FI972708A0 - Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi - Google Patents

Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi

Info

Publication number: FI972708A0
Authority: FI; Finland
Prior art keywords: amides; immunotherapeutic; imides; tnfalpha levels; tnfalpha
Prior art date: 1994-12-30

Application number

FI972708A

Other languages

English (en)

Swedish (sv)

Other versions

FI972708A7 (fi

FI972708L (fi

Inventor

Mary Shire

David I Stirling

Original Assignee

Celgene Corp

Muller George

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-30

Filing date

1995-11-20

Publication date

1997-06-23

1995-11-20 Application filed by Celgene Corp, Muller George filed Critical Celgene Corp

1997-06-23 Publication of FI972708A0 publication Critical patent/FI972708A0/fi

1997-08-29 Publication of FI972708A7 publication Critical patent/FI972708A7/fi

1997-08-29 Publication of FI972708L publication Critical patent/FI972708L/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI972708A 1994-12-30 1995-11-20 Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi FI972708L (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36666794A	1994-12-30	1994-12-30
PCT/US1995/015119 WO1996020705A1 (en)	1994-12-30	1995-11-20	IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a)

Publications (3)

Publication Number	Publication Date
FI972708A0 true FI972708A0 (fi)	1997-06-23
FI972708A7 FI972708A7 (fi)	1997-08-29
FI972708L FI972708L (fi)	1997-08-29

Family

ID=23443993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI972708A FI972708L (fi)	1994-12-30	1995-11-20	Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi

Country Status (18)

Country	Link
EP (1)	EP0797437B1 (fi)
JP (1)	JPH10511678A (fi)
AT (1)	ATE200621T1 (fi)
AU (1)	AU696817B2 (fi)
CA (1)	CA2208672C (fi)
CZ (1)	CZ290372B6 (fi)
DE (1)	DE69520750T2 (fi)
DK (1)	DK0797437T3 (fi)
ES (1)	ES2155537T3 (fi)
FI (1)	FI972708L (fi)
GR (1)	GR3036131T3 (fi)
HU (1)	HU226558B1 (fi)
NZ (1)	NZ296925A (fi)
PL (1)	PL185101B1 (fi)
PT (1)	PT797437E (fi)
RU (1)	RU2164514C2 (fi)
SK (1)	SK86997A3 (fi)
WO (1)	WO1996020705A1 (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658940A (en) *	1995-10-06	1997-08-19	Celgene Corporation	Succinimide and maleimide cytokine inhibitors
DE69700616T2 (de) *	1996-07-02	2000-03-16	Nisshin Flour Milling Co., Ltd.	Imid derivate
ES2262184T3 (es) *	1996-08-05	2006-11-16	Myriad Genetics, Inc.	Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
EP1661566A3 (en) *	1996-08-05	2008-04-16	Myriad Genetics, Inc.	Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US7091353B2 (en)	2000-12-27	2006-08-15	Celgene Corporation	Isoindole-imide compounds, compositions, and uses thereof
CA2438641A1 (en)	2001-02-15	2002-08-22	King Pharmaceuticals, Inc.	Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
CA2439410C (en)	2001-02-27	2011-09-06	William D. Figg	Analogs of thalidomide as potential angiogenesis inhibitors
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
US7498171B2 (en)	2002-04-12	2009-03-03	Anthrogenesis Corporation	Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US8952895B2 (en)	2011-06-03	2015-02-10	Apple Inc.	Motion-based device operations
EP1663223B1 (en)	2003-09-17	2014-01-01	The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services	Thalidomide analogs as tnf-alpha modulators
US8927725B2 (en)	2011-12-02	2015-01-06	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Thio compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4467097A (en) *	1982-09-29	1984-08-21	General Electric Company	Method for making aromatic bis(etherimide)s
AU1531492A (en) *	1991-02-14	1992-09-15	Rockefeller University, The	Method for controlling abnormal concentration tnf alpha in human tissues
US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines

1995
- 1995-11-20 AT AT95940063T patent/ATE200621T1/de not_active IP Right Cessation
- 1995-11-20 NZ NZ296925A patent/NZ296925A/en unknown
- 1995-11-20 JP JP8520977A patent/JPH10511678A/ja active Pending
- 1995-11-20 ES ES95940063T patent/ES2155537T3/es not_active Expired - Lifetime
- 1995-11-20 EP EP95940063A patent/EP0797437B1/en not_active Expired - Lifetime
- 1995-11-20 CZ CZ19972035A patent/CZ290372B6/cs not_active IP Right Cessation
- 1995-11-20 AU AU41667/96A patent/AU696817B2/en not_active Ceased
- 1995-11-20 WO PCT/US1995/015119 patent/WO1996020705A1/en not_active Ceased
- 1995-11-20 SK SK869-97A patent/SK86997A3/sk unknown
- 1995-11-20 RU RU97112903/04A patent/RU2164514C2/ru not_active IP Right Cessation
- 1995-11-20 PL PL95321071A patent/PL185101B1/pl not_active IP Right Cessation
- 1995-11-20 FI FI972708A patent/FI972708L/fi unknown
- 1995-11-20 CA CA002208672A patent/CA2208672C/en not_active Expired - Fee Related
- 1995-11-20 HU HU9701842A patent/HU226558B1/hu not_active IP Right Cessation
- 1995-11-20 DK DK95940063T patent/DK0797437T3/da active
- 1995-11-20 PT PT95940063T patent/PT797437E/pt unknown
- 1995-11-20 DE DE69520750T patent/DE69520750T2/de not_active Expired - Fee Related
2001
- 2001-06-27 GR GR20010400984T patent/GR3036131T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI972708A7 (fi)	1997-08-29
PL185101B1 (pl)	2003-02-28
HUT77978A (hu)	1999-01-28
CZ203597A3 (en)	1997-11-12
DK0797437T3 (da)	2001-06-05
ES2155537T3 (es)	2001-05-16
GR3036131T3 (en)	2001-09-28
EP0797437A1 (en)	1997-10-01
CZ290372B6 (cs)	2002-07-17
CA2208672C (en)	2008-02-12
AU696817B2 (en)	1998-09-17
DE69520750D1 (de)	2001-05-23
FI972708L (fi)	1997-08-29
RU2164514C2 (ru)	2001-03-27
HU226558B1 (en)	2009-03-30
NZ296925A (en)	1998-06-26
AU4166796A (en)	1996-07-24
PT797437E (pt)	2001-07-31
SK86997A3 (en)	1998-01-14
ATE200621T1 (de)	2001-05-15
CA2208672A1 (en)	1996-07-11
WO1996020705A1 (en)	1996-07-11
EP0797437B1 (en)	2001-04-18
DE69520750T2 (de)	2001-09-13
JPH10511678A (ja)	1998-11-10
PL321071A1 (en)	1997-11-24

Publication	Publication Date	Title
ATE337301T1 (de)	2006-09-15	Substituierte imide als tnf inhibitoren
PL321072A1 (en)	1997-11-24	Novel immunotherapeutic aryl amides
FI972708A0 (fi)	1997-06-23	Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi
PT862552E (pt)	2003-12-31	Succinimidas e maleimidas inibidoras de citocinas
ATE259787T1 (de)	2004-03-15	Inhibitoren des tumor-necrosis-factors
WO1998024763A3 (en)	1998-08-06	Immunotherapeutic imides/amides as pde iv and tnf inhibitors
DK37690D0 (da)	1990-02-13	Herbicider med forbedret effektivitet og anvendelse af saadanne herbicider
FI974437A7 (fi)	1997-12-05	Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
ATE181667T1 (de)	1999-07-15	Ketorolac enthaltender warmer umschlag
CY2209B1 (en)	2002-11-08	Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl) -an il ide and n- (4-trifluoromethylphenyl) 2-cyano-3-hydro xycrotonic acid amide
BG37992A3 (bg)	1985-09-16	Метод за получаване на производни на бензамида
NO852793L (no)	1986-01-13	(pyrrol-1-yl)-fenyldihydropyridazinoner og fremgangsmaate ved fremstilling derav.
DK218083D0 (da)	1983-05-16	Aminoalkadien-derivater, deres fremstilling og anvendelse
DK447284D0 (da)	1984-09-19	Aminoderivater af 2-(n-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl)),deres fremstilling og anvendelse
DK102084D0 (da)	1984-02-24	N-(3-trifluormethylphenyl)-n'-propargylpiperazin, dets fremstilling og anvendelse
GB8926611D0 (en)	1990-01-17	Compound and its use
DK370585D0 (da)	1985-08-15	Praeparat og fremgangsmaade til forbedring af effektiviteten af droevtyggeres foedeudnyttelse
ITRM910060V0 (it)	1991-03-18	Scopa con snodo cardanico interposto fra testa e manico onde realizzare la possibilita' di ottenere varie posizioni fra le due parti
IT1184327B (it)	1987-10-28	Procedimento per riunire le estre mita'di spezzoni di catenelle a pallini,nonche'dispositivo per la sua attuazione e giunto utilizzato