ATE181741T1 - Asymmetrische benzoxanthenfarbstoffe - Google Patents

Asymmetrische benzoxanthenfarbstoffe

Info

Publication number
ATE181741T1
ATE181741T1 AT97920028T AT97920028T ATE181741T1 AT E181741 T1 ATE181741 T1 AT E181741T1 AT 97920028 T AT97920028 T AT 97920028T AT 97920028 T AT97920028 T AT 97920028T AT E181741 T1 ATE181741 T1 AT E181741T1
Authority
AT
Austria
Prior art keywords
sub
compounds
invention includes
asymmetric
alkene
Prior art date
Application number
AT97920028T
Other languages
English (en)
Inventor
Scott C Benson
Steven M Menchen
Peter D Theisen
Kevin M Hennessey
Vergine C Furniss
Joan Hauser
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE181741T1 publication Critical patent/ATE181741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/38—Halogenated derivatives with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT97920028T 1996-04-01 1997-04-01 Asymmetrische benzoxanthenfarbstoffe ATE181741T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/626,085 US6020481A (en) 1996-04-01 1996-04-01 Asymmetric benzoxanthene dyes

Publications (1)

Publication Number Publication Date
ATE181741T1 true ATE181741T1 (de) 1999-07-15

Family

ID=24508885

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920028T ATE181741T1 (de) 1996-04-01 1997-04-01 Asymmetrische benzoxanthenfarbstoffe

Country Status (8)

