ATE169927T1 - Erythromycinderivate - Google Patents

Erythromycinderivate

Info

Publication number: ATE169927T1
Authority: AT; Austria
Prior art keywords: represents hydrogen; lower alkyl; represent; pair; different
Prior art date: 1992-05-26

Application number

AT93910399T

Other languages

English (en)

Inventor

Hiroshi Koga

Tsutomu Sato

Hisanori Takanashi

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-26

Filing date

1993-05-26

Publication date

1998-09-15

1993-05-26 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE169927T1 publication Critical patent/ATE169927T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000004051 gastric juice Anatomy 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93910399T 1992-05-26 1993-05-26 Erythromycinderivate ATE169927T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP13382892		1992-05-26

Publications (1)

Publication Number	Publication Date
ATE169927T1 true ATE169927T1 (de)	1998-09-15

Family

ID=15113997

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93910399T ATE169927T1 (de)	1992-05-26	1993-05-26	Erythromycinderivate

Country Status (20)

Country	Link
US (1)	US5658888A (de)
EP (1)	EP0643068B1 (de)
JP (1)	JP3068367B2 (de)
KR (1)	KR100226311B1 (de)
CN (1)	CN1036199C (de)
AT (1)	ATE169927T1 (de)
AU (1)	AU659740B2 (de)
CA (1)	CA2117883C (de)
DE (1)	DE69320476T2 (de)
DK (1)	DK0643068T3 (de)
ES (1)	ES2120499T3 (de)
HR (1)	HRP930926B1 (de)
IL (1)	IL105810A (de)
MY (1)	MY113693A (de)
SG (1)	SG52785A1 (de)
SI (1)	SI9300281B (de)
TW (1)	TW240230B (de)
WO (1)	WO1993024509A1 (de)
YU (1)	YU48771B (de)
ZA (1)	ZA933679B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007204490A (ja) *	1995-08-03	2007-08-16	Chugai Pharmaceut Co Ltd	エリスロマイシン誘導体の製造方法
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
US6077943A (en) *	1996-03-01	2000-06-20	Takeda Chemical Industries, Ltd.	Method of producing erythromycin derivative
WO1998003531A1 (fr) *	1996-07-24	1998-01-29	Chugai Seiyaku Kabushiki Kaisha	Derives d'erythromycine
US6100239A (en) *	1996-11-26	2000-08-08	Chugai Seiyaku Kabushiki Kaisha	13-membered ring macrolide compound, medicine containing the same, and process for producing the same
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
CA2399198A1 (en)	2000-02-18	2001-08-23	Christopher Carreras	Motilide compounds
KR100554562B1 (ko) *	2000-09-01	2006-03-03	쥬가이 세이야쿠 가부시키가이샤	에리트로마이신 유도체의 제조 방법
WO2002030943A1 (fr) *	2000-10-12	2002-04-18	Chugai Seiyaku Kabushiki Kaisha	Derive d'erythromycine possedant des nouvelles structures cristallines et procedes associes de production
ES2249588T3 (es)	2001-06-13	2006-04-01	Ube Industries, Ltd.	Procedimiento para preparar un compuesto de eritromicina.
TW200302830A (en) *	2002-01-11	2003-08-16	Chugai Pharmaceutical Co Ltd	Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
EP2316468A1 (de)	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
US6986901B2 (en) *	2002-07-15	2006-01-17	Warner-Lambert Company Llc	Gastrointestinal compositions
AU2003281172A1 (en) *	2002-07-10	2004-02-02	Warner-Lambert Company Llc	Gastrointestinal Compositions
US20040010035A1 (en) *	2002-07-15	2004-01-15	Ciociola Arthur A.	Gastrointestinal compositions
SI1532131T1 (sl) *	2002-08-29	2009-04-30	Pfizer	Motilidne spojine
US7091196B2 (en)	2002-09-26	2006-08-15	Rib-X Pharmaceuticals, Inc.	Bifunctional heterocyclic compounds and methods of making and using same
AU2004217919A1 (en) *	2003-03-05	2004-09-16	Rib-X Pharmaceuticals, Inc.	Bifunctional heterocyclic compounds and methods of making and using the same
DE602004025569D1 (de)	2003-06-18	2010-04-01	Tranzyme Pharma Inc	Makrozyklische motilin rezeptorantagonisten
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
WO2005042554A1 (en) *	2003-10-30	2005-05-12	Rib-X Pharmaceuticals, Inc.	Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) *	2003-11-18	2007-05-17	リブ−エックスファーマシューティカルズ，インコーポレイテッド	二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
EP2716647A3 (de)	2004-02-27	2014-08-20	Rib-X Pharmaceuticals, Inc.	Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
TW200633714A (en)	2004-12-28	2006-10-01	Chugai Pharmaceutical Co Ltd	Drugs for the treatment and/or prophylaxis of gastroparesis symptom
US7582611B2 (en)	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
EP1934237A2 (de)	2005-08-24	2008-06-25	Rib-X Pharmaceuticals, Inc.	Triazolverbindungen und verfahren zu deren herstellung und anwendung
EP1928893A2 (de)	2005-08-24	2008-06-11	Rib-X Pharmaceuticals, Inc.	Triazolverbindungen und verfahren zu ihrer herstellung und verwendung
BRPI0619556A2 (pt) *	2005-12-08	2011-10-04	Pfizer	processo para desmetilação de grupo 3' -dimetil amino de compostos eritromicina
JP5684474B2 (ja)	2006-09-11	2015-03-11	オセラセラピューティクス，インコーポレイテッド	胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
MX2009005977A (es)	2006-12-05	2009-06-17	Pfizer	Polimorfos de motilida.
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60218321A (ja) *	1984-04-13	1985-11-01	Satoshi Omura	消化管収縮運動促進剤
JPS6187625A (ja) *	1984-10-05	1986-05-06	Satoshi Omura	消化管収縮運動促進剤
JPH0759513B2 (ja) *	1985-08-31	1995-06-28	北里研究所（社団法人）	消化管収縮運動促進剤
DE3689758T2 (de) *	1985-08-31	1994-08-18	Kitasato Inst	Erythromycinderivat und Verfahren zu dessen Herstellung.
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
WO1993013780A1 (en) *	1992-01-21	1993-07-22	Abbott Laboratories	4''-deoxyerythromycin derivatives

