ATE144492T1 - Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung - Google Patents

Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung

Info

Publication number: ATE144492T1
Authority: AT; Austria
Prior art keywords: esters; acyl; pharmaceutical compositions; carnitine; long
Prior art date: 1992-01-16

Application number

AT93830009T

Other languages

English (en)

Inventor

Mose Santaniello

Maria Ornella Tinti

Domenico Misiti

Piero Foresta

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-16

Filing date

1993-01-15

Publication date

1996-11-15

1993-01-15 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE144492T1 publication Critical patent/ATE144492T1/de

Links

230000000844 anti-bacterial effect Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 title 1
150000001298 alcohols Chemical class 0.000 title 1
-1 acyl L-carnitines Chemical class 0.000 abstract 3
150000002148 esters Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93830009T 1992-01-16 1993-01-15 Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung ATE144492T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM920027A IT1254135B (it)	1992-01-16	1992-01-16	Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.

Publications (1)

Publication Number	Publication Date
ATE144492T1 true ATE144492T1 (de)	1996-11-15

Family

ID=11400572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93830009T ATE144492T1 (de)	1992-01-16	1993-01-15	Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung

Country Status (13)

Country	Link
US (2)	US5498632A (de)
EP (1)	EP0552137B1 (de)
JP (1)	JP3294653B2 (de)
KR (1)	KR100251888B1 (de)
AT (1)	ATE144492T1 (de)
CA (1)	CA2087085C (de)
DE (1)	DE69305540T2 (de)
DK (1)	DK0552137T3 (de)
ES (1)	ES2093395T3 (de)
GR (1)	GR3021479T3 (de)
HK (1)	HK1005724A1 (de)
IT (1)	IT1254135B (de)
ZA (1)	ZA93162B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1261828B (it)	1993-07-14	1996-06-03	Sigma Tau Ind Farmaceuti	Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en)	1994-06-20	1998-04-21	Tanabe Seiyaku Co., Ltd.	Hair-growth agent
IT1274156B (it) *	1994-09-08	1997-07-15	Avantgarde Spa	"sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
IT1274157B (it) *	1994-09-08	1997-07-15	Avantgarde Spa	"sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
JPH08133971A (ja) *	1994-09-16	1996-05-28	Toyama Chem Co Ltd	抗ヘリコバクター剤
IT1283955B1 (it) *	1996-03-20	1998-05-07	Sigma Tau Ind Farmaceuti	Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria.
KR100513996B1 (ko) *	1996-11-21	2005-12-07	아지노모토 가부시키가이샤	연속발효에의한l-글루탐산의제조방법
US6403124B1 (en) *	1997-04-16	2002-06-11	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Storage and maintenance of blood products including red blood cells and platelets
AU2004283464B8 (en)	2003-10-15	2011-04-14	Syncore Biotechnology Co., Ltd	Method of administering cationic liposomes comprising an active drug
CN1852659B (zh) *	2003-10-16	2011-02-09	泰克康姆集团公司	具有降低的血糖应答的可消化性降低的碳水化合物食物
US20050232911A1 (en) *	2004-04-19	2005-10-20	Schreiber Brian D	Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
JP5700909B2 (ja)	2005-05-04	2015-04-15	メディゲーネアクチエンゲゼルシャフトＭｅｄｉＧｅｎｅＡＧ	パクリタキセルを含む陽イオン性リポソーム製剤を投与する方法
RU2448697C2 (ru)	2006-03-22	2012-04-27	Медигене Аг	Лечение рака молочной железы, негативного по трем рецепторам
EP2394640A1 (de)	2010-05-21	2011-12-14	MediGene AG	Verbesserte liposomale Formulierungen von lipophilen Verbindungen
WO2011147926A2 (en)	2010-05-26	2011-12-01	Erik Reimhult	Magnetically responsive membrane structures
PT2825156T (pt)	2012-03-16	2017-11-02	Merck Patent Gmbh	Aminoácidos lipídicos de direcionamento
AU2013231819B2 (en)	2012-03-16	2017-07-20	Merck Patent Gmbh	Aminoacid lipids
JP7305088B2 (ja) *	2019-03-06	2023-07-10	源至技術有限公司	動物用飼料添加物の調製にγ－第四級アンモニウム酪酸エステル化合物の適用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH588443A5 (de) *	1974-09-25	1977-06-15	Lonza Ag
CH596147A5 (de) *	1974-09-25	1978-02-28	Lonza Ag
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1147079B (it) *	1980-05-30	1986-11-19	Sigma Tau Ind Farmacuetiche Ri	Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1170861B (it) *	1981-03-31	1987-06-03	Sigma Tau Ind Farmaceuti	Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1191945B (it) *	1986-06-04	1988-03-31	Avantgarde Spa	N-alchilammidi della d(+)-carnitina dotate di attivita' antibatterica,procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono
IT1235494B (it) *	1987-12-02	1992-09-04	Avantgarde Spa	N-alchilammidi della dl e l(-)carnitina dotate di attivita' antibatterica, procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono
IT1231751B (it) *	1989-04-12	1991-12-21	Sigma Tau Ind Farmaceuti	Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1231944B (it) *	1989-05-05	1992-01-16	Sigma Tau Ind Farmaceuti	Composizione farmaceutica per il trattamento di protozoosi, particolarmente della tripasonomiasi comprendente d-carnitina o un alcanoilderivato della d-carnitina
IT1240775B (it) *	1990-02-23	1993-12-17	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

1992
- 1992-01-16 IT ITRM920027A patent/IT1254135B/it active
1993
- 1993-01-11 CA CA002087085A patent/CA2087085C/en not_active Expired - Lifetime
- 1993-01-11 ZA ZA93162A patent/ZA93162B/xx unknown
- 1993-01-14 JP JP00476493A patent/JP3294653B2/ja not_active Expired - Lifetime
- 1993-01-15 ES ES93830009T patent/ES2093395T3/es not_active Expired - Lifetime
- 1993-01-15 DK DK93830009.2T patent/DK0552137T3/da active
- 1993-01-15 AT AT93830009T patent/ATE144492T1/de active
- 1993-01-15 EP EP93830009A patent/EP0552137B1/de not_active Expired - Lifetime
- 1993-01-15 DE DE69305540T patent/DE69305540T2/de not_active Expired - Lifetime
- 1993-01-16 KR KR1019930000522A patent/KR100251888B1/ko not_active Expired - Lifetime
1994
- 1994-05-26 US US08/250,107 patent/US5498632A/en not_active Expired - Lifetime
1995
- 1995-03-22 US US08/408,394 patent/US5498633A/en not_active Expired - Lifetime
1996
- 1996-10-24 GR GR960402838T patent/GR3021479T3/el unknown
1998
- 1998-06-05 HK HK98104924A patent/HK1005724A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2093395T3 (es)	1996-12-16
IT1254135B (it)	1995-09-08
EP0552137A3 (en)	1993-10-20
ITRM920027A1 (it)	1993-07-16
DE69305540T2 (de)	1997-03-06
JPH05339218A (ja)	1993-12-21
HK1005724A1 (en)	1999-01-22
EP0552137B1 (de)	1996-10-23
DE69305540D1 (de)	1996-11-28
US5498632A (en)	1996-03-12
CA2087085A1 (en)	1993-07-17
ITRM920027A0 (it)	1992-01-16
DK0552137T3 (da)	1996-11-18
US5498633A (en)	1996-03-12
EP0552137A2 (de)	1993-07-21
KR930016391A (ko)	1993-08-26
JP3294653B2 (ja)	2002-06-24
GR3021479T3 (en)	1997-01-31
CA2087085C (en)	2003-12-16
KR100251888B1 (ko)	2000-05-01
ZA93162B (en)	1993-09-30

Legal Events

Date	Code	Title	Description
1997-05-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE144492T1 (de)	1996-11-15	Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung
PT90251A (pt)	1989-11-10	Processo de preparacao de esteres de tetralina de fenois ou de acidos benzoicos e de composicoes farmaceuticas que os contem
KR950000142A (ko)	1995-01-03	피부질환치료용 약제조성물 제조에 사용되는 히드록시산함유 l-카르니틴에스테르 및 아실 l-카르니틴에스테르의 용도
HU9201213D0 (en)	1992-07-28	Pyrazolo-piridin-derivatives and process for their production
ZA911728B (en)	1992-11-25	Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
DE3888415D1 (de)	1994-04-21	Salpetersäureester-Derivate.
ATE157348T1 (de)	1997-09-15	Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen
DK0514357T3 (da)	1996-02-26	Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier
ATE43601T1 (de)	1989-06-15	Phosphorylalkanolamid-derivate von l-carnitin und sie enthaltende arzneimittel.
NO932843D0 (no)	1993-08-10	Farmasoeytiske preparater
DE3471587D1 (en)	1988-07-07	Derivatives of benzoic acid, process for their preparation and their use in disinfecting and conserving medicaments
ATE151744T1 (de)	1997-05-15	Verwendung von estern des acyl-carnitins mit langkettigen aliphatischen alkoholen zur herstellung von pharmazeutischen zusammensetzungen mit antimykotischer wirkung
NZ334119A (en)	2000-09-29	Use of pentynoic acid derivatives as neurotrophic and antiproliferative agents
GB2168703B (en)	1988-03-16	Trienamides
ATE147755T1 (de)	1997-02-15	Dipeptidderivate und diese als aktive bestandteile enthaltendes prophylaktisches oder therapeutisches mittel gegen knochenkrankheiten
ATE167056T1 (de)	1998-06-15	Verwendung von ester von acyl-l-carnitin mit gammahydroxybuttersäure zur behandlung von alkoholismus