ATE208392T1 - 1-(1,2-disubstituierte piperidinyl)-4- (kondensierte imidazole)-piperidin derivate - Google Patents

1-(1,2-disubstituierte piperidinyl)-4- (kondensierte imidazole)-piperidin derivate

Info

Publication number
ATE208392T1
ATE208392T1 AT96944693T AT96944693T ATE208392T1 AT E208392 T1 ATE208392 T1 AT E208392T1 AT 96944693 T AT96944693 T AT 96944693T AT 96944693 T AT96944693 T AT 96944693T AT E208392 T1 ATE208392 T1 AT E208392T1
Authority
AT
Austria
Prior art keywords
piperidine derivatives
condensed imidazole
disubstituted piperidinyl
disubstituted
piperidinyl
Prior art date
Application number
AT96944693T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Roosbroeck Yves Emiel Mari Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE208392T1 publication Critical patent/ATE208392T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT96944693T 1995-12-27 1996-12-20 1-(1,2-disubstituierte piperidinyl)-4- (kondensierte imidazole)-piperidin derivate ATE208392T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203652 1995-12-27
PCT/EP1996/005885 WO1997024356A1 (en) 1995-12-27 1996-12-20 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Publications (1)

Publication Number Publication Date
ATE208392T1 true ATE208392T1 (de) 2001-11-15

Family

ID=8221024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96944693T ATE208392T1 (de) 1995-12-27 1996-12-20 1-(1,2-disubstituierte piperidinyl)-4- (kondensierte imidazole)-piperidin derivate

Country Status (29)

Country Link
US (1) US6251894B1 (de)
EP (1) EP0843679B1 (de)
JP (1) JP4097043B2 (de)
KR (1) KR100485147B1 (de)
CN (1) CN1066733C (de)
AR (2) AR005278A1 (de)
AT (1) ATE208392T1 (de)
AU (1) AU716071B2 (de)
BR (1) BR9612307A (de)
CA (1) CA2238817C (de)
CY (1) CY2271B1 (de)
CZ (1) CZ295861B6 (de)
DE (1) DE69616802T2 (de)
DK (1) DK0843679T3 (de)
EA (1) EA001374B1 (de)
ES (1) ES2167619T3 (de)
HU (1) HU229766B1 (de)
IL (2) IL124642A (de)
MY (1) MY117680A (de)
NO (1) NO310916B1 (de)
NZ (1) NZ325845A (de)
PL (1) PL183767B1 (de)
PT (1) PT843679E (de)
SI (1) SI0843679T1 (de)
SK (1) SK283540B6 (de)
TR (1) TR199801210T2 (de)
TW (1) TW382017B (de)
WO (1) WO1997024356A1 (de)
ZA (1) ZA9610889B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
AU1146099A (en) * 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
BR9916371A (pt) * 1998-12-19 2001-09-18 Janssen Pharmaceutica Nv Composto de espiro anti-histamìnico
AU7788500A (en) * 1999-10-25 2001-05-08 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
WO2003044023A1 (en) * 2001-11-23 2003-05-30 Janssen Pharmaceutica N.V. The use of anti-histaminics for acute reduction of elevated intracranial pressure
EP1457493A4 (de) 2001-12-10 2005-11-30 Kyorin Seiyaku Kk Kondensierte, bicyclische pyridin derivate als tachykininrezeptorantagonisten
ES2242940T3 (es) * 2002-01-16 2005-11-16 Janssen Pharmaceutica N.V. Prucaloprida n-oxido.
KR100887471B1 (ko) * 2002-01-18 2009-03-10 교린 세이야꾸 가부시키 가이샤 축합 바이사이클릭 피리미딘 유도체
US7026309B2 (en) 2002-03-26 2006-04-11 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivative as tachykinin receptor antagonist
JP4677235B2 (ja) * 2002-12-23 2011-04-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換４−（４−ピペリジン−４−イル−ピペラジン−１−イル）−アゼパン誘導体およびそれらのニューロキニン拮抗薬としての使用
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
ES2346147T3 (es) 2005-03-03 2010-10-11 Janssen Pharmaceutica Nv Derivados de oxa-diaza-espiro-(5.5)-undecanona sustituidos y su uso como antagonistas de las neuroquininas.
NZ556628A (en) 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
KR20100055430A (ko) * 2007-07-19 2010-05-26 애들레이드 리서치 앤드 이노베이션 피티와이 리미티드 두개내압 감소 방법
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
EP4117673A1 (de) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Behandlung von stammzellenmangel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
EP0552292B1 (de) * 1990-10-10 1995-06-21 Schering Corporation Substituierte imidazobenzazepine und imidazopyridoazepine
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
EP0708776B1 (de) * 1993-07-13 2001-01-03 Janssen Pharmaceutica N.V. Antiallergische imidazoazepine
RU2156763C2 (ru) 1994-07-15 2000-09-27 Мейдзи Сейка Кабусики Кайся Азотсодержащие гетероциклические производные, фармацевтическая композиция на их основе и способ лечения или профилактики тромботических заболеваний
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
DE69616802T2 (de) 2002-07-04
CY2271B1 (en) 2003-07-04
NO310916B1 (no) 2001-09-17
WO1997024356A1 (en) 1997-07-10
NO982405D0 (no) 1998-05-27
KR100485147B1 (ko) 2005-09-13
PT843679E (pt) 2002-04-29
BR9612307A (pt) 1999-07-13
CZ186598A3 (cs) 1998-11-11
AU716071B2 (en) 2000-02-17
TR199801210T2 (xx) 1999-10-21
AR051817A2 (es) 2007-02-14
KR19990076715A (ko) 1999-10-15
CA2238817C (en) 2006-10-17
US6251894B1 (en) 2001-06-26
SK83098A3 (en) 1999-01-11
NO982405L (no) 1998-08-19
HUP9903948A2 (hu) 2000-03-28
MY117680A (en) 2004-07-31
DK0843679T3 (da) 2002-02-25
JP2000506503A (ja) 2000-05-30
HU229766B1 (hu) 2014-06-30
HK1011206A1 (en) 1999-07-09
HUP9903948A3 (hu) 2000-04-28
DE69616802D1 (de) 2001-12-13
EA199800603A1 (ru) 1998-12-24
ZA9610889B (en) 1998-06-23
ES2167619T3 (es) 2002-05-16
EP0843679B1 (de) 2001-11-07
AR005278A1 (es) 1999-04-28
IL124642A0 (en) 1998-12-06
NZ325845A (en) 1999-06-29
IL124641A (en) 2001-11-25
IL124641A0 (en) 1998-12-06
CZ295861B6 (cs) 2005-11-16
TW382017B (en) 2000-02-11
CN1066733C (zh) 2001-06-06
IL124642A (en) 2002-08-14
SI0843679T1 (en) 2002-06-30
CN1206417A (zh) 1999-01-27
EP0843679A1 (de) 1998-05-27
JP4097043B2 (ja) 2008-06-04
AU1308697A (en) 1997-07-28
EA001374B1 (ru) 2001-02-26
PL327136A1 (en) 1998-11-23
PL183767B1 (pl) 2002-07-31
CA2238817A1 (en) 1997-07-10
SK283540B6 (sk) 2003-09-11

