DK0737678T3 - 4-Indolylpiperazinyl-derivater - Google Patents

4-Indolylpiperazinyl-derivater

Info

Publication number: DK0737678T3
Authority: DK; Denmark
Prior art keywords: indolylpiperazinyl; derivatives; alkyl; indolylpiperazine; substd
Prior art date: 1995-04-10

Application number

DK96302420T

Other languages

English (en)

Inventor

John Patrick Yardley

Horace Fletcher

Michael Gerard Kelly

Alan Chapman White

Original Assignee

American Home Prod

Wyeth John & Brother Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-10

Filing date

1996-04-04

Publication date

2002-10-07

1996-04-04 Application filed by American Home Prod, Wyeth John & Brother Ltd filed Critical American Home Prod

2002-10-07 Application granted granted Critical

2002-10-07 Publication of DK0737678T3 publication Critical patent/DK0737678T3/da

Links

-1 4-Indolylpiperazinyl Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
FBCZWQNVHNIQOD-UHFFFAOYSA-N 2-piperazin-1-yl-1h-indole Chemical compound C1CNCCN1C1=CC2=CC=CC=C2N1 FBCZWQNVHNIQOD-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK96302420T 1995-04-10 1996-04-04 4-Indolylpiperazinyl-derivater DK0737678T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/419,342 US5486518A (en)	1995-04-10	1995-04-10	4-indolylpiperazinyl derivatives

Publications (1)

Publication Number	Publication Date
DK0737678T3 true DK0737678T3 (da)	2002-10-07

Family

ID=23661842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96302420T DK0737678T3 (da)	1995-04-10	1996-04-04	4-Indolylpiperazinyl-derivater

Country Status (12)

Country	Link
US (1)	US5486518A (da)
EP (1)	EP0737678B1 (da)
JP (1)	JPH08319274A (da)
AT (1)	ATE219484T1 (da)
CA (1)	CA2173690A1 (da)
DE (1)	DE69621877T2 (da)
DK (1)	DK0737678T3 (da)
ES (1)	ES2177727T3 (da)
HU (1)	HUP9600914A2 (da)
PT (1)	PT737678E (da)
SI (1)	SI0737678T1 (da)
TW (1)	TW454005B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5519025A (en) *	1995-04-10	1996-05-21	American Home Products Corporation	4-indolylpiperazinyl derivatives
DE69819266T2 (de)	1997-09-02	2004-07-29	Duphar International Research B.V.	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (en) *	1997-09-02	2003-10-29	Duphar International Research B.V	Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
US6376494B1 (en)	1998-06-15	2002-04-23	American Home Products Corporation	Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
WO1999065887A1 (en) *	1998-06-15	1999-12-23	American Home Products Corporation	Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
EP1157017A1 (en) *	1999-03-02	2001-11-28	American Home Products Corporation	N-substituted imide derivatives with serotonergic activity
US6306859B1 (en)	1999-03-02	2001-10-23	American Home Products Corporation	N-substituted imide derivatives with serotonergic activity
US6831084B1 (en)	1999-11-12	2004-12-14	Wyeth	Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
WO2001034586A2 (en)	1999-11-12	2001-05-17	Wyeth	Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-ht1a activity
WO2002085871A2 (en)	2001-04-04	2002-10-31	Wyeth	Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) *	2002-09-05	2006-06-27	Wyeth	Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
US7179813B2 (en) *	2003-06-11	2007-02-20	Wyeth	Bicyclic indolyl derivatives and methods for their use as serotonergic agents
BR112012005119A2 (pt) *	2009-09-07	2016-11-22	Vifor Int Ag	novos antagonistas de hepcidina etanodiaminas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641029A (en) *	1970-02-02	1972-02-08	American Cyanamid Co	Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) *	1970-02-02	1972-02-29	American Cyanamid Co	N-(tert-aminoalkyl)-2-indenecarboxamides
CA1340113C (en) *	1988-05-24	1998-11-03	Magid A. Abou-Gharbia	Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
CA2004670A1 (en) *	1988-12-08	1990-06-08	Jan Hartog	Anxiolytically active piperazine derivatives
GB8909209D0 (en) *	1989-04-22	1989-06-07	Wyeth John & Brother Ltd	Piperazine derivatives
IL94151A (en) *	1989-04-22	1995-08-31	Wyeth John & Brother Ltd	History of piperazine, their preparation and pharmaceutical preparations containing them
US5340812A (en) *	1989-04-22	1994-08-23	John Wyeth & Brother, Limited	Piperazine derivatives
GB9411099D0 (en) *	1994-06-03	1994-07-27	Wyeth John & Brother Ltd	Piperazine derivatives