1993
- 1993-05-19 MY MYPI93000927A patent/MY113693A/en unknown
- 1993-05-24 HR HR930926A patent/HRP930926B1/xx not_active IP Right Cessation
- 1993-05-25 YU YU36693A patent/YU48771B/sh unknown
- 1993-05-25 SI SI9300281A patent/SI9300281B/sl not_active IP Right Cessation
- 1993-05-25 TW TW082104109A patent/TW240230B/zh active
- 1993-05-25 IL IL10581093A patent/IL105810A/en not_active IP Right Cessation
- 1993-05-26 DE DE69320476T patent/DE69320476T2/de not_active Expired - Lifetime
- 1993-05-26 ZA ZA933679A patent/ZA933679B/xx unknown
- 1993-05-26 SG SG1996009490A patent/SG52785A1/en unknown
- 1993-05-26 AT AT93910399T patent/ATE169927T1/de not_active IP Right Cessation
- 1993-05-26 DK DK93910399T patent/DK0643068T3/da active
- 1993-05-26 JP JP5124514A patent/JP3068367B2/ja not_active Expired - Fee Related
- 1993-05-26 ES ES93910399T patent/ES2120499T3/es not_active Expired - Lifetime
- 1993-05-26 US US08/318,814 patent/US5658888A/en not_active Expired - Lifetime
- 1993-05-26 CN CN93106467A patent/CN1036199C/zh not_active Expired - Fee Related
- 1993-05-26 AU AU40897/93A patent/AU659740B2/en not_active Ceased
- 1993-05-26 WO PCT/JP1993/000702 patent/WO1993024509A1/ja not_active Ceased
- 1993-05-26 KR KR1019940704274A patent/KR100226311B1/ko not_active Expired - Fee Related
- 1993-05-26 CA CA002117883A patent/CA2117883C/en not_active Expired - Fee Related
- 1993-05-26 EP EP93910399A patent/EP0643068B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SG52785A1 (en)	1998-09-28
YU48771B (sh)	1999-12-27
TW240230B (de)	1995-02-11
ZA933679B (en)	1993-12-21
US5658888A (en)	1997-08-19
YU36693A (sh)	1996-07-24
AU4089793A (en)	1993-12-30
CN1036199C (zh)	1997-10-22
EP0643068A1 (de)	1995-03-15
DK0643068T3 (da)	1999-02-08
HK1009969A1 (en)	1999-09-10
HRP930926A2 (en)	1995-02-28
ES2120499T3 (es)	1998-11-01
DE69320476T2 (de)	1999-03-25
KR950701640A (ko)	1995-04-28
EP0643068A4 (de)	1995-08-02
KR100226311B1 (ko)	1999-10-15
JPH0656873A (ja)	1994-03-01
MY113693A (en)	2002-05-31
SI9300281A (sl)	1993-12-31
WO1993024509A1 (fr)	1993-12-09
CN1081184A (zh)	1994-01-26
HRP930926B1 (en)	2000-10-31
IL105810A0 (en)	1993-09-22
CA2117883C (en)	2003-10-21
AU659740B2 (en)	1995-05-25
SI9300281B (en)	2001-02-28
EP0643068B1 (de)	1998-08-19
IL105810A (en)	1998-12-27
DE69320476D1 (en)	1998-09-24
CA2117883A1 (en)	1993-12-09
JP3068367B2 (ja)	2000-07-24

