ATE191916T1 - Neues sphingolglycolipid und verwendung davon - Google Patents
Neues sphingolglycolipid und verwendung davonInfo
- Publication number
- ATE191916T1 ATE191916T1 AT93923043T AT93923043T ATE191916T1 AT E191916 T1 ATE191916 T1 AT E191916T1 AT 93923043 T AT93923043 T AT 93923043T AT 93923043 T AT93923043 T AT 93923043T AT E191916 T1 ATE191916 T1 AT E191916T1
- Authority
- AT
- Austria
- Prior art keywords
- galactosyl
- represent
- aminohexosyl
- glucosyl
- glycolipide
- Prior art date
Links
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 abstract 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 2
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- -1 alpha -galactosyl Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000625 hexosyl group Chemical group 0.000 abstract 1
- 230000002434 immunopotentiative effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001805 pentosyl group Chemical group 0.000 abstract 1
- 125000005629 sialic acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30812492 | 1992-10-22 | ||
| PCT/JP1993/001523 WO1994009020A1 (fr) | 1992-10-22 | 1993-10-22 | Nouveau shingoglycolipide et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191916T1 true ATE191916T1 (de) | 2000-05-15 |
Family
ID=17977176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93923043T ATE191916T1 (de) | 1992-10-22 | 1993-10-22 | Neues sphingolglycolipid und verwendung davon |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5849716A (de) |
| EP (1) | EP0666268B1 (de) |
| JP (1) | JP3717512B2 (de) |
| KR (1) | KR100281264B1 (de) |
| AT (1) | ATE191916T1 (de) |
| AU (1) | AU683026B2 (de) |
| CA (1) | CA2147629C (de) |
| DE (1) | DE69328435T2 (de) |
| WO (1) | WO1994009020A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3495740B2 (ja) * | 1997-04-10 | 2004-02-09 | 麒麟麦酒株式会社 | α−グリコシルセラミドを含有するNKT細胞活性化剤 |
| DE69943314D1 (de) * | 1998-02-12 | 2011-05-12 | Kapil N Bhalla | Sphingolipid-derivate und verfahren zu deren verwendung |
| JP4099267B2 (ja) * | 1998-08-07 | 2008-06-11 | 株式会社紀文フードケミファ | 乳化剤および乳化組成物 |
| JP2004531469A (ja) * | 2000-12-08 | 2004-10-14 | チルドレンズ メモリアル ホスピタル | 皮膚疾病の治療に使用するガングリオシドを含む組成物 |
| AU2002327338A1 (en) * | 2001-07-25 | 2003-02-17 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| US7273852B2 (en) | 2002-06-13 | 2007-09-25 | The Research Foundation Of The City University Of New York | Synthetic C-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| KR20050105215A (ko) * | 2003-02-14 | 2005-11-03 | 다이이치 아스비오파마 가부시키가이샤 | 당지질 유도체 및 그 제조 방법 및 그 합성 중간체 및 그제조 방법 |
| US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| KR101154442B1 (ko) * | 2003-07-17 | 2012-06-15 | 오츠카 세이야쿠 가부시키가이샤 | 배당체 함유 리포솜 |
| US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| CN1964626A (zh) * | 2004-03-31 | 2007-05-16 | 纽约大学 | 新型合成c-糖脂、其合成及其治疗传染病、癌症和自身免疫性疾病的用途 |
| KR101377116B1 (ko) * | 2004-08-27 | 2014-03-24 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 면역 및 자가면역의 조절제로서의 세라마이드 유도체 |
| US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| JP5269412B2 (ja) | 2004-10-07 | 2013-08-21 | アルゴス セラピューティクス,インコーポレイティド | 成熟樹状細胞組成物およびその培養方法 |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| EP1833489A4 (de) * | 2004-12-28 | 2011-08-03 | Univ Rockefeller | Glykolipide und analoga davon als antigene für nk-t-zellen |
| PL1848813T3 (pl) | 2005-01-28 | 2013-09-30 | Univ Brigham Young | Aktywacja glikolipidem bakteryjnym komórek NKT podlegających restrykcji CD1d |
| US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| JP5392451B2 (ja) * | 2005-12-27 | 2014-01-22 | 国立大学法人 琉球大学 | 抗腫瘍剤及び免疫賦活剤 |
| BRPI0710668A2 (pt) * | 2006-04-07 | 2011-08-16 | Scripps Res Insittute | alfa-galactosil ceramidas modificadas para marcar e estimular células t matadoras naturais |
| BRPI0713330A2 (pt) * | 2006-06-30 | 2012-04-17 | The Scripps Research Institute | adjuvantes e métodos de uso |
| EP2112930B1 (de) | 2007-02-21 | 2017-01-11 | Vaccinex, Inc. | Modulation der nkt-zellaktivität mit antigenbeladenen cdid-molekülen |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| EP2058011A1 (de) * | 2007-11-07 | 2009-05-13 | Wittycell | NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel |
| US8211861B2 (en) * | 2007-12-05 | 2012-07-03 | Wittycell | Compositions for and methods of enhancing the immune response to antigens |
| WO2009119692A1 (ja) | 2008-03-25 | 2009-10-01 | 独立行政法人理化学研究所 | 新規糖脂質及びその用途 |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| EP2336144B1 (de) | 2008-09-11 | 2015-01-21 | Riken | Verestertes alpha-galactosylceramid |
| WO2010040710A1 (en) * | 2008-10-08 | 2010-04-15 | Wittycell | Vaccine composition for use against influenza |
| JP2012514476A (ja) * | 2009-01-08 | 2012-06-28 | アルバート アインシュタイン カレッジ オブ メディシン オブ イェシバ ユニバーシティ,ア ディビジョン オブ イェシバ ユニバーシティ | 細胞壁結合セラミド様糖脂質による細菌ワクチンおよびその使用 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| JPWO2012074116A1 (ja) | 2010-12-02 | 2014-05-19 | 独立行政法人理化学研究所 | アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体(TCR)遺伝子のα鎖領域が均一なVα−Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング |
| BR112013017382B1 (pt) | 2011-01-05 | 2021-03-16 | National Taiwan University | método de preparação de um composto de fórmula (5) |
| CN103608019B (zh) | 2011-05-27 | 2017-02-15 | 学校法人近畿大学 | 抗肿瘤剂 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| JP6233890B2 (ja) * | 2012-08-03 | 2017-11-22 | 国立研究開発法人理化学研究所 | 水酸化krn7000類縁体及びその用途 |
| AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| JP6283809B2 (ja) | 2012-08-22 | 2018-02-28 | 株式会社レグイミューン | I型糖尿病の予防又は治療のための製剤 |
| WO2014069655A1 (ja) | 2012-11-05 | 2014-05-08 | 株式会社レグイミューン | 免疫寛容誘導剤 |
| CA2892482C (en) | 2012-11-21 | 2022-11-08 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for determining the risk of acute graft versus host disease |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (de) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glykankonjugate und verwendung davon |
| EP3041484B1 (de) | 2013-09-06 | 2021-03-03 | Academia Sinica | Humane inkt-zell-aktivierung mittels glykolipiden mit veränderten glycosylgruppen |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10023892B2 (en) | 2014-05-27 | 2018-07-17 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| AU2015206370A1 (en) | 2014-01-16 | 2016-07-07 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| JP7062361B2 (ja) | 2014-05-27 | 2022-05-06 | アカデミア シニカ | 抗her2糖操作抗体群およびその使用 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| US20150344585A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| TWI745275B (zh) | 2014-09-08 | 2021-11-11 | 中央研究院 | 使用醣脂激活人類iNKT細胞 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| WO2016118191A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| TWI764917B (zh) | 2016-08-22 | 2022-05-21 | 醣基生醫股份有限公司 | 抗體、結合片段及使用方法 |
