ATE138650T1 - Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung - Google Patents

Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung

Info

Publication number: ATE138650T1
Authority: AT; Austria
Prior art keywords: pain; phenyl; substituted; production; local anesthetic
Prior art date: 1989-12-21

Application number

AT91901571T

Other languages

English (en)

Inventor

Anna-Lena Ask

Rune Sandberg

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-17

Publication date

1996-06-15

1990-12-17 Application filed by Astra Ab filed Critical Astra Ab

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138650T1 publication Critical patent/ATE138650T1/de

Links

JPUKONSIEHCAQA-UHFFFAOYSA-N 4-phenylpiperidine-4-carboxamide Chemical class C=1C=CC=CC=1C1(C(=O)N)CCNCC1 JPUKONSIEHCAQA-UHFFFAOYSA-N 0.000 title 1
230000000694 effects Effects 0.000 title 1
239000003589 local anesthetic agent Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cosmetics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT91901571T 1989-12-21 1990-12-17 Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung ATE138650T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8904298A SE8904298D0 (sv)	1989-12-21	1989-12-21	New compounds

Publications (1)

Publication Number	Publication Date
ATE138650T1 true ATE138650T1 (de)	1996-06-15

Family

ID=20377821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91901571T ATE138650T1 (de)	1989-12-21	1990-12-17	Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung

Country Status (40)

Country	Link
US (2)	US5227389A (de)
EP (1)	EP0506778B1 (de)
JP (1)	JP2656152B2 (de)
KR (1)	KR0179382B1 (de)
CN (1)	CN1037841C (de)
AT (1)	ATE138650T1 (de)
AU (1)	AU647068B2 (de)
BG (1)	BG60912B1 (de)
BR (1)	BR1100379A (de)
CA (1)	CA2069608C (de)
CZ (1)	CZ278035B6 (de)
DE (1)	DE69027221T2 (de)
DK (1)	DK0506778T3 (de)
DZ (1)	DZ1468A1 (de)
EG (1)	EG19361A (de)
ES (1)	ES2087280T3 (de)
FI (1)	FI100881B (de)
HK (1)	HK22997A (de)
HR (1)	HRP920591B1 (de)
HU (1)	HU213110B (de)
IE (1)	IE74855B1 (de)
IL (1)	IL96636A (de)
IS (1)	IS1664B (de)
LT (1)	LT4005B (de)
LV (2)	LV10949B (de)
NO (1)	NO178858C (de)
NZ (1)	NZ236293A (de)
PL (1)	PL163591B1 (de)
PT (1)	PT96303B (de)
RO (1)	RO112864B1 (de)
RU (1)	RU2039043C1 (de)
SA (1)	SA91110209B1 (de)
SE (1)	SE8904298D0 (de)
SG (1)	SG46413A1 (de)
SI (1)	SI9012346B (de)
SK (1)	SK658190A3 (de)
UA (1)	UA26403A (de)
WO (1)	WO1991009845A1 (de)
YU (1)	YU48086B (de)
ZA (1)	ZA909903B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3916092B2 (ja) *	1993-09-17	2007-05-16	杏林製薬株式会社	イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) *	1994-02-11	1994-02-11	Astra Ab	New compounds
SE9404438D0 (sv) *	1994-12-21	1994-12-21	Astra Ab	New process
US5931809A (en) *	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
DE19642591A1 (de) *	1996-10-15	1998-04-16	Basf Ag	Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
SE9604786D0 (sv) *	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
RU2125878C1 (ru) *	1996-12-26	1999-02-10	Новокузнецкий научно-исследовательский химико-фармацевтический институт	Анальгетическое средство
RU2117481C1 (ru) *	1997-07-15	1998-08-20	Государственный научно-исследовательский институт органической химии и технологии	Анальгетическое средство и способ его приготовления
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
US20020102291A1 (en) *	1997-12-15	2002-08-01	Noven Pharmaceuticals, Inc.	Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803240D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	A pharmaceutical composition having a rapid action
SE9803239D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	Composition for the treatment of acute pain
ATE460163T1 (de) *	2001-04-12	2010-03-15	Pharmacopeia Llc	Arly und diaryl piperidinderivate verwendbar als mch-hemmer
RU2203041C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Спазмолитические таблетки бралангин
PL215006B1 (pl) *	2002-02-08	2013-10-31	Ono Pharmaceutical Co	Krystaliczna postac pochodnej piperydyny oraz jej zastosowanie
US7645771B2 (en) *	2002-12-13	2010-01-12	Smithkline Beecham Corp.	CCR5 antagonists as therapeutic agents
AR063275A1 (es) *	2006-10-12	2009-01-14	Epix Delaware Inc	Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
BRPI0820701A2 (pt)	2007-12-11	2015-06-16	Cytopathfinder Inc	Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
EP3914246A1 (de)	2019-01-22	2021-12-01	ICM (Institut du Cerveau et de la Moelle Épinière)	Lokalanästhetikum zur behandlung von neurologischen symptomen infolge von hirnfunktionsstörungen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE96980C1 (de)
US2486796A (en) *	1943-06-25	1949-11-01	Ciba Pharm Prod Inc	Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) *	1964-10-20	1967-08-01	Aldrich Chem Co Inc	N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) *	1967-06-26	1970-11-10	Janssen Pharm	4-aryl-4-aminoalkoxy-piperidines
CH498836A (de) *	1968-12-20	1970-11-15	Geigy Ag J R	Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) *	1968-12-30	1973-06-05	Ciba Geigy Corp	Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) *	1971-10-21	1973-06-01	Synthelabo	1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) *	1988-12-12	1990-08-29	Ciba Geigy	Piperidine derivatives
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

