ATE189608T1 - Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält - Google Patents

Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält

Info

Publication number: ATE189608T1
Authority: AT; Austria
Prior art keywords: pct; pharmaceutical compositions; containing pharmaceutical; sucrose; gonadotropin containing
Prior art date: 1991-12-18

Application number

AT93901557T

Other languages

English (en)

Inventor

Fabrizio Samaritani

Patrizia Natale

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-18

Filing date

1992-12-17

Publication date

2000-02-15

1992-12-17 Application filed by Applied Research Systems filed Critical Applied Research Systems

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE189608T1 publication Critical patent/ATE189608T1/de

Links

102000006771 Gonadotropins Human genes 0.000 title abstract 2
108010086677 Gonadotropins Proteins 0.000 title abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title abstract 2
229930006000 Sucrose Natural products 0.000 title abstract 2
239000002622 gonadotropin Substances 0.000 title abstract 2
239000005720 sucrose Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000003381 stabilizer Substances 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

AT93901557T 1991-12-18 1992-12-17 Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält ATE189608T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITRM910952A IT1250075B (it)	1991-12-18	1991-12-18	Composizioni farmaceutiche contenenti gonadotropine.
PCT/IT1992/000165 WO1993011788A1 (en)	1991-12-18	1992-12-17	Gonadotropin containing pharmaceutical compositions with sucrose stabilizer

Publications (1)

Publication Number	Publication Date
ATE189608T1 true ATE189608T1 (de)	2000-02-15

Family

ID=11400511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93901557T ATE189608T1 (de)	1991-12-18	1992-12-17	Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält

Country Status (13)

