ATE110412T1 - Translation von mrna. - Google Patents

Translation von mrna.

Info

Publication number
ATE110412T1
ATE110412T1 AT87903719T AT87903719T ATE110412T1 AT E110412 T1 ATE110412 T1 AT E110412T1 AT 87903719 T AT87903719 T AT 87903719T AT 87903719 T AT87903719 T AT 87903719T AT E110412 T1 ATE110412 T1 AT E110412T1
Authority
AT
Austria
Prior art keywords
mrna
translation
rna viruses
omega
enhancers
Prior art date
Application number
AT87903719T
Other languages
English (en)
Inventor
Thomas Michael Aubrey Wilson
Original Assignee
Diatech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10598884&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE110412(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diatech Ltd filed Critical Diatech Ltd
Application granted granted Critical
Publication of ATE110412T1 publication Critical patent/ATE110412T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/60—Vectors comprising a special translation-regulating system from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
AT87903719T 1986-06-04 1987-06-04 Translation von mrna. ATE110412T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868613481A GB8613481D0 (en) 1986-06-04 1986-06-04 Translation of mrna

Publications (1)

Publication Number Publication Date
ATE110412T1 true ATE110412T1 (de) 1994-09-15

Family

ID=10598884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87903719T ATE110412T1 (de) 1986-06-04 1987-06-04 Translation von mrna.

Country Status (8)

