GR3033276T3 - Gonadotropin containing pharmaceutical compositions with sucrose stabilizer. - Google Patents

Gonadotropin containing pharmaceutical compositions with sucrose stabilizer.

Info

Publication number: GR3033276T3
Authority: GR; Greece
Prior art keywords: pct; pharmaceutical compositions; containing pharmaceutical; sucrose; gonadotropin containing
Prior art date: 1991-12-18

Application number

GR20000400959T

Other languages

English (en)

Inventor

Fabrizio Samaritani

Patrizia Natale

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-18

Filing date

2000-04-19

Publication date

2000-09-29

2000-04-19 Application filed by Applied Research Systems filed Critical Applied Research Systems

2000-09-29 Publication of GR3033276T3 publication Critical patent/GR3033276T3/el

Links

102000006771 Gonadotropins Human genes 0.000 title abstract 2
108010086677 Gonadotropins Proteins 0.000 title abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title abstract 2
229930006000 Sucrose Natural products 0.000 title abstract 2
239000002622 gonadotropin Substances 0.000 title abstract 2
239000005720 sucrose Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000003381 stabilizer Substances 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

GR20000400959T 1991-12-18 2000-04-19 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer. GR3033276T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITRM910952A IT1250075B (it)	1991-12-18	1991-12-18	Composizioni farmaceutiche contenenti gonadotropine.
PCT/IT1992/000165 WO1993011788A1 (en)	1991-12-18	1992-12-17	Gonadotropin containing pharmaceutical compositions with sucrose stabilizer

Publications (1)

Publication Number	Publication Date
GR3033276T3 true GR3033276T3 (en)	2000-09-29

Family

ID=11400511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20000400959T GR3033276T3 (en)	1991-12-18	2000-04-19	Gonadotropin containing pharmaceutical compositions with sucrose stabilizer.

Country Status (13)