Country	Link
US (1)	US5650390A (de)
EP (1)	EP0618808B1 (de)
JP (1)	JP3702313B2 (de)
AT (1)	ATE189608T1 (de)
AU (1)	AU677773B2 (de)
CA (1)	CA2124801C (de)
DE (1)	DE69230672T2 (de)
DK (1)	DK0618808T3 (de)
ES (1)	ES2142860T3 (de)
GR (1)	GR3033276T3 (de)
IT (1)	IT1250075B (de)
PT (1)	PT618808E (de)
WO (1)	WO1993011788A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5828979A (en) *	1994-09-01	1998-10-27	Harris Corporation	Automatic train control system and method
PT814841E (pt) *	1995-03-21	2002-03-28	Applied Research Systems	Formulacoes liquidas de hcg
US6319504B1 (en)	1996-06-24	2001-11-20	University Of Maryland Biotechnology Institute	Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) *	1996-08-07	1998-05-22	Applied Research Systems	Hcg come inibitore della collagenasi
IL122732A0 (en) *	1997-01-15	1998-08-16	Akzo Nobel Nv	Liquid gonadotropin-containing formulation its preparation and a device containing same
US20030166525A1 (en) *	1998-07-23	2003-09-04	Hoffmann James Arthur	FSH Formulation
IL140984A0 (en) *	1998-07-23	2002-02-10	Lilly Co Eli	Fsh and fsh variant formulations, products and methods
JP2002541213A (ja)	1999-04-13	2002-12-03	インヘールセラピューティックシステムズ，インコーポレイテッド	不妊症の処置のための乾燥粉末処方物の肺投与
CZ303274B6 (cs) *	2000-02-22	2012-07-11	Merck Serono Sa	Zpusob vycištení luteinizacního hormonu
EA006605B1 (ru) *	2000-02-22	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
GB0121709D0 (en) *	2001-09-07	2001-10-31	Imp College Innovations Ltd	Food inhibition agent
DE60231892D1 (de) *	2001-09-12	2009-05-20	Serono Lab	Verwendung von lh für die kontrollierte ovarielle hyperstimulation
WO2003066585A2 (en) *	2002-02-08	2003-08-14	Alkermes Controlled Therapeutics, Inc.	Polymer-based compositions for sustained release
DK1610822T4 (en) *	2003-04-02	2019-01-14	Ares Trading Sa	Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant
ES2358330T5 (es) *	2003-04-02	2018-12-03	Ares Trading S.A.	Formulaciones farmacéuticas líquidas de FSH y LH junto con un tensioactivo no iónico
EP1638595B1 (de) *	2003-06-20	2013-03-20	Ares Trading S.A.	Gefriergetrocknete fsh / lh formulierungen
KR101105871B1 (ko) *	2005-09-27	2012-01-16	주식회사 엘지생명과학	인 난포자극호르몬의 안정한 용액 제형
BRPI0818324B8 (pt) *	2007-11-01	2021-05-25	Merck Serono Sa	formulação líquida contendo hormônio luteinizante (lh) ou uma variante do mesmo, seu uso, sua forma de apresentação, processo para a sua preparação e composição farmacêutica
CN101269215B (zh) *	2008-05-15	2011-03-23	上海天伟生物制药有限公司	一种糖蛋白激素组合物
CN102309747B (zh) *	2008-09-17	2013-04-17	上海天伟生物制药有限公司	高纯度绝经期促性腺素冻干针剂
WO2011076117A1 (zh) *	2009-12-22	2011-06-30	上海天伟生物制药有限公司	绝经期促性腺素组合物
JP6426410B2 (ja) *	2013-09-11	2018-11-21	第一三共株式会社	室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3637640A (en) *	1970-05-04	1972-01-25	Diagnostic Data Inc	Orgotein stabilized with saccharide process and products
US3816617A (en) *	1972-07-25	1974-06-11	American Home Prod	Method for inducing menses
DD141996A1 (de) *	1979-02-21	1980-06-04	Ingrid Wolf	Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) *	1982-12-15	1984-06-25	Takeda Chem Ind Ltd	凍結乾燥感作血球の製造法
EP0160699B1 (de) *	1983-11-02	1992-08-12	Applied Research Systems Ars Holding N.V.	Herstellung heterodimerer menschlicher fruchtbarkeitshormone
JPS60258125A (ja) *	1984-06-06	1985-12-20	Hayashibara Biochem Lab Inc	蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) *	1987-06-26	1989-04-14	Serono Cesare Ist Ricerca	Ormone follicolo-stimolante urinario
US5215743A (en) *	1988-04-13	1993-06-01	Maninder Singh	Tumor necrosis factor formulations
WO1989010407A1 (en) *	1988-04-29	1989-11-02	Genetics Institute, Inc.	Homogeneous dimeric m-csf and storage stable formulations thereof
JPH02121933A (ja) *	1988-10-28	1990-05-09	Kagaku Shiryo Kenkyusho:Kk	動物用油性ホルモン顆粒剤
US5087615A (en) *	1989-03-17	1992-02-11	Applied Research Systems Ars Holding N.V.	Novel method of ovulation induction in humans
IE64738B1 (en) *	1990-03-20	1995-09-06	Akzo Nv	Stabilized gonadotropin containing preparations

1991
- 1991-12-18 IT ITRM910952A patent/IT1250075B/it active IP Right Grant
1992
- 1992-12-17 WO PCT/IT1992/000165 patent/WO1993011788A1/en not_active Ceased
- 1992-12-17 AU AU32662/93A patent/AU677773B2/en not_active Expired
- 1992-12-17 JP JP51077493A patent/JP3702313B2/ja not_active Expired - Lifetime
- 1992-12-17 DE DE69230672T patent/DE69230672T2/de not_active Expired - Lifetime
- 1992-12-17 AT AT93901557T patent/ATE189608T1/de active
- 1992-12-17 EP EP93901557A patent/EP0618808B1/de not_active Expired - Lifetime
- 1992-12-17 US US08/244,575 patent/US5650390A/en not_active Expired - Lifetime
- 1992-12-17 PT PT93901557T patent/PT618808E/pt unknown
- 1992-12-17 CA CA002124801A patent/CA2124801C/en not_active Expired - Lifetime
- 1992-12-17 DK DK93901557T patent/DK0618808T3/da active
- 1992-12-17 ES ES93901557T patent/ES2142860T3/es not_active Expired - Lifetime
2000
- 2000-04-19 GR GR20000400959T patent/GR3033276T3/el unknown

