DK0618808T3 - Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator - Google Patents

Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator

Info

Publication number: DK0618808T3
Authority: DK; Denmark
Prior art keywords: pct; pharmaceuticals containing; sucrose; containing gonadotropin; sec
Prior art date: 1991-12-18

Application number

DK93901557T

Other languages

English (en)

Inventor

Fabrizio Samaritani

Patrizia Natale

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-18

Filing date

1992-12-17

Publication date

2000-05-15

1992-12-17 Application filed by Applied Research Systems filed Critical Applied Research Systems

2000-05-15 Application granted granted Critical

2000-05-15 Publication of DK0618808T3 publication Critical patent/DK0618808T3/da

Links

102000006771 Gonadotropins Human genes 0.000 title abstract 2
108010086677 Gonadotropins Proteins 0.000 title abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title abstract 2
229930006000 Sucrose Natural products 0.000 title abstract 2
239000002622 gonadotropin Substances 0.000 title abstract 2
239000005720 sucrose Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000003381 stabilizer Substances 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

DK93901557T 1991-12-18 1992-12-17 Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator DK0618808T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITRM910952A IT1250075B (it)	1991-12-18	1991-12-18	Composizioni farmaceutiche contenenti gonadotropine.
PCT/IT1992/000165 WO1993011788A1 (en)	1991-12-18	1992-12-17	Gonadotropin containing pharmaceutical compositions with sucrose stabilizer

Publications (1)

Publication Number	Publication Date
DK0618808T3 true DK0618808T3 (da)	2000-05-15

Family

ID=11400511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93901557T DK0618808T3 (da)	1991-12-18	1992-12-17	Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator

Country Status (13)

