ATE229543T1 - Polypeptide des hepatitis c-virus (hiv) - Google Patents
Polypeptide des hepatitis c-virus (hiv)Info
- Publication number
- ATE229543T1 ATE229543T1 AT92914835T AT92914835T ATE229543T1 AT E229543 T1 ATE229543 T1 AT E229543T1 AT 92914835 T AT92914835 T AT 92914835T AT 92914835 T AT92914835 T AT 92914835T AT E229543 T1 ATE229543 T1 AT E229543T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- hiv
- polypeptides
- virus
- epitopes
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72248991A | 1991-06-24 | 1991-06-24 | |
| PCT/US1992/005388 WO1993000365A2 (en) | 1991-06-24 | 1992-06-24 | Hepatitis c virus (hcv) polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229543T1 true ATE229543T1 (de) | 2002-12-15 |
Family
ID=24902063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92914835T ATE229543T1 (de) | 1991-06-24 | 1992-06-24 | Polypeptide des hepatitis c-virus (hiv) |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6346375B1 (de) |
| EP (1) | EP0591431B1 (de) |
| JP (9) | JP3516681B2 (de) |
| KR (1) | KR0185426B1 (de) |
| AT (1) | ATE229543T1 (de) |
| BG (1) | BG61843B1 (de) |
| CA (1) | CA2110058C (de) |
| DE (1) | DE69232871T2 (de) |
| ES (1) | ES2188583T3 (de) |
| FI (2) | FI110099B (de) |
| HU (1) | HU227547B1 (de) |
| NO (1) | NO309528B1 (de) |
| RO (1) | RO117329B1 (de) |
| RU (1) | RU2148587C1 (de) |
| UA (1) | UA40572C2 (de) |
| WO (1) | WO1993000365A2 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| US6861212B1 (en) | 1987-11-18 | 2005-03-01 | Chiron Corporation | NANBV diagnostics and vaccines |
| US6171782B1 (en) | 1987-11-18 | 2001-01-09 | Chiron Corporation | Antibody compositions to HCV and uses thereof |
| US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
| US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
| US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US5582968A (en) * | 1990-02-16 | 1996-12-10 | United Biomedical, Inc. | Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| GB9204274D0 (en) * | 1992-02-28 | 1992-04-08 | Wellcome Found | Novel peptides |
| US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
| US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
| DE4240980A1 (de) * | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | HCV Peptidantigene und Verfahren zur Bestimmung von HCV |
| ATE551423T1 (de) | 1993-04-27 | 2012-04-15 | Innogenetics Nv | Sequenzen von hepatitis c virus-genotypen sowie ihre verwendungen als therapeutika und diagnostika |
| US7255997B1 (en) | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
| ES2232815T5 (es) | 1993-05-10 | 2009-06-15 | Novartis Vaccines And Diagnostics, Inc. | Metodos de tipado del virus de la hepatitis c y reactivos para usar en los mismos. |
| DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
| US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
| EP0729973A4 (de) * | 1993-10-29 | 1998-12-30 | Srl Inc | Eine antigene peptidverbindung und ein immunoassay-verfahren |
| PT992580E (pt) * | 1993-11-04 | 2005-07-29 | Innogenetics Nv | Epitopos para celulas t humanas imunodominantes do virus da hepatite c |
| US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| DE69526973T3 (de) * | 1994-10-21 | 2010-01-07 | Innogenetics N.V. | Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel |
| GB2294690B (en) * | 1994-11-01 | 1998-10-28 | United Biomedical Inc | Peptides effective for diagnosis and detection of hepatitis C infection |
| JPH08333390A (ja) * | 1995-04-07 | 1996-12-17 | Hoechst Japan Ltd | ペプチド及びそれからなる自己免疫疾患治療剤 |
| US6034064A (en) * | 1995-04-07 | 2000-03-07 | Hoechst Pharmaceuticals & Chemicals K.K. | Peptides and therapeutic agent for autoimmune diseases containing the same |
| EP0829488A4 (de) * | 1995-04-28 | 1999-04-07 | Srl Inc | Antigene peptidsubstanz und immotestverfahren |
| GB9513261D0 (en) * | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| JP3945822B2 (ja) * | 1996-05-24 | 2007-07-18 | カイロン コーポレイション | 複数エピトープ融合タンパク質 |
| US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
| US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
| US6696545B1 (en) * | 1997-04-11 | 2004-02-24 | Sangstat Medical Corporation | Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation |
| WO1999015901A1 (en) | 1997-09-22 | 1999-04-01 | Chiron Corporation | Buffers for stabilizing antigens |
| CZ298268B6 (cs) * | 1998-04-17 | 2007-08-08 | Innogenetics N. V. | Imunodiagnostický test používající redukující cinidla |
| US7052830B1 (en) * | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
| US7052696B2 (en) * | 1998-07-10 | 2006-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins |
| US6191256B1 (en) * | 1998-11-20 | 2001-02-20 | Bayer Corporation | Recombinant factor VIII binding peptides |
