ATE119525T1 - (-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl>-hydrazono>propandinitril. - Google Patents

(-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl>-hydrazono>propandinitril.

Info

Publication number: ATE119525T1
Authority: AT; Austria
Prior art keywords: pct; hydrazono; pyridazinyl; tetrahydro; oxo
Prior art date: 1991-01-03

Application number

AT92901317T

Other languages

English (en)

Inventor

Pentti Nore

Erkki Honkanen

Reijo Baeckstroem

Tom Wikberg

Heimo Haikala

Jorma Haarala

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-03

Filing date

1992-01-03

Publication date

1995-03-15

1991-01-03 Priority claimed from GB919100049A external-priority patent/GB9100049D0/en

1991-09-05 Priority claimed from GB919118947A external-priority patent/GB9118947D0/en

1992-01-03 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1995-03-15 Application granted granted Critical

1995-03-15 Publication of ATE119525T1 publication Critical patent/ATE119525T1/de

Links

-1 4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL Chemical class 0.000 title 1
FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 title 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000000496 cardiotonic agent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Detergent Compositions (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

AT92901317T 1991-01-03 1992-01-03 (-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl>-hydrazono>propandinitril. ATE119525T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919100049A GB9100049D0 (en)	1991-01-03	1991-01-03	(-)-6-(4-(dicyanomethylidenehydrazino)phenyl)-4,5-dihydro-5-methylpyridazin-3(2h)one
GB919118947A GB9118947D0 (en)	1991-09-05	1991-09-05	Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof

Publications (1)

Publication Number	Publication Date
ATE119525T1 true ATE119525T1 (de)	1995-03-15

Family

ID=26298204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92901317T ATE119525T1 (de)	1991-01-03	1992-01-03	(-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl>-hydrazono>propandinitril.

Country Status (32)

Country	Link
US (3)	US5424428A (de)
EP (1)	EP0565546B1 (de)
JP (2)	JP2635445B2 (de)
KR (1)	KR100207145B1 (de)
AT (1)	ATE119525T1 (de)
AU (1)	AU645399B2 (de)
BG (1)	BG62002B1 (de)
BR (1)	BR1100737A (de)
CA (2)	CA2099262C (de)
CY (1)	CY1878A (de)
DE (1)	DE69201640T2 (de)
DK (1)	DK0565546T3 (de)
EE (1)	EE02946B1 (de)
ES (1)	ES2070627T3 (de)
FI (1)	FI105183B (de)
GB (1)	GB2251615B (de)
GE (1)	GEP19991868B (de)
HK (1)	HK117395A (de)
HR (1)	HRP921251B1 (de)
HU (1)	HU218659B (de)
IE (1)	IE72101B1 (de)
IL (2)	IL100553A (de)
LU (1)	LU90920I2 (de)
LV (1)	LV11174B (de)
NO (2)	NO300682B1 (de)
NZ (1)	NZ241194A (de)
PL (2)	PL169415B1 (de)
RO (1)	RO111847B1 (de)
RU (1)	RU2118317C1 (de)
SI (1)	SI9112003A (de)
WO (1)	WO1992012135A1 (de)
YU (1)	YU48767B (de)

