ATE228506T1 - Synthese von acridinderivaten als inhibitoren von multipler medikamentenresistenz - Google Patents
Synthese von acridinderivaten als inhibitoren von multipler medikamentenresistenzInfo
- Publication number
- ATE228506T1 ATE228506T1 AT98934892T AT98934892T ATE228506T1 AT E228506 T1 ATE228506 T1 AT E228506T1 AT 98934892 T AT98934892 T AT 98934892T AT 98934892 T AT98934892 T AT 98934892T AT E228506 T1 ATE228506 T1 AT E228506T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- inhibitors
- drug resistance
- multiple drug
- acridine derivatives
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 206010048723 Multiple-drug resistance Diseases 0.000 title 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 1
- 229940027998 antiseptic and disinfectant acridine derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- INBURRUOTJXJKO-UHFFFAOYSA-N 1-(2-phenylethyl)isoquinolin-3-amine Chemical compound N=1C(N)=CC2=CC=CC=C2C=1CCC1=CC=CC=C1 INBURRUOTJXJKO-UHFFFAOYSA-N 0.000 abstract 1
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710612.4A GB9710612D0 (en) | 1997-05-23 | 1997-05-23 | Synthesis of acridine derivatives |
| PCT/EP1998/002991 WO1998052923A1 (en) | 1997-05-23 | 1998-05-22 | Synthesis of acridine derivative multidrug-resistant inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE228506T1 true ATE228506T1 (de) | 2002-12-15 |
Family
ID=10812906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98934892T ATE228506T1 (de) | 1997-05-23 | 1998-05-22 | Synthese von acridinderivaten als inhibitoren von multipler medikamentenresistenz |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6248891B1 (de) |
| EP (1) | EP0983246B1 (de) |
| JP (1) | JP4390861B2 (de) |
| KR (1) | KR100536155B1 (de) |
| CN (1) | CN1178918C (de) |
| AT (1) | ATE228506T1 (de) |
| AU (1) | AU744402B2 (de) |
| BR (1) | BR9809143A (de) |
| CA (1) | CA2289492C (de) |
| DE (1) | DE69809733T2 (de) |
| DK (1) | DK0983246T3 (de) |
| ES (1) | ES2187984T3 (de) |
| GB (1) | GB9710612D0 (de) |
| HU (1) | HUP0002083A3 (de) |
| IL (1) | IL132593A (de) |
| PL (1) | PL190109B1 (de) |
| PT (1) | PT983246E (de) |
| WO (1) | WO1998052923A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| CA2346689A1 (en) | 1998-10-08 | 2000-04-20 | Gregor James Macdonald | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| EP1749540B1 (de) * | 1999-05-17 | 2010-10-13 | Cancer Research Ventures Limited | Zubereitungen zur Erhöhung der Bioverfügbarkeit von oral verabreichten pharmazeutischen Verbindungen |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
| WO2008064011A1 (en) | 2006-11-13 | 2008-05-29 | The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs | Acridone compounds |
| US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
| JP7436375B2 (ja) * | 2018-03-21 | 2024-02-21 | イズミ テクノロジー，エルエルシー | エラクリダールの重水素化類似体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK280864B6 (en) * | 1991-01-11 | 2000-08-14 | Laboratoires Glaxo Sa | Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon |
| EP0784474A2 (de) * | 1994-10-05 | 1997-07-23 | Glaxo Wellcome Inc. | Parenterale pharmazeutische zusammensetzungen enthaltend gf120918a |
-
1997
- 1997-05-23 GB GBGB9710612.4A patent/GB9710612D0/en active Pending
-
1998
- 1998-05-22 EP EP98934892A patent/EP0983246B1/de not_active Expired - Lifetime
- 1998-05-22 AT AT98934892T patent/ATE228506T1/de not_active IP Right Cessation
- 1998-05-22 WO PCT/EP1998/002991 patent/WO1998052923A1/en not_active Ceased
- 1998-05-22 US US09/403,158 patent/US6248891B1/en not_active Expired - Fee Related
- 1998-05-22 HU HU0002083A patent/HUP0002083A3/hu unknown
- 1998-05-22 BR BR9809143-3A patent/BR9809143A/pt not_active Application Discontinuation
- 1998-05-22 PL PL98336937A patent/PL190109B1/pl not_active IP Right Cessation
- 1998-05-22 KR KR10-1999-7010781A patent/KR100536155B1/ko not_active Expired - Fee Related
- 1998-05-22 DK DK98934892T patent/DK0983246T3/da active
- 1998-05-22 AU AU84344/98A patent/AU744402B2/en not_active Ceased
- 1998-05-22 PT PT98934892T patent/PT983246E/pt unknown
- 1998-05-22 ES ES98934892T patent/ES2187984T3/es not_active Expired - Lifetime
- 1998-05-22 JP JP54995998A patent/JP4390861B2/ja not_active Expired - Fee Related
- 1998-05-22 CA CA002289492A patent/CA2289492C/en not_active Expired - Fee Related
- 1998-05-22 DE DE69809733T patent/DE69809733T2/de not_active Expired - Lifetime
- 1998-05-22 IL IL13259398A patent/IL132593A/en not_active IP Right Cessation
- 1998-05-22 CN CNB988051265A patent/CN1178918C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100536155B1 (ko) | 2005-12-14 |
| BR9809143A (pt) | 2000-08-01 |
| EP0983246B1 (de) | 2002-11-27 |
| EP0983246A1 (de) | 2000-03-08 |
| IL132593A0 (en) | 2001-03-19 |
| JP4390861B2 (ja) | 2009-12-24 |
| PL336937A1 (en) | 2000-07-17 |
| HUP0002083A2 (hu) | 2001-04-28 |
| CA2289492C (en) | 2009-03-24 |
| IL132593A (en) | 2004-07-25 |
| ES2187984T3 (es) | 2003-06-16 |
| AU744402B2 (en) | 2002-02-21 |
| CA2289492A1 (en) | 1998-11-26 |
| PT983246E (pt) | 2003-04-30 |
| JP2002502371A (ja) | 2002-01-22 |
| PL190109B1 (pl) | 2005-10-31 |
| DE69809733T2 (de) | 2003-09-18 |
| AU8434498A (en) | 1998-12-11 |
| CN1178918C (zh) | 2004-12-08 |
| HUP0002083A3 (en) | 2002-03-28 |
| GB9710612D0 (en) | 1997-07-16 |
| DE69809733D1 (de) | 2003-01-09 |
| US6248891B1 (en) | 2001-06-19 |
| DK0983246T3 (da) | 2003-03-24 |
| WO1998052923A1 (en) | 1998-11-26 |
| CN1255918A (zh) | 2000-06-07 |
| KR20010012817A (ko) | 2001-02-26 |
| HK1023995A1 (en) | 2000-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0983246 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |