ATE209255T1 - Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase - Google Patents

Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase

Info

Publication number: ATE209255T1
Authority: AT; Austria
Prior art keywords: pct; adca; expandase; penicillins; reaction
Prior art date: 1995-06-02

Application number

AT96917498T

Other languages

English (en)

Inventor

Roelof Ary Lans Bovenberg

Bertus Pieter Koekman

Dirk Schipper

Adrianus Wilhelmus Vollebregt

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-06-03

Publication date

2001-12-15

1996-06-03 Application filed by Dsm Nv filed Critical Dsm Nv

1996-06-03 Priority claimed from PCT/EP1996/002434 external-priority patent/WO1996038580A1/en

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209255T1 publication Critical patent/ATE209255T1/de

Links

NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 title abstract 3
101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 title abstract 2
229930182555 Penicillin Natural products 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000002960 penicillins Chemical class 0.000 title 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
241000228150 Penicillium chrysogenum Species 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940056360 penicillin g Drugs 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
238000006049 ring expansion reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT96917498T 1995-06-02 1996-06-03 Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase ATE209255T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95201455		1995-06-02
PCT/EP1996/002434 WO1996038580A1 (en)	1995-06-02	1996-06-03	Process for the production of 7-adca via expandase activity on penicillin g

Publications (1)

Publication Number	Publication Date
ATE209255T1 true ATE209255T1 (de)	2001-12-15

Family

ID=8220352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96917498T ATE209255T1 (de)	1995-06-02	1996-06-03	Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase

Country Status (14)

Country	Link
US (1)	US6020151A (de)
JP (1)	JPH11505726A (de)
KR (1)	KR100421225B1 (de)
CN (1)	CN1084791C (de)
AT (1)	ATE209255T1 (de)
BR (1)	BR9608954A (de)
CA (1)	CA2223105A1 (de)
DE (1)	DE69617228T2 (de)
DK (1)	DK0828850T3 (de)
ES (1)	ES2167568T3 (de)
HU (1)	HUP9801906A3 (de)
PL (1)	PL182509B1 (de)
RU (1)	RU2192471C2 (de)
SK (1)	SK280539B6 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6383773B2 (en) *	1998-04-23	2002-05-07	Massachusetts Institute Of Technology	Penicillin conversion
MD4030C2 (ro) *	2009-12-12	2010-11-30	Тимофей ПОПЕСКУ	Bază pentru prepararea mediilor nutritive pentru cultivarea microorganismelor din genul Mycobacterium şi procedeu de obţinere a acesteia
CN101880302B (zh) *	2010-06-11	2012-10-24	中国科学院海洋研究所	一种多羟基甾醇衍生物及其制备和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT43644A (en) *	1986-11-17	1987-11-30	Univ Oxford	Process for producing 3-substituted-cephalosporines
US5070020A (en) *	1988-05-09	1991-12-03	Eli Lilly And Company	Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
SK280569B6 (sk) *	1991-10-15	2000-03-13	Gist-Brocades B.V.	Biologický spôsob výroby kyseliny7-aminodeacetylce
KR100336174B1 (ko) *	1993-07-30	2002-11-01	디에스엠 기스트 베.파우.	2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
PT711348E (pt) *	1993-07-30	2003-08-29	Dsm Nv	Processo para a eficiente producao de 7-adca por via de 3-(carboxietiltio)propionil-7-adca
US5731165A (en) *	1995-06-02	1998-03-24	Gist-Brocades, B.V.	Process for the production of 7-ADCA via expandase activity on penicillin G

1996
- 1996-06-03 RU RU98100072/13A patent/RU2192471C2/ru not_active IP Right Cessation
- 1996-06-03 JP JP8536220A patent/JPH11505726A/ja not_active Abandoned
- 1996-06-03 SK SK1630-97A patent/SK280539B6/sk unknown
- 1996-06-03 BR BR9608954A patent/BR9608954A/pt not_active Application Discontinuation
- 1996-06-03 DK DK96917498T patent/DK0828850T3/da active
- 1996-06-03 AT AT96917498T patent/ATE209255T1/de not_active IP Right Cessation
- 1996-06-03 US US08/973,292 patent/US6020151A/en not_active Expired - Fee Related
- 1996-06-03 PL PL96323639A patent/PL182509B1/pl not_active IP Right Cessation
- 1996-06-03 HU HU9801906A patent/HUP9801906A3/hu unknown
- 1996-06-03 ES ES96917498T patent/ES2167568T3/es not_active Expired - Lifetime
- 1996-06-03 KR KR1019970708709A patent/KR100421225B1/ko not_active Expired - Fee Related
- 1996-06-03 CN CN96195316A patent/CN1084791C/zh not_active Expired - Lifetime
- 1996-06-03 DE DE69617228T patent/DE69617228T2/de not_active Expired - Fee Related
- 1996-06-03 CA CA002223105A patent/CA2223105A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2192471C2 (ru)	2002-11-10
DK0828850T3 (da)	2002-05-21
BR9608954A (pt)	1999-03-02
PL182509B1 (pl)	2002-01-31
HUP9801906A2 (hu)	1998-11-30
ES2167568T3 (es)	2002-05-16
JPH11505726A (ja)	1999-05-25
CN1190440A (zh)	1998-08-12
US6020151A (en)	2000-02-01
CN1084791C (zh)	2002-05-15
KR19990022230A (ko)	1999-03-25
PL323639A1 (en)	1998-04-14
DE69617228T2 (de)	2002-06-27
DE69617228D1 (de)	2002-01-03
HUP9801906A3 (en)	2001-01-29
CA2223105A1 (en)	1996-12-05
KR100421225B1 (ko)	2004-06-18
SK280539B6 (sk)	2000-03-13
SK163097A3 (en)	1998-05-06

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Legal Events

Date	Code	Title	Description
2002-05-15	UEP	Publication of translation of european patent specification
2011-03-15	REN	Ceased due to non-payment of the annual fee