HUT77978A - Immunoterápiás alkalmazású imidek/amidok, ezek alkalmazása a TNFalfa koncentrációjának csökkentésében - Google Patents

Immunoterápiás alkalmazású imidek/amidok, ezek alkalmazása a TNFalfa koncentrációjának csökkentésében

Info

Publication number: HUT77978A
Authority: HU; Hungary
Prior art keywords: imides; immunotherapy; amides; reducing; tnfalpha
Prior art date: 1994-12-30

Application number

HU9701842A

Other languages

English (en)

Other versions

HU226558B1 (en

Inventor

George W. Muller

Mary Shire

David I. Stirling

Original Assignee

Celgene Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-30

Filing date

1995-11-20

Publication date

1999-01-28

1995-11-20 Application filed by Celgene Corporation filed Critical Celgene Corporation

1999-01-28 Publication of HUT77978A publication Critical patent/HUT77978A/hu

2009-03-30 Publication of HU226558B1 publication Critical patent/HU226558B1/hu

Links

108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 2
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title abstract 2
150000003949 imides Chemical class 0.000 title abstract 2
150000001408 amides Chemical class 0.000 title 1
238000009169 immunotherapy Methods 0.000 title 1
KVMCPRAFESVWBU-UHFFFAOYSA-N 2-[1-(3,4-dimethoxyphenyl)-1-hydroxypropyl]isoindole-1,3-dione Chemical group O=C1C2=CC=CC=C2C(=O)N1C(O)(CC)C1=CC=C(OC)C(OC)=C1 KVMCPRAFESVWBU-UHFFFAOYSA-N 0.000 abstract 1
206010006895 Cachexia Diseases 0.000 abstract 1
206010014824 Endotoxic shock Diseases 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
-1 amide ethers Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

HU9701842A 1994-12-30 1995-11-20 Immunotherapeutic imides/amides and their use for reducing levels of tnfalpha HU226558B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36666794A	1994-12-30	1994-12-30
PCT/US1995/015119 WO1996020705A1 (en)	1994-12-30	1995-11-20	IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a)

Publications (2)

Publication Number	Publication Date
HUT77978A true HUT77978A (hu)	1999-01-28
HU226558B1 HU226558B1 (en)	2009-03-30

Family

ID=23443993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9701842A HU226558B1 (en)	1994-12-30	1995-11-20	Immunotherapeutic imides/amides and their use for reducing levels of tnfalpha

Country Status (18)

Country	Link
EP (1)	EP0797437B1 (hu)
JP (1)	JPH10511678A (hu)
AT (1)	ATE200621T1 (hu)
AU (1)	AU696817B2 (hu)
CA (1)	CA2208672C (hu)
CZ (1)	CZ290372B6 (hu)
DE (1)	DE69520750T2 (hu)
DK (1)	DK0797437T3 (hu)
ES (1)	ES2155537T3 (hu)
FI (1)	FI972708L (hu)
GR (1)	GR3036131T3 (hu)
HU (1)	HU226558B1 (hu)
NZ (1)	NZ296925A (hu)
PL (1)	PL185101B1 (hu)
PT (1)	PT797437E (hu)
RU (1)	RU2164514C2 (hu)
SK (1)	SK86997A3 (hu)
WO (1)	WO1996020705A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658940A (en) *	1995-10-06	1997-08-19	Celgene Corporation	Succinimide and maleimide cytokine inhibitors
EP0818439B1 (en) *	1996-07-02	1999-10-13	Nisshin Flour Milling Co., Ltd.	Imide derivatives
EP1661566A3 (en) *	1996-08-05	2008-04-16	Myriad Genetics, Inc.	Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
ES2262184T3 (es) *	1996-08-05	2006-11-16	Myriad Genetics, Inc.	Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
US7091353B2 (en)	2000-12-27	2006-08-15	Celgene Corporation	Isoindole-imide compounds, compositions, and uses thereof
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
EP1389203B8 (en)	2001-02-27	2010-03-10	The Governement of the United States of America, represented by The Secretary Department of Health and Human services	Analogs of thalidomide as angiogenesis inhibitors
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
US7498171B2 (en)	2002-04-12	2009-03-03	Anthrogenesis Corporation	Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US8952895B2 (en)	2011-06-03	2015-02-10	Apple Inc.	Motion-based device operations
WO2005028436A2 (en)	2003-09-17	2005-03-31	The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	Thalidomide analogs as tnf-alpha modulators
US8927725B2 (en)	2011-12-02	2015-01-06	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Thio compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4467097A (en) *	1982-09-29	1984-08-21	General Electric Company	Method for making aromatic bis(etherimide)s
AU1531492A (en) *	1991-02-14	1992-09-15	Rockefeller University, The	Method for controlling abnormal concentration tnf alpha in human tissues
US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines

