ATE196655T1 - Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wird - Google Patents
Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wirdInfo
- Publication number
- ATE196655T1 ATE196655T1 AT94902795T AT94902795T ATE196655T1 AT E196655 T1 ATE196655 T1 AT E196655T1 AT 94902795 T AT94902795 T AT 94902795T AT 94902795 T AT94902795 T AT 94902795T AT E196655 T1 ATE196655 T1 AT E196655T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- immunosuppressants
- microbial species
- species used
- novel microbial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI925940A FI92334C (fi) | 1992-12-30 | 1992-12-30 | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
| PCT/FI1993/000568 WO1994016091A1 (en) | 1992-12-30 | 1993-12-29 | A process for producing immunosuppressives and a novel microbial species to be employed therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE196655T1 true ATE196655T1 (de) | 2000-10-15 |
Family
ID=8536483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94902795T ATE196655T1 (de) | 1992-12-30 | 1993-12-29 | Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wird |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5409816A (de) |
| EP (1) | EP0677116B1 (de) |
| JP (1) | JP3530531B2 (de) |
| KR (1) | KR100283503B1 (de) |
| AT (1) | ATE196655T1 (de) |
| AU (1) | AU674723B2 (de) |
| CA (1) | CA2152963C (de) |
| DE (1) | DE69329500T2 (de) |
| DK (1) | DK0677116T3 (de) |
| EE (1) | EE03114B1 (de) |
| ES (1) | ES2150980T3 (de) |
| FI (1) | FI92334C (de) |
| GR (1) | GR3035139T3 (de) |
| HU (1) | HU217683B (de) |
| PL (1) | PL177023B1 (de) |
| PT (1) | PT677116E (de) |
| RU (1) | RU2112807C1 (de) |
| SG (1) | SG49072A1 (de) |
| WO (1) | WO1994016091A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100304324B1 (ko) | 1994-10-13 | 2001-11-22 | 김용규 | 사이클로스포린a의제조방법 |
| EP0725076B1 (de) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | Verfahren zur Gewinnung von Cyclosporin A aus einer Tolypocladiumspecies |
| KR100360675B1 (ko) * | 1995-02-28 | 2003-01-14 | 내셔널 리서어치 디벨럽먼트 코포레이션 | 사이클로스포린a제조방법 |
| US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
| US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| US6423233B1 (en) * | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
| HU223054B1 (hu) * | 1997-03-25 | 2004-03-01 | BIOGAL Gyógyszergyár Rt. | Tisztítási eljárás nagytisztaságú ciklosporin A előállítására |
| KR100496929B1 (ko) * | 1997-03-25 | 2005-09-30 | 테바 기오기스제르갸르 레스즈베니타르사사그 | 시클로스포린의정제방법 |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| WO2000040219A1 (en) | 1998-12-30 | 2000-07-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
| US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| MXPA02007052A (es) * | 2000-01-20 | 2002-12-13 | Basilea Pharmaceutica Ag | Composiciones que se administran nasalmente y que contienen peptidos ciclicos. |
| WO2001064935A1 (en) * | 2000-02-29 | 2001-09-07 | Biocon India Limited | Manufacture and purification of cyclosporin a |
| DE60231570D1 (de) | 2001-10-19 | 2009-04-23 | Isotechnika Inc | Synthese von Cyclosporinanalogen |
| RU2247776C2 (ru) * | 2003-02-28 | 2005-03-10 | Баер Нисон Александрович | Способ активации ферментов в тканях убойных животных |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| EP2151450A1 (de) | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
| WO2019067423A1 (en) * | 2017-09-29 | 2019-04-04 | Valent Biosciences Llc | NEW TOLYPOCLADIUM ALBUM STRAIN |