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GB2251615B (en) *	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) *	1992-05-06	1993-11-17	Orion Yhtymae Oy	Compounds for use as anti-ischemic medicaments
JP2806192B2 (ja) *	1992-11-02	1998-09-30	日本曹達株式会社	血小板凝集抑制剤
AU3855995A (en) *	1994-11-11	1996-06-06	Nippon Soda Co., Ltd.	Optically active compound
GB9606474D0 (en) *	1996-03-27	1996-06-05	Orion Yhytmo Oy	Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en)	1996-07-05	1996-09-04	Orion Yhtymae Oy	Transdermal delivery of levosimendan
FI973804A7 (fi) *	1997-09-26	1999-03-27	Orion Yhtymae Oy	Levosimendaanin oraalisia koostumuksia
FI974578L (fi) *	1997-12-19	1999-06-20	Orion Yhtymae Oyj	Menetelmä levosimendaanin antamiseksi
FI980901A7 (fi)	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A7 (fi) *	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaanin stabiileja koostumuksia
FI104718B (fi) *	1998-06-18	2000-03-31	Orion Yhtymae Oyj	[[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) *	1998-06-19	1999-05-18	Orion Corporation	Use of a pyridazinone derivative
FI981473L (fi) *	1998-06-25	1999-12-26	Orion Yhtymae Oyj	Menetelmä pulmonaalihypertension hoitamiseksi
GB9915179D0 (en) *	1999-06-29	1999-09-01	Orion Corp	A method for the treatment or prevention of coronary graft vasospasm
FI109659B (fi)	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia
AU7928700A (en)	1999-10-22	2001-04-30	Jeffrey Hosenpud	A new use of levosimendan
FI20001542L (fi) *	2000-06-29	2001-12-30	Orion Yhtymae Oyj	Menetelmä septisen sokin hoitamiseksi
FI20002525A7 (fi)	2000-11-17	2002-05-18	Orion Yhtymae Oyj	Tulehduksenvastaisia aineita
FI20002526A7 (fi) *	2000-11-17	2002-05-18	Orion Yhtymae Oyj	Pyridatsinonijohdannaisten uusi käyttö
FI20002755A0 (fi) *	2000-12-15	2000-12-15	Orion Yhtymae Oyj	Menetelmä erektiilin dysfunktion hoitamiseen
FI20010233A0 (fi) *	2001-02-08	2001-02-08	Orion Corp	Menetelmä sydämen vajaatoiminnan hoitoon
FI20011464A0 (fi) *	2001-07-04	2001-07-04	Orion Corp	Yhdistelmäterapia sydämen vajaatoiminnan hoitoon
FI20030015A0 (fi) *	2003-01-03	2003-01-03	Orion Corp	Menetelmä munuaisten vajaatoiminnan hoitamiseksi
WO2004087641A1 (ja) *	2003-03-31	2004-10-14	Daiichi Pharmaceutical Co., Ltd.	ヒドラゾン誘導体
DE102004011512B4 (de) *	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (de) *	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
FI20040675A0 (fi) *	2004-05-12	2004-05-12	Orion Corp	Menetelmä sydämen hypertrofian hoitoon ja estoon
FI20040674A0 (fi)	2004-05-12	2004-05-12	Orion Corp	Menetelmä tromboembolisten sairauksien estoon
JP2008501033A (ja) *	2004-05-28	2008-01-17	アボット・ラボラトリーズ	心停止前、心停止中および心停止後の哺乳動物の治療法
JP2008533109A (ja)	2005-03-14	2008-08-21	オリオンコーポレーション	利尿を促進するための複合治療
AU2006310997B2 (en)	2005-11-14	2013-01-10	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (de)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Pimobendan-Cyclodextrin Komplex enthaltendes flüssiges Präparat
AU2008206903B2 (en) *	2007-01-17	2012-07-05	Orion Corporation	Levosimendan for use in treating chronic valvular disease
EP2370070B9 (de)	2008-11-25	2014-04-23	Boehringer Ingelheim Vetmedica GmbH	Verwendung von Pimobendan zur Behandlung der hypertrophe Kardiomyopathie in Katzen
AU2010272364B2 (en) *	2009-07-14	2014-04-10	Cipla Limited	Process for preparing levosimendan and intermediates for use in the process
HUE060093T2 (hu)	2012-03-15	2023-01-28	Boehringer Ingelheim Vetmedica Gmbh	Gyógyszerészeti tablettakészítmény az állatgyógyászati ágazat számára, eljárás annak elõállítására és annak alkalmazása
WO2014164704A2 (en) *	2013-03-11	2014-10-09	The Broad Institute, Inc.	Compounds and compositions for the treatment of cancer
HUE054186T2 (hu)	2013-07-19	2021-08-30	Boehringer Ingelheim Vetmedica Gmbh	Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény
CN104418810A (zh) *	2013-09-04	2015-03-18	北京博时安泰科技发展有限公司	一种左西孟旦的合成新路线
CN103554033A (zh) *	2013-11-12	2014-02-05	江苏正大清江制药有限公司	一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) *	2013-11-12	2014-02-05	江苏正大清江制药有限公司	高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ES2883448T3 (es)	2013-12-04	2021-12-07	Boehringer Ingelheim Vetmedica Gmbh	Composiciones farmacéuticas mejoradas de pimobendán
EP3334404B1 (de)	2015-08-13	2024-09-18	The Broad Institute, Inc.	Zusammensetzungen und verfahren für pde3a und slfn12 exprimierenden krebs
CN105784895B (zh) *	2015-10-30	2018-05-22	成都欣捷高新技术开发有限公司	一种用高效液相色谱仪检测左西孟旦中杂质的方法
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP3424908A1 (de)	2017-07-07	2019-01-09	Melody Healthcare Pvt. Ltd.	Verfahren zur herstellung von levosimendan
US9962384B1 (en) *	2017-09-07	2018-05-08	Korea Institute Of Science And Technology	Levosimendan compound for preventing or treating tau-related diseases
CN111548310B (zh) *	2020-05-12	2021-07-02	成都欣捷高新技术开发股份有限公司	一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) *	2020-07-23	2023-03-10	成都欣捷高新技术开发股份有限公司	一种左西孟旦钠晶型b及其制备方法
US11760730B2 (en)	2021-01-11	2023-09-19	Navinta, Llc	Process for the preparation of high purity Levosimendan