Country Link
US (5) US6020481A (de)
EP (1) EP0891393B1 (de)
JP (4) JP3386473B2 (de)
AT (1) ATE181741T1 (de)
AU (1) AU707242B2 (de)
CA (1) CA2250014C (de)
DE (1) DE69700303T2 (de)
WO (1) WO1997036960A1 (de)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US6162931A (en) * 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US5847162A (en) * 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US6080852A (en) * 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
US7550570B2 (en) 2000-05-25 2009-06-23 Applied Biosystems, Llc. 4,7-dichlororhodamine dyes labeled polynucleotides
EP1009802B1 (de) * 1997-02-12 2004-08-11 Eugene Y. Chan Verfahren zur analyse von polymeren
US6130101A (en) * 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6583168B1 (en) * 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US5936087A (en) * 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
DE19940750A1 (de) 1998-08-28 2000-06-21 Febit Ferrarius Biotech Gmbh Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
ATE334197T1 (de) * 1999-02-19 2006-08-15 Febit Biotech Gmbh Verfahren zur herstellung von polymeren
US6605434B1 (en) 1999-03-16 2003-08-12 Human Genome Sciences, Inc. Direct bacterial lysate sequencing
DE19919120A1 (de) 1999-04-27 2000-11-02 Drexhage Karl Heinz Neue Amidopyrylium-Fluoreszenz-Farbstoffe
WO2001016371A2 (en) * 1999-08-27 2001-03-08 Gen-Probe Incorporated Method for identifying nucleic acid base phosphoramidites by fluorescence spectroscopy
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6232076B1 (en) 2000-02-04 2001-05-15 Genaissance Pharmaceuticals, Inc. Stabilizer of dye sequencing products
US6221604B1 (en) 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
CA2425663C (en) * 2000-10-11 2009-12-29 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
DE60216468T2 (de) * 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US6764710B2 (en) 2001-07-18 2004-07-20 Scimed Life Systems, Inc. Light emitting markers for use with substrates
US7052512B2 (en) * 2001-07-18 2006-05-30 Boston Scientific Scimed, Inc. Fluorescent dyed lubricant for medical devices
EP1412724B1 (de) * 2001-07-25 2016-03-23 Life Technologies Corporation Zeitverzögerungintegration in elektrophoretischen nachweissystemen
US8569516B2 (en) * 2001-09-07 2013-10-29 Elitech Holding B.V. Compounds and methods for fluorescent labeling
US6972339B2 (en) * 2001-09-07 2005-12-06 Epoch Biosciences, Inc. Compounds and methods for fluorescent labeling
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
EP1575990B1 (de) 2002-09-08 2009-11-18 Applera Corporation Festphasengebundene PNA-Dimere und deren Synthese
AU2003301148A1 (en) 2002-12-23 2004-07-22 Vical Incorporated Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
US7491830B2 (en) * 2003-05-09 2009-02-17 Applied Biosystems Inc. Phenyl xanthene dyes
US7432298B2 (en) * 2003-05-09 2008-10-07 Applied Biosystems Inc. Fluorescent polymeric materials containing lipid soluble rhodamine dyes
BRPI0411672A (pt) * 2003-06-20 2006-08-08 Baker Hughes Inc testes aperfeiçoados de pv de fundo de furo para pressão de ponto de bolha
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US7541454B2 (en) * 2003-10-24 2009-06-02 Epoch Biosciences, Inc. Compounds and methods for fluorescent labeling
US7504495B2 (en) * 2003-11-20 2009-03-17 Exiqon A/S Quencher compositions comprising anthraquinone moieties
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
US7488820B2 (en) * 2004-01-19 2009-02-10 Massachusetts Institute Of Technology Naphthofluorescein-based metal sensors, and methods of making and using the same
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
EP2290073A3 (de) * 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
EP1781675B1 (de) 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Fluoreszierende phosphonatfarbstoffe und konjugate
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
US20060166238A1 (en) * 2004-12-22 2006-07-27 Ramsing Niels B Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
US20060228726A1 (en) * 2005-01-06 2006-10-12 Martin Patrick K Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
EP1872135A2 (de) 2005-03-15 2008-01-02 Applera Corporation Verwendung von antikörper-surrogatantigen-systemen zum nachweis von analyten
EP1886145A2 (de) 2005-05-03 2008-02-13 Applera Corporation Fluoreszenznachweissystem und farbstoffsatz zur verwendung damit
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
US9677123B2 (en) 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
WO2007115265A2 (en) * 2006-03-31 2007-10-11 Applied Biosystems Inc. Reagents useful for synthesizing rhodamine-labeled oligonucleotides
WO2007140015A2 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc Biochemical analysis of partitioned cells
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
WO2008073919A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
WO2008073920A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
CA2689974A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009067632A1 (en) * 2007-11-20 2009-05-28 Applied Biosystems Inc. Method of sequencing nucleic acids using elaborated nucleotide phosphorothiolate compounds
US8017338B2 (en) 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
JP5130540B2 (ja) * 2007-12-12 2013-01-30 学校法人福岡大学 蛍光誘導体化試薬ならびに蛍光誘導体化方法
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
US20100159452A1 (en) * 2008-12-22 2010-06-24 Roche Molecular Systems, Inc. Method For Detecting a Target Nucleic Acid in a Sample
US20120142004A1 (en) 2009-05-21 2012-06-07 Siemens Healthcare Diagnostics Inc. Universal Tags With Non-Natural Nucleobases
WO2010135692A2 (en) 2009-05-22 2010-11-25 Asuragen, Inc. Mirna biomarkers of prostate disease
CN102725632A (zh) 2009-08-28 2012-10-10 奥斯瑞根公司 肺病的miRNA生物标志物
BR112013010585B1 (pt) 2010-10-29 2020-12-01 Asuragen, Inc. método de caracterização de um locus de fmr1 ou um locus de frm2 em uma amostra de dna e método de análise de um locus fmr1 ou um locus fmr2 de uma amostra de dna humana
CN107326073A (zh) 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
DK2714939T3 (en) 2011-05-24 2015-06-29 Elitech Holding Bv DETECTION OF METHICILLIN-RESISTENT STAPHYLOCOCCUS AUREUS
CN103813713A (zh) * 2011-07-20 2014-05-21 乔治亚州大学研究基金会 细胞识别缀合物及使用maldi-ms成像对癌症组织进行组织学分析的方法
US9945608B2 (en) 2011-08-02 2018-04-17 Air Products And Chemicals, Inc. Natural gas processing plant
AU2012309824A1 (en) 2011-09-12 2013-04-18 Abbvie Biotherapeutics Inc. Artificial NK cells and uses thereof
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
CN102942553B (zh) * 2012-10-15 2015-01-14 石平 一种6-羧基荧光素的制备方法
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
US10377734B2 (en) 2013-02-08 2019-08-13 Mitsubishi Gas Chemical Company, Inc. Resist composition, method for forming resist pattern, polyphenol derivative for use in the composition
WO2014164479A1 (en) 2013-03-11 2014-10-09 Elitech Holding B.V. Methods for true isothermal strand displacement amplification
US9328384B2 (en) 2013-05-13 2016-05-03 Elitechgroup B.V. Droplet digital PCR with short minor groove probes
TWI707038B (zh) 2013-08-05 2020-10-11 美商扭轉生物科技有限公司 重新合成之基因庫
CN104672198B (zh) * 2013-11-26 2018-11-16 东友精细化工有限公司 化合物及着色固化性树脂组合物
CN122038564A (zh) 2014-01-05 2026-05-15 G·索兹 使用mirna比率确定肺癌
US10619210B2 (en) 2014-02-07 2020-04-14 The Johns Hopkins University Predicting response to epigenetic drug therapy
ES2832748T3 (es) 2014-08-19 2021-06-11 Hoffmann La Roche Procedimientos y composiciones para la detección de ácidos nucleicos
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
EP3230468B1 (de) 2014-12-12 2020-09-16 ELITechGroup, Inc. Verfahren und kits zum nachweis von antibiotikaresistenten bakterien
EP3230467A1 (de) 2014-12-12 2017-10-18 ELITechGroup B.V. Verfahren und zusammensetzungen zum nachweis von antibiotikaresistenten bakterien
JP7026439B2 (ja) 2014-12-25 2022-02-28 三菱瓦斯化学株式会社 化合物、樹脂、リソグラフィー用下層膜形成材料、リソグラフィー用下層膜、パターン形成方法及び精製方法
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
JP6845991B2 (ja) 2015-03-31 2021-03-24 三菱瓦斯化学株式会社 化合物、レジスト組成物及びそれを用いるレジストパターン形成方法
US11480877B2 (en) 2015-03-31 2022-10-25 Mitsubishi Gas Chemical Company, Inc. Resist composition, method for forming resist pattern, and polyphenol compound used therein
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3292214A1 (de) 2015-05-04 2018-03-14 Academisch Medisch Centrum Verfahren zur quantifizierung von mirnas mittels normalisierung
WO2017015543A1 (en) 2015-07-23 2017-01-26 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
EP3346334B1 (de) 2015-08-31 2020-08-12 Mitsubishi Gas Chemical Company, Inc. Verwendung einer zusammensetzung zur formung eines fotoresist- unterschichtfilms für lithografie, fotoresist-unterschichtfilm für lithographie und dessen produktionsverfahren und verfahren zur formung einer resiststruktur
EP3346335A4 (de) 2015-08-31 2019-06-26 Mitsubishi Gas Chemical Company, Inc. Material zur bildung von unterschichtfilmen zur lithographie, zusammensetzung zur bildung von unterschichtfilmen zur lithographie, unterschichtfilme zur lithographie und verfahren zur herstellung davon, musterbildungsverfahren, harz und reinigungsverfahren
CN108137478B (zh) 2015-09-10 2021-09-28 三菱瓦斯化学株式会社 化合物、其组合物、纯化方法以及抗蚀图案形成方法、非晶膜的制造方法
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
WO2017095958A1 (en) 2015-12-01 2017-06-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
KR102212257B1 (ko) 2016-08-22 2021-02-04 트위스트 바이오사이언스 코포레이션 드 노보 합성된 핵산 라이브러리
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
WO2018057526A2 (en) 2016-09-21 2018-03-29 Twist Bioscience Corporation Nucleic acid based data storage
EP3554514A4 (de) 2016-12-16 2020-08-05 Twist Bioscience Corporation Variante bibliotheken der immunologischen synapse und synthese davon
JP6858545B2 (ja) * 2016-12-19 2021-04-14 株式会社Ｄｎｐファインケミカル 色素
CN110892485B (zh) 2017-02-22 2024-03-22 特韦斯特生物科学公司 基于核酸的数据存储
AU2018234629A1 (en) 2017-03-15 2019-10-17 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
JP7169999B2 (ja) 2017-06-12 2022-11-11 ツイスト バイオサイエンス コーポレーション シームレス核酸アセンブリのための方法
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
AU2018328847A1 (en) 2017-09-11 2020-04-23 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
WO2019079769A1 (en) 2017-10-20 2019-04-25 Twist Bioscience Corporation HEATED NANOWELLS FOR THE SYNTHESIS OF POLYNUCLEOTIDES
EP4715681A2 (de) 2018-01-04 2026-03-25 Atlas Data Storage, Inc. Digitale informationsspeicherung auf dna-basis
IL278771B2 (en) 2018-05-18 2025-09-01 Twist Bioscience Corp Polynucleotides, reagents and methods for nucleic acid hybridization
MX2021007492A (es) 2018-12-20 2021-10-13 Life Technologies Corp Colorante de rodamina asimétrica y uso de este en ensayos biológicos.
CA3124333A1 (en) 2018-12-20 2020-06-25 Life Technologies Corporation Modified rhodamine dye and use thereof in biological assays
WO2020139871A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
AU2020227802A1 (en) 2019-02-26 2021-10-14 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
WO2020176678A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
CA3144644A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US20220267857A1 (en) 2019-07-19 2022-08-25 Fundación Para La Investigación Biomédikca Del Hospital Universitario La Paz (Fibhulp) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
US12091777B2 (en) 2019-09-23 2024-09-17 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
EP4034564A4 (de) 2019-09-23 2023-12-13 Twist Bioscience Corporation Variante nukleinsäurebibliotheken für einzeldomänenantikörper
WO2021080629A1 (en) 2019-10-23 2021-04-29 Elitechgroup, Inc. Methods for true isothermal strand displacement amplification
BR112022011235A2 (pt) 2019-12-09 2022-12-13 Twist Bioscience Corp Bibliotecas de variantes de ácido nucleico para receptores de adenosina
US20230304932A1 (en) 2020-07-23 2023-09-28 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
CA3186955A1 (en) 2020-07-23 2022-01-27 Scott Benson Energy transfer dye conjugates for use in biological assays
KR102783485B1 (ko) 2021-10-15 2025-03-20 아주대학교산학협력단 miR-625-3p의 건선 중증도 진단용 바이오마커로서의 용도
CN114736213B (zh) * 2022-04-01 2024-02-02 合肥华纳生物医药科技有限公司 一种羧基-四氯-荧光素的制备方法
PL443955A1 (pl) * 2023-03-02 2024-09-09 Instytut Chemii Organicznej Polskiej Akademii Nauk Barwniki merocyjaninowe, sposób ich otrzymywania i zastosowanie
KR20240177780A (ko) 2023-06-19 2024-12-30 재단법인 아산사회복지재단 맥락막 비후 질환의 진단 또는 예후 예측용 조성물, 키트 및 진단 또는 예후 예측을 위한 정보를 제공하는 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE84990C (de) *
DE290508C (de) *
GB1336955A (en) * 1970-12-15 1973-11-14 Yamamoto Kagaku Gosei Kk Fluoran compounds and their use in pressure sensitive copying paper
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
CA1244786A (en) * 1983-12-20 1988-11-15 Lloyd M. Smith Synthesis of amino-derivitized oligonucleotides
US5118800A (en) * 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
JPS60242368A (ja) * 1984-05-16 1985-12-02 Hitachi Ltd 核酸塩基配列決定方法
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5093232A (en) * 1985-12-11 1992-03-03 Chiron Corporation Nucleic acid probes
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
JPH07113606B2 (ja) * 1986-10-27 1995-12-06 株式会社島津製作所 塩基配列決定装置
US4945171A (en) * 1987-08-10 1990-07-31 Molecular Probes, Inc. Xanthene dyes having a fused (C) benzo ring
US5231191A (en) * 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US4965349A (en) * 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US4933471A (en) * 1988-08-31 1990-06-12 Becton, Dickinson And Company Xanthene dyes
US5066580A (en) * 1988-08-31 1991-11-19 Becton Dickinson And Company Xanthene dyes that emit to the red of fluorescein
US5366860A (en) * 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
JP2612359B2 (ja) 1990-03-01 1997-05-21 三井東圧化学株式会社 電子写真用感光体
DE69322266T2 (de) * 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
EP0658167B1 (de) * 1992-09-03 1999-04-14 The Perkin-Elmer Corporation 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes

Also Published As

Publication number Publication date
AU2432397A (en) 1997-10-22
US20040225119A1 (en) 2004-11-11
AU707242B2 (en) 1999-07-08
JP3386473B2 (ja) 2003-03-17
EP0891393B1 (de) 1999-06-30
JP2003192931A (ja) 2003-07-09
CA2250014A1 (en) 1997-10-09
US6020481A (en) 2000-02-01
US6617445B2 (en) 2003-09-09
US7179906B2 (en) 2007-02-20
JP2010070769A (ja) 2010-04-02
JP2000500183A (ja) 2000-01-11
JP2006307218A (ja) 2006-11-09
US6303775B1 (en) 2001-10-16
CA2250014C (en) 2004-02-24
JP4644155B2 (ja) 2011-03-02
EP0891393A1 (de) 1999-01-20
US5840999A (en) 1998-11-24
WO1997036960A1 (en) 1997-10-09
DE69700303D1 (de) 1999-08-05
US20020115067A1 (en) 2002-08-22
DE69700303T2 (de) 2000-02-17

Similar Documents

Publication Publication Date Title
DE69700303D1 (de) Asymmetrische benzoxanthenfarbstoffe
CA2304645A1 (en) Aromatic-substituted xanthene dyes
US5707804A (en) Primers labeled with energy transfer coupled dyes for DNA sequencing
ATE199563T1 (de) 4,7-dichlorrhodaminfarbstoffe
KR830001907A (ko) 사이클로 헥실 피리미딘류
ATE301122T1 (de) Kernerweiterte perylenbisimide und ihre verwendung als fluoreszenzfarbstoffe
ATE275172T1 (de) Mobilitaetsveraendernde cyaninfarbstoffe
Hung et al. Energy transfer primers with 5-or 6-carboxyrhodamine-6G as acceptor chromophores
KR830002699A (ko) 신규의 안트라센-9,10-비스-카르보닐-히드라존 및 그 유도체 제조방법
EA199900375A1 (ru) Способ получения замещенных пиридинов
CA2450501A1 (en) Asymmetric benzoxanthene dyes
TR199801756T2 (xx) Bir amid ba�� i�eren yeni sulf�r t�revleri.
KR830004210A (ko) 2-아미노-3-벤조일-페닐아세트아미드 및 환상 동족체
BR0302533A (pt) Misturas de corantes não-azo dispersos
CO4810299A1 (es) Procedimiento para alquilar sulfonamidas impedidas esteri- camente
EA199800242A1 (ru) Амиды карбамоилкарбоновой кислоты
ES2029252T3 (es) Procedimiento para producir un compuesto poliazoico.
EA199900281A1 (ru) Стереоспецифический синтез хиральных 1-арил- и 1-гетероарил-2-замещенных этил-2-аминов
TR200103154T2 (tr) Simetrik ve simetrik-olmayan kırmızı reaktif boyaların karışımı.
Gopalakrishnan et al. Formation and structural features of a sterigmatocystin-formamidopyrimidine adduct at the DNA duplex level
DK0731787T3 (da) Krystallinsk, polymorf form af (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)-propyl]-1-cyclopentylcarbonyl)-tyrosin
US3941780A (en) Coumarin compounds
TR199800957T2 (xx) Dioksoazabisikloheksanlar haz�rlama i�lemi.
ATE278834T1 (de) Verwendung von pigmenten als dispersionsfarbstoffe
KR850004583A (ko) 페닐아세트아닐리드 유도체의 제조방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties