DK0983246T3 - Syntese af acridinafledte multidrug-resistente inhibitorer - Google Patents
Syntese af acridinafledte multidrug-resistente inhibitorerInfo
- Publication number
- DK0983246T3 DK0983246T3 DK98934892T DK98934892T DK0983246T3 DK 0983246 T3 DK0983246 T3 DK 0983246T3 DK 98934892 T DK98934892 T DK 98934892T DK 98934892 T DK98934892 T DK 98934892T DK 0983246 T3 DK0983246 T3 DK 0983246T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- multidrug
- acridine
- derived
- formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- INBURRUOTJXJKO-UHFFFAOYSA-N 1-(2-phenylethyl)isoquinolin-3-amine Chemical compound N=1C(N)=CC2=CC=CC=C2C=1CCC1=CC=CC=C1 INBURRUOTJXJKO-UHFFFAOYSA-N 0.000 abstract 1
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710612.4A GB9710612D0 (en) | 1997-05-23 | 1997-05-23 | Synthesis of acridine derivatives |
| PCT/EP1998/002991 WO1998052923A1 (en) | 1997-05-23 | 1998-05-22 | Synthesis of acridine derivative multidrug-resistant inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0983246T3 true DK0983246T3 (da) | 2003-03-24 |
Family
ID=10812906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98934892T DK0983246T3 (da) | 1997-05-23 | 1998-05-22 | Syntese af acridinafledte multidrug-resistente inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6248891B1 (da) |
| EP (1) | EP0983246B1 (da) |
| JP (1) | JP4390861B2 (da) |
| KR (1) | KR100536155B1 (da) |
| CN (1) | CN1178918C (da) |
| AT (1) | ATE228506T1 (da) |
| AU (1) | AU744402B2 (da) |
| BR (1) | BR9809143A (da) |
| CA (1) | CA2289492C (da) |
| DE (1) | DE69809733T2 (da) |
| DK (1) | DK0983246T3 (da) |
| ES (1) | ES2187984T3 (da) |
| GB (1) | GB9710612D0 (da) |
| HU (1) | HUP0002083A3 (da) |
| IL (1) | IL132593A (da) |
| PL (1) | PL190109B1 (da) |
| PT (1) | PT983246E (da) |
| WO (1) | WO1998052923A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| CA2346689A1 (en) | 1998-10-08 | 2000-04-20 | Gregor James Macdonald | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| EP1749540B1 (en) * | 1999-05-17 | 2010-10-13 | Cancer Research Ventures Limited | Compositions for improving bioavailability of orally administered drugs |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
| WO2008064011A1 (en) | 2006-11-13 | 2008-05-29 | The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs | Acridone compounds |
| US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
| JP7436375B2 (ja) * | 2018-03-21 | 2024-02-21 | イズミ テクノロジー，エルエルシー | エラクリダールの重水素化類似体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK280864B6 (en) * | 1991-01-11 | 2000-08-14 | Laboratoires Glaxo Sa | Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon |
| EP0784474A2 (en) * | 1994-10-05 | 1997-07-23 | Glaxo Wellcome Inc. | Parenteral pharmaceutical compositions containing gf120918a |
-
1997
- 1997-05-23 GB GBGB9710612.4A patent/GB9710612D0/en active Pending
-
1998
- 1998-05-22 EP EP98934892A patent/EP0983246B1/en not_active Expired - Lifetime
- 1998-05-22 AT AT98934892T patent/ATE228506T1/de not_active IP Right Cessation
- 1998-05-22 WO PCT/EP1998/002991 patent/WO1998052923A1/en not_active Ceased
- 1998-05-22 US US09/403,158 patent/US6248891B1/en not_active Expired - Fee Related
- 1998-05-22 HU HU0002083A patent/HUP0002083A3/hu unknown
- 1998-05-22 BR BR9809143-3A patent/BR9809143A/pt not_active Application Discontinuation
- 1998-05-22 PL PL98336937A patent/PL190109B1/pl not_active IP Right Cessation
- 1998-05-22 KR KR10-1999-7010781A patent/KR100536155B1/ko not_active Expired - Fee Related
- 1998-05-22 DK DK98934892T patent/DK0983246T3/da active
- 1998-05-22 AU AU84344/98A patent/AU744402B2/en not_active Ceased
- 1998-05-22 PT PT98934892T patent/PT983246E/pt unknown
- 1998-05-22 ES ES98934892T patent/ES2187984T3/es not_active Expired - Lifetime
- 1998-05-22 JP JP54995998A patent/JP4390861B2/ja not_active Expired - Fee Related
- 1998-05-22 CA CA002289492A patent/CA2289492C/en not_active Expired - Fee Related
- 1998-05-22 DE DE69809733T patent/DE69809733T2/de not_active Expired - Lifetime
- 1998-05-22 IL IL13259398A patent/IL132593A/en not_active IP Right Cessation
- 1998-05-22 CN CNB988051265A patent/CN1178918C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100536155B1 (ko) | 2005-12-14 |
| BR9809143A (pt) | 2000-08-01 |
| EP0983246B1 (en) | 2002-11-27 |
| EP0983246A1 (en) | 2000-03-08 |
| IL132593A0 (en) | 2001-03-19 |
| JP4390861B2 (ja) | 2009-12-24 |
| PL336937A1 (en) | 2000-07-17 |
| HUP0002083A2 (hu) | 2001-04-28 |
| CA2289492C (en) | 2009-03-24 |
| IL132593A (en) | 2004-07-25 |
| ES2187984T3 (es) | 2003-06-16 |
| AU744402B2 (en) | 2002-02-21 |
| CA2289492A1 (en) | 1998-11-26 |
| PT983246E (pt) | 2003-04-30 |
| JP2002502371A (ja) | 2002-01-22 |
| PL190109B1 (pl) | 2005-10-31 |
| DE69809733T2 (de) | 2003-09-18 |
| AU8434498A (en) | 1998-12-11 |
| CN1178918C (zh) | 2004-12-08 |
| HUP0002083A3 (en) | 2002-03-28 |
| GB9710612D0 (en) | 1997-07-16 |
| DE69809733D1 (de) | 2003-01-09 |
| US6248891B1 (en) | 2001-06-19 |
| WO1998052923A1 (en) | 1998-11-26 |
| CN1255918A (zh) | 2000-06-07 |
| ATE228506T1 (de) | 2002-12-15 |
| KR20010012817A (ko) | 2001-02-26 |
| HK1023995A1 (en) | 2000-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20021999D0 (no) | Spaltning av intermediater i syntesen av hovedsakelig rent bicalutamid | |
| ATE245351T1 (de) | Eletrolytische synthese von peressigsäure | |
| DE60027420D1 (de) | Tri-aryl-säurederivate als ppar rezeptor liganden | |
| FI971489A0 (fi) | Uusia bentsoksatsoleja | |
| NO20022318D0 (no) | Nye forbindelser | |
| IL148932A0 (en) | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION | |
| NO20062092L (no) | Nye fremgangsmater for fremstilling av N-desmetylzopiklon og optisk rent (+)-N-desmetylzopiklon og optisk rent (-)-N-desmetylzopiklon | |
| AR036331A1 (es) | Compuestos utiles como intermediarios en la elaboracion de inhibidores de cetp y procedimiento para obtener dichos intermediarios e inhibidores | |
| ATE244699T1 (de) | Substituierte anilinverbindungen | |
| IL132593A0 (en) | Synthesis of acridine derivative multidrug-resistant inhibitors | |
| BR0109048A (pt) | Processo para a sìntese de citalopram | |
| DK1204658T3 (da) | Benzofurylpiperazin-serotoninagonister | |
| DE60041001D1 (de) | Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien | |
| MX9801190A (es) | Inhibidores de prolil endopeptidasa. | |
| DE69911603D1 (de) | Synthese von 5- oder 8-bromoisoquinolin derivaten | |
| MXPA03002493A (es) | Proceso eficiente para preparacion de un inhibidor del factor xa. | |
| DK1347960T3 (da) | Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidin | |
| BR0010488A (pt) | Tienocicloalqu(en)ilamino-1,3,5-triazinas substituìdas | |
| DK0975601T3 (da) | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor | |
| ATE265418T1 (de) | Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine | |
| DK0555283T3 (da) | Mellemprodukter ved fremstillingen af 4,5-difluoranthranilinsyre | |
| DK1320527T3 (da) | Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler | |
| BG106321A (en) | Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists | |
| ES2136028B1 (es) | Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos. | |
| DE60324776D1 (de) | Verfahren zur synthese von pergolid |