| CN116528839A (zh) | 2020-12-04 | 2023-08-01 | 瑞格国际生技股份有限公司 | 药代动力学被改善的含CD1d配体化合物的脂质体制剂 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4598051A (en) * | 1980-03-12 | 1986-07-01 | The Regents Of The University Of California | Liposome conjugates and diagnostic methods therewith |
| US4806466A (en) * | 1981-10-29 | 1989-02-21 | The Regents Of The University Of California | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes |
| IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
| EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
| DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
| ATE71104T1 (de) * | 1985-08-13 | 1992-01-15 | Solco Basel Ag | Neues verfahren zur herstellung von sphingosinderivaten. |
| JPS6239597A (ja) * | 1985-08-13 | 1987-02-20 | ソルコ バ−ゼル アクチエンゲゼルシヤフト | スフインゴシン誘導体の製造方法 |
| JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
| US4990603A (en) * | 1986-07-04 | 1991-02-05 | Mect Corporation | Sialic acid derivatives and process therefor |
| US4937232A (en) * | 1986-09-15 | 1990-06-26 | Duke University | Inhibition of protein kinase C by long-chain bases |
| US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
| US5026557A (en) * | 1987-09-09 | 1991-06-25 | The Liposome Company, Inc. | Adjuvant composition |
| JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
| US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
| US5028715A (en) * | 1989-02-06 | 1991-07-02 | Southwest Research Institute | Radioprotective agents and their method of manufacture |
| EP0425821B1 (de) * | 1989-09-29 | 1994-08-10 | Ajinomoto Co., Inc. | Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten |
| JP3068910B2 (ja) * | 1990-11-08 | 2000-07-24 | 麒麟麦酒株式会社 | 新規スフィンゴ糖脂質、その製造法および使用 |
| JPH06145189A (ja) * | 1991-01-23 | 1994-05-24 | Kitasato Inst:The | スフィンゴ糖脂質 |
| JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
| TW261533B (de) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
| JPH06239597A (ja) * | 1993-02-18 | 1994-08-30 | Hitachi Zosen Corp | 箱型ブロック用作業台装置 |
| US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
-
1993
- 1993-10-22 EP EP93923043A patent/EP0666268B1/de not_active Expired - Lifetime
- 1993-10-22 KR KR1019950701544A patent/KR100281264B1/ko not_active Expired - Fee Related
- 1993-10-22 WO PCT/JP1993/001523 patent/WO1994009020A1/ja not_active Ceased
- 1993-10-22 CA CA002147629A patent/CA2147629C/en not_active Expired - Fee Related
- 1993-10-22 DE DE69328435T patent/DE69328435T2/de not_active Expired - Fee Related
- 1993-10-22 AU AU52860/93A patent/AU683026B2/en not_active Ceased
- 1993-10-22 AT AT93923043T patent/ATE191916T1/de not_active IP Right Cessation
- 1993-10-22 US US08/416,917 patent/US5849716A/en not_active Expired - Fee Related
- 1993-10-22 JP JP50984894A patent/JP3717512B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3717512B2 (ja) | 2005-11-16 |
| US5849716A (en) | 1998-12-15 |
| WO1994009020A1 (fr) | 1994-04-28 |
| CA2147629C (en) | 2005-03-22 |
| HK1009968A1 (en) | 1999-09-17 |
| CA2147629A1 (en) | 1994-04-28 |
| DE69328435T2 (de) | 2000-09-14 |
| AU5286093A (en) | 1994-05-09 |
| EP0666268A1 (de) | 1995-08-09 |
| KR950704341A (ko) | 1995-11-20 |
| AU683026B2 (en) | 1997-10-30 |
| EP0666268B1 (de) | 2000-04-19 |
| DE69328435D1 (de) | 2000-05-25 |
| KR100281264B1 (ko) | 2001-02-01 |
| EP0666268A4 (de) | 1995-06-27 |
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