Legal Events

Date	Code	Title	Description
1999-04-15	UEP	Publication of translation of european patent specification
2011-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0643068T3 (da)	1999-02-08	Erythromycinderivat
CA2311742A1 (en)	1999-06-10	6-amino-9-benzyl-8-hydroxypurine derivatives
DK0934950T3 (da)	2002-07-29	Tetrapeptidderivat
NO933376L (no)	1993-09-23	Morfinan-derivater og medisinsk anvendelse derav
IE781878L (en)	1979-03-19	Imidazole derivatives
NO905572L (no)	1991-06-24	Fremgangsmaate for fremstilling av peptidforbindelser.
ATE157368T1 (de)	1997-09-15	6-0-methylerythromycin a-derivat
DK0585155T3 (da)	1997-06-09	Trifluormethylketon-peptidderivater med HLE-inhiberende aktivitet, deres fremstilling og farmaceutiske præparater
EP0522173A4 (en)	1993-06-16	4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acceptable salt thereof
DE68929368D1 (de)	2002-02-21	Cephemderivate und Verfahren zu ihrer Herstellung
MX9206093A (es)	1993-04-01	Derivado de oxazolidona
ATE267191T1 (de)	2004-06-15	Tricyclische aminderivate
ES2013035A6 (es)	1990-04-16	Un metodo para preparar derivados de acilfenol.
EP0696585A4 (de)	1996-03-27
DE3866012D1 (de)	1991-12-12	Antiarrhythmische heilmittel.
ES8503354A1 (es)	1985-02-16	Un procedimiento de preparacion de nuevos derivados de carbapenem.
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
FR2616663B1 (fr)	1989-08-18	Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0299076A4 (en)	1991-01-09	5-hydroxyindole-3-carboxamide compound and medicinal use thereof
DK540589A (da)	1990-05-01	Pyrrolidinderivater
MY106269A (en)	1995-04-29	Novel antimicrobial quinolonyl lactam esters.