Country Link
US (2) US5489527A (de)
EP (1) EP0270611B1 (de)
JP (2) JP2814433B2 (de)
AT (1) ATE110412T1 (de)
AU (1) AU614062B2 (de)
DE (1) DE3750422T2 (de)
GB (2) GB8613481D0 (de)
WO (1) WO1987007644A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135855A (en) * 1986-09-03 1992-08-04 The United States Of America As Represented By The Department Of Health And Human Services Rapid, versatile and simple system for expressing genes in eukaryotic cells
CA1339841C (en) * 1988-07-15 1998-04-28 Robert L. Erwing Synthesis of stereospecific enzyme by non-chromosomal transformation a host
JPH0253491A (ja) * 1988-08-17 1990-02-22 Japan Tobacco Inc ベクター及びその利用方法
KR900702041A (ko) * 1988-08-19 1990-12-05 로버트 에이. 아미테이지 식물의 발현 카셋트
EP0418695A1 (de) * 1989-09-13 1991-03-27 Ciba-Geigy Ag Regulatorische DNA-Sequenz
US5994526A (en) * 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
CA2385134A1 (en) * 1999-10-15 2001-04-19 Wakenyaku Co., Ltd. Template molecule having broad applicability and highly efficient function means of cell-free synthesis of proteins by using the same
FI20000182A0 (fi) * 2000-01-28 2000-01-28 Teemu Teeri Nukleotidisekvenssien käyttö proteiinisynteesin ja proteiinien ilmentämisen lisäämiseksi
AU8020201A (en) * 2000-08-30 2002-03-13 Wakenyaku Co Ltd Design and construction of transcription template for synthesizing cell-free protein, and dilution batch-type method of synthesizing cell-free wheat germ protein by using the same
JP4723713B2 (ja) * 2000-09-25 2011-07-13 トヨタ自動車株式会社 mRNAの潜在的翻訳制御因子のスクリーニング方法
FR2815969B1 (fr) 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
WO2002046395A1 (fr) * 2000-12-07 2002-06-13 Keio University Proteine a c-terminaison modifiee et procede permettant d'obtenir cette proteine, agent de modification et matrice de traduction necessaire a la production d'une proteine a c-terminaison modifiee, et procede de detection de l'interaction proteique avec l'utilisation de ladite proteine
EP1362113B1 (de) 2001-02-22 2011-01-12 Biogemma Konstitutiver promotor aus arabidopsis
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20030166282A1 (en) * 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
EP1478656B1 (de) * 2002-02-01 2009-09-16 Life Technologies Corporation Oligonukleotidzusammensetzungen mit verbesserter effizienz
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
WO2003106630A2 (en) * 2002-06-12 2003-12-24 Ambion, Inc. Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
US20100075423A1 (en) * 2002-06-12 2010-03-25 Life Technologies Corporation Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
FR2848570B1 (fr) 2002-12-12 2005-04-01 Bayer Cropscience Sa Cassette d'expression codant pour une 5-enol pyruvylshikimate-3-phosphate synthase (epsps) et plantes tolerantes aux herbicides la contenant
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
KR20080075855A (ko) 2005-11-04 2008-08-19 다우 아그로사이언시즈 엘엘씨 재조합 식물 현탁배양을 이용한 백신 마스터 세포주제조방법
ITUD20060280A1 (it) * 2006-12-29 2008-06-30 Univ Degli Studi Udine Sequenza artificiale di dna evente funzione di leader in 5' (5'-utr) ottimizzata per la sovraespressione di proteine eterologhe in pianta
JP5048524B2 (ja) 2007-03-08 2012-10-17 住友化学株式会社 植物における、化学物質による外来遺伝子の誘導発現方法
WO2010037593A1 (en) * 2008-10-01 2010-04-08 Tet Systems Holding Gmbh & Co.Kg Tetracycline inducible transcription control sequence
AR074941A1 (es) 2009-01-07 2011-02-23 Bayer Cropscience Sa Plantas transplastomicas exentas de marcador de seleccion
US9057072B2 (en) 2009-11-24 2015-06-16 Katholieke Universiteit Leuven, K.U. Leuven R&D Banana promoters