Similar Documents

Publication Publication Date Title
DE69616802D1 (de) 1-(1,2-disubstituierte piperidinyl)-4-(kondensierte imidazole)-piperidin derivate
DE69615700D1 (de) 1-(1,2-disubstituierte piperidinyl)-4-substituierte piperidin derivate als tachykinin receptor antagonisten
DK0862566T3 (da) 1-(1,2-Disubstitueret piperidinyl)-4-substituerede piperazindeivater
DE69531331D1 (de) Phenylpiperidinderivate als neurokinin antagonists
DE69718026D1 (de) Fluorierte 1,4-disubstituierte piperidin-derivate
TR199600930A2 (tr) Kristal yapida (R)-(-)-2-{N-£4-(1,1-dioksido-3-okzo-2, 3-dihidrobenzizotiazol-2-il)-butil|- aminometil}-kroman hidroklorür.
PT1123287E (pt) 1-(piridil substituido)-1,2,4-triazoles insecticidas
NO991563L (no) N-substituerte, azaheterosykliske forbindelser
FI964898A7 (fi) 4-aryyli-1-(indaanimetyyli-, dihydrobentsofuraanimetyyli- tai dihydrobentsotiofeenimetyyli) piperidiinejä, -tetra-hydropyridiinejä tai -piperatsiineja
ZA96702B (en) 4-(1H-indol-1-yl)-1-piperidinyl derivatives.
ID15912A (id) Turunan-turunan 1-(1,2-piperidinil yang didwisubstitusi)-4-(imidazol yang dilebur)-piperidin
ATE344244T1 (de) Substituierte 4-phenyl-1-(1-phenyl-cyclohexyl)-1, 2,3,6-tetrahydropyridine
DE69714019D1 (de) 1,4-dihydropyridin-verbindungen als bradykinin-antagonisten
ZA9610894B (en) 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives.
ITMI941593A0 (it) Tetraidropiridine 3,3-disostituite

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification