ES2150980T3 - Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo. - Google Patents

Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo.

Info

Publication number
ES2150980T3
ES2150980T3 ES94902795T ES94902795T ES2150980T3 ES 2150980 T3 ES2150980 T3 ES 2150980T3 ES 94902795 T ES94902795 T ES 94902795T ES 94902795 T ES94902795 T ES 94902795T ES 2150980 T3 ES2150980 T3 ES 2150980T3
Authority
ES
Spain
Prior art keywords
producing
immunosuppressants
procedure
microbial species
new microbial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902795T
Other languages
English (en)
Inventor
Juhani Lundell
Anja Kopio
Timo Korpela
Matti Ankelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Oy
Original Assignee
Santen Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Oy filed Critical Santen Oy
Application granted granted Critical
Publication of ES2150980T3 publication Critical patent/ES2150980T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE AL PROCESO PARA PRODUCIR CICLOSPORINA, ESPECIALMENTE CICLOSPORINA A, CULTIVANDO UNA CLASE DE LAS NUEVAS ESPECIES DE TOLYPOCLADIUM EN UN MEDIO NUTRIENTE QUE CONTENGA FUENTES DE CARBON, FUENTES DE NITROGENO Y SALES MINERALES, Y, SI SE DESEA, AISLANDO Y PURIFICANDO LA CICLOSPORINA RESULTANTE.
ES94902795T 1992-12-30 1993-12-29 Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo. Expired - Lifetime ES2150980T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI925940A FI92334C (fi) 1992-12-30 1992-12-30 Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
PCT/FI1993/000568 WO1994016091A1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein

Publications (1)

Publication Number Publication Date
ES2150980T3 true ES2150980T3 (es) 2000-12-16

Family

ID=8536483

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902795T Expired - Lifetime ES2150980T3 (es) 1992-12-30 1993-12-29 Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo.

Country Status (19)

Country Link
US (1) US5409816A (es)
EP (1) EP0677116B1 (es)
JP (1) JP3530531B2 (es)
KR (1) KR100283503B1 (es)
AT (1) ATE196655T1 (es)
AU (1) AU674723B2 (es)
CA (1) CA2152963C (es)
DE (1) DE69329500T2 (es)
DK (1) DK0677116T3 (es)
EE (1) EE03114B1 (es)
ES (1) ES2150980T3 (es)
FI (1) FI92334C (es)
GR (1) GR3035139T3 (es)
HU (1) HU217683B (es)
PL (1) PL177023B1 (es)
PT (1) PT677116E (es)
RU (1) RU2112807C1 (es)
SG (1) SG49072A1 (es)
WO (1) WO1994016091A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100304324B1 (ko) 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
KR100360675B1 (ko) * 1995-02-28 2003-01-14 내셔널 리서어치 디벨럽먼트 코포레이션 사이클로스포린a제조방법
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
HU223054B1 (hu) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
KR100496929B1 (ko) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 시클로스포린의정제방법
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
DE69832984T2 (de) 1997-10-08 2006-09-21 Isotechnika, Inc., Edmonton DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
BR0107764A (pt) * 2000-01-20 2002-11-12 Basilea Pharmaceutica Ag Composições de peptìdeo cìclico nasalmente administráveis
ATE306558T1 (de) * 2000-02-29 2005-10-15 Biocon Ltd Herstellung und reinigung von cyclosporin-a
HRP20070058B1 (hr) 2001-10-19 2014-05-23 Isotechnika Inc. Sinteza ciklosporinskih analoga
RU2247776C2 (ru) * 2003-02-28 2005-03-10 Баер Нисон Александрович Способ активации ферментов в тканях убойных животных
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
US10945443B2 (en) 2017-09-29 2021-03-16 Valent Biosciences Llc Tolypocladium album strain
RU2679051C1 (ru) * 2018-02-16 2019-02-05 Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295870C (es) *
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
DD295870A5 (de) * 1988-10-11 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur mikrobiellen gewinnung von cyclosporinen
DD298276A5 (de) * 1988-10-11 1992-02-13 Institut Fuer Mikrobiologie Und Experimentelle Therapie,De Verfahren zur herstellung von cyclosporin a
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
DE69222150T2 (de) * 1991-01-25 1998-01-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.

Also Published As

Publication number Publication date
PT677116E (pt) 2001-01-31
CA2152963A1 (en) 1994-07-21
CA2152963C (en) 2003-05-27
EP0677116A1 (en) 1995-10-18
HU217683B (hu) 2000-03-28
HUT72702A (en) 1996-05-28
US5409816A (en) 1995-04-25
HK1014035A1 (en) 1999-09-17
PL309613A1 (en) 1995-10-30
GR3035139T3 (en) 2001-04-30
JP3530531B2 (ja) 2004-05-24
DK0677116T3 (da) 2000-12-27
HU9501951D0 (en) 1995-08-28
EE03114B1 (et) 1998-08-17
FI925940A0 (fi) 1992-12-30
FI92334C (fi) 1994-10-25
PL177023B1 (pl) 1999-09-30
RU2112807C1 (ru) 1998-06-10
FI92334B (fi) 1994-07-15
AU674723B2 (en) 1997-01-09
SG49072A1 (en) 1998-05-18
DE69329500D1 (de) 2000-11-02
ATE196655T1 (de) 2000-10-15
WO1994016091A1 (en) 1994-07-21
AU5701494A (en) 1994-08-15
EP0677116B1 (en) 2000-09-27
KR960700346A (ko) 1996-01-19
JPH08505059A (ja) 1996-06-04
KR100283503B1 (ko) 2001-03-02
DE69329500T2 (de) 2001-06-07

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