EE03114B1 - Meetod tsüklosporiin A tootmiseks - Google Patents

Meetod tsüklosporiin A tootmiseks

Info

Publication number
EE03114B1
EE03114B1 EE9400184A EE9400184A EE03114B1 EE 03114 B1 EE03114 B1 EE 03114B1 EE 9400184 A EE9400184 A EE 9400184A EE 9400184 A EE9400184 A EE 9400184A EE 03114 B1 EE03114 B1 EE 03114B1
Authority
EE
Estonia
Prior art keywords
cyclosporin
production
lea3
aerobically
cultivating
Prior art date
Application number
EE9400184A
Other languages
English (en)
Estonian (et)
Inventor
Lundell Juhani
Kopio Anja
Korpela Timo
Ankelo Matti
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of EE03114B1 publication Critical patent/EE03114B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
EE9400184A 1992-12-30 1994-11-16 Meetod tsüklosporiin A tootmiseks EE03114B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI925940A FI92334C (fi) 1992-12-30 1992-12-30 Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta

Publications (1)

Publication Number Publication Date
EE03114B1 true EE03114B1 (et) 1998-08-17

Family

ID=8536483

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400184A EE03114B1 (et) 1992-12-30 1994-11-16 Meetod tsüklosporiin A tootmiseks

Country Status (19)

Country Link
US (1) US5409816A (de)
EP (1) EP0677116B1 (de)
JP (1) JP3530531B2 (de)
KR (1) KR100283503B1 (de)
AT (1) ATE196655T1 (de)
AU (1) AU674723B2 (de)
CA (1) CA2152963C (de)
DE (1) DE69329500T2 (de)
DK (1) DK0677116T3 (de)
EE (1) EE03114B1 (de)
ES (1) ES2150980T3 (de)
FI (1) FI92334C (de)
GR (1) GR3035139T3 (de)
HU (1) HU217683B (de)
PL (1) PL177023B1 (de)
PT (1) PT677116E (de)
RU (1) RU2112807C1 (de)
SG (1) SG49072A1 (de)
WO (1) WO1994016091A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100304324B1 (ko) 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법
EP0725076B1 (de) * 1995-02-01 2001-06-06 National Research Development Corporation of India Verfahren zur Gewinnung von Cyclosporin A aus einer Tolypocladiumspecies
KR100360675B1 (ko) * 1995-02-28 2003-01-14 내셔널 리서어치 디벨럽먼트 코포레이션 사이클로스포린a제조방법
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
HU223054B1 (hu) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
KR100496929B1 (ko) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 시클로스포린의정제방법
EP0991660B8 (de) 1997-10-08 2006-04-05 Isotechnika,Inc. DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP1154759B1 (de) 1998-12-30 2008-08-13 Dexcel Ltd. Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
JP2003535042A (ja) * 2000-01-20 2003-11-25 バジリア ファルマスーチカ アーゲー 鼻腔に投与可能な環式ペプチド組成物
AU2000235743A1 (en) * 2000-02-29 2001-09-12 Biocon India Limited Manufacture and purification of cyclosporin a
US7141648B2 (en) 2001-10-19 2006-11-28 Isotechnika Inc. Synthesis of cyclosporin analogs
RU2247776C2 (ru) * 2003-02-28 2005-03-10 Баер Нисон Александрович Способ активации ферментов в тканях убойных животных
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
US10945443B2 (en) 2017-09-29 2021-03-16 Valent Biosciences Llc Tolypocladium album strain
RU2679051C1 (ru) * 2018-02-16 2019-02-05 Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295870C (de) *
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
DD295870A5 (de) * 1988-10-11 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur mikrobiellen gewinnung von cyclosporinen
DD298276A5 (de) * 1988-10-11 1992-02-13 Institut Fuer Mikrobiologie Und Experimentelle Therapie,De Verfahren zur herstellung von cyclosporin a
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
DE69222150T2 (de) * 1991-01-25 1998-01-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.

Also Published As

Publication number Publication date
FI92334C (fi) 1994-10-25
US5409816A (en) 1995-04-25
DE69329500T2 (de) 2001-06-07
DE69329500D1 (de) 2000-11-02
ES2150980T3 (es) 2000-12-16
PT677116E (pt) 2001-01-31
PL309613A1 (en) 1995-10-30
AU674723B2 (en) 1997-01-09
EP0677116A1 (de) 1995-10-18
ATE196655T1 (de) 2000-10-15
RU2112807C1 (ru) 1998-06-10
WO1994016091A1 (en) 1994-07-21
FI92334B (fi) 1994-07-15
CA2152963A1 (en) 1994-07-21
DK0677116T3 (da) 2000-12-27
SG49072A1 (en) 1998-05-18
KR100283503B1 (ko) 2001-03-02
PL177023B1 (pl) 1999-09-30
CA2152963C (en) 2003-05-27
HU9501951D0 (en) 1995-08-28
JP3530531B2 (ja) 2004-05-24
GR3035139T3 (en) 2001-04-30
HUT72702A (en) 1996-05-28
KR960700346A (ko) 1996-01-19
AU5701494A (en) 1994-08-15
HK1014035A1 (en) 1999-09-17
FI925940A0 (fi) 1992-12-30
EP0677116B1 (de) 2000-09-27
JPH08505059A (ja) 1996-06-04
HU217683B (hu) 2000-03-28

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

MM4A Lapsed by not paying the annual fees

Effective date: 20051116