ATE191916T1 - Neues sphingolglycolipid und verwendung davon - Google Patents
Neues sphingolglycolipid und verwendung davonInfo
- Publication number
- ATE191916T1 ATE191916T1 AT93923043T AT93923043T ATE191916T1 AT E191916 T1 ATE191916 T1 AT E191916T1 AT 93923043 T AT93923043 T AT 93923043T AT 93923043 T AT93923043 T AT 93923043T AT E191916 T1 ATE191916 T1 AT E191916T1
- Authority
- AT
- Austria
- Prior art keywords
- galactosyl
- represent
- aminohexosyl
- glucosyl
- glycolipide
- Prior art date
Links
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 abstract 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 2
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- -1 alpha -galactosyl Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000625 hexosyl group Chemical group 0.000 abstract 1
- 230000002434 immunopotentiative effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001805 pentosyl group Chemical group 0.000 abstract 1
- 125000005629 sialic acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30812492 | 1992-10-22 | ||
| PCT/JP1993/001523 WO1994009020A1 (fr) | 1992-10-22 | 1993-10-22 | Nouveau shingoglycolipide et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191916T1 true ATE191916T1 (de) | 2000-05-15 |
Family
ID=17977176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93923043T ATE191916T1 (de) | 1992-10-22 | 1993-10-22 | Neues sphingolglycolipid und verwendung davon |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5849716A (de) |
| EP (1) | EP0666268B1 (de) |
| JP (1) | JP3717512B2 (de) |
| KR (1) | KR100281264B1 (de) |
| AT (1) | ATE191916T1 (de) |
| AU (1) | AU683026B2 (de) |
| CA (1) | CA2147629C (de) |
| DE (1) | DE69328435T2 (de) |
| WO (1) | WO1994009020A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1520583B1 (de) * | 1997-04-10 | 2009-01-28 | Kyowa Hakko Kirin Co., Ltd. | NKT-Zellenaktivatoren, die Alpha-Glycosylceramide enthalten |
| EP1053243B1 (de) * | 1998-02-12 | 2011-03-30 | Emory University | Sphingolipid-derivate und verfahren zu deren verwendung |
| JP4099267B2 (ja) * | 1998-08-07 | 2008-06-11 | 株式会社紀文フードケミファ | 乳化剤および乳化組成物 |
| EP1349567A4 (de) * | 2000-12-08 | 2005-10-12 | Childrens Memorial Hospital | Zusammensetzungen mit gangliosiden zur verwendung bei der behandlung von hauterkrankungen |
| AU2002327338A1 (en) * | 2001-07-25 | 2003-02-17 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| WO2003105769A2 (en) * | 2002-06-13 | 2003-12-24 | New York University | Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| ES2450043T3 (es) | 2003-02-14 | 2014-03-21 | Japan As Represented By President Of National Center Of Neurology And Psychiatry Ministry Of Healt | Derivados del glicolípido, proceso para su producción, intermedios para la síntesis del mismo, y proceso para la producción de los intermedios |
| US7645873B2 (en) * | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| EP1647277A4 (de) * | 2003-07-17 | 2011-09-21 | Otsuka Pharma Co Ltd | Glycosid enthaltendes liposom |
| US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| CA2560969A1 (en) * | 2004-03-31 | 2005-11-03 | New York University | Novel synthetic c-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases |
| US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| AU2005280163B2 (en) * | 2004-08-27 | 2011-11-24 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| DE602005025005D1 (de) | 2004-10-07 | 2011-01-05 | Argos Therapeutics Inc | Zusammensetzungen reifer dendritischer zellen und verfahren zu deren kultivierung |
| JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| DK1848813T3 (da) | 2005-01-28 | 2013-07-15 | Univ Brigham Young | Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler |
| US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| JP5392451B2 (ja) * | 2005-12-27 | 2014-01-22 | 国立大学法人 琉球大学 | 抗腫瘍剤及び免疫賦活剤 |
| WO2007118234A2 (en) | 2006-04-07 | 2007-10-18 | The Scripps Research Institute | Modified -galactosyl ceramides for staining and stimulating natural killer t cells |
| AU2007269299B2 (en) * | 2006-06-30 | 2013-01-17 | Brigham Young University | Adjuvants and methods of use |
| EP2112930B1 (de) | 2007-02-21 | 2017-01-11 | Vaccinex, Inc. | Modulation der nkt-zellaktivität mit antigenbeladenen cdid-molekülen |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| EP2058011A1 (de) * | 2007-11-07 | 2009-05-13 | Wittycell | NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel |
| BRPI0820960B8 (pt) * | 2007-12-05 | 2021-05-25 | Abivax | composição, composição farmacêutica, e uso da composição |
| WO2009119692A1 (ja) | 2008-03-25 | 2009-10-01 | 独立行政法人理化学研究所 | 新規糖脂質及びその用途 |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| WO2010030012A1 (ja) | 2008-09-11 | 2010-03-18 | 独立行政法人理化学研究所 | エステル化α-ガラクトシルセラミド類 |
| US9220767B2 (en) * | 2008-10-08 | 2015-12-29 | Abivax | Vaccine composition for use against influenza |
| KR101928684B1 (ko) * | 2009-01-08 | 2018-12-12 | 앨버트 아인슈타인 컬리지 오브 메디신, 인크. | 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| US10813950B2 (en) | 2010-12-02 | 2020-10-27 | Riken | Immunotherapy using allo-NKT cells, cells for immunotherapy in which alpha chain of t-cell receptor (TCR) gene has been rearranged to uniform Vα-Jα, and banking of NKT cells derived from said cells |
| JP6057300B2 (ja) | 2011-01-05 | 2017-01-11 | ナショナル タイワン ユニバーシティ | グリコスフィンゴ脂質の調製及びその使用の方法 |
| WO2012165394A1 (ja) * | 2011-05-27 | 2012-12-06 | 学校法人近畿大学 | 抗腫瘍剤 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| US9464105B2 (en) | 2012-08-03 | 2016-10-11 | Riken | Hydroxylated KRN7000 analogue and use thereof |
| US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| US9821035B2 (en) | 2012-08-22 | 2017-11-21 | Regimmune Corporation | Preparation for preventing or treating type I diabetes |
| US20150283235A1 (en) | 2012-11-05 | 2015-10-08 | Regimmune Corporation | Immune-tolerance inducer |
| EP2923208B1 (de) | 2012-11-21 | 2019-01-16 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Verfahren zur bestimmung des risikos zur akuten transplantat-wirt-reaktion |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (de) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glykankonjugate und verwendung davon |
| EP3041484B1 (de) | 2013-09-06 | 2021-03-03 | Academia Sinica | Humane inkt-zell-aktivierung mittels glykolipiden mit veränderten glycosylgruppen |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
| JP2017518989A (ja) | 2014-05-27 | 2017-07-13 | アカデミア シニカAcademia Sinica | 抗cd20糖操作抗体群およびその使用 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR20170010003A (ko) | 2014-05-27 | 2017-01-25 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
| EP4116329A1 (de) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2-glykoantikörper und verwendungen davon |
| JP7063538B2 (ja) | 2014-05-28 | 2022-05-09 | アカデミア シニカ | 抗TNFα糖操作抗体群およびその使用 |
| EP3191500A4 (de) | 2014-09-08 | 2018-04-11 | Academia Sinica | Aktivierung menschlicher inkt-zellen mithilfe von glykolipiden |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| CN109195996A (zh) | 2016-03-08 | 2019-01-11 | 中央研究院 | N-聚醣及其阵列的模组化合成方法 |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| WO2022118913A1 (ja) | 2020-12-04 | 2022-06-09 | 株式会社レグイミューン | 体内動態が改善されたCD1dリガンド化合物含有リポソーム製剤 |
