ATE110963T1 - Mittel zur hemmung der alpha-amylase aktivität. - Google Patents
Mittel zur hemmung der alpha-amylase aktivität.Info
- Publication number
- ATE110963T1 ATE110963T1 AT90107475T AT90107475T ATE110963T1 AT E110963 T1 ATE110963 T1 AT E110963T1 AT 90107475 T AT90107475 T AT 90107475T AT 90107475 T AT90107475 T AT 90107475T AT E110963 T1 ATE110963 T1 AT E110963T1
- Authority
- AT
- Austria
- Prior art keywords
- tea
- agents
- theaflavin
- amylase activity
- inhibiting alpha
- Prior art date
Links
- 244000269722 Thea sinensis Species 0.000 abstract 4
- 235000013616 tea Nutrition 0.000 abstract 3
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 abstract 2
- 229930013915 (+)-catechin Natural products 0.000 abstract 1
- 235000007219 (+)-catechin Nutrition 0.000 abstract 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 abstract 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 abstract 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 abstract 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 abstract 1
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 abstract 1
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 abstract 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 abstract 1
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 abstract 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 abstract 1
- 235000006468 Thea sinensis Nutrition 0.000 abstract 1
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- KMJPKUVSXFVQGZ-WQLSNUALSA-N [(2r,3r)-5,7-dihydroxy-2-[3,4,5-trihydroxy-6-oxo-1-[(2r,3r)-3,5,7-trihydroxy-3,4-dihydro-2h-chromen-2-yl]benzo[7]annulen-8-yl]-3,4-dihydro-2h-chromen-3-yl] 3,4,5-trihydroxybenzoate Chemical class O([C@@H]1CC2=C(O)C=C(O)C=C2O[C@@H]1C1=CC(=O)C(O)=C2C(O)=C(O)C=C(C2=C1)[C@H]1OC2=CC(O)=CC(O)=C2C[C@H]1O)C(=O)C1=CC(O)=C(O)C(O)=C1 KMJPKUVSXFVQGZ-WQLSNUALSA-N 0.000 abstract 1
- 102000004139 alpha-Amylases Human genes 0.000 abstract 1
- 108090000637 alpha-Amylases Proteins 0.000 abstract 1
- 229940024171 alpha-amylase Drugs 0.000 abstract 1
- 235000020279 black tea Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 abstract 1
- 235000012734 epicatechin Nutrition 0.000 abstract 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 abstract 1
- 229940030275 epigallocatechin gallate Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 235000013824 polyphenols Nutrition 0.000 abstract 1
- 235000014620 theaflavin Nutrition 0.000 abstract 1
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 abstract 1
- 229940026509 theaflavin Drugs 0.000 abstract 1
- FJYGFTHLNNSVPY-BBXLVSEPSA-N theaflavin digallate Chemical compound C1=C([C@@H]2[C@@H](CC3=C(O)C=C(O)C=C3O2)O)C=C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(=O)C2=C1C([C@H]1OC3=CC(O)=CC(O)=C3C[C@H]1O)=CC(O)=C2OC(=O)C1=CC(O)=C(O)C(O)=C1 FJYGFTHLNNSVPY-BBXLVSEPSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Tea And Coffee (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1270228A JP3018013B2 (ja) | 1989-10-19 | 1989-10-19 | α―アミラーゼ活性阻害剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110963T1 true ATE110963T1 (de) | 1994-09-15 |
Family
ID=17483335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90107475T ATE110963T1 (de) | 1989-10-19 | 1990-04-19 | Mittel zur hemmung der alpha-amylase aktivität. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0423419B1 (de) |
| JP (1) | JP3018013B2 (de) |
| KR (1) | KR0178522B1 (de) |
| AT (1) | ATE110963T1 (de) |
| AU (1) | AU628514B2 (de) |
| CA (1) | CA2014971C (de) |
| DE (1) | DE69012268T2 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2727471B2 (ja) * | 1989-09-14 | 1998-03-11 | 三井農林株式会社 | インフルエンザウィルス感染予防剤 |
| JPH04253918A (ja) * | 1991-02-05 | 1992-09-09 | Mitsui Norin Kk | 血糖上昇抑制剤 |
| FR2788438B1 (fr) * | 1999-01-14 | 2003-10-03 | Arkopharma Laboratoires | Composition pour le traitement de l'obesite et procede de traitement esthetique |
| JP5354833B2 (ja) * | 2000-03-10 | 2013-11-27 | 株式会社ヤクルト本社 | α−アミラーゼ活性阻害剤 |
| JP2011105763A (ja) * | 2000-06-21 | 2011-06-02 | Kao Corp | Ppar依存的遺伝子転写活性化剤 |
| WO2002009734A1 (en) * | 2000-08-01 | 2002-02-07 | Oryza Oil & Fat Chemical Co.,Ltd. | Sugar absorption inhibitors and process for producing the same |
| JP4727790B2 (ja) * | 2000-08-02 | 2011-07-20 | グンゼ株式会社 | 抗肥満剤 |
| ES2236331T3 (es) | 2000-11-17 | 2005-07-16 | Kao Corporation | Bebidas envasadas. |
| WO2003024468A1 (en) * | 2001-09-19 | 2003-03-27 | Bioneer Corporation | Substances extracted from corn which can inhibit the activities of amylase, pharmaceutical compositions and food additives containing the same extracts for treatment or prevention of obesity and diabetes mellitus, and processes for their preparations |
| JP3403400B1 (ja) | 2001-09-28 | 2003-05-06 | 花王株式会社 | 容器詰飲料 |
| JP3378577B1 (ja) | 2001-09-28 | 2003-02-17 | 花王株式会社 | 飲 料 |
| US7157493B2 (en) | 2001-11-28 | 2007-01-02 | Nashai Biotech, Llc | Methods of making and using theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate and theaflavin 3,3′-digallate and mixtures thereof |
| NZ533190A (en) * | 2001-11-28 | 2008-07-31 | Nashai Biotech Llc | Methods of making and using theaflavin, theaflavin-3-gallate, theaflavin-3'-gallate and theaflavin 3,3'-digallate and mixtures thereof |
| FR2836336B1 (fr) * | 2002-02-26 | 2004-08-27 | Diana Ingredients | Utilisation dans un traitement cosmetique d'une fraction phenolique riche en dihydrochalcones |
| FR2836337B1 (fr) * | 2002-02-28 | 2004-11-19 | Bio Serae Laboratoires | Utilisation des polymeres procyanidoliques a titre d'agents inhibuteurs des alpha-amylases et application dans des compositions a visees dietetiques |
| EP1557097B1 (de) | 2002-10-28 | 2013-10-23 | Kao Corporation | Verfahren zur entfernung von koffein aus einer koffeinhaltigen katechinverbindungszusammensetzung |
| US20060165671A1 (en) * | 2002-11-07 | 2006-07-27 | Daniel Raederstorff | Novel nutraceutical compositions comprising epigallocatechin gallate |
| JP4776149B2 (ja) * | 2003-03-28 | 2011-09-21 | クラシエフーズ株式会社 | 糖質吸収抑制剤および食品 |
| US7220444B2 (en) | 2003-09-26 | 2007-05-22 | Kao Corporation | Packaged beverages |
| JP3597857B2 (ja) | 2003-10-31 | 2004-12-08 | 花王株式会社 | 容器詰茶飲料 |
| EP1690457B1 (de) | 2003-12-02 | 2010-08-11 | Kao Corporation | Verpacktes getränk |
| JP3766670B2 (ja) | 2003-12-16 | 2006-04-12 | 花王株式会社 | 容器詰飲料 |
| ES2367889T3 (es) | 2003-12-18 | 2011-11-10 | Kao Corporation | Bebida embotellada. |
| JP3597859B2 (ja) | 2003-12-22 | 2004-12-08 | 花王株式会社 | 容器詰緑茶飲料及びその製造法 |
| JP2006016367A (ja) * | 2004-07-05 | 2006-01-19 | Suntory Ltd | リパーゼ阻害剤 |
| JP3742096B1 (ja) * | 2005-02-08 | 2006-02-01 | 花王株式会社 | 非茶系容器詰飲料 |
| JP3742094B1 (ja) * | 2004-11-04 | 2006-02-01 | 花王株式会社 | 非茶系容器詰飲料 |
| KR20070026005A (ko) * | 2005-09-01 | 2007-03-08 | 카오카부시키가이샤 | 정제 녹차 추출물의 제조 방법 |
| JP4884003B2 (ja) | 2005-12-27 | 2012-02-22 | 花王株式会社 | 容器詰烏龍茶飲料 |
| WO2007099715A1 (ja) | 2006-03-02 | 2007-09-07 | Kao Corporation | 精製茶抽出物の製造方法 |
| JP4569965B2 (ja) | 2006-04-17 | 2010-10-27 | 花王株式会社 | 精製緑茶抽出物の製造法 |
| JP4562682B2 (ja) | 2006-04-17 | 2010-10-13 | 花王株式会社 | 精製緑茶抽出物の製造法 |
| JP5080835B2 (ja) | 2006-07-04 | 2012-11-21 | 花王株式会社 | 発泡性容器詰飲料 |
| JP2008088146A (ja) | 2006-09-08 | 2008-04-17 | Kao Corp | インスリン感受性改善剤 |
| EP2098121B1 (de) | 2006-12-22 | 2013-09-18 | Kao Corporation | Containerverpacktes grünteegetränk |
| EP2095718B1 (de) | 2006-12-28 | 2013-04-17 | Kao Corporation | Teeextrakt |
| JP2008200032A (ja) | 2007-01-24 | 2008-09-04 | Kao Corp | パン類 |
| WO2008090740A1 (ja) | 2007-01-24 | 2008-07-31 | Kao Corporation | 菓子類 |
| KR101463639B1 (ko) | 2007-05-08 | 2014-12-04 | 카오카부시키가이샤 | 환원 음료용 농축 조성물 |
| JP5517412B2 (ja) | 2007-05-24 | 2014-06-11 | 花王株式会社 | 精製緑茶抽出物 |
| KR101475758B1 (ko) | 2007-08-08 | 2014-12-23 | 가오 가부시키가이샤 | 차 추출물의 제조방법 |
| US20100209585A1 (en) | 2007-08-30 | 2010-08-19 | Kao Corporation | Instant powder drink |
| KR20100055448A (ko) | 2007-09-05 | 2010-05-26 | 가오 가부시키가이샤 | 정제 차추출물의 제조방법 |
| JP2009268420A (ja) * | 2008-05-09 | 2009-11-19 | Kataoka & Co Ltd | 機能性食品組成物 |
| JP2010222277A (ja) * | 2009-03-23 | 2010-10-07 | Kao Corp | 食後の血糖値上昇抑制剤 |
| JP2011182703A (ja) * | 2010-03-08 | 2011-09-22 | Asahi Group Holdings Ltd | 1,2−ジ−O−ガロイル−4,6−HHDP−b−d−グルコピラノースを高濃度で含有する飲食品 |
| JP5744507B2 (ja) * | 2010-12-24 | 2015-07-08 | 三井農林株式会社 | α−アミラーゼ阻害剤 |
| US20170182110A1 (en) * | 2014-04-23 | 2017-06-29 | Nippon Paper Industries Co., Ltd. | Agent for preventing or ameliorating diabetes |
| JP6355129B2 (ja) * | 2014-11-06 | 2018-07-11 | 国立研究開発法人農業・食品産業技術総合研究機構 | 1,2−ジ−O−ガロイル−4,6−HHDP−b−d−グルコピラノースを高濃度で含有する飲食品 |
| WO2018117002A1 (ja) | 2016-12-21 | 2018-06-28 | サントリーホールディングス株式会社 | エピガロカテキンガレート及びシクロプロリルトレオニンを含有する飲食品 |
| KR20220101432A (ko) | 2021-01-11 | 2022-07-19 | (주)아모레퍼시픽 | 갈로카테킨 갈레이트를 함유하는 녹차 추출물을 유효성분으로 포함하는 체지방 감소용 조성물 및 이의 제조방법 |
| KR102690119B1 (ko) | 2021-03-22 | 2024-07-30 | 카오카부시키가이샤 | 카테킨류 함유 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59219384A (ja) * | 1983-05-30 | 1984-12-10 | Mitsui Norin Kk | 天然抗酸化剤の製造方法 |
| JPS6013780A (ja) * | 1983-07-05 | 1985-01-24 | Mitsui Norin Kk | 茶カテキン類の製造方法 |
| JPS63214183A (ja) * | 1987-03-03 | 1988-09-06 | Mitsui Norin Kk | アンジオテンシン1変換酵素阻害剤 |
| JP2727471B2 (ja) * | 1989-09-14 | 1998-03-11 | 三井農林株式会社 | インフルエンザウィルス感染予防剤 |
-
1989
- 1989-10-19 JP JP1270228A patent/JP3018013B2/ja not_active Expired - Lifetime
-
1990
- 1990-04-12 AU AU53195/90A patent/AU628514B2/en not_active Ceased
- 1990-04-19 EP EP90107475A patent/EP0423419B1/de not_active Expired - Lifetime
- 1990-04-19 CA CA002014971A patent/CA2014971C/en not_active Expired - Fee Related
- 1990-04-19 DE DE69012268T patent/DE69012268T2/de not_active Expired - Fee Related
- 1990-04-19 AT AT90107475T patent/ATE110963T1/de not_active IP Right Cessation
- 1990-04-20 KR KR1019900005521A patent/KR0178522B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3018013B2 (ja) | 2000-03-13 |
| KR0178522B1 (ko) | 1999-03-20 |
| JPH03133928A (ja) | 1991-06-07 |
| KR910007538A (ko) | 1991-05-30 |
| DE69012268T2 (de) | 1995-02-23 |
| CA2014971C (en) | 1999-12-14 |
| EP0423419A1 (de) | 1991-04-24 |
| DE69012268D1 (de) | 1994-10-13 |
| AU628514B2 (en) | 1992-09-17 |
| CA2014971A1 (en) | 1991-04-19 |
| EP0423419B1 (de) | 1994-09-07 |
| AU5319590A (en) | 1991-04-26 |
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