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GB228004A (en) *	1924-01-24	1925-01-29	Daimler Co Ltd	Improvements in locking devices for sliding windows
JPS58113180A (ja) *	1981-12-28	1983-07-05	Mitsui Toatsu Chem Inc	ピリダジノン誘導体
JPS6193169A (ja) *	1984-10-12	1986-05-12	Sankyo Co Ltd	ピリダジノン誘導体及びその製法
US4946842A (en) *	1985-07-05	1990-08-07	Smith Kline & French Laboratories Limited	Novel guanidino pyridazinones as cardiac stimulants
JPH0629254B2 (ja) *	1986-09-08	1994-04-20	帝国臓器製薬株式会社	ピリダジノン誘導体
GB8824458D0 (en) *	1988-10-19	1988-11-23	Orion Yhtymae Oy	Substituted pyridazinones
GB8903130D0 (en) *	1989-02-11	1989-03-30	Orion Yhtymae Oy	Substituted pyridazinones
GB2251615B (en) *	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile

1991
- 1991-12-20 GB GB9127145A patent/GB2251615B/en not_active Revoked
- 1991-12-27 SI SI9112003A patent/SI9112003A/sl unknown
- 1991-12-27 YU YU200391A patent/YU48767B/sh unknown
- 1991-12-30 IL IL10055391A patent/IL100553A/en active Protection Beyond IP Right Term
- 1991-12-30 IL IL11402891A patent/IL114028A/en not_active IP Right Cessation
1992
- 1992-01-03 CA CA002099262A patent/CA2099262C/en not_active Expired - Lifetime
- 1992-01-03 GE GEAP19922483A patent/GEP19991868B/en unknown
- 1992-01-03 RO RO93-00896A patent/RO111847B1/ro unknown
- 1992-01-03 AT AT92901317T patent/ATE119525T1/de active
- 1992-01-03 WO PCT/FI1992/000003 patent/WO1992012135A1/en not_active Ceased
- 1992-01-03 EP EP92901317A patent/EP0565546B1/de not_active Expired - Lifetime
- 1992-01-03 AU AU11535/92A patent/AU645399B2/en not_active Expired
- 1992-01-03 KR KR1019930701800A patent/KR100207145B1/ko not_active Expired - Lifetime
- 1992-01-03 JP JP4501428A patent/JP2635445B2/ja not_active Expired - Lifetime
- 1992-01-03 CA CA002314115A patent/CA2314115C/en not_active Expired - Lifetime
- 1992-01-03 DK DK92901317.5T patent/DK0565546T3/da active
- 1992-01-03 HU HU9301911A patent/HU218659B/hu active Protection Beyond IP Right Term
- 1992-01-03 DE DE69201640T patent/DE69201640T2/de not_active Expired - Lifetime
- 1992-01-03 RU RU93052411A patent/RU2118317C1/ru active
- 1992-01-03 ES ES92901317T patent/ES2070627T3/es not_active Expired - Lifetime
- 1992-01-03 US US08/081,360 patent/US5424428A/en not_active Expired - Lifetime
- 1992-01-06 NZ NZ241194A patent/NZ241194A/xx not_active IP Right Cessation
- 1992-11-12 HR HR921251A patent/HRP921251B1/xx not_active IP Right Cessation
1993
- 1993-06-09 FI FI932618A patent/FI105183B/fi active Protection Beyond IP Right Term
- 1993-06-25 IE IE920002A patent/IE72101B1/en not_active IP Right Cessation
- 1993-06-25 PL PL92310250A patent/PL169415B1/pl unknown
- 1993-06-25 PL PL92299920A patent/PL169435B1/pl unknown
- 1993-06-28 NO NO932367A patent/NO300682B1/no not_active IP Right Cessation
- 1993-06-29 BG BG97915A patent/BG62002B1/bg unknown
1994
- 1994-11-17 EE EE9400252A patent/EE02946B1/xx unknown
1995
- 1995-05-31 US US08/455,035 patent/US5512571A/en not_active Expired - Lifetime
- 1995-05-31 US US08/454,856 patent/US5569657A/en not_active Expired - Lifetime
- 1995-07-20 HK HK117395A patent/HK117395A/en not_active IP Right Cessation
- 1995-11-30 LV LVP-95-358A patent/LV11174B/en unknown
1996
- 1996-04-05 CY CY187896A patent/CY1878A/xx unknown
- 1996-11-19 JP JP8308528A patent/JP3015748B2/ja not_active Expired - Lifetime
1997
- 1997-05-09 BR BR1100737A patent/BR1100737A/pt active IP Right Grant
2001
- 2001-11-20 NO NO2001021C patent/NO2001021I1/no unknown
2002
- 2002-05-17 LU LU90920C patent/LU90920I2/en unknown

