DK0654031T3 - Stereoselektiv syntese af nucleosidanaloger under anvendelse af bicyklisk mellemprodukt - Google Patents

Stereoselektiv syntese af nucleosidanaloger under anvendelse af bicyklisk mellemprodukt

Info

Publication number
DK0654031T3
DK0654031T3 DK94918252T DK94918252T DK0654031T3 DK 0654031 T3 DK0654031 T3 DK 0654031T3 DK 94918252 T DK94918252 T DK 94918252T DK 94918252 T DK94918252 T DK 94918252T DK 0654031 T3 DK0654031 T3 DK 0654031T3
Authority
DK
Denmark
Prior art keywords
pct
formula
image
sec
nucleoside analogs
Prior art date
Application number
DK94918252T
Other languages
Danish (da)
English (en)
Inventor
Tarek S Mansour
Colleen A Evans
Arshad M Siddiqui
Allan H L Tse
Haolun Jin
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Application granted granted Critical
Publication of DK0654031T3 publication Critical patent/DK0654031T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94918252T 1993-06-07 1994-06-07 Stereoselektiv syntese af nucleosidanaloger under anvendelse af bicyklisk mellemprodukt DK0654031T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939311709A GB9311709D0 (en) 1993-06-07 1993-06-07 Stereoselective synthesis of nucleoside analogues using bicycle intermediate
PCT/CA1994/000311 WO1994029301A1 (en) 1993-06-07 1994-06-07 Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

Publications (1)

Publication Number Publication Date
DK0654031T3 true DK0654031T3 (da) 2000-06-13

Family

ID=10736757

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94918252T DK0654031T3 (da) 1993-06-07 1994-06-07 Stereoselektiv syntese af nucleosidanaloger under anvendelse af bicyklisk mellemprodukt

Country Status (21)

Country Link
US (1) US5763606A (de)
EP (1) EP0654031B1 (de)
JP (1) JP3110461B2 (de)
KR (1) KR100304072B1 (de)
CN (1) CN1046720C (de)
AT (1) ATE188215T1 (de)
AU (1) AU668829B2 (de)
BR (1) BR9405423A (de)
CA (1) CA2141029C (de)
DE (1) DE69422374T2 (de)
DK (1) DK0654031T3 (de)
ES (1) ES2139744T3 (de)
FI (1) FI112078B (de)
GB (1) GB9311709D0 (de)
HU (1) HU219199B (de)
NO (1) NO303449B1 (de)
NZ (1) NZ267379A (de)
OA (1) OA10349A (de)
PL (1) PL180870B1 (de)
RU (1) RU2139870C1 (de)
WO (1) WO1994029301A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
JP3047045B2 (ja) * 1994-10-22 2000-05-29 チョン クン ダン コーポレーション ヌクレオシド誘導体およびその製造方法
CA2340214C (en) 1998-08-12 2007-10-30 Triangle Pharmaceuticals, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en) 2000-05-16 2005-07-26 Brantford Chemicals Inc. 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
ATE383355T1 (de) * 2001-03-01 2008-01-15 Abbott Lab Polymorph und andere kristallinische formen von zusammen-ftc
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
KR101157468B1 (ko) 2004-02-03 2012-07-06 에모리 유니버시티 1,3-디옥솔란 뉴클레오시드 제조방법
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
AU9125991A (en) * 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates

Also Published As

Publication number Publication date
JPH08505643A (ja) 1996-06-18
AU6966794A (en) 1995-01-03
CA2141029C (en) 2000-07-25
OA10349A (en) 2001-10-18
FI112078B (fi) 2003-10-31
ES2139744T3 (es) 2000-02-16
ATE188215T1 (de) 2000-01-15
US5763606A (en) 1998-06-09
WO1994029301A1 (en) 1994-12-22
DE69422374D1 (de) 2000-02-03
NO950432L (no) 1995-03-13
EP0654031B1 (de) 1999-12-29
CA2141029A1 (en) 1994-12-22
KR100304072B1 (ko) 2001-11-22
PL180870B1 (pl) 2001-04-30
HUT73630A (en) 1996-08-28
NO303449B1 (no) 1998-07-13
FI950535L (fi) 1995-02-07
NZ267379A (en) 1997-04-24
FI950535A0 (fi) 1995-02-07
HU219199B (en) 2001-03-28
HK1008673A1 (en) 1999-05-14
CN1110479A (zh) 1995-10-18
DE69422374T2 (de) 2000-06-29
JP3110461B2 (ja) 2000-11-20
HU9500364D0 (en) 1995-05-29
RU95108553A (ru) 1996-11-20
BR9405423A (pt) 1999-05-25
RU2139870C1 (ru) 1999-10-20
AU668829B2 (en) 1996-05-16
CN1046720C (zh) 1999-11-24
GB9311709D0 (en) 1993-07-21
PL307350A1 (en) 1995-05-15
NO950432D0 (no) 1995-02-06
EP0654031A1 (de) 1995-05-24

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