Country	Link
US (1)	US5650390A (el)
EP (1)	EP0618808B1 (el)
JP (1)	JP3702313B2 (el)
AT (1)	ATE189608T1 (el)
AU (1)	AU677773B2 (el)
CA (1)	CA2124801C (el)
DE (1)	DE69230672T2 (el)
DK (1)	DK0618808T3 (el)
ES (1)	ES2142860T3 (el)
GR (1)	GR3033276T3 (el)
IT (1)	IT1250075B (el)
PT (1)	PT618808E (el)
WO (1)	WO1993011788A1 (el)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5828979A (en) *	1994-09-01	1998-10-27	Harris Corporation	Automatic train control system and method
DE69524456T2 (de) *	1995-03-21	2002-08-01	Applied Research Systems	Flüssige hcg-formulierungen
US6319504B1 (en)	1996-06-24	2001-11-20	University Of Maryland Biotechnology Institute	Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) *	1996-08-07	1998-05-22	Applied Research Systems	Hcg come inibitore della collagenasi
TW518235B (en) *	1997-01-15	2003-01-21	Akzo Nobel Nv	A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) *	1998-07-23	2003-09-04	Hoffmann James Arthur	FSH Formulation
CA2335340C (en) *	1998-07-23	2013-03-05	Eli Lilly And Company	Fsh and fsh variant formulations, products and methods
AU779869B2 (en)	1999-04-13	2005-02-17	Nektar Therapeutics	Pulmonary administration of dry powder formulations for treating infertility
HRP20020651B1 (en) *	2000-02-22	2011-01-31	Laboratoires Serono Sa	Purified lh
PL205149B1 (pl) *	2000-02-22	2010-03-31	Serono Lab	Sposób przygotowania rekombinowanej hCG
GB0121709D0 (en) *	2001-09-07	2001-10-31	Imp College Innovations Ltd	Food inhibition agent
SI1434600T1 (sl) *	2001-09-12	2009-06-30	Serono Lab	Uporaba lh za kontrolirano hiperstimulacijo ovarijev
NZ535008A (en) *	2002-02-08	2005-09-30	Alkermes Inc	Polymer-based compositions for sustained release
WO2004087213A1 (en) *	2003-04-02	2004-10-14	Ares Trading S.A.	Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
ES2358330T5 (es) *	2003-04-02	2018-12-03	Ares Trading S.A.	Formulaciones farmacéuticas líquidas de FSH y LH junto con un tensioactivo no iónico
WO2004112826A1 (en) *	2003-06-20	2004-12-29	Ares Trading Sa	Freeze-dried fsh / lh formulations
KR101105871B1 (ko) *	2005-09-27	2012-01-16	주식회사 엘지생명과학	인 난포자극호르몬의 안정한 용액 제형
ES2393233T3 (es) *	2007-11-01	2012-12-19	Merck Serono S.A.	Formulaciones de LH líquidas
CN101269215B (zh) *	2008-05-15	2011-03-23	上海天伟生物制药有限公司	一种糖蛋白激素组合物
CN102309747B (zh) *	2008-09-17	2013-04-17	上海天伟生物制药有限公司	高纯度绝经期促性腺素冻干针剂
CN102100908B (zh) *	2009-12-22	2013-05-08	上海天伟生物制药有限公司	一种蛋白质组合物
JP6426410B2 (ja) *	2013-09-11	2018-11-21	第一三共株式会社	室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3637640A (en) *	1970-05-04	1972-01-25	Diagnostic Data Inc	Orgotein stabilized with saccharide process and products
US3816617A (en) *	1972-07-25	1974-06-11	American Home Prod	Method for inducing menses
DD141996A1 (de) *	1979-02-21	1980-06-04	Ingrid Wolf	Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) *	1982-12-15	1984-06-25	Takeda Chem Ind Ltd	凍結乾燥感作血球の製造法
DE10199028I2 (de) *	1983-11-02	2004-07-01	Applied Research Systems	Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
JPS60258125A (ja) *	1984-06-06	1985-12-20	Hayashibara Biochem Lab Inc	蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) *	1987-06-26	1989-04-14	Serono Cesare Ist Ricerca	Ormone follicolo-stimolante urinario
US5215743A (en) *	1988-04-13	1993-06-01	Maninder Singh	Tumor necrosis factor formulations
ATE111157T1 (de) *	1988-04-29	1994-09-15	Genetics Inst	Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf.
JPH02121933A (ja) *	1988-10-28	1990-05-09	Kagaku Shiryo Kenkyusho:Kk	動物用油性ホルモン顆粒剤
US5087615A (en) *	1989-03-17	1992-02-11	Applied Research Systems Ars Holding N.V.	Novel method of ovulation induction in humans
IE64738B1 (en) *	1990-03-20	1995-09-06	Akzo Nv	Stabilized gonadotropin containing preparations

1991
- 1991-12-18 IT ITRM910952A patent/IT1250075B/it active IP Right Grant
1992
- 1992-12-17 EP EP93901557A patent/EP0618808B1/en not_active Expired - Lifetime
- 1992-12-17 JP JP51077493A patent/JP3702313B2/ja not_active Expired - Lifetime
- 1992-12-17 AT AT93901557T patent/ATE189608T1/de active
- 1992-12-17 AU AU32662/93A patent/AU677773B2/en not_active Expired
- 1992-12-17 CA CA002124801A patent/CA2124801C/en not_active Expired - Lifetime
- 1992-12-17 US US08/244,575 patent/US5650390A/en not_active Expired - Lifetime
- 1992-12-17 PT PT93901557T patent/PT618808E/pt unknown
- 1992-12-17 DK DK93901557T patent/DK0618808T3/da active
- 1992-12-17 DE DE69230672T patent/DE69230672T2/de not_active Expired - Lifetime
- 1992-12-17 ES ES93901557T patent/ES2142860T3/es not_active Expired - Lifetime
- 1992-12-17 WO PCT/IT1992/000165 patent/WO1993011788A1/en not_active Ceased
2000
- 2000-04-19 GR GR20000400959T patent/GR3033276T3/el unknown

Also Published As

Publication number	Publication date
DE69230672D1 (de)	2000-03-16
CA2124801A1 (en)	1993-06-24
PT618808E (pt)	2000-07-31
DE69230672T2 (de)	2000-09-21
CA2124801C (en)	2007-08-07
EP0618808A1 (en)	1994-10-12
US5650390A (en)	1997-07-22
DK0618808T3 (da)	2000-05-15
IT1250075B (it)	1995-03-30
EP0618808B1 (en)	2000-02-09
ITRM910952A0 (it)	1991-12-18
ES2142860T3 (es)	2000-05-01
WO1993011788A1 (en)	1993-06-24
ATE189608T1 (de)	2000-02-15
AU677773B2 (en)	1997-05-08
AU3266293A (en)	1993-07-19
ITRM910952A1 (it)	1993-06-18
JPH07507047A (ja)	1995-08-03
JP3702313B2 (ja)	2005-10-05

Publication	Publication Date	Title
DK0618808T3 (da)	2000-05-15	Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator
IL112112A (en)	2000-06-29	Peptides with growth hormone releasing properties and pharmaceutical compositions containing them
MY128629A (en)	2007-02-28	Stabilized interleukin 2
EP0346429A4 (en)	1990-10-10	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
NO905472D0 (no)	1990-12-19	Insulinanaloger fra menneske og blandinger som inneholderdem.
IL133220A0 (en)	2001-03-19	Stabilized antibody formulation
GR3029791T3 (en)	1999-06-30	Improved immunogenic compositions against human gastrin 17
AU7362391A (en)	1991-09-26	Stabilized gonadotropin containing preparations
CA2151732A1 (en)	1994-07-07	Stable lyophilized pharmaceutical preparations of g-csf
NZ512792A (en)	2002-11-26	Stable liquid interferon beta formulations
CA2240541A1 (en)	1997-07-03	Stabilisers for live vaccines
EP0276166A3 (en)	1989-12-27	Composition and method for producing superovulation in cattle
EP0999220A3 (en)	2000-09-20	Low molecular weight peptidomimetic growth hormone secretagogues
GR3024708T3 (en)	1997-12-31	Pharmaceutical compositions containing il-6.
ATE177645T1 (de)	1999-04-15	Stabilisierte pharmazeutische formulierung, die wachstumshormon und asparagin enthält
GR3031687T3 (en)	2000-02-29	Hgh containing pharmaceutical compositions
TR200003063T2 (tr)	2001-02-21	Üreme bozukluklarının tedavisi
IT1272252B (it)	1997-06-16	Formulazioni liquide di interferone beta
IL103383A0 (en)	1993-03-15	Pharmaceutical compositions containing glutamine and methods for the use thereof
IL87778A0 (en)	1989-03-31	Pharmaceutical compositions containing stabilized therapeutically active proteins and their preparation
Jöchle	1976	Influence of prostaglandin F autoantibodies on the estrous cycle of the guinea pig: Hildebrandt-Stark, HE, GJ Marcus, K. Yoshinaga, HR Behrman and RO Greep: Prostaglandins 9: 231, 1975. Lab. of Human Reprod. & Reprod. Biol., Dept. Anatomy, Harvard Medical School, Boston, Massachusetts 02115
MX9800309A (es)	1998-07-31	Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento y un peptido que comprende al menos un residuo de aminoacido basico y al menos un residuo de aminoacido acido.
MX9710377A (es)	1998-03-29	Compuestos con propiedades de liberacion de la hormona de crecimiento.
IL97933A0 (en)	1992-06-21	Monoclonal antibodies to porcine somatotropin and pharmaceutical compositions containing the same