ES2084622T3 - Derivados de pirrolo(2,1-b)tiazol. - Google Patents

Derivados de pirrolo(2,1-b)tiazol.

Info

Publication number
ES2084622T3
ES2084622T3 ES90113378T ES90113378T ES2084622T3 ES 2084622 T3 ES2084622 T3 ES 2084622T3 ES 90113378 T ES90113378 T ES 90113378T ES 90113378 T ES90113378 T ES 90113378T ES 2084622 T3 ES2084622 T3 ES 2084622T3
Authority
ES
Spain
Prior art keywords
group
substitutes
molecula
aril
rental
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113378T
Other languages
English (en)
Inventor
Norio Suzuki
Atsushi Nakayama
Toru Hosokami
Masashi Hasegawa
Shuichi Yokohama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2084622T3 publication Critical patent/ES2084622T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE PRESENTA UN NUEVO COMPUESTO REPRESENTADO POR LA FORMULA (I) EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL O UN GRUPO ALQUIL CICLICO; R2 REPRESENTA UN GRUPO HIDROXIL, UN GRUPO ALCOXIDO QUE PUEDE TENER DE 1 A 3 SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ALQUIL, UN GRUPO ARILTIO QUE PUEDE TENER 1 O MAS SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ARIL, UN GRUPO ARILOXIDO QUE PUEDE TENER UNO O MAS SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ARIL, UN GRUMO AMINO, UN GRUPO ALQUILAMINO, O UN GRUPO AMINO CICLICO QUE PUEDE CONTENER OTROS ATOMOS ETEROS COMO ATOMOS DEL ANILLO SELECCIONADOS ENTRE UN ATOMO DE NITROGENO, UN ATOMO DE OXIGENO Y UN ATOMO DE AZUFRE; R3 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL, UN GRUPO ARIL QUE PUEDE TENER UNO O MAS SUBSTITUYENTES O UN GRUPO ARIL ETERO QUE PUEDE TENER UNO O MAS SUBSTITUYENTES; REPRESNTAN UN ENLACE SIMPLE O UN DOBLE ENLACE. TAMBIEN SE PRESENTAN LAS SALES DE DICHO COMPUESTO Y LAS PREPARACIONES FARMACEUTICAS PARA EVITAR Y TRATAR ENFERMEDADES HEPATICAS CONTENIENDO EL COMPUESTO DE LA FORMULA (I) O LAS SALES DEL MISMO COMO INGREDIENTES ACTIVOS.
ES90113378T 1989-06-13 1990-07-12 Derivados de pirrolo(2,1-b)tiazol. Expired - Lifetime ES2084622T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15114189 1989-06-13

Publications (1)

Publication Number Publication Date
ES2084622T3 true ES2084622T3 (es) 1996-05-16

Family

ID=15512262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113378T Expired - Lifetime ES2084622T3 (es) 1989-06-13 1990-07-12 Derivados de pirrolo(2,1-b)tiazol.

Country Status (23)

Country Link
US (1) US5098919A (es)
EP (1) EP0410224B1 (es)
JP (1) JP2875605B2 (es)
KR (1) KR910002874A (es)
CN (1) CN1025337C (es)
AT (1) ATE132870T1 (es)
AU (1) AU624724B2 (es)
CA (1) CA2021135A1 (es)
DD (1) DD296492A5 (es)
DE (1) DE69024713T2 (es)
DK (1) DK0410224T3 (es)
ES (1) ES2084622T3 (es)
FI (1) FI903511A7 (es)
GR (1) GR3018798T3 (es)
HU (1) HU207331B (es)
IE (1) IE902545A1 (es)
IL (1) IL95021A (es)
NO (1) NO903084L (es)
NZ (1) NZ234450A (es)
PT (1) PT94688A (es)
RU (2) RU1836374C (es)
YU (1) YU136490A (es)
ZA (1) ZA905407B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0891978B1 (en) * 1997-07-18 2002-03-20 F. Hoffmann-La Roche Ag 5H-Thiazolo (3,2-a) pyrimidine derivatives
US20050244892A1 (en) * 2004-02-27 2005-11-03 Lazar Mitchell A Resistin as a marker and therapeutic target for cardiovascular disease
JP5415520B2 (ja) * 2008-04-09 2014-02-12 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 最大酸素消費量低下の予測のためのプロ−エンドセリン−１

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein

Also Published As

Publication number Publication date
JP2875605B2 (ja) 1999-03-31
RU1836374C (ru) 1993-08-23
KR910002874A (ko) 1991-02-26
HUT57221A (en) 1991-11-28
NO903084L (no) 1991-01-14
HU904214D0 (en) 1990-12-28
NZ234450A (en) 1991-10-25
FI903511A0 (fi) 1990-07-11
US5098919A (en) 1992-03-24
EP0410224A1 (en) 1991-01-30
CN1049350A (zh) 1991-02-20
CA2021135A1 (en) 1991-01-14
DE69024713D1 (de) 1996-02-22
PT94688A (pt) 1991-03-20
NO903084D0 (no) 1990-07-11
FI903511A7 (fi) 1991-01-14
RU2026288C1 (ru) 1995-01-09
AU5890490A (en) 1991-01-17
DE69024713T2 (de) 1996-06-13
IL95021A (en) 1994-06-24
HU207331B (en) 1993-03-29
AU624724B2 (en) 1992-06-18
DD296492A5 (de) 1991-12-05
GR3018798T3 (en) 1996-04-30
JPH03128385A (ja) 1991-05-31
IE902545A1 (en) 1991-02-27
IL95021A0 (en) 1991-06-10
DK0410224T3 (da) 1996-02-05
ATE132870T1 (de) 1996-01-15
CN1025337C (zh) 1994-07-06
ZA905407B (en) 1991-04-24
EP0410224B1 (en) 1996-01-10
YU136490A (sh) 1992-09-07

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