Also Published As

Publication number	Publication date
JP3702313B2 (ja)	2005-10-05
DK0618808T3 (da)	2000-05-15
ITRM910952A0 (it)	1991-12-18
DE69230672T2 (de)	2000-09-21
ITRM910952A1 (it)	1993-06-18
PT618808E (pt)	2000-07-31
DE69230672D1 (de)	2000-03-16
GR3033276T3 (en)	2000-09-29
AU677773B2 (en)	1997-05-08
CA2124801A1 (en)	1993-06-24
EP0618808B1 (de)	2000-02-09
JPH07507047A (ja)	1995-08-03
WO1993011788A1 (en)	1993-06-24
US5650390A (en)	1997-07-22
AU3266293A (en)	1993-07-19
EP0618808A1 (de)	1994-10-12
IT1250075B (it)	1995-03-30
CA2124801C (en)	2007-08-07
ES2142860T3 (es)	2000-05-01

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2011-04-15	EEFA	Change of the company name

Publication	Publication Date	Title
ATE189608T1 (de)	2000-02-15	Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält
FI910286A0 (fi)	1991-01-18	Analoger av humant insulin och preparat innehaollande dessa.
ES2183023T3 (es)	2003-03-16	Composicion farmaceutica estabilizada con un agente basico.
EP0607297A4 (en)	1995-10-25	Hormone analogs with multiple ctp extensions.
KR920019371A (ko)	1992-11-19	안정화된 인자 ⅷ 제제
HU227154B1 (en)	2010-08-30	Liquid gonadotropin containing formulations
IL112112A (en)	2000-06-29	Peptides with growth hormone releasing properties and pharmaceutical compositions containing them
HUP0002704A2 (hu)	2000-12-28	Az 5. és a 6. helyzetben módosított GnRH antagonisták
ATE230277T1 (de)	2003-01-15	Stabilisierte antikörperformulierung
EP0346429A4 (en)	1990-10-10	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
ID905B (id)	1996-09-10	Sediaan-sediaan mengandung gonadotropin yang distabilkan
IL85523A (en)	1992-11-15	Stable alpha interferon complex,its preparation and pharmaceutical compositions comprising it
KR940703689A (ko)	1994-12-12	성장호르몬과 아스파라진으로 이루어지는 안정화된 약학제제(a stabil-ized pharmaceutical formulation comprising growth gormone and asparagine)
ITRM920349A1 (it)	1993-11-11	Composizioni farmaceutiche contenenti il-6
ATE184798T1 (de)	1999-10-15	Hgh enthaltende pharmazeutische zubereitungen
FI973745A0 (fi)	1997-09-22	HCG:n nestemäiset koostumukset
DE3854290D1 (de)	1995-09-14	Stabilisierung von therapeutisch wirksamen Proteinen in pharmazeutischen Zubereitungen.
DE69217686D1 (de)	1997-04-10	Pharmazeutische Zusammensetzung von stabilisiertem [Leu 13]-Motilin-Hse
DE59105075D1 (de)	1995-05-11	Galenische wässrige Formulierungen von Erythropoietin und ihre Verwendung.
Jöchle	1976	Influence of prostaglandin F autoantibodies on the estrous cycle of the guinea pig: Hildebrandt-Stark, HE, GJ Marcus, K. Yoshinaga, HR Behrman and RO Greep: Prostaglandins 9: 231, 1975. Lab. of Human Reprod. & Reprod. Biol., Dept. Anatomy, Harvard Medical School, Boston, Massachusetts 02115
IT1127218B (it)	1986-05-21	Polipeptidi contraccettivi
Singh et al.	1990	Plasma prolactin in relation to estrus induction during synchronization & superovulation among peri-pubertal buffaloes
DK661888A (da)	1989-01-27	Biologisk aktive molekyler