1995
- 1995-11-20 JP JP8520977A patent/JPH10511678A/ja active Pending
- 1995-11-20 WO PCT/US1995/015119 patent/WO1996020705A1/en not_active Ceased
- 1995-11-20 NZ NZ296925A patent/NZ296925A/en unknown
- 1995-11-20 EP EP95940063A patent/EP0797437B1/en not_active Expired - Lifetime
- 1995-11-20 ES ES95940063T patent/ES2155537T3/es not_active Expired - Lifetime
- 1995-11-20 AT AT95940063T patent/ATE200621T1/de not_active IP Right Cessation
- 1995-11-20 PL PL95321071A patent/PL185101B1/pl not_active IP Right Cessation
- 1995-11-20 AU AU41667/96A patent/AU696817B2/en not_active Ceased
- 1995-11-20 DE DE69520750T patent/DE69520750T2/de not_active Expired - Fee Related
- 1995-11-20 PT PT95940063T patent/PT797437E/pt unknown
- 1995-11-20 DK DK95940063T patent/DK0797437T3/da active
- 1995-11-20 RU RU97112903/04A patent/RU2164514C2/ru not_active IP Right Cessation
- 1995-11-20 HU HU9701842A patent/HU226558B1/hu not_active IP Right Cessation
- 1995-11-20 FI FI972708A patent/FI972708L/fi unknown
- 1995-11-20 CZ CZ19972035A patent/CZ290372B6/cs not_active IP Right Cessation
- 1995-11-20 CA CA002208672A patent/CA2208672C/en not_active Expired - Fee Related
- 1995-11-20 SK SK869-97A patent/SK86997A3/sk unknown
2001
- 2001-06-27 GR GR20010400984T patent/GR3036131T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ203597A3 (en)	1997-11-12
ATE200621T1 (de)	2001-05-15
DK0797437T3 (da)	2001-06-05
DE69520750T2 (de)	2001-09-13
PL321071A1 (en)	1997-11-24
PL185101B1 (pl)	2003-02-28
CA2208672A1 (en)	1996-07-11
FI972708A7 (fi)	1997-08-29
FI972708L (fi)	1997-08-29
DE69520750D1 (de)	2001-05-23
GR3036131T3 (en)	2001-09-28
CZ290372B6 (cs)	2002-07-17
RU2164514C2 (ru)	2001-03-27
WO1996020705A1 (en)	1996-07-11
AU4166796A (en)	1996-07-24
JPH10511678A (ja)	1998-11-10
ES2155537T3 (es)	2001-05-16
AU696817B2 (en)	1998-09-17
EP0797437B1 (en)	2001-04-18
CA2208672C (en)	2008-02-12
EP0797437A1 (en)	1997-10-01
FI972708A0 (fi)	1997-06-23
NZ296925A (en)	1998-06-26
PT797437E (pt)	2001-07-31
SK86997A3 (en)	1998-01-14
HU226558B1 (en)	2009-03-30

Legal Events

Date	Code	Title	Description
2009-07-28	MM4A	Lapse of definitive patent protection due to non-payment of fees

Publication	Publication Date	Title
ATE337301T1 (de)	2006-09-15	Substituierte imide als tnf inhibitoren
PL321072A1 (en)	1997-11-24	Novel immunotherapeutic aryl amides
ATE248145T1 (de)	2003-09-15	Succinimid und maleimid cytokin-inhibitoren
FI972708A0 (fi)	1997-06-23	Immunoterapeuttisia imideja/amideja ja niiden käyttö TNFalfa:n tasojen alentamiseksi
ATE259787T1 (de)	2004-03-15	Inhibitoren des tumor-necrosis-factors
WO1998024763A3 (en)	1998-08-06	Immunotherapeutic imides/amides as pde iv and tnf inhibitors
NO996529D0 (no)	1999-12-28	Substituerte alkanohydroksamsyrer og metode for reduksjon av TNF<alfa>-nivåer
SE8406053L (sv)	1985-06-02	Kirurgisk mikroklemma
FI954944A7 (fi)	1995-10-17	Indolijohdannaisia 5-HT1-kaltaisina agonisteina käytettäväksi migreenin hoitoon
DK0494631T3 (da)	1995-10-09	Bærbar brænder for brændgas og med to blanderør
DK37690D0 (da)	1990-02-13	Herbicider med forbedret effektivitet og anvendelse af saadanne herbicider
DE59505916D1 (de)	1999-06-17	Verbindungselement mit beidseitigem gewinde
DE50208151D1 (de)	2006-10-26	Schwingdrossel
DK176586A (da)	1986-10-20	Leukotrienantagonister
BG37992A3 (bg)	1985-09-16	Метод за получаване на производни на бензамида
NO990300L (no)	1999-01-22	<Alfa>-aminosyreamider, fremstilling og terapeutisk anvendelse derav
NO852793L (no)	1986-01-13	(pyrrol-1-yl)-fenyldihydropyridazinoner og fremgangsmaate ved fremstilling derav.
NO980524L (no)	1998-08-10	Innspenningsverkt°y
GB8926611D0 (en)	1990-01-17	Compound and its use
DK102084A (da)	1984-08-29	N-(3-trifluormethylphenyl)-n'-propargylpiperazin, dets fremstilling og anvendelse
ES1027287U (es)	1994-08-01	Mordaza de fijacion a cuerpos tubulares.
ITRM910060V0 (it)	1991-03-18	Scopa con snodo cardanico interposto fra testa e manico onde realizzare la possibilita' di ottenere varie posizioni fra le due parti
ES2007679A6 (es)	1989-07-01	Mejoras en el objeto de la patente principal n 544.781 por un procedimiento para la obtencion de 1-(n-(1(r,s)-(etoxi-carbonil)-3-fenilpropil)-l-alanil)-l-prolina.
IT8519659A0 (it)	1985-02-26	Procedimento per riunire le estre mita'di spezzoni di catenelle a pallini,nonche'dispositivo per lasua attuazione e giunto utilizzato