1989
- 1989-12-21 SE SE8904298A patent/SE8904298D0/xx unknown
1990
- 1990-11-30 NZ NZ236293A patent/NZ236293A/xx unknown
- 1990-12-10 ZA ZA909903A patent/ZA909903B/xx unknown
- 1990-12-11 IL IL9663690A patent/IL96636A/en not_active IP Right Cessation
- 1990-12-12 YU YU234690A patent/YU48086B/sh unknown
- 1990-12-12 SI SI9012346A patent/SI9012346B/sl not_active IP Right Cessation
- 1990-12-12 DZ DZ900223A patent/DZ1468A1/xx active
- 1990-12-17 WO PCT/SE1990/000818 patent/WO1991009845A1/en not_active Ceased
- 1990-12-17 EP EP91901571A patent/EP0506778B1/de not_active Expired - Lifetime
- 1990-12-17 RO RO92-0832A patent/RO112864B1/ro unknown
- 1990-12-17 CA CA002069608A patent/CA2069608C/en not_active Expired - Fee Related
- 1990-12-17 SG SG1996004491A patent/SG46413A1/en unknown
- 1990-12-17 UA UA5052485A patent/UA26403A/uk unknown
- 1990-12-17 DE DE69027221T patent/DE69027221T2/de not_active Expired - Fee Related
- 1990-12-17 AT AT91901571T patent/ATE138650T1/de not_active IP Right Cessation
- 1990-12-17 KR KR1019920701484A patent/KR0179382B1/ko not_active Expired - Fee Related
- 1990-12-17 DK DK91901571.9T patent/DK0506778T3/da active
- 1990-12-17 ES ES91901571T patent/ES2087280T3/es not_active Expired - Lifetime
- 1990-12-17 AU AU69783/91A patent/AU647068B2/en not_active Ceased
- 1990-12-17 JP JP3501896A patent/JP2656152B2/ja not_active Expired - Fee Related
- 1990-12-17 IE IE453490A patent/IE74855B1/en not_active IP Right Cessation
- 1990-12-17 IS IS3659A patent/IS1664B/is unknown
- 1990-12-17 HU HU9202044A patent/HU213110B/hu unknown
- 1990-12-20 PT PT96303A patent/PT96303B/pt active IP Right Grant
- 1990-12-20 EG EG74690A patent/EG19361A/xx active
- 1990-12-21 CZ CS906581A patent/CZ278035B6/cs not_active IP Right Cessation
- 1990-12-21 SK SK6581-90A patent/SK658190A3/sk unknown
- 1990-12-21 US US07/633,246 patent/US5227389A/en not_active Expired - Lifetime
- 1990-12-21 CN CN90106009A patent/CN1037841C/zh not_active Expired - Fee Related
- 1990-12-21 PL PL90288409A patent/PL163591B1/pl not_active IP Right Cessation
1991
- 1991-01-09 SA SA91110209A patent/SA91110209B1/ar unknown
1992
- 1992-06-17 NO NO922380A patent/NO178858C/no unknown
- 1992-06-17 FI FI922806A patent/FI100881B/fi not_active IP Right Cessation
- 1992-06-19 BG BG96513A patent/BG60912B1/bg unknown
- 1992-06-19 RU SU925052485A patent/RU2039043C1/ru not_active IP Right Cessation
- 1992-09-29 HR HRP-2346/90A patent/HRP920591B1/xx not_active IP Right Cessation
1993
- 1993-07-12 US US08/090,416 patent/US5360805A/en not_active Expired - Lifetime
- 1993-08-27 LV LVP-93-1042A patent/LV10949B/lv unknown
- 1993-12-30 LT LTIP1731A patent/LT4005B/lt not_active IP Right Cessation
1996
- 1996-07-17 LV LV960262A patent/LV5766B4/xx unknown
1997
- 1997-02-27 HK HK22997A patent/HK22997A/en not_active IP Right Cessation
- 1997-04-30 BR BR1100379-0A patent/BR1100379A/pt active IP Right Grant

