ATE161250T1 - Indolinyl n-hydroxyharnstoffe und n-hydroxamsäure derivate als lipoxygenese inhibitoren - Google Patents

Indolinyl n-hydroxyharnstoffe und n-hydroxamsäure derivate als lipoxygenese inhibitoren

Info

Publication number: ATE161250T1
Authority: AT; Austria
Prior art keywords: alkyl; aryl; halosubstituted; alkoxy; independently
Prior art date: 1992-07-23

Application number

AT93915230T

Other languages

English (en)

Inventor

Takafumi Ikeda

Rodney W Stevens

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-23

Filing date

1993-06-10

Publication date

1998-01-15

1993-06-10 Application filed by Pfizer filed Critical Pfizer

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161250T1 publication Critical patent/ATE161250T1/de

Links

-1 INDOLINYL Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
206010027654 Allergic conditions Diseases 0.000 abstract 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
125000003320 C2-C6 alkenyloxy group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000005128 aryl amino alkyl group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000005164 aryl thioalkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93915230T 1992-07-23 1993-06-10 Indolinyl n-hydroxyharnstoffe und n-hydroxamsäure derivate als lipoxygenese inhibitoren ATE161250T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4197242A JP2661841B2 (ja)	1992-07-23	1992-07-23	インドリン誘導体

Publications (1)

Publication Number	Publication Date
ATE161250T1 true ATE161250T1 (de)	1998-01-15

Family

ID=16371216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93915230T ATE161250T1 (de)	1992-07-23	1993-06-10	Indolinyl n-hydroxyharnstoffe und n-hydroxamsäure derivate als lipoxygenese inhibitoren

Country Status (24)

Country	Link
EP (1)	EP0651743B1 (de)
JP (1)	JP2661841B2 (de)
KR (1)	KR950702533A (de)
CN (1)	CN1085894A (de)
AT (1)	ATE161250T1 (de)
AU (1)	AU675654B2 (de)
BR (1)	BR9306762A (de)
CA (1)	CA2140344C (de)
CZ (1)	CZ15995A3 (de)
DE (1)	DE69315841T2 (de)
DK (1)	DK0651743T3 (de)
ES (1)	ES2110101T3 (de)
FI (1)	FI104068B (de)
GR (1)	GR3025809T3 (de)
HU (1)	HUT70182A (de)
IL (1)	IL106359A0 (de)
MX (1)	MX9304441A (de)
NZ (1)	NZ253881A (de)
PL (1)	PL307229A1 (de)
SK (1)	SK8695A3 (de)
TW (1)	TW227556B (de)
WO (1)	WO1994002459A1 (de)
YU (1)	YU50893A (de)
ZA (1)	ZA935304B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992006573A1 (en) *	1990-10-02	1992-04-16	Stat-Tech International Corporation	Electric charge discharge and dissipation device
WO1998015530A1 (en) *	1996-10-08	1998-04-16	Fujisawa Pharmaceutical Co., Ltd.	Indole derivatives
US5952322A (en) *	1996-12-05	1999-09-14	Pfizer Inc.	Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
WO2000003703A1 (en) *	1998-07-17	2000-01-27	Fuji Yakuhin Kogyo Kabushiki Kaisha	Novel remedies for allergic diseases
EP1283199A4 (de) *	2000-05-16	2003-12-17	Takeda Chemical Industries Ltd	Antagonisten des melanin-konzentrierenden hormons
UA95084C2 (en) *	2005-11-04	2011-07-11	Амира Фармасутикалз, Инк.	5-lipoxygenase-activating protein (flap) inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2059408T3 (es) *	1987-02-10	1994-11-16	Abbott Lab	Un proceso para la preparacion de un compuesto.
IL95584A (en) *	1989-09-07	1995-03-15	Abbott Lab	Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them
KR900016822A (ko) *	1990-04-20	1990-11-14	하라 레이노스께	슬라이드 프로젝터
US5132319A (en) *	1991-03-28	1992-07-21	Merck Frosst Canada, Inc.	1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis

1992
- 1992-07-23 JP JP4197242A patent/JP2661841B2/ja not_active Expired - Fee Related
1993
- 1993-06-10 CZ CZ95159A patent/CZ15995A3/cs unknown
- 1993-06-10 DE DE69315841T patent/DE69315841T2/de not_active Expired - Fee Related
- 1993-06-10 PL PL93307229A patent/PL307229A1/xx unknown
- 1993-06-10 ES ES93915230T patent/ES2110101T3/es not_active Expired - Lifetime
- 1993-06-10 AT AT93915230T patent/ATE161250T1/de not_active IP Right Cessation
- 1993-06-10 CA CA002140344A patent/CA2140344C/en not_active Expired - Fee Related
- 1993-06-10 SK SK86-95A patent/SK8695A3/sk unknown
- 1993-06-10 AU AU45291/93A patent/AU675654B2/en not_active Expired - Fee Related
- 1993-06-10 WO PCT/US1993/005391 patent/WO1994002459A1/en not_active Ceased
- 1993-06-10 BR BR9306762A patent/BR9306762A/pt not_active Application Discontinuation
- 1993-06-10 DK DK93915230.2T patent/DK0651743T3/da active
- 1993-06-10 EP EP93915230A patent/EP0651743B1/de not_active Expired - Lifetime
- 1993-06-10 NZ NZ253881A patent/NZ253881A/en unknown
- 1993-06-12 TW TW082104672A patent/TW227556B/zh active
- 1993-07-15 IL IL106359A patent/IL106359A0/xx unknown
- 1993-07-22 HU HU9302126A patent/HUT70182A/hu unknown
- 1993-07-22 CN CN93108985A patent/CN1085894A/zh active Pending
- 1993-07-22 ZA ZA935304A patent/ZA935304B/xx unknown
- 1993-07-22 MX MX9304441A patent/MX9304441A/es unknown
- 1993-07-22 YU YU50893A patent/YU50893A/sh unknown
- 1993-07-22 FI FI933307A patent/FI104068B/fi not_active IP Right Cessation
1994
- 1994-01-25 KR KR1019940700233A patent/KR950702533A/ko not_active Withdrawn
1997
- 1997-12-30 GR GR970403456T patent/GR3025809T3/el unknown

Also Published As

Publication number	Publication date
JP2661841B2 (ja)	1997-10-08
ZA935304B (en)	1995-01-23
AU675654B2 (en)	1997-02-13
SK8695A3 (en)	1995-07-11
DE69315841T2 (de)	1998-04-09
DE69315841D1 (de)	1998-01-29
EP0651743A1 (de)	1995-05-10
FI933307L (fi)	1994-01-24
BR9306762A (pt)	1998-12-08
AU4529193A (en)	1994-02-14
TW227556B (de)	1994-08-01
PL307229A1 (en)	1995-05-15
EP0651743B1 (de)	1997-12-17
NZ253881A (en)	1996-01-26
FI933307A0 (fi)	1993-07-22
MX9304441A (es)	1994-07-29
CA2140344C (en)	1997-08-26
CN1085894A (zh)	1994-04-27
HUT70182A (en)	1995-09-28
FI104068B1 (fi)	1999-11-15
CA2140344A1 (en)	1994-02-03
GR3025809T3 (en)	1998-03-31
YU50893A (sh)	1996-07-24
DK0651743T3 (da)	1998-02-02
JPH0641068A (ja)	1994-02-15
FI104068B (fi)	1999-11-15
CZ15995A3 (en)	1995-09-13
WO1994002459A1 (en)	1994-02-03
IL106359A0 (en)	1993-11-15
ES2110101T3 (es)	1998-02-01
KR950702533A (ko)	1995-07-29
HU9302126D0 (en)	1993-10-28

Legal Events

Date	Code	Title	Description
1998-05-15	UEP	Publication of translation of european patent specification
2007-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO20015448L (no)	2002-01-07	Kinolinderivater som inhibitorer av MEK-enzymer
DE69614147D1 (de)	2001-08-30	Chinazolin-derivate
NO20015447L (no)	2001-12-12	Kinolinderivater som inhibitorer av MEK enzymer
DK0862567T3 (da)	2001-10-08	5-azabicyclo[3.1.0]hexylalkyl-2-piperidoner og-glutarimider som neurokininreceptorantagonister
NO20015446L (no)	2001-12-12	Kinolin-derivater som inhibitorer for MEK-enzymer
NO930244D0 (no)	1993-01-25	Umettede 17beta-substituerte 3-karboksysteroider
DE69315841D1 (de)	1998-01-29	Indolinyl n-hydroxyharnstoffe und n-hydroxamsäure derivate als lipoxygenese inhibitoren
DE69200665D1 (de)	1994-12-15	Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate.
ATE215075T1 (de)	2002-04-15	Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend
DE69207597D1 (de)	1996-02-22	Lipoxygenase inhibierende tetrahydrobenzazepinderivate
ATE131162T1 (de)	1995-12-15	Lipoxygenase inhibierende n- hydroyharnstoffderivate.
NO20004679L (no)	2000-10-26	Farmasøytisk sammensetning inneholdende en cystein- proteasehemmer for forebygging og terapi av hjernevevsforringelse
TH18165A (th)	1996-04-19	สารยับยั้งการเกิดคีโมแทกซิของอีโอซีโนฟีล