| RU2679051C1 (ru) * | 2018-02-16 | 2019-02-05 | Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук | Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE295870C (de) * | ||||
| US3878047A (en) * | 1973-02-02 | 1975-04-15 | Upjohn Co | Process for production of AT-125 |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| US4215199A (en) * | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
| DD295870A5 (de) * | 1988-10-11 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | Verfahren zur mikrobiellen gewinnung von cyclosporinen |
| DD298276A5 (de) * | 1988-10-11 | 1992-02-13 | Institut Fuer Mikrobiologie Und Experimentelle Therapie,De | Verfahren zur herstellung von cyclosporin a |
| HU201577B (en) * | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
| ATE158022T1 (de) * | 1991-01-25 | 1997-09-15 | Fujisawa Pharmaceutical Co | Prozess zur produktion von cyclosporin-a und/oder c |
| ES2078374T3 (es) * | 1991-04-06 | 1995-12-16 | Dresden Arzneimittel | Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina. |
-
1992
- 1992-12-30 FI FI925940A patent/FI92334C/fi not_active IP Right Cessation
-
1993
- 1993-02-22 US US08/020,545 patent/US5409816A/en not_active Expired - Fee Related
- 1993-12-29 HU HU9501951A patent/HU217683B/hu not_active IP Right Cessation
- 1993-12-29 AT AT94902795T patent/ATE196655T1/de not_active IP Right Cessation
- 1993-12-29 RU RU95114383A patent/RU2112807C1/ru not_active IP Right Cessation
- 1993-12-29 KR KR1019950702677A patent/KR100283503B1/ko not_active Expired - Fee Related
- 1993-12-29 SG SG1996005777A patent/SG49072A1/en unknown
- 1993-12-29 JP JP51571394A patent/JP3530531B2/ja not_active Expired - Fee Related
- 1993-12-29 CA CA002152963A patent/CA2152963C/en not_active Expired - Fee Related
- 1993-12-29 WO PCT/FI1993/000568 patent/WO1994016091A1/en not_active Ceased
- 1993-12-29 PT PT94902795T patent/PT677116E/pt unknown
- 1993-12-29 DK DK94902795T patent/DK0677116T3/da active
- 1993-12-29 DE DE69329500T patent/DE69329500T2/de not_active Expired - Fee Related
- 1993-12-29 ES ES94902795T patent/ES2150980T3/es not_active Expired - Lifetime
- 1993-12-29 EP EP94902795A patent/EP0677116B1/de not_active Expired - Lifetime
- 1993-12-29 PL PL93309613A patent/PL177023B1/pl not_active IP Right Cessation
- 1993-12-29 AU AU57014/94A patent/AU674723B2/en not_active Ceased
-
1994
- 1994-11-16 EE EE9400184A patent/EE03114B1/xx not_active IP Right Cessation
-
2000
- 2000-12-22 GR GR20000402825T patent/GR3035139T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1014035A1 (en) | 1999-09-17 |
| EP0677116B1 (de) | 2000-09-27 |
| DE69329500D1 (de) | 2000-11-02 |
| PL177023B1 (pl) | 1999-09-30 |
| EP0677116A1 (de) | 1995-10-18 |
| CA2152963A1 (en) | 1994-07-21 |
| US5409816A (en) | 1995-04-25 |
| KR960700346A (ko) | 1996-01-19 |
| CA2152963C (en) | 2003-05-27 |
| RU2112807C1 (ru) | 1998-06-10 |
| FI925940A0 (fi) | 1992-12-30 |
| HU9501951D0 (en) | 1995-08-28 |
| GR3035139T3 (en) | 2001-04-30 |
| JP3530531B2 (ja) | 2004-05-24 |
| EE03114B1 (et) | 1998-08-17 |
| KR100283503B1 (ko) | 2001-03-02 |
| ES2150980T3 (es) | 2000-12-16 |
| JPH08505059A (ja) | 1996-06-04 |
| AU5701494A (en) | 1994-08-15 |
| AU674723B2 (en) | 1997-01-09 |
| FI92334C (fi) | 1994-10-25 |
| PT677116E (pt) | 2001-01-31 |
| DE69329500T2 (de) | 2001-06-07 |
| WO1994016091A1 (en) | 1994-07-21 |
| HU217683B (hu) | 2000-03-28 |
| PL309613A1 (en) | 1995-10-30 |
| SG49072A1 (en) | 1998-05-18 |
| DK0677116T3 (da) | 2000-12-27 |
| FI92334B (fi) | 1994-07-15 |
| HUT72702A (en) | 1996-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |