ATE188476T1 - Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung - Google Patents

Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung

Info

Publication number
ATE188476T1
ATE188476T1 AT94932063T AT94932063T ATE188476T1 AT E188476 T1 ATE188476 T1 AT E188476T1 AT 94932063 T AT94932063 T AT 94932063T AT 94932063 T AT94932063 T AT 94932063T AT E188476 T1 ATE188476 T1 AT E188476T1
Authority
AT
Austria
Prior art keywords
strain
antiparasite
polycyclic
derivatives
production
Prior art date
Application number
AT94932063T
Other languages
English (en)
Inventor
Anne W Dombrowski
Richard G Endris
Gregory L Helms
Otto D Hensens
John G Ondeyka
Dan A Ostlind
Jon D Polishook
Deborah L Zink
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE188476T1 publication Critical patent/ATE188476T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
AT94932063T 1993-11-01 1994-10-27 Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung ATE188476T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/146,638 US5399582A (en) 1993-11-01 1993-11-01 Antiparasitic agents
PCT/US1994/012302 WO1995012599A1 (en) 1993-11-01 1994-10-27 Polycyclic antiparasitic agents, process and strain for their preparation and their use

Publications (1)

Publication Number Publication Date
ATE188476T1 true ATE188476T1 (de) 2000-01-15

Family

ID=22518283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94932063T ATE188476T1 (de) 1993-11-01 1994-10-27 Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung

Country Status (24)

Country Link
US (2) US5399582A (de)
EP (1) EP0726902B1 (de)
JP (1) JP3557212B2 (de)
KR (1) KR100333017B1 (de)
CN (2) CN1046943C (de)
AT (1) ATE188476T1 (de)
AU (1) AU688405B2 (de)
CA (1) CA2174645C (de)
CZ (1) CZ286032B6 (de)
DE (1) DE69422526T2 (de)
DK (1) DK0726902T3 (de)
ES (1) ES2143558T3 (de)
FI (2) FI110871B (de)
GR (1) GR3032493T3 (de)
HU (1) HU221276B1 (de)
NO (1) NO315942B1 (de)
NZ (1) NZ275339A (de)
PL (1) PL178879B1 (de)
PT (1) PT726902E (de)
RU (1) RU2139874C1 (de)
SI (1) SI0726902T1 (de)
SK (1) SK281510B6 (de)
WO (1) WO1995012599A1 (de)
ZA (1) ZA948542B (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399582A (en) * 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
US5541208A (en) * 1994-01-24 1996-07-30 Merck & Co., Inc. Indole diterpene alkaloid compounds
EP0819000B1 (de) * 1995-03-20 2009-07-08 Merck & Co., Inc. Derivaten von Nodulisporen Säure
US5595991A (en) * 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof
US5962499A (en) * 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US5834260A (en) * 1996-08-30 1998-11-10 Merck & Co., Inc. Antiparasitic agents
ATE234841T1 (de) * 1996-09-19 2003-04-15 Merck & Co Inc Nodulisporinsäurederivate
AU1155499A (en) * 1997-10-09 1999-05-03 Rhone-Poulenc Agro Pesticidal combination
ES2359973T3 (es) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6399786B1 (en) * 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US6586452B1 (en) 2000-07-14 2003-07-01 Merck & Co., Inc. C1 to C4 side chain modified nodulisporic acid analogs
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
EP2465851A1 (de) 2006-07-05 2012-06-20 Aventis Agriculture Derivate von 1-Aryl-5-alkyl-pyrazol-Verbindungen, Verfahren zu ihrer Herstellung und Methoden ihrer Verwendung
RS55271B1 (sr) 2007-05-15 2017-02-28 Merial Sas Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009080546A1 (en) 2007-12-21 2009-07-02 Basf Se The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
AR074024A1 (es) 2008-11-14 2010-12-15 Merial Ltd Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria
MY155497A (en) 2008-11-19 2015-10-30 Merial Inc Compositions comprising an aryl pyrazole and/or a formamidine, methods and use thereof
JP5595412B2 (ja) 2008-12-04 2014-09-24 メリアル リミテッド 二量体アベルメクチン及びミルベマイシン誘導体
CN102596968B (zh) 2009-07-30 2015-05-06 梅里亚有限公司 杀虫的4-氨基-噻吩并[2,3-d]-嘧啶化合物及其使用方法
CN102712583B (zh) 2009-12-04 2015-04-08 梅里亚有限公司 农药用双-有机硫化合物
BR112012014933B1 (pt) 2009-12-17 2020-10-27 Merial, Inc. composições que compreendem compostos lactonas macrocíclicas e spirodioxepinoindóis
RS54772B1 (sr) 2009-12-17 2016-10-31 Merial Sas Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže
WO2011095581A1 (en) 2010-02-05 2011-08-11 Intervet International B.V. S piroindoline compounds for use as anthelminthi cs
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
KR101916481B1 (ko) 2010-09-29 2018-11-07 인터벳 인터내셔널 비.브이. Ｎ-헤테로아릴 화합물
US8883791B2 (en) 2010-09-29 2014-11-11 Intervet Inc. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
US8822528B2 (en) 2010-11-16 2014-09-02 Merial Limited Monensin derivatives for the treatment and prevention of protozoal infections
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
ES2618813T3 (es) 2011-06-27 2017-06-22 Merial, Inc. Compuestos y composiciones de éter amido-piridílico y uso contra los parásitos
WO2013017678A1 (en) 2011-08-04 2013-02-07 Intervet International B.V. Novel spiroindoline compounds
RS58417B1 (sr) 2011-09-12 2019-04-30 Merial Inc Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima
WO2013044118A2 (en) 2011-09-23 2013-03-28 Merial Limited Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
AU2012340351B2 (en) 2011-11-17 2017-06-15 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof
TW201326128A (zh) 2011-11-28 2013-07-01 Du Pont 磺醯胺驅蟲劑
BR112014013371B1 (pt) 2011-12-02 2020-04-07 Merial Ltd formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
EP3216448B8 (de) 2012-02-06 2019-06-05 Boehringer Ingelheim Animal Health USA Inc. Parasitizide orale tiermedizinische zusammensetzungen mit systemisch wirkenden wirkstoffen, verfahren und verwendungen davon
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
AU2013241854B2 (en) 2012-03-28 2017-11-02 Intervet International B.V. Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
ES2744597T3 (es) 2012-03-28 2020-02-25 Intervet Int Bv Compuestos de heteroarilo con una unidad acíclica como puente
BR122015032741B1 (pt) 2012-04-20 2019-11-26 Merial Ltd composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos
NZ723198A (en) 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
WO2015066277A1 (en) 2013-11-01 2015-05-07 Merial Limited Antiparisitic and pesticidal isoxazoline compounds
EP3131398B1 (de) 2014-04-17 2019-10-23 Boehringer Ingelheim Animal Health USA Inc. Verwendung von malonsäuredinitrilverbindungen für den schutz von tieren gegen parasiten
ES2842592T3 (es) 2014-05-19 2021-07-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos antihelmínticos
EP3157912B1 (de) 2014-06-19 2019-02-20 Merial, Inc. Parasitizide zusammensetzungen mit indolderivaten, verfahren und verwendungen davon
US10864193B2 (en) 2014-10-31 2020-12-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising fipronil at high concentrations
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
LT3298027T (lt) 2015-05-20 2021-08-10 Boehringer Ingelheim Animal Health USA Inc. Antihelmintiniai depsipeptido junginiai
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
AR111260A1 (es) 2017-03-31 2019-06-19 Intervet Int Bv Formulación farmacéutica de la sal de crotonil amino piridina
BR112020003217A2 (pt) 2017-08-14 2020-10-06 Boehringer Ingelheim Animal Health USA Inc. compostos pesticidas e parasiticidas de pirazolisoxazolina
JP7688973B2 (ja) 2017-09-29 2025-06-05 ヴィクトリア リンク リミテッド ノズリスポル酸の異種生合成
EP3749096A1 (de) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasitizide zusammensetzungen mit eprinomectin und praziquantel, verfahren und verwendungen davon
WO2020002593A1 (en) 2018-06-29 2020-01-02 Intervet International B.V. Compound for use against helminthic infection
AU2019301510B2 (en) 2018-07-09 2024-06-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
CN113260419A (zh) 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
NZ776819A (en) 2019-01-16 2023-04-28 Boehringer Ingelheim Animal Health Usa Inc Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof
AU2020231319A1 (en) 2019-03-01 2021-10-21 Boehringer Ingelheim Animal Health USA Inc. Injectable clorsulon compositions, methods and uses thereof
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
AU2020406093A1 (en) 2019-12-18 2022-06-16 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
EP4077322A1 (de) 2019-12-18 2022-10-26 Intervet International B.V. Anthelmintische verbindungen mit azaindolstruktur
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
US20240043446A1 (en) 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
IL326231A (en) 2023-08-02 2026-03-01 Intervet Int Bv Carboxamide-4-quinoline compounds with anthelmintic activity
WO2025257633A1 (en) 2024-06-12 2025-12-18 Boehringer Ingelheim Vetmedica Gmbh Long-acting castor oil-containing injectable formulations and methods of use thereof
WO2026073866A1 (en) 2024-10-01 2026-04-09 Syngenta Crop Protection Ag Methods of controlling an insect of the family pentatomidae

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
DE3611168C2 (de) * 1985-04-02 1994-01-20 Asahi Chemical Ind Hydroxybenzoesäurephenylester, deren Herstellung und deren Verwendung als physiologisch wirksame Substanzen
US4873247A (en) * 1987-11-27 1989-10-10 Goegelman Robert T Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
JP2805564B2 (ja) * 1992-08-13 1998-09-30 明治製菓株式会社 新規物質ｐｆ１１０１ｂ物質及びその製造法
US5399582A (en) * 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents

Also Published As

Publication number Publication date
WO1995012599A1 (en) 1995-05-11
CZ286032B6 (cs) 1999-12-15
FI110871B (fi) 2003-04-15
EP0726902B1 (de) 2000-01-05
HU221276B1 (en) 2002-09-28
CZ124996A3 (en) 1996-10-16
NO315942B1 (no) 2003-11-17
US5614546A (en) 1997-03-25
SK281510B6 (sk) 2001-04-09
AU688405B2 (en) 1998-03-12
FI961839A0 (fi) 1996-04-30
ZA948542B (en) 1995-06-27
AU8092994A (en) 1995-05-23
CN1137796A (zh) 1996-12-11
CN1082543C (zh) 2002-04-10
JP3557212B2 (ja) 2004-08-25
DK0726902T3 (da) 2000-05-01
GR3032493T3 (en) 2000-05-31
PL314190A1 (en) 1996-09-02
CN1236012A (zh) 1999-11-24
CN1046943C (zh) 1999-12-01
DE69422526T2 (de) 2000-07-27
NZ275339A (en) 1997-11-24
EP0726902A1 (de) 1996-08-21
CA2174645C (en) 2004-09-07
KR100333017B1 (ko) 2002-09-27
FI20012318L (fi) 2001-11-27
US5399582A (en) 1995-03-21
FI112503B (fi) 2003-12-15
NO961748L (no) 1996-07-01
FI961839L (fi) 1996-04-30
PT726902E (pt) 2000-06-30
JPH09505567A (ja) 1997-06-03
HU9601138D0 (en) 1996-06-28
CA2174645A1 (en) 1995-05-11
SI0726902T1 (en) 2000-04-30
SK53996A3 (en) 1997-03-05
DE69422526D1 (de) 2000-02-10
KR960705828A (ko) 1996-11-08
PL178879B1 (pl) 2000-06-30
NO961748D0 (no) 1996-04-30
ES2143558T3 (es) 2000-05-16
RU2139874C1 (ru) 1999-10-20
HUT74959A (en) 1997-03-28

Similar Documents

Publication Publication Date Title
ATE188476T1 (de) Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung
BG102474A (en) (-)-cis-6(s)-phenyl-5(r)-[4-(2-pyrrolidine-1-yletoxi)phenyl)-5,6,7 ,8-tetrahydronaphthalen-2-ol-d-tartarate
DE3867743D1 (de) Benzamid-derivat, verfahren zu dessen herstellung und pflanzenwachstumsregulator.
UA32566C2 (uk) Спосіб одержання штаму мікроорганізму, спосіб продукування триптофану
ATE131161T1 (de) Substanz pf 1022, verfahren zu ihrer herstellung und diese substanz enthaltende anthelmintische zusammensetzung.
AU2294788A (en) Apparatus for the intensive, controlled production of microorganisms by photosynthesis
BG102016A (en) Method for the diagnostics of schizophrenia
NO20016226D0 (no) Fremgangsmåte for fremstilling av substituerte formamider
AU5104196A (en) Modified starch from plants, plants synthesizing the same, as well as process for their production
DK0879228T3 (da) Fremgangsmåde til fremstilling af d-threo-(R,R)-methylphenidat og recirkulering af uønskede enantiomerer ved epimerisering
DE3576955D1 (de) Beta-carbolin-3-oxadiazolylderivate, verfahren zu ihrer herstellung und ihre verwendung.
AU2102497A (en) Resolution of threo-methylphenidate
BG102788A (en) New methods for the preparation of intermediate compounds for presticides
ATE236139T1 (de) Verfahren zur herstellung von 2-chlor-5- chlomethyl-thiazol-derivaten
ES2039195T3 (es) Derivado de la pirazolsulfonamida, procedimiento para su fabricacion y herbicida que lo contiene.
ATE109774T1 (de) Substituierte sulfonyldiamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pflanzenwachstumsregulatoren.
DE69724141D1 (de) Verbindungen verwendbar zur perhaloalkylierung, reagenz für ihrer durchführung und verfahren zu ihrer herstellung
DE60014374D1 (de) Taxan-derivate und verfahren zu ihrer herstellung
CA2275253A1 (en) Method for producing n-substituted 3-hydroxypyrazoles
ATE154008T1 (de) Lacton-verbindung und verfahren zu ihrer herstellung
ATE175957T1 (de) Verfahren zur herstellung von alkoxyiminoacetamid-verbindungen
NO974155L (no) Ny fremgangsmåte for fremstilling av 2,3-dihydrobenzofuranolderivater
DE3866733D1 (de) Azoxyverbindungen und verfahren zu ihrer herstellung.
EP0911415A3 (de) Microbiologische Herstellung von L-Ascorbinsäure
ATE196292T1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.