WO2011076885A1 (en) 2009-12-23 2011-06-30 Bayer Cropscience Ag Plants tolerant to hppd inhibitor herbicides
CN102869769A (zh) 2009-12-23 2013-01-09 拜尔知识产权有限公司 耐受hppd抑制剂型除草剂的植物
AU2010334808B2 (en) 2009-12-23 2015-07-09 Bayer Intellectual Property Gmbh Plants tolerant to HPPD inhibitor herbicides
ES2658990T3 (es) 2009-12-23 2018-03-13 Bayer Intellectual Property Gmbh Plantas tolerantes a herbicidas inhibidores de HPPD
EA201290560A1 (ru) 2009-12-23 2014-05-30 Байер Интеллектуэль Проперти Гмбх Растения, устойчивые к гербицидам - ингибиторам hppd
WO2011095460A1 (en) 2010-02-02 2011-08-11 Bayer Cropscience Ag Soybean transformation using hppd inhibitors as selection agents
CA2788238C (en) 2010-02-04 2019-09-03 Fritz Kreuzaler A method for increasing photosynthetic carbon fixation using glycolate dehydrogenase multi-subunit fusion protein
EP2669371A1 (de) 2010-11-10 2013-12-04 Bayer CropScience AG HPPD-Varianten und Anwendungsverfahren
EP2468882A1 (de) 2010-12-27 2012-06-27 Bayer CropScience AG Aurorakinaseaktivatorpolypeptide zum Identifizieren von fungizid wirksamen Verbindungen
AU2012210618B2 (en) 2011-01-24 2017-02-02 Bayer Cropscience N.V. Use of the rd29 promoter or fragments thereof for stress-inducible expression of transgenes in cotton
PL2688406T3 (pl) 2011-03-25 2015-10-30 Bayer Ip Gmbh Zastosowanie N-(tetrazol-4-ilo)- lub N-(triazol-3-ilo)arylokarboksamidów lub ich soli do zwalczania niepożądanych roślin w obszarach transgenicznych roślin uprawnych tolerancyjnych na środki chwastobójcze będące inhibitorem HPPD
CA2830802A1 (en) 2011-03-25 2012-10-04 Bayer Intellectual Property Gmbh Use of n-(1,2,5-oxadiazol-3-yl)benzamides for controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides
BR112013025819A2 (pt) 2011-04-07 2016-12-20 Bayer Crospscience N V promotor específico para semente em algodão
CN103562386A (zh) 2011-05-25 2014-02-05 国立大学法人冈山大学 Reic表达腺病毒载体
WO2013023992A1 (en) 2011-08-12 2013-02-21 Bayer Cropscience Nv Guard cell-specific expression of transgenes in cotton
BR112014003919A2 (pt) 2011-08-22 2017-03-14 Bayer Cropscience Ag métodos e meios para modificar um genoma de planta
US20140283819A1 (en) 2011-10-12 2014-09-25 Bayer Cropscience Ag Plants with decreased activity of a starch dephosphorylating enzyme
US20140251317A1 (en) 2011-10-12 2014-09-11 Bayer Cropscience Ag Plants with decreased activity of a starch dephosphorylating enzyme
UY35035A (es) 2012-09-14 2014-04-30 Bayer Cropscience Ag ?molécula de ácido nucleico recombinante que codifica una enzima hppd, vector, célula huésped, semilla, planta, polipéptido, producto primario, métodos y usos?.
WO2014118123A1 (en) 2013-01-29 2014-08-07 The University Court Of The University Of Glasgow Methods and means for increasing stress tolerance and biomass in plants
EP3017049B1 (de) 2013-07-01 2018-08-22 Bayer CropScience NV Verfahren und mittel zur modulierung der blütezeit bei einkeimblättrigen pflanzen
CA2917103C (en) 2013-07-09 2021-01-12 Board Of Trustees Of Michigan State University Transgenic plants produced with a k-domain, and methods and expression cassettes related thereto
US11459579B2 (en) 2013-07-09 2022-10-04 Board Of Trustees Of Michigan State University Transgenic plants produced with a K-domain, and methods and expression cassettes related thereto
BR112016005859A2 (pt) 2013-09-24 2017-09-19 Basf Se Heterotransglicosilase e usos da mesma
CN106459986B (zh) 2014-03-11 2020-06-30 拜耳作物科学有限合伙公司 Hppd变体和使用方法
ES2773601T3 (es) 2014-07-22 2020-07-13 Nmc Inc Sistemas de fijación de carbono mejorados en plantas y algas
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
MA41180A (fr) 2014-12-17 2017-10-24 Bayer Cropscience Nv Plantes caractérisées par une capacité améliorée de fixation du carbone photosynthétique
WO2017042259A1 (en) 2015-09-11 2017-03-16 Bayer Cropscience Aktiengesellschaft Hppd variants and methods of use
WO2017184727A1 (en) 2016-04-21 2017-10-26 Bayer Cropscience Lp Tal-effector mediated herbicide tolerance
US20190225974A1 (en) 2016-09-23 2019-07-25 BASF Agricultural Solutions Seed US LLC Targeted genome optimization in plants
BR112019010476A2 (pt) 2016-11-23 2019-09-10 BASF Agricultural Solutions Seed US LLC molécula de ácido nucleico recombinante, vetor, célula hospedeira, planta transgênica, semente transgênica, polipeptídeo recombinante, composição, método para controlar uma população de pragas, para matar pragas, para produzir um polipeptídeo, planta ou célula vegetal, método para proteger uma planta contra uma praga, para aumentar o rendimento em uma planta, uso e produto primário
US20190364908A1 (en) 2016-12-22 2019-12-05 BASF Agricultural Solutions Seed US LLC Use of cry14 for the control of nematode pests
AR110756A1 (es) 2017-01-18 2019-05-02 Bayer Cropscience Lp Uso de bp005 para el control de patógenos de planta
CN110431234B (zh) 2017-01-18 2024-04-16 巴斯夫农业种子解决方案美国有限责任公司 Bp005毒素基因及其使用方法
MX2019009070A (es) 2017-02-01 2019-10-30 Modernatx Inc Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion.
US11708565B2 (en) 2017-03-07 2023-07-25 BASF Agricultural Solutions Seesi US LLC HPPD variants and methods of use
EP4253544A3 (de) 2017-05-18 2023-12-20 ModernaTX, Inc. Modifizierte messenger-rna mit funktionellen rna-elementen
EP3638292A1 (de) 2017-06-14 2020-04-22 ModernaTX, Inc. Für koagulationsfaktor viii kodierende polynukleotide
BR112020008096A2 (pt) 2017-10-24 2020-11-03 Basf Se método para conferir tolerância a um herbicida e planta de soja transgênica
BR112020008092A2 (pt) 2017-10-24 2020-09-15 BASF Agricultural Solutions Seed US LLC método para conferir tolerância a um herbicida e planta de soja transgênica
US11939601B2 (en) 2017-11-22 2024-03-26 Modernatx, Inc. Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria
JP7424976B2 (ja) 2017-11-22 2024-01-30 モダーナティエックス・インコーポレイテッド プロピオン酸血症の治療用のプロピオニルCoAカルボキシラーゼアルファ及びベータサブユニットをコードするポリヌクレオチド
EP3714048B1 (de) 2017-11-22 2025-04-09 ModernaTX, Inc. Für ornithintranscarbamylase codierende polynukleotide zur behandlung von harnstoffzyklusstörungen
US20210163928A1 (en) 2018-04-11 2021-06-03 Modernatx, Inc. Messenger rna comprising functional rna elements
WO2019233349A1 (zh) 2018-06-04 2019-12-12 青岛清原化合物有限公司 突变型对羟苯基丙酮酸双氧化酶、其编码核酸以及应用
WO2020023390A1 (en) 2018-07-25 2020-01-30 Modernatx, Inc. Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
MA53545A (fr) 2018-09-02 2021-07-14 Modernatx Inc Polynucléotides codant pour l'acyl-coa déshydrogénase à très longue chaîne pour le traitement de l'insuffisance en acyl-coa déshydrogénase à très longue chaîne
US12644102B2 (en) 2018-09-13 2026-06-02 Modernatx, Inc. Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex E1-α, E1-β, and E2 subunits for the treatment of maple syrup urine disease
JP2022500436A (ja) 2018-09-13 2022-01-04 モダーナティエックス・インコーポレイテッドModernaTX, Inc. 糖原病を処置するためのグルコース−6−ホスファターゼをコードするポリヌクレオチド
MA53615A (fr) 2018-09-14 2021-07-21 Modernatx Inc Polynucléotides codant pour le polypeptide a1, de la famille de l'uridine diphosphate glycosyltransférase 1, pour le traitement du syndrome de crigler-najjar
WO2020069169A1 (en) 2018-09-27 2020-04-02 Modernatx, Inc. Polynucleotides encoding arginase 1 for the treatment of arginase deficiency
WO2020227642A1 (en) 2019-05-08 2020-11-12 Modernatx, Inc. Compositions for skin and wounds and methods of use thereof
MA56517A (fr) 2019-06-24 2022-04-27 Modernatx Inc Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations
BR112022007119A2 (pt) 2019-10-14 2022-07-05 BASF Agricultural Solutions Seed US LLC Molécula de ácido nucleico, ácido nucleico, polipeptídeos, vetor, célula hospedeira, planta transgênica, semente transgênica, composição, métodos para controlar uma população de pragas, para matar uma praga, para produzir um polipeptídeo, para proteger uma planta e para aumentar o rendimento em uma planta, planta, uso do ácido nucleico e produto básico
MX2022004552A (es) 2019-10-14 2022-10-10 BASF Agricultural Solutions Seed US LLC Nuevos genes de resistencia a insectos y métodos de uso.
JP2022552371A (ja) 2019-10-15 2022-12-15 モデルナティエックス インコーポレイテッド 免疫調節ポリペプチドをコードするmRNA及びその使用
CA3158013A1 (en) 2019-10-15 2021-04-22 Modernatx, Inc. Mrnas encoding granulocyte-macrophage colony stimulating factor for treating parkinson's disease
EP4087544A1 (de) 2020-01-10 2022-11-16 ModernaTX, Inc. Verfahren zur herstellung tolerogener dendritischer zellen
EP4096720A2 (de) 2020-01-30 2022-12-07 ModernaTX, Inc. Für metabolische umprogrammierungspolypeptide codierende mrnas und deren verwendungen
AU2021270587A1 (en) 2020-05-14 2022-12-08 Modernatx, Inc. LNP compositions comprising an mRNA therapeutic and an effector molecule
AU2021285812A1 (en) 2020-06-01 2023-01-05 Modernatx, Inc. Phenylalanine hydroxylase variants and uses thereof
IL299196A (en) 2020-06-23 2023-02-01 Modernatx Inc LNP preparations that include mRNA treatments with extended lifespan
US20240189449A1 (en) 2021-03-24 2024-06-13 Modernatx, Inc. Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency
WO2022204067A1 (en) 2021-03-24 2022-09-29 Dna Twopointo Inc. Tetracycline-inducible expression systems
US20240207374A1 (en) 2021-03-24 2024-06-27 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
WO2022204380A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
WO2022204390A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
WO2022204369A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
US20240376445A1 (en) 2021-06-22 2024-11-14 Modernatx, Inc. Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
US20250017867A1 (en) 2021-10-01 2025-01-16 Modernatx, Inc. Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
WO2023196399A1 (en) 2022-04-06 2023-10-12 Modernatx, Inc. Lipid nanoparticles and polynucleotides encoding argininosuccinate lyase for the treatment of argininosuccinic aciduria
AU2023408197A1 (en) 2022-12-19 2025-06-26 Basf Agricultural Solutions Us Llc Insect toxin genes and methods for their use
WO2024182301A2 (en) 2023-02-27 2024-09-06 Modernatx, Inc. Lipid nanoparticles and polynucleotides encoding galactose-1-phosphate uridylyltransferase (galt) for the treatment of galactosemia
WO2024218400A1 (en) 2023-04-21 2024-10-24 Inprother Aps Improved expression of surface-displayed antigens
EP4704816A1 (de) 2023-05-03 2026-03-11 ModernaTX, Inc. Polynukleotide zur codierung des transmembranleitungsregulators bei zystischer fibrose zur behandlung von zystischer fibrose
JP2026522972A (ja) 2023-07-07 2026-07-09 ビーエーエスエフ アグリカルチュラル ソリューションズ ユーエス エルエルシー 線虫有害生物を防除するためのcry遺伝子の使用
KR20260096857A (ko) 2023-10-27 2026-06-24 바스프 아그리컬쳐럴 솔루션즈 유에스 엘엘씨 선충 해충의 방제를 위한 신규 유전자의 사용
WO2026010930A1 (en) 2024-07-05 2026-01-08 BASF Agricultural Solutions Seed US LLC Use of axmi277 for the control of rotylenchulus reniformis nematode pests