| WO2001021189A1 (en) * | 1999-07-19 | 2001-03-29 | Epimmune Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| SK287694B6 (sk) | 2000-06-15 | 2011-06-06 | Novartis Vaccines & Diagnostics, Inc. | Pevný nosič imunoeseje a spôsob jeho prípravy, spôsob detekcie infekcie HIV a súprava na imunodiagnostickú skúšku |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| AU2001292151B2 (en) | 2000-08-17 | 2006-05-04 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
| JP4261195B2 (ja) | 2001-04-24 | 2009-04-30 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 酵母のコア−グリコシル化されたhcvエンベロープタンパク質の発現 |
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| US7196183B2 (en) | 2001-08-31 | 2007-03-27 | Innogenetics N.V. | Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent |
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| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| US7332269B2 (en) * | 2001-11-11 | 2008-02-19 | Ortho-Clinical Diagnostics, Inc. | HCV core protein sequences |
| CN1659436A (zh) * | 2002-02-28 | 2005-08-24 | 英特塞尔股份公司 | 分离配体的方法 |
| DE60326327D1 (de) * | 2002-03-11 | 2009-04-09 | Lab 21 Ltd | Verfahren und zusammensetzungen zur identifikation und charakterisierung von hepatitis c |
| WO2004041842A2 (en) * | 2002-05-16 | 2004-05-21 | The General Hospital Corporation | Epitopes of hepatitis c virus |
| FR2839722A1 (fr) * | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
| CA2484941A1 (en) * | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| US7166426B2 (en) | 2002-09-09 | 2007-01-23 | Novartis Vaccines And Diagnostics, Inc. | HCV assay |
| WO2004024182A2 (en) | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| EP1601770B1 (de) * | 2003-03-04 | 2009-09-02 | Intercell AG | Streptococcus pyogenes antigene |
| CN100355453C (zh) * | 2003-03-24 | 2007-12-19 | 英特塞尔股份公司 | 改进的疫苗 |
| ES2562456T3 (es) | 2003-03-24 | 2016-03-04 | Valneva Austria Gmbh | Uso de un adyuvante que induce una respuesta inmune Th1 para mejorar las respuestas inmunes |
| EP2333114A1 (de) | 2003-04-15 | 2011-06-15 | Intercell AG | S. pneumoniae Antigene |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| CA2530062A1 (en) * | 2003-07-11 | 2005-01-20 | Intercell Ag | Hcv vaccines |
| WO2005010035A2 (en) * | 2003-07-22 | 2005-02-03 | Branch Andrea D | Alternate reading frame polypeptides derived from hepatitis c and methods of their use |
| ES2596753T3 (es) | 2003-08-29 | 2017-01-11 | Fujirebio Europe N.V. | Nuevo clado del virus de la hepatitis C y secuencias prototipo del mismo |
| FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| RU2365624C2 (ru) * | 2003-10-27 | 2009-08-27 | Вертекс Фармасьютикалз Инкорпорейтед | Резистентные мутанты протеазы ns3-ns4a hcv |
| EP1735336A2 (de) * | 2004-04-16 | 2006-12-27 | Genentech, Inc. | Omi pdz-modulatoren |
| ATE542140T1 (de) * | 2004-08-27 | 2012-02-15 | Novartis Vaccines & Diagnostic | Nichtstrukturelle hcv-proteinmutanten und verwendungsmöglichkeiten dafür |
| DE602006014126D1 (de) | 2005-04-20 | 2010-06-17 | Viromed Co Ltd | Zusammensetzungen und verfahren zur trennung von fusionsproteinen |
| WO2007031867A2 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-stru tural ns3/4a fusion gene |
| WO2008024518A2 (en) | 2006-08-25 | 2008-02-28 | Novartis Ag | Hcv fusion polypeptides |
| JP4975600B2 (ja) * | 2007-03-16 | 2012-07-11 | シスメックス株式会社 | Hcv抗体測定用試薬キット及びhcv抗体測定方法 |
| WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| EP2244695A1 (de) | 2007-12-07 | 2010-11-03 | Novartis AG | Zusammensetzungen zur induktion von immunantworten |
| WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| RU2649133C2 (ru) | 2011-07-06 | 2018-03-29 | Новартис Аг | Катионные эмульсии масло-в-воде |
| AU2012280901B2 (en) | 2011-07-06 | 2016-11-10 | Glaxosmithkline Biologicals S.A. | Oil-in-water emulsions that contain nucleic acids |
| FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
| WO2013150450A1 (en) * | 2012-04-02 | 2013-10-10 | Universidade Do Porto | Hcv homolog fragments, cell-lines and applications thereof |
| CN105378099B (zh) | 2013-03-14 | 2021-05-11 | 雅培制药有限公司 | Hcv核心脂质结合结构域单克隆抗体 |
| JP6505076B2 (ja) | 2013-03-14 | 2019-04-24 | アボット・ラボラトリーズAbbott Laboratories | Hcv抗原−抗体組み合わせアッセイおよびこれに使用するための方法および組成物 |
| EP2970947A4 (de) | 2013-03-14 | 2016-10-12 | Abbott Lab | Rekombinante hcv-ns3-antigene und mutanten für den verbesserten nachweis von antikörpern |
| EP3274478B1 (de) | 2015-03-27 | 2020-09-23 | Ortho-Clinical Diagnostics, Inc. | Hcv-ns4a/modifizierte ns3-polypeptide und verwendungen davon |
| CN111153963B (zh) * | 2020-01-19 | 2021-08-10 | 华南理工大学 | 抗炎五肽及其提取分离方法和在改善记忆中的应用 |
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