| WO2025121339A1 (ja) | 2023-12-04 | 2025-06-12 | 株式会社アンビシオン | リポソーム剤、nkt細胞活性化剤、医薬組成物、およびこれらの用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4598051A (en) * | 1980-03-12 | 1986-07-01 | The Regents Of The University Of California | Liposome conjugates and diagnostic methods therewith |
| US4806466A (en) * | 1981-10-29 | 1989-02-21 | The Regents Of The University Of California | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes |
| IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
| EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
| DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
| EP0212400B1 (de) * | 1985-08-13 | 1992-01-02 | Solco Basel AG | Neues Verfahren zur Herstellung von Sphingosinderivaten |
| DD261165A5 (de) * | 1985-08-13 | 1988-10-19 | Solco Basel Ag,Ch | Neues verfahren zur herstellung von sphingosinderivaten |
| JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
| US4990603A (en) * | 1986-07-04 | 1991-02-05 | Mect Corporation | Sialic acid derivatives and process therefor |
| US4937232A (en) * | 1986-09-15 | 1990-06-26 | Duke University | Inhibition of protein kinase C by long-chain bases |
| US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
| US5026557A (en) * | 1987-09-09 | 1991-06-25 | The Liposome Company, Inc. | Adjuvant composition |
| JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
| US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
| US5028715A (en) * | 1989-02-06 | 1991-07-02 | Southwest Research Institute | Radioprotective agents and their method of manufacture |
| EP0425821B1 (de) * | 1989-09-29 | 1994-08-10 | Ajinomoto Co., Inc. | Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten |
| JP3068910B2 (ja) * | 1990-11-08 | 2000-07-24 | 麒麟麦酒株式会社 | 新規スフィンゴ糖脂質、その製造法および使用 |
| JPH06145189A (ja) * | 1991-01-23 | 1994-05-24 | Kitasato Inst:The | スフィンゴ糖脂質 |
| JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
| TW261533B (de) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
| JPH06239597A (ja) * | 1993-02-18 | 1994-08-30 | Hitachi Zosen Corp | 箱型ブロック用作業台装置 |
| US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
-
1993
- 1993-10-22 AT AT93923043T patent/ATE191916T1/de not_active IP Right Cessation
- 1993-10-22 WO PCT/JP1993/001523 patent/WO1994009020A1/ja not_active Ceased
- 1993-10-22 KR KR1019950701544A patent/KR100281264B1/ko not_active Expired - Fee Related
- 1993-10-22 DE DE69328435T patent/DE69328435T2/de not_active Expired - Fee Related
- 1993-10-22 AU AU52860/93A patent/AU683026B2/en not_active Ceased
- 1993-10-22 JP JP50984894A patent/JP3717512B2/ja not_active Expired - Fee Related
- 1993-10-22 US US08/416,917 patent/US5849716A/en not_active Expired - Fee Related
- 1993-10-22 CA CA002147629A patent/CA2147629C/en not_active Expired - Fee Related
- 1993-10-22 EP EP93923043A patent/EP0666268B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU683026B2 (en) | 1997-10-30 |
| KR100281264B1 (ko) | 2001-02-01 |
| CA2147629C (en) | 2005-03-22 |
| JP3717512B2 (ja) | 2005-11-16 |
| DE69328435D1 (de) | 2000-05-25 |
| AU5286093A (en) | 1994-05-09 |
| EP0666268A4 (de) | 1995-06-27 |
| DE69328435T2 (de) | 2000-09-14 |
| EP0666268A1 (de) | 1995-08-09 |
| KR950704341A (ko) | 1995-11-20 |
| CA2147629A1 (en) | 1994-04-28 |
| WO1994009020A1 (fr) | 1994-04-28 |
| HK1009968A1 (en) | 1999-09-17 |
| US5849716A (en) | 1998-12-15 |
| EP0666268B1 (de) | 2000-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |