IL95880A - Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis - Google Patents

Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis

Info

Publication number: IL95880A
Authority: IL; Israel
Prior art keywords: pharmaceutically; compound; acceptable base; base salt; mammal
Prior art date: 1989-10-13

Application number

IL9588090A

Other languages

English (en)

Hebrew (he)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-13

Filing date

1990-10-02

Publication date

1995-12-31

1990-10-02 Application filed by Pfizer filed Critical Pfizer

1995-12-31 Publication of IL95880A publication Critical patent/IL95880A/en

Links

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230000002401 inhibitory effect Effects 0.000 title claims abstract description 11
238000002360 preparation method Methods 0.000 title claims description 14
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150000001875 compounds Chemical class 0.000 claims abstract description 64
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238000007911 parenteral administration Methods 0.000 claims description 6
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229910052895 riebeckite Inorganic materials 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
210000001562 sternum Anatomy 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
208000008732 thymoma Diseases 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL9588090A 1989-10-13 1990-10-02 Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis IL95880A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42144589A	1989-10-13	1989-10-13
US52905090A	1990-05-25	1990-05-25

Publications (1)

Publication Number	Publication Date
IL95880A true IL95880A (en)	1995-12-31

Family

ID=27025248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9588090A IL95880A (en)	1989-10-13	1990-10-02	Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis

Country Status (14)

Country	Link
US (1)	US5192790A (de)
EP (1)	EP0425109B1 (de)
JP (1)	JPH0684300B2 (de)
KR (1)	KR910007526A (de)
AT (1)	ATE109349T1 (de)
AU (1)	AU624739B2 (de)
CA (1)	CA2027394C (de)
DE (1)	DE69011272T2 (de)
DK (1)	DK0425109T3 (de)
HU (2)	HUT59004A (de)
IE (1)	IE63140B1 (de)
IL (1)	IL95880A (de)
MY (1)	MY106834A (de)
PT (1)	PT95566B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110296A (en) *	1993-07-16	1999-12-31	Smithkline Beecham Corp	Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US6266485B1 (en)	1998-02-19	2001-07-24	Emerson Electric Co.	One-piece plastic tank and temperature control system for a hot water dispenser
AU6330799A (en) *	1998-09-30	2000-04-17	Roche Diagnostics Gmbh	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN162090B (de) *	1984-03-19	1988-03-26	Pfizer
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN161509B (de) *	1984-05-04	1987-12-19	Pfizer
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) *	1985-07-16	1985-08-21	Cellena Cell Eng Ag	Compositions containing melatonin/homologues
EP0284612B1 (de) *	1986-01-30	1991-07-24	University of Utah	Behandlung von knochenschwund
US4677132A (en) *	1986-03-12	1987-06-30	American Home Products Corporation	Inhibition of bone resorption by etodolac
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives

1990
- 1990-10-02 IL IL9588090A patent/IL95880A/en not_active IP Right Cessation
- 1990-10-03 DK DK90310806.6T patent/DK0425109T3/da active
- 1990-10-03 DE DE69011272T patent/DE69011272T2/de not_active Expired - Fee Related
- 1990-10-03 EP EP90310806A patent/EP0425109B1/de not_active Expired - Lifetime
- 1990-10-03 AT AT90310806T patent/ATE109349T1/de not_active IP Right Cessation
- 1990-10-11 MY MYPI90001771A patent/MY106834A/en unknown
- 1990-10-11 PT PT95566A patent/PT95566B/pt not_active IP Right Cessation
- 1990-10-11 JP JP2273150A patent/JPH0684300B2/ja not_active Expired - Lifetime
- 1990-10-11 CA CA002027394A patent/CA2027394C/en not_active Expired - Fee Related
- 1990-10-12 AU AU64582/90A patent/AU624739B2/en not_active Ceased
- 1990-10-12 HU HU906436A patent/HUT59004A/hu unknown
- 1990-10-12 KR KR1019900016153A patent/KR910007526A/ko not_active Ceased
- 1990-10-12 IE IE364890A patent/IE63140B1/en not_active IP Right Cessation
1991
- 1991-12-17 US US07/808,491 patent/US5192790A/en not_active Expired - Fee Related
1995
- 1995-05-11 HU HU95P/P00128P patent/HU210902A9/hu unknown

Also Published As

Publication number	Publication date
HU210902A9 (en)	1995-09-28
DE69011272D1 (de)	1994-09-08
DK0425109T3 (da)	1994-11-21
AU624739B2 (en)	1992-06-18
DE69011272T2 (de)	1994-11-24
HU906436D0 (en)	1991-04-29
HUT59004A (en)	1992-04-28
PT95566B (pt)	1997-11-28
EP0425109A3 (en)	1992-01-15
PT95566A (pt)	1991-08-14
CA2027394C (en)	1995-01-03
AU6458290A (en)	1991-04-18
KR910007526A (ko)	1991-05-30
MY106834A (en)	1995-07-31
JPH03133929A (ja)	1991-06-07
EP0425109B1 (de)	1994-08-03
CA2027394A1 (en)	1991-04-14
IE903648A1 (en)	1991-04-24
JPH0684300B2 (ja)	1994-10-26
ATE109349T1 (de)	1994-08-15
IE63140B1 (en)	1995-03-22
US5192790A (en)	1993-03-09
EP0425109A2 (de)	1991-05-02

Legal Events

Date	Code	Title
1996-06-18	FF	Patent granted
1996-12-05	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
HU203670B (en)	1991-09-30	Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus
EP1259239B1 (de)	2007-03-28	VERWENDUNG VON 2-(4-ETHOXY-PHENYL)-3-(4-METHANESULFONYL-PHENYL)-PYRAZOLO[1,5-b]PYRIDAZINE ZUR BEHANDLUNG VON NICHTULZERATIVER DYSPEPSIE
KR20020015334A (ko)	2002-02-27	항균제로서의 화합물의 신규한 용도
US4861794A (en)	1989-08-29	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
KR20020075797A (ko)	2002-10-05	엔도텔린 유발성 질환 치료제
US4853409A (en)	1989-08-01	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
EP0425109B1 (de)	1994-08-03	3-Substituierte-2-Oxindolderivate als Interleukin-Biosynthesehemmer
JPH10511978A (ja)	1998-11-17	アルツハイマー病の治療用薬剤
AU605702B2 (en)	1991-01-17	Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
NZ237451A (en)	1997-02-24	The use of 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)indole-1-carboxamide in the preparation of a pharmaceutical composition
WO1992003130A1 (en)	1992-03-05	Use of aryl hydroxyurea compounds for the treatment of atherosclerosis
US20040053968A1 (en)	2004-03-18	Methods and compositions for treating peridontal disease
NZ235638A (en)	1997-02-24	The use of indole derivatives for treating interleukin-1 related disorders
US5071852A (en)	1991-12-10	Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
EP1349548A2 (de)	2003-10-08	Verfahren und zusammensetzungen zur behandlung von parodontose
CN109260197B (zh)	2021-02-12	靛玉红类化合物和硼替佐米在制备治疗多发性骨髓瘤的药物中的用途
US7955623B2 (en)	2011-06-07	Pharmaceutical preparations for treating inflammatory diseases
KR100286141B1 (ko)	2001-04-16	6,7-치환-2-아미노테트랄린을 함유한 패혈성 쇼크 치료용 및 해열, 소염용 의약 조성물
RU2345775C1 (ru)	2009-02-10	Нестероидное противовоспалительное лекарственное средство
CA2156120A1 (en)	1996-02-18	3-substituted-2-oxindoles as inhibitors of viral replication