1995
- 1995-04-10 US US08/419,342 patent/US5486518A/en not_active Expired - Lifetime
- 1995-12-09 TW TW084113142A patent/TW454005B/zh not_active IP Right Cessation
1996
- 1996-03-29 JP JP8076390A patent/JPH08319274A/ja not_active Withdrawn
- 1996-04-04 DK DK96302420T patent/DK0737678T3/da active
- 1996-04-04 EP EP96302420A patent/EP0737678B1/en not_active Expired - Lifetime
- 1996-04-04 AT AT96302420T patent/ATE219484T1/de not_active IP Right Cessation
- 1996-04-04 PT PT96302420T patent/PT737678E/pt unknown
- 1996-04-04 DE DE69621877T patent/DE69621877T2/de not_active Expired - Fee Related
- 1996-04-04 ES ES96302420T patent/ES2177727T3/es not_active Expired - Lifetime
- 1996-04-04 SI SI9630483T patent/SI0737678T1/xx unknown
- 1996-04-09 CA CA002173690A patent/CA2173690A1/en not_active Abandoned
- 1996-04-09 HU HU9600914A patent/HUP9600914A2/hu unknown

Also Published As

Publication number	Publication date
ATE219484T1 (de)	2002-07-15
PT737678E (pt)	2002-11-29
TW454005B (en)	2001-09-11
US5486518A (en)	1996-01-23
HU9600914D0 (en)	1996-05-28
JPH08319274A (ja)	1996-12-03
SI0737678T1 (en)	2002-10-31
HK1010102A1 (en)	1999-06-11
DE69621877D1 (de)	2002-07-25
HUP9600914A2 (hu)	1998-09-28
ES2177727T3 (es)	2002-12-16
EP0737678B1 (en)	2002-06-19
CA2173690A1 (en)	1996-10-11
EP0737678A1 (en)	1996-10-16
DE69621877T2 (de)	2002-12-19

Publication	Publication Date	Title
DE69621877D1 (de)	2002-07-25	4-Indolylpiperazinyl-Derivate
ATE174334T1 (de)	1998-12-15	Piperidinderivate, verwendbar als neurokinin- rezeptor-antagonisten
DK0920421T3 (da)	2003-03-10	Isoxazolinderivater anvendelige som antimikrobielle midler
DK705888A (da)	1989-08-13	Pyridazinonderivater
DK394189D0 (da)	1989-08-11	Arylalkylaminer og -amider med antikonvulsive og neurobeskyttende egenskaber
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
NO963374D0 (no)	1996-08-13	Substituerte 4H-pyraner
UY26568A1 (es)	2001-08-27	Nuevos derivados de amidas heterocíclicas
NO955103D0 (no)	1995-12-15	Anvendelse av 1,2-broholdige 1,4-dihydropyridiner som legemiddel
DK0713865T3 (da)	1999-09-20	Derivater af 2-aminobenzensulfonsyre og 2-aminobenzensulfonylchlorid, fremstilling og anvendelse heraf som syntesemellempro
DE69837628D1 (de)	2007-05-31	Aminderivate, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
ATE195936T1 (de)	2000-09-15	Bis-imide derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitung
DK0758647T3 (da)	2000-12-11	Acylsubstituerede aminopyraner med en modulerende virkning på kaliumkanaler
ATE479653T1 (de)	2010-09-15	Carboxyalkoxy-substituierte acyl-carboxyphenyl- harnstoffderivate, verfahren zu ihre herstellung und ihre verwendung als arzneimittel
ATE176903T1 (de)	1999-03-15	Cyclohexadienderivate
PT72383A (en)	1981-02-01	Novel 1-(cyclohexyl)-4-aryl-4-pipedinecarboxylic acid derivatives