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1192510A (en) * 1981-05-27 1985-08-27 Lawrence E. Pelcher Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom
DE3485850T2 (de) * 1983-11-08 1993-01-21 Teijin Ltd Genfragmente, abgeleitet vom menschlichen immunoglobulin-gen.
DE3431140A1 (de) * 1984-08-24 1986-03-06 Behringwerke Ag, 3550 Marburg Enhancer fuer eukaryotische expressionssysteme
US5466788A (en) * 1985-03-07 1995-11-14 Mycogen Plant Science, Inc. Subgenomic promoter
CA1288073C (en) * 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
JPS629984A (ja) * 1985-07-08 1987-01-17 Ookura Eng Kk 自動選字装置
US4820639A (en) * 1985-12-04 1989-04-11 Massachusetts Institute Of Technology Process for enhancing translational efficiency of eukaryotic mRNA
IL98886A (en) * 1986-04-09 1992-12-01 Lilly Co Eli Method for producing a functional polypeptide in a eukaryotic cell
US4962028A (en) * 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors

Also Published As

Publication number Publication date
GB8801508D0 (en) 1988-03-16
EP0270611A1 (de) 1988-06-15
WO1987007644A1 (en) 1987-12-17
US5489527A (en) 1996-02-06
JP3658654B2 (ja) 2005-06-08
JP2814433B2 (ja) 1998-10-22
GB8613481D0 (en) 1986-07-09
JPH10146197A (ja) 1998-06-02
AU7489687A (en) 1988-01-11
DE3750422D1 (de) 1994-09-29
DE3750422T2 (de) 1994-12-15
GB2199328A (en) 1988-07-06
US5891665A (en) 1999-04-06
JPH01500961A (ja) 1989-04-06
GB2199328B (en) 1990-10-24
EP0270611B1 (de) 1994-08-24
AU614062B2 (en) 1991-08-22

Similar Documents

Publication Publication Date Title
DE3750422D1 (de) Translation von mrna.
DE69938255D1 (de) Verfahren und zusammensetzung zur konservierung von adenoviren
DK0804163T3 (da) Forbedret fremgangsmåde til stabilisering af biologiske stoffer under tørring og efterfølgende opbevaring samt præparater deraf
IT8422580A0 (it) Composizioni che le contengono e proteine di membrana cellulare, procedimento per prepararle.
ATE12485T1 (de) Salze der valproinsaeure, ihre herstellung und ihre verwendung.
NO973685L (no) Multi-tumor avvikende vekstgener
DE69033700D1 (de) Il-11 aus säugetier
ATE273320T1 (de) Fusogene liposomen
BR9105737A (pt) Processo para reduzir a contaminacao de um produto de amplificacao,conjunto para uso em um tipo de procedimento de amplificacao e processo para amplificar uma sequencia de amplificacao de uma sequencia-alvo
DE3683374D1 (de) Mikrobielle zusammensetzungen und verfahren zur behandlung vom boden.
ATE22562T1 (de) 6-substituierte s-triazolo(3,4-a)phthalazinderivate.
TR199802789T2 (xx) Eksendin analoglar� bunlar�n �retimi i�in y�ntemler ve bunlar� i�eren farmas�tik m�stahzarlar.
ATE216590T1 (de) Arzneimittelformulierungen für il-12
ES8603950A1 (es) Un procedimiento para inactivar un virus asociado a un material biologico
FI931714A0 (fi) Fukthaerdbar en-komponent polysiloxanfoerening
ES2054612T3 (es) Secuencias de adn que codifican para proteinas con actividad biologica de los inhibidores husi tipo-i y procedimientos tecnologicos geneticos para la preparacion de estas proteinas.
MA19882A1 (fr) Derives d'acides w-amines, leur preparation et utilisation ainsi que les compositions contenant ces acides.
DE3886213D1 (de) Verfahren zur Herstellung von Antioxidant-Zubereitungen.
DE60102147D1 (de) Anti-gefrier proteine, deren herstellung und verwendung
DK403384A (da) Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf
FI880636A7 (fi) Menetelmä vaipallisten virusten inaktivoimiseksi solun avulla in vitro valmistetuissa proteiinivalmisteissa.
DE68917817D1 (de) Verfahren zur Herstellung von vernetzten Polycarbonaten und Zusammensetzungen daraus.
IT1191211B (it) Procedimento per la preparazione di nitroaniline,nitroaniline e composizioni tintorie comprendenti nitroaniline
DE3850261D1 (de) Gen des hüllproteins des gurkenmosaikvirus.
BG90414A (bg) 2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time