Also Published As

Publication number	Publication date
NO932367L (no)	1993-06-28
LU90920I2 (en)	2002-07-17
JPH06504275A (ja)	1994-05-19
PL169435B1 (pl)	1996-07-31
CA2314115A1 (en)	1992-07-04
IL100553A0 (en)	1992-09-06
US5569657A (en)	1996-10-29
CA2099262C (en)	2002-03-12
US5424428A (en)	1995-06-13
HRP921251A2 (en)	1995-08-31
GB2251615A (en)	1992-07-15
HU9301911D0 (en)	1993-09-28
FI932618A0 (fi)	1993-06-09
IE72101B1 (en)	1997-03-12
JP2635445B2 (ja)	1997-07-30
GB9127145D0 (en)	1992-02-19
IL100553A (en)	1995-12-31
LV11174B (en)	1996-12-20
BG97915A (bg)	1994-04-29
DE69201640D1 (de)	1995-04-13
HUT64754A (en)	1994-02-28
IL114028A (en)	1996-09-12
DK0565546T3 (da)	1995-05-22
GB2251615B (en)	1995-02-08
JP3015748B2 (ja)	2000-03-06
LV11174A (lv)	1996-04-20
NO932367D0 (no)	1993-06-28
AU1153592A (en)	1992-08-17
BR1100737A (pt)	2000-03-21
KR930703266A (ko)	1993-11-29
AU645399B2 (en)	1994-01-13
BG62002B1 (bg)	1998-12-30
RO111847B1 (ro)	1997-02-28
WO1992012135A1 (en)	1992-07-23
IE920002A1 (en)	1992-07-15
HRP921251B1 (en)	2000-06-30
JPH09183767A (ja)	1997-07-15
EP0565546B1 (de)	1995-03-08
DE69201640T2 (de)	1995-08-10
CY1878A (en)	1996-04-05
FI932618L (fi)	1993-06-09
KR100207145B1 (ko)	1999-07-15
US5512571A (en)	1996-04-30
GEP19991868B (en)	1999-12-06
PL169415B1 (pl)	1996-07-31
SI9112003A (sl)	1998-10-31
HK117395A (en)	1995-07-28
NZ241194A (en)	1993-06-25
EP0565546A1 (de)	1993-10-20
YU48767B (sh)	1999-12-27
NO300682B1 (no)	1997-07-07
EE02946B1 (et)	1996-12-16
RU2118317C1 (ru)	1998-08-27
FI105183B (fi)	2000-06-30
CA2099262A1 (en)	1992-07-04
YU200391A (sh)	1994-05-10
IL114028A0 (en)	1995-10-31
HU218659B (hu)	2000-10-28
ES2070627T3 (es)	1995-06-01
CA2314115C (en)	2004-03-30
NO2001021I1 (no)	2001-12-03

Publication	Publication Date	Title
ATE119525T1 (de)	1995-03-15	(-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl>-hydrazono>propandinitril.
RU93052411A (ru)	1996-06-20	(-)-энантиомер-{([4-(1,4,5,6-тетрагидро-4-метил-6-оксо-3-пиридазинил)фенил])-гидразоно} пропандинитрил
DE69329381D1 (de)	2000-10-12	Anti-ischaemisches arzneimittel
FR2712591B1 (fr)	1996-02-09	Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
DE59308848D1 (de)	1998-09-10	Anwendung von urodilatin bei lungen- und bronchialerkrankungen
NO971182L (no)	1997-05-14	Anvendelse av 2,4-diaminopyrimidin-3-oksyd eller et salt derav for behandling av maturasjons- og struktureringsforstyrrelser av kollagen
IT1243801B (it)	1994-06-28	Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
HUT77768A (hu)	1998-08-28	N-szubsztituált azabicikloheptánszármazékok, eljárás előállításukra és alkalmazásuk
GR3033333T3 (en)	2000-09-29	Carbamoyl carboxylic acid amides
SE9704770D0 (sv)	1997-12-19	New use
HUP0102929A2 (hu)	2002-04-29	Levozimendan alkalmazása pulmonáris hipertenzió kezelésére alkalmas gyógyszerkészítmény előállítására
PL311296A1 (en)	1996-02-05	Derivatives of benzo [f] quinoxalinodione, method of obtaining them and their application in therapeutic agents
YU7604A (sh)	2006-08-17	Polimorf soli derivata piridazinona za tretman aritmije
MX9708031A (es)	1997-11-29	Sales de 3-fenil-1,4-dialquil-1,2,4-triazolio y su uso como antidepresivos.
AU4120697A (en)	1998-03-06	Use of efaroxan for producing medicine for treating huntington disease