-15
CA2036657A1 (en)	1991-08-21
CA2036657C (en)	2003-02-11
AU7117691A (en)	1991-08-22
PT96807B (pt)	1998-07-31
DE69102659D1 (de)	1994-08-04
ZA911233B (en)	1992-10-28
FI910788A0 (fi)	1991-02-19
JP2927978B2 (ja)	1999-07-28
HU910543D0 (en)	1991-09-30
FI102538B (fi)	1998-12-31
EP0443532A3 (en)	1992-02-26
FI102538B1 (fi)	1998-12-31
EP0443532A2 (de)	1991-08-28
NO910664L (no)	1991-08-21
HU208158B (en)	1993-08-30
HK43097A (en)	1997-04-11
IE71945B1 (en)	1997-03-12
PT96807A (pt)	1991-10-31
NO910664D0 (no)	1991-02-19
ES2057624T3 (es)	1994-10-16
KR0152276B1 (ko)	1998-10-01
FI910788L (fi)	1991-08-21
JPH04211096A (ja)	1992-08-03
PH31062A (en)	1998-02-05
IE910556A1 (en)	1991-08-28
NZ237159A (en)	1992-11-25
KR910021411A (ko)	1991-12-20
HUT57234A (en)	1991-11-28
DE69102659T2 (de)	1995-02-23
AU639751B2 (en)	1993-08-05

Publication	Publication Date	Title
DK0580635T3 (da)	1998-01-19	Modificerede plantevirus som vektorer
DK550787A (da)	1988-04-23	1,5-diphenylpyrazol-3-carboxylsyrederivater til beskyttelse af kulturplanter
IT1270882B (it)	1997-05-13	Oligopeptidi ad attivita' fungicida
FI945557L (fi)	1995-05-27	Isoksatsoliiniyhdisteet tulehduksenvastaisina aineina
ATE136888T1 (de)	1996-05-15	Retrovirale proteaseinhibitoren
FI942005L (fi)	1994-10-30	Peptidianalogeja irreversiibeleinä interleukiini-1beta-proteaasi-inhibiittoreina
DE69126987D1 (de)	1997-09-04	Retrovirale protease-inhibitoren
KR960702830A (ko)	1996-05-23	방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
NO921256D0 (no)	1992-03-31	Aminosyre-beta-lyaseenzyminhibitor som deodoranter
DE69021872D1 (de)	1995-09-28	Modifizierte Lösungsmittelzusammensetzungen.
DE59409672D1 (de)	2001-04-12	Festphasensynthese von Oligoribonucleotiden
DE68916850D1 (de)	1994-08-25	Antikoagulierende Peptid-Alkohole.
DK0443532T3 (da)	1994-07-25	Syntese af LH-RH analoger ved temporær minimalbeskyttelse
AR224003A1 (es)	1981-10-15	Compuestos herbicidas derivados de(2,6-dihaloisonicotinol)aminoacidos
DE69130265D1 (de)	1998-11-05	Positive arbeitende Photolackzusammensetzung
DE69209520D1 (de)	1996-05-02	Anordnung von halbleiterlasern.
SE9402253D0 (sv)	1994-06-27	Process
FI914018A7 (fi)	1992-02-28	Parannetut gemfibrotsiilikoostumukset
ITTO920891A1 (it)	1994-05-03	Macchina spandiconcime di tipo centrifugo.
SU1820511A1 (ru)	2000-04-10	Пептид для защиты животных от вируса ящура a
IT223880Z2 (it)	1995-10-03	P.c.b. - protezione catodica bollitori.
ITTO910563A0 (it)	1991-07-17	Macchina spandiconcime di tipo centrifugo
IT9029546V0 (it)	1990-06-08	Gioco di societa'.
IT1237400B (it)	1993-06-01	Composizioni erbicide a base di acetanilidi a selettivita' migliorata.