ES2142860T3 - Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa. - Google Patents

Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa.

Info

Publication number
ES2142860T3
ES2142860T3 ES93901557T ES93901557T ES2142860T3 ES 2142860 T3 ES2142860 T3 ES 2142860T3 ES 93901557 T ES93901557 T ES 93901557T ES 93901557 T ES93901557 T ES 93901557T ES 2142860 T3 ES2142860 T3 ES 2142860T3
Authority
ES
Spain
Prior art keywords
sacarosa
stabilizer
pharmaceutical compositions
compositions containing
gonadotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93901557T
Other languages
English (en)
Inventor
Fabrizio Samaritani
Patrizia Natale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of ES2142860T3 publication Critical patent/ES2142860T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COMPUESTOS FARMACEUTICOS QUE CONTIENEN FSH, LH O HCG ESTABILIZADOS POR MEDIOS DE SACAROSA. LA FORMULA ES PARTICULARMENTE CONVENIENTE PARA ESTABILIZAR LIOFILISATO DE GONADOTROPINES RECOMBINANTES.
ES93901557T 1991-12-18 1992-12-17 Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa. Expired - Lifetime ES2142860T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910952A IT1250075B (it) 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine.

Publications (1)

Publication Number Publication Date
ES2142860T3 true ES2142860T3 (es) 2000-05-01

Family

ID=11400511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93901557T Expired - Lifetime ES2142860T3 (es) 1991-12-18 1992-12-17 Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa.

Country Status (13)

Country Link
US (1) US5650390A (es)
EP (1) EP0618808B1 (es)
JP (1) JP3702313B2 (es)
AT (1) ATE189608T1 (es)
AU (1) AU677773B2 (es)
CA (1) CA2124801C (es)
DE (1) DE69230672T2 (es)
DK (1) DK0618808T3 (es)
ES (1) ES2142860T3 (es)
GR (1) GR3033276T3 (es)
IT (1) IT1250075B (es)
PT (1) PT618808E (es)
WO (1) WO1993011788A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5828979A (en) * 1994-09-01 1998-10-27 Harris Corporation Automatic train control system and method
DE69524456T2 (de) * 1995-03-21 2002-08-01 Applied Research Systems Flüssige hcg-formulierungen
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) * 1996-08-07 1998-05-22 Applied Research Systems Hcg come inibitore della collagenasi
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
CA2335340C (en) * 1998-07-23 2013-03-05 Eli Lilly And Company Fsh and fsh variant formulations, products and methods
AU779869B2 (en) 1999-04-13 2005-02-17 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
HRP20020651B1 (en) * 2000-02-22 2011-01-31 Laboratoires Serono Sa Purified lh
PL205149B1 (pl) * 2000-02-22 2010-03-31 Serono Lab Sposób przygotowania rekombinowanej hCG
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
SI1434600T1 (sl) * 2001-09-12 2009-06-30 Serono Lab Uporaba lh za kontrolirano hiperstimulacijo ovarijev
NZ535008A (en) * 2002-02-08 2005-09-30 Alkermes Inc Polymer-based compositions for sustained release
WO2004087213A1 (en) * 2003-04-02 2004-10-14 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
ES2358330T5 (es) * 2003-04-02 2018-12-03 Ares Trading S.A. Formulaciones farmacéuticas líquidas de FSH y LH junto con un tensioactivo no iónico
WO2004112826A1 (en) * 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
ES2393233T3 (es) * 2007-11-01 2012-12-19 Merck Serono S.A. Formulaciones de LH líquidas
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
CN102309747B (zh) * 2008-09-17 2013-04-17 上海天伟生物制药有限公司 高纯度绝经期促性腺素冻干针剂
CN102100908B (zh) * 2009-12-22 2013-05-08 上海天伟生物制药有限公司 一种蛋白质组合物
JP6426410B2 (ja) * 2013-09-11 2018-11-21 第一三共株式会社 室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637640A (en) * 1970-05-04 1972-01-25 Diagnostic Data Inc Orgotein stabilized with saccharide process and products
US3816617A (en) * 1972-07-25 1974-06-11 American Home Prod Method for inducing menses
DD141996A1 (de) * 1979-02-21 1980-06-04 Ingrid Wolf Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) * 1982-12-15 1984-06-25 Takeda Chem Ind Ltd 凍結乾燥感作血球の製造法
DE10199028I2 (de) * 1983-11-02 2004-07-01 Applied Research Systems Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5215743A (en) * 1988-04-13 1993-06-01 Maninder Singh Tumor necrosis factor formulations
ATE111157T1 (de) * 1988-04-29 1994-09-15 Genetics Inst Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf.
JPH02121933A (ja) * 1988-10-28 1990-05-09 Kagaku Shiryo Kenkyusho:Kk 動物用油性ホルモン顆粒剤
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations

Also Published As

Publication number Publication date
DE69230672D1 (de) 2000-03-16
CA2124801A1 (en) 1993-06-24
PT618808E (pt) 2000-07-31
DE69230672T2 (de) 2000-09-21
CA2124801C (en) 2007-08-07
EP0618808A1 (en) 1994-10-12
US5650390A (en) 1997-07-22
DK0618808T3 (da) 2000-05-15
IT1250075B (it) 1995-03-30
EP0618808B1 (en) 2000-02-09
ITRM910952A0 (it) 1991-12-18
GR3033276T3 (en) 2000-09-29
WO1993011788A1 (en) 1993-06-24
ATE189608T1 (de) 2000-02-15
AU677773B2 (en) 1997-05-08
AU3266293A (en) 1993-07-19
ITRM910952A1 (it) 1993-06-18
JPH07507047A (ja) 1995-08-03
JP3702313B2 (ja) 2005-10-05

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