Country	Link
US (1)	US5650390A (da)
EP (1)	EP0618808B1 (da)
JP (1)	JP3702313B2 (da)
AT (1)	ATE189608T1 (da)
AU (1)	AU677773B2 (da)
CA (1)	CA2124801C (da)
DE (1)	DE69230672T2 (da)
DK (1)	DK0618808T3 (da)
ES (1)	ES2142860T3 (da)
GR (1)	GR3033276T3 (da)
IT (1)	IT1250075B (da)
PT (1)	PT618808E (da)
WO (1)	WO1993011788A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5828979A (en) *	1994-09-01	1998-10-27	Harris Corporation	Automatic train control system and method
DE69524456T2 (de) *	1995-03-21	2002-08-01	Applied Research Systems	Flüssige hcg-formulierungen
US6319504B1 (en)	1996-06-24	2001-11-20	University Of Maryland Biotechnology Institute	Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) *	1996-08-07	1998-05-22	Applied Research Systems	Hcg come inibitore della collagenasi
TW518235B (en) *	1997-01-15	2003-01-21	Akzo Nobel Nv	A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) *	1998-07-23	2003-09-04	Hoffmann James Arthur	FSH Formulation
CA2335340C (en) *	1998-07-23	2013-03-05	Eli Lilly And Company	Fsh and fsh variant formulations, products and methods
AU779869B2 (en)	1999-04-13	2005-02-17	Nektar Therapeutics	Pulmonary administration of dry powder formulations for treating infertility
HRP20020651B1 (en) *	2000-02-22	2011-01-31	Laboratoires Serono Sa	Purified lh
PL205149B1 (pl) *	2000-02-22	2010-03-31	Serono Lab	Sposób przygotowania rekombinowanej hCG
GB0121709D0 (en) *	2001-09-07	2001-10-31	Imp College Innovations Ltd	Food inhibition agent
SI1434600T1 (sl) *	2001-09-12	2009-06-30	Serono Lab	Uporaba lh za kontrolirano hiperstimulacijo ovarijev
NZ535008A (en) *	2002-02-08	2005-09-30	Alkermes Inc	Polymer-based compositions for sustained release
WO2004087213A1 (en) *	2003-04-02	2004-10-14	Ares Trading S.A.	Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
ES2358330T5 (es) *	2003-04-02	2018-12-03	Ares Trading S.A.	Formulaciones farmacéuticas líquidas de FSH y LH junto con un tensioactivo no iónico
WO2004112826A1 (en) *	2003-06-20	2004-12-29	Ares Trading Sa	Freeze-dried fsh / lh formulations
KR101105871B1 (ko) *	2005-09-27	2012-01-16	주식회사 엘지생명과학	인 난포자극호르몬의 안정한 용액 제형
ES2393233T3 (es) *	2007-11-01	2012-12-19	Merck Serono S.A.	Formulaciones de LH líquidas
CN101269215B (zh) *	2008-05-15	2011-03-23	上海天伟生物制药有限公司	一种糖蛋白激素组合物
CN102309747B (zh) *	2008-09-17	2013-04-17	上海天伟生物制药有限公司	高纯度绝经期促性腺素冻干针剂
CN102100908B (zh) *	2009-12-22	2013-05-08	上海天伟生物制药有限公司	一种蛋白质组合物
JP6426410B2 (ja) *	2013-09-11	2018-11-21	第一三共株式会社	室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3637640A (en) *	1970-05-04	1972-01-25	Diagnostic Data Inc	Orgotein stabilized with saccharide process and products
US3816617A (en) *	1972-07-25	1974-06-11	American Home Prod	Method for inducing menses
DD141996A1 (de) *	1979-02-21	1980-06-04	Ingrid Wolf	Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) *	1982-12-15	1984-06-25	Takeda Chem Ind Ltd	凍結乾燥感作血球の製造法
DE10199028I2 (de) *	1983-11-02	2004-07-01	Applied Research Systems	Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
JPS60258125A (ja) *	1984-06-06	1985-12-20	Hayashibara Biochem Lab Inc	蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) *	1987-06-26	1989-04-14	Serono Cesare Ist Ricerca	Ormone follicolo-stimolante urinario
US5215743A (en) *	1988-04-13	1993-06-01	Maninder Singh	Tumor necrosis factor formulations
ATE111157T1 (de) *	1988-04-29	1994-09-15	Genetics Inst	Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf.
JPH02121933A (ja) *	1988-10-28	1990-05-09	Kagaku Shiryo Kenkyusho:Kk	動物用油性ホルモン顆粒剤
US5087615A (en) *	1989-03-17	1992-02-11	Applied Research Systems Ars Holding N.V.	Novel method of ovulation induction in humans
IE64738B1 (en) *	1990-03-20	1995-09-06	Akzo Nv	Stabilized gonadotropin containing preparations

1991
- 1991-12-18 IT ITRM910952A patent/IT1250075B/it active IP Right Grant
1992
- 1992-12-17 EP EP93901557A patent/EP0618808B1/en not_active Expired - Lifetime
- 1992-12-17 JP JP51077493A patent/JP3702313B2/ja not_active Expired - Lifetime
- 1992-12-17 AT AT93901557T patent/ATE189608T1/de active
- 1992-12-17 AU AU32662/93A patent/AU677773B2/en not_active Expired
- 1992-12-17 CA CA002124801A patent/CA2124801C/en not_active Expired - Lifetime
- 1992-12-17 US US08/244,575 patent/US5650390A/en not_active Expired - Lifetime
- 1992-12-17 PT PT93901557T patent/PT618808E/pt unknown
- 1992-12-17 DK DK93901557T patent/DK0618808T3/da active
- 1992-12-17 DE DE69230672T patent/DE69230672T2/de not_active Expired - Lifetime
- 1992-12-17 ES ES93901557T patent/ES2142860T3/es not_active Expired - Lifetime
- 1992-12-17 WO PCT/IT1992/000165 patent/WO1993011788A1/en not_active Ceased
2000
- 2000-04-19 GR GR20000400959T patent/GR3033276T3/el unknown

