ATE200621T1 - Immunotherapeutische imide/amide und ihre verwendung zur verminderung des tnfalpha-spiegels - Google Patents

Immunotherapeutische imide/amide und ihre verwendung zur verminderung des tnfalpha-spiegels

Info

Publication number: ATE200621T1
Authority: AT; Austria
Prior art keywords: amides; reducing; immunotherapeutic; imides; tnfalpha levels
Prior art date: 1994-12-30

Application number

AT95940063T

Other languages

English (en)

Inventor

George Muller

Mary Shire

David I Stirling

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-30

Filing date

1995-11-20

Publication date

2001-05-15

1995-11-20 Application filed by Celgene Corp filed Critical Celgene Corp

2001-05-15 Application granted granted Critical

2001-05-15 Publication of ATE200621T1 publication Critical patent/ATE200621T1/de

Links

150000003949 imides Chemical class 0.000 title abstract 2
150000001408 amides Chemical class 0.000 title 1
230000001024 immunotherapeutic effect Effects 0.000 title 1
KVMCPRAFESVWBU-UHFFFAOYSA-N 2-[1-(3,4-dimethoxyphenyl)-1-hydroxypropyl]isoindole-1,3-dione Chemical group O=C1C2=CC=CC=C2C(=O)N1C(O)(CC)C1=CC=C(OC)C(OC)=C1 KVMCPRAFESVWBU-UHFFFAOYSA-N 0.000 abstract 1
206010006895 Cachexia Diseases 0.000 abstract 1
206010014824 Endotoxic shock Diseases 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
-1 amide ethers Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

AT95940063T 1994-12-30 1995-11-20 Immunotherapeutische imide/amide und ihre verwendung zur verminderung des tnfalpha-spiegels ATE200621T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36666794A	1994-12-30	1994-12-30
PCT/US1995/015119 WO1996020705A1 (en)	1994-12-30	1995-11-20	IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a)

Publications (1)

Publication Number	Publication Date
ATE200621T1 true ATE200621T1 (de)	2001-05-15

Family

ID=23443993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95940063T ATE200621T1 (de)	1994-12-30	1995-11-20	Immunotherapeutische imide/amide und ihre verwendung zur verminderung des tnfalpha-spiegels

Country Status (18)

Country	Link
EP (1)	EP0797437B1 (de)
JP (1)	JPH10511678A (de)
AT (1)	ATE200621T1 (de)
AU (1)	AU696817B2 (de)
CA (1)	CA2208672C (de)
CZ (1)	CZ290372B6 (de)
DE (1)	DE69520750T2 (de)
DK (1)	DK0797437T3 (de)
ES (1)	ES2155537T3 (de)
FI (1)	FI972708A7 (de)
GR (1)	GR3036131T3 (de)
HU (1)	HU226558B1 (de)
NZ (1)	NZ296925A (de)
PL (1)	PL185101B1 (de)
PT (1)	PT797437E (de)
RU (1)	RU2164514C2 (de)
SK (1)	SK86997A3 (de)
WO (1)	WO1996020705A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658940A (en) *	1995-10-06	1997-08-19	Celgene Corporation	Succinimide and maleimide cytokine inhibitors
DE69700616T2 (de) *	1996-07-02	2000-03-16	Nisshin Flour Milling Co., Ltd.	Imid derivate
ES2262184T3 (es) *	1996-08-05	2006-11-16	Myriad Genetics, Inc.	Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
EP1661566A3 (de) *	1996-08-05	2008-04-16	Myriad Genetics, Inc.	Verwendung von Beta-Blatt Mimetika als Protease und Kinase Hemmer sowie als Hemmer eines Transkriptionsfaktors
US7091353B2 (en)	2000-12-27	2006-08-15	Celgene Corporation	Isoindole-imide compounds, compositions, and uses thereof
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
JP4361273B2 (ja)	2001-02-27	2009-11-11	アメリカ合衆国	潜在的な血管形成阻害剤としてのサリドマイド類似体
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
US7498171B2 (en)	2002-04-12	2009-03-03	Anthrogenesis Corporation	Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CA2808646C (en)	2003-09-17	2016-08-23	The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en)	2011-06-03	2015-02-10	Apple Inc.	Motion-based device operations
US8927725B2 (en)	2011-12-02	2015-01-06	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Thio compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4467097A (en) *	1982-09-29	1984-08-21	General Electric Company	Method for making aromatic bis(etherimide)s
AU1531492A (en) *	1991-02-14	1992-09-15	Rockefeller University, The	Method for controlling abnormal concentration tnf alpha in human tissues
US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines

1995
- 1995-11-20 WO PCT/US1995/015119 patent/WO1996020705A1/en not_active Ceased
- 1995-11-20 AT AT95940063T patent/ATE200621T1/de not_active IP Right Cessation
- 1995-11-20 PL PL95321071A patent/PL185101B1/pl not_active IP Right Cessation
- 1995-11-20 PT PT95940063T patent/PT797437E/pt unknown
- 1995-11-20 DK DK95940063T patent/DK0797437T3/da active
- 1995-11-20 FI FI972708A patent/FI972708A7/fi unknown
- 1995-11-20 AU AU41667/96A patent/AU696817B2/en not_active Ceased
- 1995-11-20 DE DE69520750T patent/DE69520750T2/de not_active Expired - Fee Related
- 1995-11-20 RU RU97112903/04A patent/RU2164514C2/ru not_active IP Right Cessation
- 1995-11-20 SK SK869-97A patent/SK86997A3/sk unknown
- 1995-11-20 HU HU9701842A patent/HU226558B1/hu not_active IP Right Cessation
- 1995-11-20 CA CA002208672A patent/CA2208672C/en not_active Expired - Fee Related
- 1995-11-20 NZ NZ296925A patent/NZ296925A/en unknown
- 1995-11-20 JP JP8520977A patent/JPH10511678A/ja active Pending
- 1995-11-20 EP EP95940063A patent/EP0797437B1/de not_active Expired - Lifetime
- 1995-11-20 CZ CZ19972035A patent/CZ290372B6/cs not_active IP Right Cessation
- 1995-11-20 ES ES95940063T patent/ES2155537T3/es not_active Expired - Lifetime
2001
- 2001-06-27 GR GR20010400984T patent/GR3036131T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2208672C (en)	2008-02-12
ES2155537T3 (es)	2001-05-16
EP0797437A1 (de)	1997-10-01
DE69520750D1 (de)	2001-05-23
GR3036131T3 (en)	2001-09-28
FI972708L (fi)	1997-08-29
EP0797437B1 (de)	2001-04-18
DE69520750T2 (de)	2001-09-13
FI972708A0 (fi)	1997-06-23
WO1996020705A1 (en)	1996-07-11
FI972708A7 (fi)	1997-08-29
PT797437E (pt)	2001-07-31
SK86997A3 (en)	1998-01-14
JPH10511678A (ja)	1998-11-10
RU2164514C2 (ru)	2001-03-27
CZ203597A3 (en)	1997-11-12
AU696817B2 (en)	1998-09-17
PL185101B1 (pl)	2003-02-28
HU226558B1 (en)	2009-03-30
CA2208672A1 (en)	1996-07-11
DK0797437T3 (da)	2001-06-05
NZ296925A (en)	1998-06-26
PL321071A1 (en)	1997-11-24
AU4166796A (en)	1996-07-24
HUT77978A (hu)	1999-01-28
CZ290372B6 (cs)	2002-07-17

Legal Events

Date	Code	Title	Description
2001-07-15	UEP	Publication of translation of european patent specification
2009-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
PL321072A1 (en)	1997-11-24	Novel immunotherapeutic aryl amides
ATE337301T1 (de)	2006-09-15	Substituierte imide als tnf inhibitoren
DE69629716D1 (en)	2003-10-02	Succinimid und maleimid cytokin-inhibitoren
ATE259787T1 (de)	2004-03-15	Inhibitoren des tumor-necrosis-factors
DE69520750D1 (de)	2001-05-23	IMMUNOTHERAPEUTISCHE IMIDE/AMIDE UND IHRE VERWENDUNG ZUR VERMINDERUNG DES TNFalpha-SPIEGELS
WO1998024763A3 (en)	1998-08-06	Immunotherapeutic imides/amides as pde iv and tnf inhibitors
FI974437A0 (fi)	1997-12-05	Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina
NO996529D0 (no)	1999-12-28	Substituerte alkanohydroksamsyrer og metode for reduksjon av TNF<alfa>-nivåer
DE3768689D1 (de)	1991-04-25	N-substituierte 3,4,5,6-tetrahydrophthalimide und deren vorprodukte.
ATE244713T1 (de)	2003-07-15	Substituierte indazolderivate und ihre verwendung als inhibitoren des phosphodiesterase (pde) typs 4 und des tumor-necrosin-factors (tnf)
CY2209B1 (en)	2002-11-08	Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl) -an il ide and n- (4-trifluoromethylphenyl) 2-cyano-3-hydro xycrotonic acid amide
DE50208151D1 (de)	2006-10-26	Schwingdrossel
FR2433822A1 (fr)	1980-03-14	Transformateur a champ de fuites magnetiques ou inductance utilisable, en particulier, en ballast pour les lampes luminescentes a gaz
DK176586A (da)	1986-10-20	Leukotrienantagonister
ATE220396T1 (de)	2002-07-15	4-benzoyl isoxazole derivate und ihre anwendung als herbizide
NO852793L (no)	1986-01-13	(pyrrol-1-yl)-fenyldihydropyridazinoner og fremgangsmaate ved fremstilling derav.
DK102084D0 (da)	1984-02-24	N-(3-trifluormethylphenyl)-n'-propargylpiperazin, dets fremstilling og anvendelse
GB8926611D0 (en)	1990-01-17	Compound and its use
KR950033840U (ko)	1995-12-18	휴대용 가스버너의 가스통 접속구
KR930014978U (ko)	1993-07-27	휴대용 가스버너의 가스통 결합장치
KR960008687U (ko)	1996-03-16	휴대용 가스렌지의 가스통 안내장치
NO920756D0 (no)	1992-02-26	Fremgangsmaate og anordning for kjoeling av karbonelektrode