Also Published As

Publication number	Publication date
WO1991009845A1 (en)	1991-07-11
FI100881B (fi)	1998-03-13
SK278283B6 (en)	1996-08-07
HU9202044D0 (en)	1992-09-28
SI9012346B (sl)	1999-08-31
NO922380L (no)	1992-06-17
HRP920591B1 (en)	1998-12-31
LV10949B (en)	1996-06-20
IE74855B1 (en)	1997-08-13
EG19361A (en)	1994-12-30
LV5766B4 (lv)	1997-06-20
LTIP1731A (en)	1995-07-25
BG60912B1 (bg)	1996-06-28
BR1100379A (pt)	1999-12-07
IL96636A (en)	1994-11-28
IS3659A7 (is)	1991-06-22
LV5766A4 (lv)	1996-12-20
NO178858C (no)	1996-06-19
CZ658190A3 (en)	1993-01-13
EP0506778A1 (de)	1992-10-07
HU213110B (en)	1997-02-28
CA2069608C (en)	2001-07-10
SA91110209B1 (ar)	2004-05-08
SG46413A1 (en)	1998-02-20
JP2656152B2 (ja)	1997-09-24
KR0179382B1 (ko)	1999-03-20
DK0506778T3 (da)	1996-10-07
CA2069608A1 (en)	1991-06-22
FI922806L (fi)	1992-06-17
LV10949A (lv)	1995-12-20
LT4005B (en)	1996-07-25
AU6978391A (en)	1991-07-24
BG96513A (bg)	1993-12-24
ES2087280T3 (es)	1996-07-16
UA26403A (uk)	1999-08-30
PL163591B1 (pl)	1994-04-29
IS1664B (is)	1997-07-04
NO922380D0 (no)	1992-06-17
IE904534A1 (en)	1991-07-03
DE69027221T2 (de)	1996-10-10
RU2039043C1 (ru)	1995-07-09
DE69027221D1 (de)	1996-07-04
NZ236293A (en)	1992-10-28
SI9012346A (sl)	1998-08-31
PT96303B (pt)	1998-07-31
HUT64518A (en)	1994-01-28
JPH05502869A (ja)	1993-05-20
PL288409A1 (en)	1991-12-02
HK22997A (en)	1997-02-27
US5360805A (en)	1994-11-01
ZA909903B (en)	1991-08-28
NO178858B (no)	1996-03-11
CN1037841C (zh)	1998-03-25
CN1053605A (zh)	1991-08-07
DZ1468A1 (fr)	2004-09-13
IL96636A0 (en)	1991-09-16
FI922806A0 (fi)	1992-06-17
SK658190A3 (en)	1996-08-07
YU234690A (sh)	1993-10-20
HRP920591A2 (en)	1997-08-31
RO112864B1 (ro)	1998-01-30
US5227389A (en)	1993-07-13
YU48086B (sh)	1997-01-08
SE8904298D0 (sv)	1989-12-21
CZ278035B6 (en)	1993-07-14
EP0506778B1 (de)	1996-05-29
KR927003531A (ko)	1992-12-18
PT96303A (pt)	1991-09-30
AU647068B2 (en)	1994-03-17

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2006-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE138650T1 (de)	1996-06-15	Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
EA199800477A1 (ru)	1998-12-24	Производные хинолина
ATE147736T1 (de)	1997-02-15	Benzopyranone, verfahren zu ihrer herstellung und verwendung
ATE151764T1 (de)	1997-05-15	Neue benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltenden zubereitungen
KR950702181A (ko)	1995-06-19	20-위치가 변형된 비타민 D계열의 유도체, 이들의 제조 방법, 이 제조 방법을 위한 중간 생성물, 이들 유도체를 함유하는 제약 제제, 및 약제 제조를 위한 이들의 용도(Derivatives in the Vitamin D Series Modified at the 20 Position a Method of Preparing Such Derivatives, Intermediates Used in This Method, Pharmaceutical Preparations Containing the Derivatives and Their Use in the Preparation of Drugs)
DE69207429D1 (de)	1996-02-15	Verfahren zur herstellung von substituierten piperidinen
ATE90676T1 (de)	1993-07-15	Dioxyalkylenaryl-dihydropyridine zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung.
ATE137753T1 (de)	1996-05-15	Codeinsalz einer substituierten carbonsäure, verfahren zu seiner herstellung, seine verwendung und pharmazeutische präparate
PT100415A (pt)	1993-06-30	Novas morfolinas de accao farmaceutica, e processo para a sua preparacao
ATE85334T1 (de)	1993-02-15	Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
PT93450A (pt)	1990-11-07	Processo para a preparacao de novos derivados azetidinicos de acidos piridinocarboxilicos e de composicoes farmaceuticas que os contem
YU31995A (sh)	1998-12-23	Benzotiofeni glikopiranozida, postupak za njihovo dobijanje i njihova farmaceutska formulacija
ATE130845T1 (de)	1995-12-15	Verfahren zur herstellung von 3-amino-2- (het)aroyl-acrylsäurederivaten.
BR9610175A (pt)	1998-08-11	Composto processo de preparação do composto composição farmacêutica e utilização do composto
PT82407A (fr)	1986-05-01	Procede de preparation de nouveaux derives du triazole
SE9203824L (sv)	1993-06-28	Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
ATE133177T1 (de)	1996-02-15	3'-deamino-4'-deoxy-4'-amino-8-fluoranthracycli e und verfahren zu ihrer herstellung
RU93004405A (ru)	1995-06-19	Производные хинолон- и нафтиридонкарбоновой кислоты в виде смеси изомеров или отдельных изомеров, их гидраты и соли, способ их получения и содержащее их лекарственное средство
ATE118773T1 (de)	1995-03-15	Verfahren zur herstellung von 2-(3-pyridyl)- tetrahydrothiopyran-2-carbonsäurethioamid-1- (1r,2r)oxyden, die so erhaltenen 2-(3-pyridyl)- tetrahydrothiopyran-2-carbothioamid-1- (1r,2r)oxyde und diese enthaltende pharmazeutische zusammenstellungen.
ATE7298T1 (de)	1984-05-15	Basisch substituierte 5-phenyltetrazole, verfahren zu ihrer herstellung und ihre verwendung als heilmittel.
ES531447A0 (es)	1984-12-16	Procedimiento de preparar derivados de n-cicloalcoilmetil-2 oxo-3 diaril 5-6 as triacina
DE68920022D1 (de)	1995-01-26	Indolessigsäure-derivate, verfahren zur herstellung sowie arzneimittel, die diese als aktive mittel enthalten.
ATE145647T1 (de)	1996-12-15	Gem-diphosphonsäure-nitrosocarbamoylderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zubereitungen
FI911616A0 (fi)	1991-04-04	Substituerade 3-tia- eller 3-oxa-alkyl -flavoner, foerfarande foer deras framstaellning, deras anvaendning, pao dessa foereningar baserade laekemedel samt mellanprodukter.
ATE164573T1 (de)	1998-04-15	Verfahren zur herstellung von 1-unsubstituierten 3-aminopyrrolen