Also Published As

Publication number	Publication date
DE69230672D1 (de)	2000-03-16
CA2124801A1 (en)	1993-06-24
PT618808E (pt)	2000-07-31
DE69230672T2 (de)	2000-09-21
CA2124801C (en)	2007-08-07
EP0618808A1 (en)	1994-10-12
US5650390A (en)	1997-07-22
IT1250075B (it)	1995-03-30
EP0618808B1 (en)	2000-02-09
ITRM910952A0 (it)	1991-12-18
ES2142860T3 (es)	2000-05-01
GR3033276T3 (en)	2000-09-29
WO1993011788A1 (en)	1993-06-24
ATE189608T1 (de)	2000-02-15
AU677773B2 (en)	1997-05-08
AU3266293A (en)	1993-07-19
ITRM910952A1 (it)	1993-06-18
JPH07507047A (ja)	1995-08-03
JP3702313B2 (ja)	2005-10-05

Publication	Publication Date	Title
GR3033276T3 (en)	2000-09-29	Gonadotropin containing pharmaceutical compositions with sucrose stabilizer.
IL133220A0 (en)	2001-03-19	Stabilized antibody formulation
FI910286A0 (fi)	1991-01-18	Analoger av humant insulin och preparat innehaollande dessa.
EP0346429A4 (en)	1990-10-10	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
ITRM920349A1 (it)	1993-11-11	Composizioni farmaceutiche contenenti il-6
KR940703689A (ko)	1994-12-12	성장호르몬과 아스파라진으로 이루어지는 안정화된 약학제제(a stabil-ized pharmaceutical formulation comprising growth gormone and asparagine)
NZ512792A (en)	2002-11-26	Stable liquid interferon beta formulations
DK1629849T3 (da)	2013-08-12	Farmaceutiske sammensætninger indeholdende exendiner og deres agonister
DK0448146T3 (da)	1994-10-24	Stabiliserede gonadotropinholdige præparater
SE8703938D0 (sv)	1987-10-12	Peptide derivatives
NO941186D0 (no)	1994-03-30	Hormonanaloger med multiple CTP-forlengelser
MX9703550A (es)	1997-08-30	Secretagogos de hormona del crecimiento, peptidomimeticos, de bajo peso molecular.
NO982861D0 (no)	1998-06-19	Stabilisatorer for levende vaksiner
SE8804570L (sv)	1989-06-22	Ciclosporinkristallform, foerfarande foer dess framstaellning, farmaceutiska kompositioner innehaallande densamma samt dess anvaendning
DK0804223T3 (da)	2000-01-24	Farmaceutiske præparater indeholdende hGH
DE69228749D1 (de)	1999-04-29	Neuartige polypeptide und ihre verwendung
NZ336793A (en)	2000-08-25	Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture
NO884123D0 (no)	1988-09-16	Stabilisering av terapeutisk virksomme proteiner i farmasoeytiske preparater.
DK0441106T3 (da)	1994-10-24	Thyoxin til genopbygning af neuronal plasticitet
HUP9802286A2 (hu)	1999-02-01	Stabilizált gyógyszerkészítmény amely valamely növekedési hormont és legalább egy bázikus aminosavmaradékot és legalább egy savas aminosav maradékot tartalmazó peptidet foglal magában
DE69217686D1 (de)	1997-04-10	Pharmazeutische Zusammensetzung von stabilisiertem [Leu 13]-Motilin-Hse
Jöchle	1976	Influence of prostaglandin F autoantibodies on the estrous cycle of the guinea pig: Hildebrandt-Stark, HE, GJ Marcus, K. Yoshinaga, HR Behrman and RO Greep: Prostaglandins 9: 231, 1975. Lab. of Human Reprod. & Reprod. Biol., Dept. Anatomy, Harvard Medical School, Boston, Massachusetts 02115
IT1127218B (it)	1986-05-21	Polipeptidi contraccettivi
MX9710377A (es)	1998-03-29	Compuestos con propiedades de liberacion de la hormona de crecimiento.