ATE123533T1 - Enzymatisches verfahren zur herstellung von 7- aminocephalosporansäure. - Google Patents

Enzymatisches verfahren zur herstellung von 7- aminocephalosporansäure.

Info

Publication number
ATE123533T1
ATE123533T1 AT90906671T AT90906671T ATE123533T1 AT E123533 T1 ATE123533 T1 AT E123533T1 AT 90906671 T AT90906671 T AT 90906671T AT 90906671 T AT90906671 T AT 90906671T AT E123533 T1 ATE123533 T1 AT E123533T1
Authority
AT
Austria
Prior art keywords
producing
enzymatic process
aminocephalosporanic acid
mutant strain
increased amounts
Prior art date
Application number
AT90906671T
Other languages
English (en)
Inventor
Bing L Wong
Yong-Qiang Shen
Original Assignee
Biopure Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopure Corp filed Critical Biopure Corp
Application granted granted Critical
Publication of ATE123533T1 publication Critical patent/ATE123533T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT90906671T 1989-04-04 1990-03-30 Enzymatisches verfahren zur herstellung von 7- aminocephalosporansäure. ATE123533T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33354689A 1989-04-04 1989-04-04

Publications (1)

Publication Number Publication Date
ATE123533T1 true ATE123533T1 (de) 1995-06-15

Family

ID=23303257

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90906671T ATE123533T1 (de) 1989-04-04 1990-03-30 Enzymatisches verfahren zur herstellung von 7- aminocephalosporansäure.

Country Status (9)

Country Link
US (1) US5618687A (de)
EP (1) EP0465600B1 (de)
JP (1) JPH04504362A (de)
KR (1) KR0173124B1 (de)
AT (1) ATE123533T1 (de)
CA (1) CA2049958A1 (de)
DE (1) DE69019967T2 (de)
HK (1) HK36997A (de)
WO (1) WO1990012110A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2020792A6 (es) * 1990-08-03 1991-09-16 Antibioticos Sa Un procedimiento enzimatico para la presentacion de acido 7-amino-cefa-losporanico y un procedimiento para expresar la enzima 7b (4-carboxibutanamido) cefalosporinacilasa.
DE4028119C1 (de) * 1990-09-05 1991-12-05 Hoechst Ag, 6230 Frankfurt, De
GB9022907D0 (en) * 1990-10-22 1990-12-05 Fujisawa Pharmaceutical Co Novel gl-7aca acylase
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
ES2097080B1 (es) * 1993-03-08 1997-11-16 Asahi Chemical Ind Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
US5512454A (en) * 1994-02-03 1996-04-30 Bristol-Myers Squibb Company Enzymatic acylation of 3-hydroxymethyl cephalosporins
KR100345994B1 (ko) * 1994-06-22 2002-12-16 제일제당주식회사 7-아미노세팔로스포란산의효소적제조방법
CN1065278C (zh) * 1994-08-27 2001-05-02 中国科学院上海植物生理研究所 一步两酶法制造7－氨基头孢烷酸
JP2002505587A (ja) * 1997-06-25 2002-02-19 ブリストル−マイヤーズ・スクイブ・カンパニー Ｔ．バリアビリス由来のｄ−アミノ酸オキシダーゼプロモーター
KR100481138B1 (ko) * 1997-09-09 2005-04-11 바이오케미 게젤샤프트 엠베하 효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법
AU733991B2 (en) * 1997-10-30 2001-05-31 Bristol-Myers Squibb Company Chemical acetylation of desacetyl-cephalosporins
AU9688601A (en) * 2000-09-22 2002-04-02 Bristol Myers Squibb Co Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203
AU2002310863A1 (en) 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives
EP1344830A1 (de) * 2002-03-12 2003-09-17 Bioferma Murcia, S.A. Verfahren zur Herstellung von Cephalosporansäure-Derivaten aus Cephalosporin C
JP5085936B2 (ja) 2003-12-02 2012-11-28 チバ スペシャルティ ケミカルズ ウォーター トリートメント リミテッド アミドの製造
CN110554097A (zh) * 2018-05-30 2019-12-10 青岛谱尼测试有限公司 一种水和废水中7-氨基头孢烷酸残留量的测定方法
CN114618410A (zh) * 2022-03-03 2022-06-14 清华大学 一种利用微反应器溶解d-7-aca的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239394A (en) * 1964-06-15 1966-03-08 Merck & Co Inc Process for producing 7-amino-cephalosporanic acid
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
US3682777A (en) * 1968-09-18 1972-08-08 Kyowa Hakko Kogyo Kk Process for producing penicillin derivatives
CH547268A (de) * 1968-10-25 1974-03-29 Merck Patent Gmbh Verfahren zur herstellung von n-disubstituierten 3-amino3,5-dien-19-nor-steroiden.
CH541579A (de) * 1969-05-13 1973-09-15 Ciba Geigy Ag Verfahren zur Abtrennung von Cephalosporin C aus Rohlösungen
CH553850A (de) * 1970-01-21 1974-09-13 Ciba Geigy Ag Verfahren zur darstellung von fuer die gesteuerte biosynthese von cephalosporin c, geeigneten mangel-mutanten und deren verwendung zur gesteuerten biosynthese von cephalosporin c.
US3655864A (en) * 1970-09-21 1972-04-11 Smith Kline French Lab Glyceryl tristerate and higher fatty acid mixture for improving digestive absorption
JPS5417032B2 (de) * 1974-01-23 1979-06-27
DE2528622A1 (de) * 1975-06-26 1977-01-13 Bayer Ag Verfahren zur reinigung der bei der enzymatischen spaltung von beta-lactam- antibiotika anfallenden produkte
JPS5829079B2 (ja) * 1976-04-20 1983-06-20 藤沢薬品工業株式会社 セファロスポリン化合物の分離・精製方法
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt

Also Published As

Publication number Publication date
US5618687A (en) 1997-04-08
EP0465600A1 (de) 1992-01-15
EP0465600B1 (de) 1995-06-07
CA2049958A1 (en) 1990-10-05
JPH04504362A (ja) 1992-08-06
DE69019967T2 (de) 1996-02-22
KR0173124B1 (ko) 1999-02-01
HK36997A (en) 1997-04-04
DE69019967D1 (de) 1995-07-13
KR920701468A (ko) 1992-08-11
WO1990012110A1 (en) 1990-10-18

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee