ATE222912T1 - Ausgewählte k-252a derivate - Google Patents

Ausgewählte k-252a derivate

Info

Publication number: ATE222912T1
Authority: AT; Austria
Prior art keywords: derivatives; survival; enhancing; compounds; represented
Prior art date: 1996-06-03

Application number

AT97927906T

Other languages

English (en)

Inventor

Robert L Hudkins

John P Mallamo

Masami Hamano

Reiko Tanaka

Chikara Murakata

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-03

Filing date

1997-06-02

Publication date

2002-09-15

1997-06-02 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE222912T1 publication Critical patent/ATE222912T1/de

Links

KOZFSFOOLUUIGY-IYYJOCMQSA-N k-252a, nocardiopsis sp. Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@](C(=O)OC)(O)[C@@]4(C)O1 KOZFSFOOLUUIGY-IYYJOCMQSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical class C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 abstract 1
230000004073 interleukin-2 production Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1
230000001228 trophic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

AT97927906T 1996-06-03 1997-06-02 Ausgewählte k-252a derivate ATE222912T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65736696A	1996-06-03	1996-06-03
PCT/US1997/009448 WO1997046565A1 (en)	1996-06-03	1997-06-02	SELECTED DERIVATIVES OF K-252a

Publications (1)

Publication Number	Publication Date
ATE222912T1 true ATE222912T1 (de)	2002-09-15

Family

ID=24636859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97927906T ATE222912T1 (de)	1996-06-03	1997-06-02	Ausgewählte k-252a derivate

Country Status (17)

Country	Link
US (1)	US6306849B1 (de)
EP (1)	EP0918777B1 (de)
JP (1)	JP2000511902A (de)
CN (1)	CN1198827C (de)
AT (1)	ATE222912T1 (de)
AU (1)	AU716656B2 (de)
BR (1)	BR9711093A (de)
CA (1)	CA2256633C (de)
DE (1)	DE69715010T2 (de)
DK (1)	DK0918777T3 (de)
ES (1)	ES2183184T3 (de)
NO (1)	NO312464B1 (de)
NZ (2)	NZ333018A (de)
PT (1)	PT918777E (de)
RU (1)	RU2205184C2 (de)
UA (1)	UA67725C2 (de)
WO (1)	WO1997046565A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6200968B1 (en)	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US7795246B2 (en)	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
HK1040053B (en)	1998-09-25	2007-09-21	Cephalon, Inc.	Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
US7018999B2 (en)	2001-05-16	2006-03-28	Cephalon, Inc.	Methods for the treatment and prevention of pain
AU2003259846A1 (en) *	2002-08-16	2004-03-03	The General Hospital Corporation	Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1545615A4 (de) *	2002-10-04	2006-03-01	Rinat Neuroscience Corp	Verfahren zur behandlung von herzarrhythmie und zur verhinderung von tod durch herzarrhythmie mit ngf antagonisten
US7255860B2 (en) *	2002-10-08	2007-08-14	Rinat Neuroscience Corp.	Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
WO2004032870A2 (en)	2002-10-08	2004-04-22	Rinat Neuroscience Corp.	Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same
UA80447C2 (en)	2002-10-08	2007-09-25		Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
DK1575517T3 (da) *	2002-12-24	2012-05-14	Rinat Neuroscience Corp	Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme
US9498530B2 (en)	2002-12-24	2016-11-22	Rinat Neuroscience Corp.	Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
US7569364B2 (en) *	2002-12-24	2009-08-04	Pfizer Inc.	Anti-NGF antibodies and methods using same
KR20050111598A (ko)	2003-02-19	2005-11-25	리나트 뉴로사이언스 코퍼레이션	신경 성장 인자 길항제 및 ｎｓａｉｄ를 투여함으로써통증을 치료하는 방법 및 그것을 함유하는 조성물
US20060014165A1 (en) *	2003-07-14	2006-01-19	Decode Genetics Ehf.	Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association
KR101637908B1 (ko) *	2004-04-07	2016-07-11	리나트 뉴로사이언스 코프.	신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법
MX2007001155A (es) *	2004-07-29	2007-08-14	Creabilis Therapeutics Spa	Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
MY171292A (en) *	2008-12-22	2019-10-07	Creabilis S A	Synthesis of polymer conjugates of indolocarbazole compounds

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4554402A (en)	1983-12-23	1985-11-19	Aluminum Company Of America	Vibration damper for overhead conductor
JPS62120388A (ja)	1985-11-19	1987-06-01	Meiji Seika Kaisha Ltd	Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法
JPS62155285A (ja)	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62155284A (ja)	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62220196A (ja)	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１
US4816450A (en)	1986-09-15	1989-03-28	Duke University	Inhibition of protein kinase C by long-chain bases
JPH0826037B2 (ja)	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) *	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
US4735939A (en)	1987-02-27	1988-04-05	The Dow Chemical Company	Insecticidal activity of staurosporine
WO1988007045A1 (fr)	1987-03-09	1988-09-22	Kyowa Hakko Kogyo Co., Ltd.	Derives de la substance physiologiquement active k-252
IL86632A0 (en)	1987-06-15	1988-11-30	Ciba Geigy Ag	Derivatives substituted at methyl-amino nitrogen
US5093330A (en)	1987-06-15	1992-03-03	Ciba-Geigy Corporation	Staurosporine derivatives substituted at methylamino nitrogen
JPH07113027B2 (ja)	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
EP0383919A4 (en)	1988-02-04	1992-08-05	Kyowa Hakko Kogyo Co., Ltd.	Staurosporin derivatives
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE3924538A1 (de)	1989-07-25	1991-01-31	Goedecke Ag	Indolocarbazol und dessen verwendung
WO1991009034A1 (en)	1989-12-14	1991-06-27	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
US5168103A (en) *	1991-01-22	1992-12-01	American Home Products Corporation	[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
JPH0586068A (ja)	1991-03-04	1993-04-06	Rikagaku Kenkyusho	新規抗生物質ｒｋ−１４０９、その製造法並びに抗腫瘍剤及び抗炎症剤
AU3064992A (en)	1991-11-08	1993-06-07	University Of Southern California	Compositions containing k-252 compounds for potentiation of neurotrophin activity
JP2593021B2 (ja)	1991-12-13	1997-03-19	伊藤ハム株式会社	ウシ胚の性の識別方法
US6271242B1 (en)	1992-02-10	2001-08-07	Bristol-Myers Squibb Co.	Method for treating cancer using a tyrosine protein kinase inhibitor
JPH05247055A (ja)	1992-03-03	1993-09-24	Meiji Seika Kaisha Ltd	スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤
JPH0673063A (ja)	1992-06-22	1994-03-15	Kyowa Hakko Kogyo Co Ltd	Ｕｃｎ−０１誘導体
EP0575955B1 (de)	1992-06-22	1999-09-15	Kyowa Hakko Kogyo Co., Ltd.	Verfahren zur Herstellung von Staurosporin-Derivaten
US5461146A (en)	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders
US5621100A (en)	1992-07-24	1997-04-15	Cephalon, Inc.	K-252a derivatives for treatment of neurological disorders
DE69331228T4 (de)	1992-09-21	2002-09-05	Kyowa Hakko Kogyo Co., Ltd.	Heilmittel für thrombozytopenia
WO1994027982A1 (en)	1993-05-28	1994-12-08	Cephalon, Inc.	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
EP0703917A1 (de)	1993-06-17	1996-04-03	Novartis AG	Indolcarbazolverbindung verwendbar als proteinkinase c inhibitor
US5468872A (en)	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

1997
- 1997-02-06 UA UA98126949A patent/UA67725C2/uk unknown
- 1997-06-02 PT PT97927906T patent/PT918777E/pt unknown
- 1997-06-02 DK DK97927906T patent/DK0918777T3/da active
- 1997-06-02 JP JP10500751A patent/JP2000511902A/ja active Pending
- 1997-06-02 RU RU99100050/04A patent/RU2205184C2/ru not_active IP Right Cessation
- 1997-06-02 DE DE69715010T patent/DE69715010T2/de not_active Expired - Lifetime
- 1997-06-02 CA CA002256633A patent/CA2256633C/en not_active Expired - Fee Related
- 1997-06-02 NZ NZ333018A patent/NZ333018A/xx not_active IP Right Cessation
- 1997-06-02 CN CNB97196985XA patent/CN1198827C/zh not_active Expired - Fee Related
- 1997-06-02 US US08/867,084 patent/US6306849B1/en not_active Expired - Fee Related
- 1997-06-02 AU AU32253/97A patent/AU716656B2/en not_active Ceased
- 1997-06-02 WO PCT/US1997/009448 patent/WO1997046565A1/en not_active Ceased
- 1997-06-02 BR BR9711093A patent/BR9711093A/pt active Search and Examination
- 1997-06-02 EP EP97927906A patent/EP0918777B1/de not_active Expired - Lifetime
- 1997-06-02 ES ES97927906T patent/ES2183184T3/es not_active Expired - Lifetime
- 1997-06-02 AT AT97927906T patent/ATE222912T1/de not_active IP Right Cessation
1998
- 1998-12-02 NO NO19985622A patent/NO312464B1/no not_active IP Right Cessation
2000
- 2000-04-19 NZ NZ504097A patent/NZ504097A/en unknown

Also Published As

Publication number	Publication date
UA67725C2 (en)	2004-07-15
EP0918777A1 (de)	1999-06-02
EP0918777B1 (de)	2002-08-28
CN1226893A (zh)	1999-08-25
HK1018703A1 (en)	1999-12-30
US6306849B1 (en)	2001-10-23
DE69715010T2 (de)	2003-04-03
CN1198827C (zh)	2005-04-27
ES2183184T3 (es)	2003-03-16
CA2256633A1 (en)	1997-12-11
BR9711093A (pt)	1999-08-17
RU2205184C2 (ru)	2003-05-27
DK0918777T3 (da)	2002-12-30
AU716656B2 (en)	2000-03-02
NZ504097A (en)	2005-06-24
NO985622L (no)	1999-02-02
NO985622D0 (no)	1998-12-02
JP2000511902A (ja)	2000-09-12
AU3225397A (en)	1998-01-05
WO1997046565A1 (en)	1997-12-11
NO312464B1 (no)	2002-05-13
PT918777E (pt)	2003-01-31
NZ333018A (en)	2000-05-26
CA2256633C (en)	2009-04-07
DE69715010D1 (de)	2002-10-02

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2010-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69715010D1 (de)	2002-10-02	Ausgewählte k-252a derivate
AU1676200A (en)	2000-06-13	Polyhydroxylated heterocyclic derivatives as anti-coagulants
MY126559A (en)	2006-10-31	Fungicidal 2-methoxybenzophenones
DE69721008D1 (de)	2003-05-22	Bicyclische pyrimidine derivate und ihre verwendung als antikoagulantien
EA199700061A1 (ru)	1997-12-30	Способ получения силденафила
MY137566A (en)	2009-02-27	Indolylmaleimide derivatives
EP0630898A4 (de)	1995-04-26	Heilmittel für thrombozytopenia.
ATE289810T1 (de)	2005-03-15	Ecteinascidinderivate
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
ATE265455T1 (de)	2004-05-15	Tetrahydropyridoverbindungen
DE69727305D1 (de)	2004-02-26	Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
IE780922L (en)	1978-11-11	1,3,5-s-HEXAHYDROSUBSTITUTED TRIAZINES
MY109069A (en)	1996-11-30	Fungicidal derivatives of 2-alkoxy-2-imidazolin-5-ones
SE9604582D0 (sv)	1996-12-13	Novel compounds
ATE234308T1 (de)	2003-03-15	3'-epi k-252a derivate
DE3588094D1 (de)	1996-04-25	Antihypertensive Derivate
DE69703115D1 (de)	2000-10-19	Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
DE69706950D1 (de)	2001-10-31	Furoindolizine
DE69601451D1 (de)	1999-03-11	UCK14-Verbindungen
ES2058182T3 (es)	1994-11-01	Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas.
ES2095032T3 (es)	1997-02-01	Derivados 2- y 3-amino y azido de 1,5-iminoazucares como compuestos antivirales.